EP0378644A1 - Ethanol und glycerolmonooleat enthaltende permeabilitätserhöher - Google Patents

Ethanol und glycerolmonooleat enthaltende permeabilitätserhöher

Info

Publication number
EP0378644A1
EP0378644A1 EP19890907548 EP89907548A EP0378644A1 EP 0378644 A1 EP0378644 A1 EP 0378644A1 EP 19890907548 EP19890907548 EP 19890907548 EP 89907548 A EP89907548 A EP 89907548A EP 0378644 A1 EP0378644 A1 EP 0378644A1
Authority
EP
European Patent Office
Prior art keywords
ethanol
drug
skin
gmo
rate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19890907548
Other languages
English (en)
French (fr)
Inventor
Juan M. E. Harrison
Eun Soo Lee
Su Il Yum
Felix Theeuwes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of EP0378644A1 publication Critical patent/EP0378644A1/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Definitions

  • This invention relates to the transdermal delivery of drugs and other biologically active agents. More particularly, this invention relates to novel methods and compositions for enhancing the percutaneous absorption of drugs when incorporated in transdermal drug delivery systems. Still more particularly, but without limitation thereto, this invention relates to the transdermal delivery of drugs utilizing a mixture of glycerol monooleate (GMO) and ethanol .
  • GMO glycerol monooleate
  • FIGURE 4 illustrates still another embodiment of the invention, system 54, where the drug, GMO and ethanol are incorporated into a common reservoir 56.
  • system 54 is comprised of an impermeable backing 58, an in-line contact adhesive 60 and a strippable release liner 62.
  • System 54 is preferably heat sealed around its periphery, as illustrated by line 64. In this embodiment, the rate controlling membrane has been omitted.
  • the flux was also measured with 20/80, 40/60 and 60/40 ethanol/GMO ratios. It was found that the hydrocortisone flux from the ethanol/GMO compositions increased as the amount of ethanol increased. Additionally, the effect of the inclusion of water in the donor composition was also studied. Lower hydrocortisone fluxes were observed when the donor compositions had separated into two phases. On the other hand, water content did not significantly affect the drug flux from single phase donor compositions.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
EP19890907548 1988-06-09 1989-06-08 Ethanol und glycerolmonooleat enthaltende permeabilitätserhöher Ceased EP0378644A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20480888A 1988-06-09 1988-06-09
US204808 1988-06-09

Publications (1)

Publication Number Publication Date
EP0378644A1 true EP0378644A1 (de) 1990-07-25

Family

ID=22759518

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890907548 Ceased EP0378644A1 (de) 1988-06-09 1989-06-08 Ethanol und glycerolmonooleat enthaltende permeabilitätserhöher

Country Status (7)

Country Link
EP (1) EP0378644A1 (de)
JP (1) JPH03501386A (de)
AU (1) AU611307B2 (de)
DK (1) DK33590A (de)
FI (1) FI900636A0 (de)
PT (1) PT90784A (de)
WO (1) WO1989011872A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8804214L (sv) * 1988-11-22 1990-05-23 Jean Cassuto Antiinflammatoriskt och antiinfektioest medikament
JP2849950B2 (ja) * 1990-11-30 1999-01-27 日東電工株式会社 経皮吸収製剤
JP2001503035A (ja) * 1996-10-14 2001-03-06 興和株式会社 外用局所麻酔剤
US20060238702A1 (en) 1999-04-30 2006-10-26 Advanced Medical Optics, Inc. Ophthalmic lens combinations
US7763069B2 (en) 2002-01-14 2010-07-27 Abbott Medical Optics Inc. Accommodating intraocular lens with outer support structure
US7662180B2 (en) 2002-12-05 2010-02-16 Abbott Medical Optics Inc. Accommodating intraocular lens and method of manufacture thereof
US20080161914A1 (en) 2006-12-29 2008-07-03 Advanced Medical Optics, Inc. Pre-stressed haptic for accommodating intraocular lens
US8034108B2 (en) 2008-03-28 2011-10-11 Abbott Medical Optics Inc. Intraocular lens having a haptic that includes a cap
WO2010151693A2 (en) 2009-06-26 2010-12-29 Abbott Medical Optics Inc. Accommodating intraocular lenses
AU2010279561B2 (en) 2009-08-03 2014-11-27 Johnson & Johnson Surgical Vision, Inc. Intraocular lens for providing accomodative vision
US20170273974A1 (en) 2016-03-24 2017-09-28 Medrx Co., Ltd Patch preparations with misuse prevention features
JPWO2017164084A1 (ja) * 2016-03-24 2019-02-07 株式会社 メドレックス 誤用防止特性を有する貼付製剤
EP3681438A1 (de) 2017-09-11 2020-07-22 AMO Groningen B.V. Verfahren und vorrichtungen zur erhöhung der positionsstabilität von intraokularlinsen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335115A (en) * 1976-11-01 1982-06-15 The Procter & Gamble Company Anti-acne composition
DE3779999T2 (de) * 1986-11-14 1992-12-10 Theratech Inc Erhoehung des penetrationsvermoegens mittels eines aus die zellhuelle veraendernden substanzen und kurzkettigen alkoholen bestehenden binaeren systems.
US4764379A (en) * 1987-08-24 1988-08-16 Alza Corporation Transdermal drug delivery device with dual permeation enhancers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8911872A1 *

Also Published As

Publication number Publication date
JPH03501386A (ja) 1991-03-28
DK33590D0 (da) 1990-02-08
AU3771689A (en) 1990-01-05
DK33590A (da) 1990-02-08
AU611307B2 (en) 1991-06-06
PT90784A (pt) 1989-12-29
FI900636A0 (fi) 1990-02-08
WO1989011872A1 (en) 1989-12-14

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19900227

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Effective date: 19910905

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18R Application refused

Effective date: 19930502