EP0423236A4 - Peptides with extraordinary opioid receptor selectivity - Google Patents

Peptides with extraordinary opioid receptor selectivity

Info

Publication number
EP0423236A4
EP0423236A4 EP19890908922 EP89908922A EP0423236A4 EP 0423236 A4 EP0423236 A4 EP 0423236A4 EP 19890908922 EP19890908922 EP 19890908922 EP 89908922 A EP89908922 A EP 89908922A EP 0423236 A4 EP0423236 A4 EP 0423236A4
Authority
EP
European Patent Office
Prior art keywords
extraordinary
peptides
opioid receptor
receptor selectivity
selectivity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19890908922
Other languages
English (en)
Other versions
EP0423236A1 (de
Inventor
Victor Joseph Hruby
Geza Toth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Publication of EP0423236A1 publication Critical patent/EP0423236A1/de
Publication of EP0423236A4 publication Critical patent/EP0423236A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP19890908922 1988-07-06 1989-07-06 Peptides with extraordinary opioid receptor selectivity Ceased EP0423236A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21674588A 1988-07-06 1988-07-06
US216745 1988-07-06

Publications (2)

Publication Number Publication Date
EP0423236A1 EP0423236A1 (de) 1991-04-24
EP0423236A4 true EP0423236A4 (en) 1991-09-25

Family

ID=22808339

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890908922 Ceased EP0423236A4 (en) 1988-07-06 1989-07-06 Peptides with extraordinary opioid receptor selectivity

Country Status (3)

Country Link
EP (1) EP0423236A4 (de)
JP (1) JPH03505734A (de)
WO (1) WO1990000564A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009051A1 (en) * 1989-12-15 1991-06-27 G.D. Searle & Co. Substituted cyclic penicillanic acid tetrapeptides
US5216124A (en) * 1989-12-15 1993-06-01 G. D. Searle & Co. Substituted cyclic tetrapeptides
US5169833A (en) * 1989-12-15 1992-12-08 G. D. Searle & Co. Substituted cyclic pentapeptides
FR2697850B1 (fr) * 1992-11-10 1994-12-02 Univ Pasteur Nouveaux polypeptides ayant une activité de récepteur opioïde, acides nucléiques codant pour ces polypeptides et utilisations.
US5780589A (en) * 1994-11-30 1998-07-14 The United States Of America As Represented By The Department Of Health And Human Services Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof
US8338565B2 (en) 2008-08-20 2012-12-25 Ensemble Therapeutics Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148786A (en) * 1978-06-26 1979-04-10 American Home Products Corporation Analgesic polypeptide
US4304715A (en) * 1979-06-08 1981-12-08 Derek Hudson Enkephalin analogues
US4518711A (en) * 1983-05-16 1985-05-21 Gibson-Stephens Institute Conformationally constrained cyclic enkephalin analogs with delta receptor specificity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Peptides, Proc. 9th American Peptide Symposium, 1985, pages 496-497; Ed. C.M. DEBER et al.; Pierce Chemical Company, P.D. GESELLCHEN et al.: "Opioid receptor binding affinity and efficacy of metkephamid analogs modified at the phenylalanine residue", the whole document. *
See also references of WO9000564A1 *

Also Published As

Publication number Publication date
WO1990000564A1 (en) 1990-01-25
JPH03505734A (ja) 1991-12-12
EP0423236A1 (de) 1991-04-24

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Legal Events

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