EP0399972B1 - Rührer zur aseptischen Verwendung - Google Patents

Rührer zur aseptischen Verwendung Download PDF

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Publication number
EP0399972B1
EP0399972B1 EP90850180A EP90850180A EP0399972B1 EP 0399972 B1 EP0399972 B1 EP 0399972B1 EP 90850180 A EP90850180 A EP 90850180A EP 90850180 A EP90850180 A EP 90850180A EP 0399972 B1 EP0399972 B1 EP 0399972B1
Authority
EP
European Patent Office
Prior art keywords
impeller
vessel
blade
rotation
cylindrical recess
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP90850180A
Other languages
English (en)
French (fr)
Other versions
EP0399972A1 (de
Inventor
Nils Arthun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
roplan International AB
Roplan International AB
Original Assignee
Steridose Systems AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20376064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0399972(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Steridose Systems AB filed Critical Steridose Systems AB
Publication of EP0399972A1 publication Critical patent/EP0399972A1/de
Application granted granted Critical
Publication of EP0399972B1 publication Critical patent/EP0399972B1/de
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4535—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using a stud for supporting the stirring element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
    • B01F35/41—Mounting or supporting stirrer shafts or stirrer units on receptacles
    • B01F35/411—Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting only one extremity of the shaft
    • B01F35/4112—Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting only one extremity of the shaft at the bottom of the receptacle, e.g. by studs

Definitions

  • the present invention relates to an impeller for aseptic purposes, rotatable by inductive drive means in a predetermined direction within a vessel for stirring and mixing sterile fluids, comprising a plurality of radially extending stirring blades located on an outer surface of the impeller and bearing means on an inner surface of said impeller for rotatably mounting the impeller on the vessel wall.
  • the object of the invention is thus to provide an impeller with a considerably greater self-cleaning capability so that sterilization with steam or other fluids can occur in a considerably shorter time.
  • an impeller which is characterized by through-flow passages which outwardly extend from the inside of the impeller in a direction away from the axis of rotation, to orifices situated on the outer surfaces of the impeller immediately adjacent and behind each blade, seen in said direction of rotation, so that cleaning fluid can be sucked through the passages due to the low pressure region occurring behind each blade.
  • the bearing means includes a stub-axle centrally locatable on an end wall of an inwardly extending cylindrical recess in the vessel's bottom wall.
  • the cylindrical recess is appropriately surrounded by a peripheral section having a particular small clearance which permits the flow of cleaning fluid between the cylindrical recess and the peripheral section of the impeller.
  • the impeller 10 shown in the drawing is located in a mixing vessel whose bottom wall 11 is shown in figure 2.
  • the vessel is intended for use in a large process plant, for example for preparation of medicaments, and is provided with a number of inlets, outlets and regulating valves.
  • Various sterile fluids are delivered to the vessel where they are mixed together by means of the impeller 10, after which the resulting mixture is drawn from the vessel.
  • the bearing- and drive means of the impeller are shown in figure 2 and include an inwardly-directed cylindrical recess 12 in the vessel wall 11, the recess being welded in such a way that no opening or inlets occur in this section of the tank wall.
  • the impeller 10 is rotatably supported by means of a bush 10a on a stub axle 13 which is centrally located on an end wall 14, which demarcates the cylindrical recess 12.
  • the impeller 10 is, like the vessel 11, principally manufactured from acidproof stainless steel, with a number of angled blades 15 and a central lifting ring 16.
  • the impeller presents a peripheral section 17 which surrounds the cylindrical recess 12 and contains a number of permanent magnets 18 which are inductively connected to a corresponding number of permanent magnets 19 which are located in a rotor 20.
  • This rotor is arranged to be driven in the direction of arrow 21 (see figure 1) by a (not shown) conventional electric motor, whereby the impeller 10 surrounding the recess is caused to rotate.
  • the impeller is provided with through-flow passages 22,23, which extend from within the impeller 10 in a direction away from the axis of rotation 24 to orifices 25 resp. 26, situated on the outer surface of the impeller immediately adjacent and behind each blade 15, seen in said direction of rotation.
  • through-flow passages 22,23 which extend from within the impeller 10 in a direction away from the axis of rotation 24 to orifices 25 resp. 26, situated on the outer surface of the impeller immediately adjacent and behind each blade 15, seen in said direction of rotation.
  • the invention is not restricted to above described example, but may be varied within the scope of the following claims.
  • the passages and the orifices can be greater or fewer in number.
  • the device for driving the impeller can be differently designed.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Food-Manufacturing Devices (AREA)
  • Materials For Medical Uses (AREA)
  • Thermally Insulated Containers For Foods (AREA)
  • Prostheses (AREA)
  • Accessories For Mixers (AREA)

Claims (3)

