EP0347749A3 - Pyrazoloacridonderivate mit Antitumoraktivität - Google Patents

Pyrazoloacridonderivate mit Antitumoraktivität Download PDF

Info

Publication number
EP0347749A3
EP0347749A3 EP19890110867 EP89110867A EP0347749A3 EP 0347749 A3 EP0347749 A3 EP 0347749A3 EP 19890110867 EP19890110867 EP 19890110867 EP 89110867 A EP89110867 A EP 89110867A EP 0347749 A3 EP0347749 A3 EP 0347749A3
Authority
EP
European Patent Office
Prior art keywords
pyrazoloacridone
tumoral activity
derivatives
pyrazoloacridone derivatives
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19890110867
Other languages
English (en)
French (fr)
Other versions
EP0347749B1 (de
EP0347749A2 (de
Inventor
Toru Sugaya
Yukiteru Mimura
Yasushi Shida
Yutaka Osawa
Ikuo Matsukuma
Shiro Akinaga
Makoto Morimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of EP0347749A2 publication Critical patent/EP0347749A2/de
Publication of EP0347749A3 publication Critical patent/EP0347749A3/de
Application granted granted Critical
Publication of EP0347749B1 publication Critical patent/EP0347749B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP89110867A 1988-06-20 1989-06-15 Pyrazoloacridonderivate mit Antitumoraktivität Expired - Lifetime EP0347749B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15167788 1988-06-20
JP151677/88 1988-06-20

Publications (3)

Publication Number Publication Date
EP0347749A2 EP0347749A2 (de) 1989-12-27
EP0347749A3 true EP0347749A3 (de) 1991-06-05
EP0347749B1 EP0347749B1 (de) 1996-04-24

Family

ID=15523838

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89110867A Expired - Lifetime EP0347749B1 (de) 1988-06-20 1989-06-15 Pyrazoloacridonderivate mit Antitumoraktivität

Country Status (4)

Country Link
US (1) US5079358A (de)
EP (1) EP0347749B1 (de)
JP (1) JP2795460B2 (de)
DE (1) DE68926320T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220026A (en) * 1990-11-22 1993-06-15 Kyowa Hakko Kogyo Co., Ltd. Pyrazoloacridone derivatives
GB9104548D0 (en) * 1991-03-05 1991-04-17 Cholody Wienlaw M Antineoplastic modified imidazoacridines
IT1269862B (it) * 1994-05-30 1997-04-15 Indena Spa Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
KR100704137B1 (ko) 1998-10-14 2007-04-09 교와 핫꼬 고교 가부시끼가이샤 피라졸로아크리돈 유도체 수용액의 안정화 방법 및 이를 포함하는 밀봉 용기
EP1627877A4 (de) * 2003-04-24 2006-12-13 Kyowa Hakko Kogyo Kk Verfahren zur herstellung eines pyrazoloacridonderivats und zwischenprodukt dafür
US9376406B2 (en) 2011-03-03 2016-06-28 Indiana University Research And Technology Corporation uPAR-uPA interaction inhibitors and methods for treating cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138302A1 (de) * 1983-07-19 1985-04-24 Warner-Lambert Company Pyrazolo(3,4,5-kl)acridinderivate, pharmazeutische Zubereitungen die sie enthalten und Verfahren zu ihrer Herstellung
US4556654A (en) * 1983-06-28 1985-12-03 Warner-Lambert Company Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2238378C3 (de) * 1972-08-04 1975-01-09 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Perlnonfarbstoffe und Verfahren zu Ihrer Herstellung
US4202897A (en) * 1977-07-25 1980-05-13 Sandoz, Inc. Prolactin secretion inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556654A (en) * 1983-06-28 1985-12-03 Warner-Lambert Company Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones
EP0138302A1 (de) * 1983-07-19 1985-04-24 Warner-Lambert Company Pyrazolo(3,4,5-kl)acridinderivate, pharmazeutische Zubereitungen die sie enthalten und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
DE68926320T2 (de) 1996-10-17
DE68926320D1 (de) 1996-05-30
JPH0276878A (ja) 1990-03-16
US5079358A (en) 1992-01-07
EP0347749B1 (de) 1996-04-24
JP2795460B2 (ja) 1998-09-10
EP0347749A2 (de) 1989-12-27

Similar Documents

Publication Publication Date Title
IE821210L (en) Guanine derivatives
DK0379979T3 (de)
CA2011329A1 (en) Xanthine derivatives
IT1240360B (it) Uso di un derivato dell'1alfa-idrossivitamina d per la preparazione di un medicamento per il trattamento dell' iperparatiroidismo
EP0369262A3 (de) Pyrrol-Derivate
CA2040248A1 (en) Method of inhibiting gastric acid secretion
IT8722481A0 (it) Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse.
AU9049391A (en) 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
EP0057546A3 (de) Harnstoff-N-Oxide
TW221441B (de)
YU54189A (en) Process for obtaining cephem derivatives and midproducts for the same
GEP19971030B (en) Method for preparation of derivatives of 1-benzil-3-oximetil-indazolului or salts with pharmaceutically acceptable bases
EP0347749A3 (de) Pyrazoloacridonderivate mit Antitumoraktivität
EP0205334A3 (de) Benzazepinderivate
AU6633990A (en) Improved intravenous administration set
GR3004487T3 (de)
NO912992D0 (no) 1-aminopropandiol-2,3 med hoey renhet, samt fremgangsmaate for fremstilling av forbindelsen.
EP0331092A3 (en) Alpha-amino-carboxylic-acid derivatives, their preparation and use
EP0238285A3 (de) 2-Heterocyclylthio-Peneme
EP0121830A3 (de) Substituierte Dipeptide als Antihypertensiva
IE780514L (en) Morphine derivatives
EP0342423A3 (de) Heteroaroylhydrazid-Derivate von monocyclischen beta-Lactamantibiotika
IT1216560B (it) Procedimento per la preparazione di bis(2,2,6,6_tetrametil_4_piperidil)ammina.
CA1271748C (en) BENZAZEPINE DERIVATIVES
FI901239A7 (fi) Menetelmä farmaseuttisesti aktiivisen 1,3,4,6,7,8-heksahydro-2H-pyrimido-(1,2-a)-pyrimidiinijohdannaisen valmistamiseksi

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): DE FR GB IT

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): DE FR GB IT

17P Request for examination filed

Effective date: 19910812

17Q First examination report despatched

Effective date: 19931216

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): DE FR GB IT

ITF It: translation for a ep patent filed
ET Fr: translation filed
REF Corresponds to:

Ref document number: 68926320

Country of ref document: DE

Date of ref document: 19960530

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20030610

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20030611

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20030626

Year of fee payment: 15

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040615

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050101

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20040615

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050228

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 20050615