EP0370097A1 - Matiere therapeutique destinee a recouvrir des blessure et des lesions cutanees et son procede de preparation - Google Patents

Matiere therapeutique destinee a recouvrir des blessure et des lesions cutanees et son procede de preparation

Info

Publication number
EP0370097A1
EP0370097A1 EP89906189A EP89906189A EP0370097A1 EP 0370097 A1 EP0370097 A1 EP 0370097A1 EP 89906189 A EP89906189 A EP 89906189A EP 89906189 A EP89906189 A EP 89906189A EP 0370097 A1 EP0370097 A1 EP 0370097A1
Authority
EP
European Patent Office
Prior art keywords
oil
emulsion
biologically active
therapeutical
skin lesions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP89906189A
Other languages
German (de)
English (en)
Inventor
Zoltán KALISZKY
Istvan Czappan
Gizella Miholics
Marta Kovacs
Gyula Sebestyen
Anna Zavodszkyne Szabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Licencia Talalmanyokat Ertekesito Es Innovacios Kuelkereskedelmi Vallalat
Licencia Talalmanyokat Ertekesito Vallalat
Original Assignee
Licencia Talalmanyokat Ertekesito Es Innovacios Kuelkereskedelmi Vallalat
Licencia Talalmanyokat Ertekesito Vallalat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Licencia Talalmanyokat Ertekesito Es Innovacios Kuelkereskedelmi Vallalat, Licencia Talalmanyokat Ertekesito Vallalat filed Critical Licencia Talalmanyokat Ertekesito Es Innovacios Kuelkereskedelmi Vallalat
Publication of EP0370097A1 publication Critical patent/EP0370097A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01008—Non-adhesive bandages or dressings characterised by the material
    • A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00157—Wound bandages for burns or skin transplants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00365—Plasters use
    • A61F2013/00519—Plasters use for treating burn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Definitions

