EP0401445B1 - Préparation aqueuse à base de sels minéraux et d'acide acétique pour la prévention et le traitement des maladies virales - Google Patents
Préparation aqueuse à base de sels minéraux et d'acide acétique pour la prévention et le traitement des maladies virales Download PDFInfo
- Publication number
- EP0401445B1 EP0401445B1 EP89401487A EP89401487A EP0401445B1 EP 0401445 B1 EP0401445 B1 EP 0401445B1 EP 89401487 A EP89401487 A EP 89401487A EP 89401487 A EP89401487 A EP 89401487A EP 0401445 B1 EP0401445 B1 EP 0401445B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- fact
- process according
- hydrous solution
- solution
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title claims description 12
- 150000003839 salts Chemical class 0.000 title claims description 5
- 201000010099 disease Diseases 0.000 title description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 3
- 230000002265 prevention Effects 0.000 title description 3
- 230000003612 virological effect Effects 0.000 title description 3
- 238000002360 preparation method Methods 0.000 title description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims description 2
- 229910052796 boron Inorganic materials 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 239000000460 chlorine Substances 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 150000002823 nitrates Chemical class 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 235000021317 phosphate Nutrition 0.000 claims description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000013535 sea water Substances 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229910052712 strontium Inorganic materials 0.000 claims description 2
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 2
- 239000000052 vinegar Substances 0.000 claims description 2
- 235000021419 vinegar Nutrition 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 6
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 235000019270 ammonium chloride Nutrition 0.000 claims 1
- 230000003139 buffering effect Effects 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- -1 potassium cations Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
Definitions
- the present invention provides, for the prevention and treatment of viral diseases, an aqueous solution containing, on the one hand, from 15 to 20 g / l of a mixture of salts formed from the sodium, magnesium, calcium, potassium cations , strontium and boron and anions of chlorine, sulphate, carbonate and bicarbonate and, on the other hand, from 3 to 4% of acetic acid, and its preparation process.
- acetic acid can also give salts with the aforementioned alkali and alkaline earth metals.
- the aqueous solution also contains nitrogenous mineral compounds chosen from nitrites, nitrates and ammoniacal salts.
- the aqueous solution also contains phosphates and silica.
- the aqueous solution is prepared from seawater and white vinegar, raw materials which provide the various constituents desired for the solution.
- the resulting solution is sterilized by cold filtration on a porous candle.
- the solution according to the invention can be administered parenterally, in particular by intravenous or intramuscular injection, in which case it will be suitably buffered and / or diluted to be isotonic with blood plasma.
- the solution can also be administered as an intestinal enema.
- the resulting drug is suitable for the prevention and treatment of viral diseases, including AIDS.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89401487A EP0401445B1 (fr) | 1989-05-31 | 1989-05-31 | Préparation aqueuse à base de sels minéraux et d'acide acétique pour la prévention et le traitement des maladies virales |
| ES89401487T ES2052040T3 (es) | 1989-05-31 | 1989-05-31 | Preparacion acuosa a base de sales minerales y de acido acetico para la prevencion y el tratamiento de enfermedades virales. |
| GR920400444T GR3004056T3 (enrdf_load_stackoverflow) | 1989-05-31 | 1992-03-17 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89401487A EP0401445B1 (fr) | 1989-05-31 | 1989-05-31 | Préparation aqueuse à base de sels minéraux et d'acide acétique pour la prévention et le traitement des maladies virales |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0401445A1 EP0401445A1 (fr) | 1990-12-12 |
| EP0401445B1 true EP0401445B1 (fr) | 1991-12-18 |
Family
ID=8202952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP89401487A Expired - Lifetime EP0401445B1 (fr) | 1989-05-31 | 1989-05-31 | Préparation aqueuse à base de sels minéraux et d'acide acétique pour la prévention et le traitement des maladies virales |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0401445B1 (enrdf_load_stackoverflow) |
| ES (1) | ES2052040T3 (enrdf_load_stackoverflow) |
| GR (1) | GR3004056T3 (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999048505A1 (es) * | 1998-03-26 | 1999-09-30 | Pedro Fernandez De Haro | Composicion farmacologica a base de minerales |
| FR2926465B1 (fr) * | 2008-01-17 | 2016-08-12 | Alix Roland Commin | Composition anti-virale notamment le sida |
| WO2011010000A1 (fr) * | 2009-07-22 | 2011-01-27 | Alix Roland Commin | Composition antivirale et retrovirale notamment pour le traitement du sida |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3676553A (en) * | 1969-12-15 | 1972-07-11 | Cybersol | Therapeutic composition |
| FR2108935A1 (en) * | 1970-10-21 | 1972-05-26 | Destal Guyonnaud Michele | Sterile,diluted seawater - specific isotonic solns for treating haemorrhage,shock,diarrhoea in man and animals |
| FR2625679B1 (fr) * | 1988-01-08 | 1990-02-09 | Commin Alix | Preparation aqueuse a base de sels mineraux et d'acide acetique pour la prevention et le traitement des maladies virales |
-
1989
- 1989-05-31 ES ES89401487T patent/ES2052040T3/es not_active Expired - Lifetime
- 1989-05-31 EP EP89401487A patent/EP0401445B1/fr not_active Expired - Lifetime
-
1992
- 1992-03-17 GR GR920400444T patent/GR3004056T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0401445A1 (fr) | 1990-12-12 |
| GR3004056T3 (enrdf_load_stackoverflow) | 1993-03-31 |
| ES2052040T3 (es) | 1994-07-01 |
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