  1. Rührer für aseptischen Gebrauch, der in einem Gefäß (11) zum Rühren und Mischen von sterilen Fluiden durch induktive Antriebsmittel (20) in einer vorbestimmten Richtung drehbar ist, und eine Mehrzahl von auf einer äußeren Oberfläche (10) des Rührers angebrachten, sich radial erstreckenden Rührblättern (15) sowie Lagermittel (10a, 13) zum drehbaren Befestigen des Rührers an der Gefäßwand auf einer inneren Oberfläche des Rührers umfaßt, gekennzeichnet durch Durchströmkanäle (22, 23), die sich von der Innenseite des Rührers (10) in einer von der Rotationsachse (24) weg weisenden Richtung zu auf der äußeren Oberfläche des Rührers unmittelbar anschließend an und, in Rotationsrichtung gesehen, hinter jedem Blatt (15) angeordneten Öffnungen (25, 26) hin erstrecken, so daß wegen des hinter jedem Blatt auftretenden Unterdruckbereichs Reinigungsfluid durch die Kanäle (22, 23) gesaugt werden kann.
  2. Rührer nach Anspruch 1, dadurch gekennzeichnet, daß die Lagermittel eine Stummelachse (13) umfassen, die mittig auf einer Endwand (14) eines sich nach innen erstreckenden zylindrischen Rücksprungs (12) in der unteren Gefäßwand (11 ) gelagert werden kann.
  3. Rührer nach Anspruch 2, dadurch gekennzeichnet, daß ein peripheren Abschnitt (17) den zylindrischen Rücksprung mit besonders kleinem Spiel umgeben kann, was das Strömen von Reinigungsfluid zwischen dem zylindrischen Rücksprung (12) und dem peripheren Abschnitt (17) des Rührers erlaubt.
EP90850180A 1989-05-26 1990-05-17 Rührer zur aseptischen Verwendung Expired - Lifetime EP0399972B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8901877 1989-05-26
SE8901877A SE463750B (sv) 1989-05-26 1989-05-26 Omroerare foer aseptiska aendamaal, vilken aer vridbar i en foerutbestaemd rotationsriktning genom induktiva drivorgan inuti en tank

Publications (2)

Publication Number Publication Date
EP0399972A1 EP0399972A1 (de) 1990-11-28
EP0399972B1 true EP0399972B1 (de) 1993-04-21

Family

ID=20376064

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90850180A Expired - Lifetime EP0399972B1 (de) 1989-05-26 1990-05-17 Rührer zur aseptischen Verwendung

Country Status (8)

Country Link
EP (1) EP0399972B1 (de)
AT (1) ATE88374T1 (de)
DE (1) DE69001388T2 (de)
DK (1) DK0399972T3 (de)
ES (1) ES2041522T3 (de)
FI (1) FI92475C (de)
NO (1) NO169326C (de)
SE (1) SE463750B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220023810A1 (en) * 2018-11-29 2022-01-27 Alfa Laval Corporate Ab Magnetically-coupled liquid mixer

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5533803A (en) * 1992-10-01 1996-07-09 Mavag Verfahrenstechnik Ag Magnetic stirring apparatus with contactless coupling between stirring shaft and stirring tool
DE4232934C2 (de) * 1992-10-01 1996-03-28 Mavag Verfahrenstech Ag Doppel-Impeller zum Rühren von sterilen Flüssigkeiten
DE4232936C2 (de) * 1992-10-01 1996-03-28 Mavag Verfahrenstech Ag Impeller zum Rühren von sterilen Flüssigkeiten
US5758965A (en) * 1996-12-05 1998-06-02 General Signal Corporation Mixer system
US5779359A (en) * 1996-12-05 1998-07-14 General Signal Corporation Mixer having exposed clean-in-place bearing assemblies
FR2788995B1 (fr) * 1999-01-28 2001-04-06 Mixel Agitateur a entrainement magnetique et procede du reglage du couple limite de transmission d'effort d'un tel agitateur
FR2779361B1 (fr) * 1998-06-05 2000-07-28 Mixel Agitateur a entrainement magnetique
CN100340329C (zh) * 2004-10-29 2007-10-03 中国石油化工股份有限公司 自引气式气液混合叶轮
US7396153B2 (en) * 2005-04-05 2008-07-08 Andersson Per-Olof K Ultraclean magnetic mixer
DE502006008592D1 (de) 2005-07-29 2011-02-10 Zeta Biopharma Gmbh Magnetrührer
WO2008088371A2 (en) 2006-06-16 2008-07-24 Xcellerex, Inc. Gas delivery configurations, foam control systems, and bag molding methods and articles for collapsible bag vessels and bioreactors
AT518668B1 (de) * 2017-01-25 2017-12-15 Zeta Biopharma Gmbh Rührwerk für einen Rührbehälter
CN111167295A (zh) * 2020-01-15 2020-05-19 邓智超 一种地下工程施工用酸性气体净化装置
CN116510596B (zh) * 2023-06-29 2023-09-29 中科圣杰(深圳)科技集团有限公司 一种无菌投料工作站

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138167A (en) * 1963-06-18 1964-06-23 Sprout Waldron & Co Inc Mixer for feeds and the like
NL7503044A (nl) * 1974-03-21 1975-09-23 Raess Paul Beluchtingsschroef.
DE3046542A1 (de) * 1980-12-10 1982-07-22 Friedrich Walter Dr. 5982 Neuenrade Herfeld Mischvorrichtung und verfahren zum reinigen derselben
SE445712B (sv) * 1983-12-08 1986-07-14 Boliden Ab Forfarande for distribution av en vattenreningskemikalie samt anordning for genomforande av forfarandet

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220023810A1 (en) * 2018-11-29 2022-01-27 Alfa Laval Corporate Ab Magnetically-coupled liquid mixer

Also Published As

Publication number Publication date
FI92475C (fi) 1994-11-25
SE8901877L (sv) 1990-11-27
ES2041522T3 (es) 1993-11-16
SE8901877D0 (sv) 1989-05-26
NO169326B (no) 1992-03-02
ATE88374T1 (de) 1993-05-15
SE463750B (sv) 1991-01-21
DK0399972T3 (da) 1993-08-09
FI902451A0 (fi) 1990-05-17
DE69001388D1 (de) 1993-05-27
EP0399972A1 (de) 1990-11-28
NO902321D0 (no) 1990-05-25
FI92475B (fi) 1994-08-15
NO169326C (no) 1992-06-10
NO902321L (no) 1990-11-27
DE69001388T2 (de) 1993-10-21

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