  • the invention relates to therapeutic material for covering wounds and skin lesions and for the process for the preparation thereof.
  • the secretion dries in the conventional gauze layer, it forms a solid surface, not permeable to the secretion; - the quantity of the optionally used biologically active materials is not optimal owing to the mode of application;
  • the aim of our invention is to provide a therapeutic material for covering wounds and skin. lesions, which
  • any biologically active material i.e. with water soluble, oil soluble or fat soluble active ingredients if desired, and so an optimal active ingredient level can be ensured on the surface to be treated;
  • - is storable in sterile form for a long time and can be simply used at any time.
  • a carrier suitable for covering wounds and skin lesions, is laminated or impregnated with an emulsion prepared of the mixture of different polyoxyethylene glycols and an oil in the presence of emulsifying agent(s) of o/w type, having particularly high HLB value (e.g. HLB >10) and admixed optionally with an effective amount of a biologically active material, the desired aim can be achieved.
  • said solution enables the controlled administration and release of the optionally used active ingredient too.
  • the present invention relates to a therapeutic material for covering wounds and skin lesions which comprises a) a carrier made of textile or paper material or synthetic fibre, laminated or impregnated with b) an emulsion having the following composition: propylene glycol 0-20% by weight polyoxyethylene glycols 5-95% " oil 10-25% " emulsifying agent 5-20% " which is optionally admixed with c) an effective amount of biologically active ingredient, selected from antibiotics, antiseptics, desinfectants, antimycotics, biologically active vegetable extracts and dermatologica.
  • a carrier made of textile or paper material or synthetic fibre, laminated or impregnated with b) an emulsion having the following composition: propylene glycol 0-20% by weight polyoxyethylene glycols 5-95% " oil 10-25% " emulsifying agent 5-20% " which is optionally admixed with c) an effective amount of biologically active ingredient, selected from antibiotics, antiseptics, desinfectants,
  • the therapeutic material for covering wounds and skin lesions according to the invention may be prepared by producing an emulsion from the ingredients listed in point b) by method per se by optionally admixing the emulsion obtained with an effective amount of biologically active material according to point c), then impregnating the carrier according to point a) with said mixture, thereafter packing the product obtained and optionally sterilizing.
  • woven textile materials of different density prepared of twisted or monofilament yarn, (e.g. gauze or loose fabrics), or materials without weaving, (e.g. veil fabrics), paper sheets, viscose sheets both optionally perforated or nets and/or foils made of synthetic materials, may be used.
  • the oil phase may be any known oil generally used for injection preparations, for example vegetable oils (e.g. sunflower oil, olive oil, peanut oil, linseed oil, castor oil, etc.), animal oils (e.g. fish oil), mineral oils (e.g. paraffin oil), synthetic oils (e.g. silicone oil, types Myritol, Levitol, etc.).
  • vegetable oils e.g. sunflower oil, olive oil, peanut oil, linseed oil, castor oil, etc.
  • animal oils e.g. fish oil
  • mineral oils e.g. paraffin oil
  • synthetic oils e.g. silicone oil, types Myritol, Levitol, etc.
  • ionic or non-ionic emulsifying agents of a high HLB value may be used, e.g. esters of ethoxylated fatty alcohols, ester prepared from polyhydric alcohols and fatty acids, ethoxylated dianhydrosorbitol-stearates, ethylene oxide adducts, e.g. fatty acid-polyethylene glycols esters, fatty alcohol-ethylene oxide adducts, etc.
  • the emulsion of o/w type used in the therapeutic material for covering wounds and skin lesions according to the invention makes it possible that optionally any kind of biologically active material, i.e. material being soluble in water, oil or fat, may be admixed with the composition and so the active material may be administered simply to the surface to be treated in an optimal, predetermined amount and the treatment may be carried out by non--qualified persons too.
  • any kind of biologically active material i.e. material being soluble in water, oil or fat
  • the product according to the invention may be produced in any size and shape as required, so. e.g. sheets of 13x8cm, 5x6cm and 8x15cm can be prepared.
  • the sheets obtained are placed onto cardboard or polymer sheets and packed by covering with metal or polymer foil and sterilized if desired.
  • the products thus obtained form sterile, closed, easy to handle units.
  • the products according to the invention are well suitable for treating burn wounds, ulcus crusis, surfacial wounds with purulent discharge and different oozing skin lesions, for covering wounds after plastic operations, for use in ambulatory treatments, in first--aid sets and everywhere where the presence of wound-treating materials is permanently needed, so e.g. in army, on ships or traumatology etc.
  • the sterility of the impregnated gauze sheets to be used was checked in the following way: the gauze sheets, having been welded around with PE foil, were sterilized under aseptic conditions in steril box, thereafter cut into pieces of about 1/2cm 2 by the use of sterile scissors and forceps, thereafter these pieces of gauze were inoculated into sterile liquid soya-casein and Sabouraud culture media. The cultures obtained were incubated at 32°C and 26°C for one week. Thereafter they were evaluated visually and it was found that all gauze sheets were sterile. 2) Microbiological stability test
  • the material serving for impregnation (e.g. any of the emulsions according to Examples 1-10) was infected by the above microorganisms and after an incubation for 24, 48 and 72 hours the number of germs was determined.
  • Example 1 Composition:
  • Example 8 Composition:
  • the emulsion according to the above Examples 1-10 may be prepared by method known perse, e.g. by melting the different polyoxyethylene glycols and admixing the melt obtained under stirring with the other ingredients.
  • Myritol 318 caprilicacid-capric acid-trigliceride
  • Solutol HS 15 diethylene glycol-monoethyl ether
  • Cremophor RH 60 polyethylene (660)-12-hydroxy ⁇
  • Cremophor EL polyoxyethylene glycerol ⁇
  • Cremophor S 9 polyethylene glycol(400)-stearate
  • a loose-woven gauze sheet is arranged thereafter the gauze sheet is impregnated with the emulsion according to Example 1, then it is covered with a metal foil, cut into pieces and sterilized by radiation.
  • Example 11 The procedure of Example 11 is followed, with the difference that an effective amount of gentamycin as active ingredient is suspended in the emulsion before impregnation.
  • Example 11 The procedure of Example 11 is followed, with the difference that a perforated sheet made of synthetic material (e.g. polypropylene, polyamide, viscose etc.) is used as a carrier.
  • a perforated sheet made of synthetic material e.g. polypropylene, polyamide, viscose etc.
  • Example 12 The procedure of Example 12 is followed, with the difference that one of the following ingredients is used in an effective amount: erithromycin, neomycin, sisomycin, tetrane; chlorohexidine gluconate, benzalconiumchloride, micanozole or metronidazole.

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne une matière thérapeutique destinée à recouvrir des blessures et des lésions cutanées ainsi que la préparation de ladite matière. La matière thérapeutique selon l'invention contient un support imprégné ou recouvert d'une émulsion non irritante que l'on peut facultativement mélanger avec une quantité efficace de matière biologiquement active. La matière thérapeutique recouvrant les blessures ne colle pas à la surface, est perméable aux sécrétions et facile à manipuler.
EP89906189A 1988-05-30 1989-05-30 Matiere therapeutique destinee a recouvrir des blessure et des lesions cutanees et son procede de preparation Withdrawn EP0370097A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU272288 1988-05-30
HU272288 1988-05-30

Publications (1)

Publication Number Publication Date
EP0370097A1 true EP0370097A1 (fr) 1990-05-30

Family

ID=10960833

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89906189A Withdrawn EP0370097A1 (fr) 1988-05-30 1989-05-30 Matiere therapeutique destinee a recouvrir des blessure et des lesions cutanees et son procede de preparation

Country Status (7)

Country Link
EP (1) EP0370097A1 (fr)
JP (1) JPH03500853A (fr)
KR (1) KR900701327A (fr)
AU (1) AU616769B2 (fr)
DK (1) DK19990D0 (fr)
FI (1) FI900422A0 (fr)
WO (1) WO1989011879A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920158A (en) * 1989-10-11 1990-04-24 Medipro Sciences Limited Hydrogel-forming wound dressing or skin coating material
GR890100385A (el) * 1989-06-08 1991-11-15 Licencia Talalmanyokat Μεθοδος παρασκευης θεραπευτικου υλικου για την επικαλυψη τραυματων και λυσεων συνεχειας του δερματος
JP2875140B2 (ja) * 1993-08-16 1999-03-24 明治製菓株式会社 抗ｍｒｓａ組成物
GB9510226D0 (en) * 1995-05-20 1995-07-19 Smith & Nephew Sterilisable cream or paste product for topical application
AUPR564301A0 (en) * 2001-06-13 2001-07-12 Cooper, Barrie David Antibacterial material

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT323333B (de) * 1973-02-15 1975-07-10 Hurka Wilhelm Mit wirkstoffen getränkter träger
FR2375861A1 (fr) * 1976-12-31 1978-07-28 Merieux Inst Tampon adhesif pour tests epicutanes
AT378122B (de) * 1977-07-05 1985-06-25 Braun Karl Otto Kg Einreissbares breitbindengewebe
JPS55102653A (en) * 1979-01-30 1980-08-06 Japan Synthetic Rubber Co Ltd Production of water-containing polymer molding
US4588400A (en) * 1982-12-16 1986-05-13 Johnson & Johnson Products, Inc. Liquid loaded pad for medical applications
US4696821A (en) * 1983-10-11 1987-09-29 Warner-Lambert Company Transdermal delivery system for administration of nitroglycerin
US4563184A (en) * 1983-10-17 1986-01-07 Bernard Korol Synthetic resin wound dressing and method of treatment using same
CA1280111C (fr) * 1985-04-03 1991-02-12 Richard E. Reever. Composition servant a administrer un medicament par voie transdermique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8911879A1 *

Also Published As

Publication number Publication date
WO1989011879A1 (fr) 1989-12-14
DK19990A (da) 1990-01-25
KR900701327A (ko) 1990-12-01
JPH03500853A (ja) 1991-02-28
AU3693989A (en) 1990-01-05
FI900422A0 (fi) 1990-01-26
DK19990D0 (da) 1990-01-25
AU616769B2 (en) 1991-11-07

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