EP0292887A1 - Process and apparatus for producing physiological solutions - Google Patents

Process and apparatus for producing physiological solutions Download PDF

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Publication number
EP0292887A1
EP0292887A1 EP88108081A EP88108081A EP0292887A1 EP 0292887 A1 EP0292887 A1 EP 0292887A1 EP 88108081 A EP88108081 A EP 88108081A EP 88108081 A EP88108081 A EP 88108081A EP 0292887 A1 EP0292887 A1 EP 0292887A1
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Prior art keywords
distilled water
ingredients
mixing tube
physiological solutions
arrangement
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
EP88108081A
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German (de)
French (fr)
Inventor
Heinz-Werner Roesen
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Schiwa GmbH
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Schiwa GmbH
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Publication of EP0292887A1 publication Critical patent/EP0292887A1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/49—Mixing systems, i.e. flow charts or diagrams

Definitions

  • the invention relates to a method for producing physiological solutions, in which a quantity of solid or liquid ingredients corresponding to the desired concentration of the solution is added to a mixture of distilled water and mixed therewith.
  • the invention further relates to a procedural arrangement for performing the method.
  • the task was to avoid the disadvantages, which are characteristic of a discontinuous production process, of a new production process, with particular attention being given to the smallest possible space requirement and low operating costs.
  • the object was achieved in that the distilled water and the ingredients are combined in an apparatus for continuous mixing and mixed in the process.
  • the arrangement according to the invention for carrying out the manufacturing process consists of a mixing tube, the inputs of which are connected via metering devices to storage containers for distilled water and for the ingredients, and the output of which is connected to a filling device.
  • the central part for the new process for the production of physiological solutions is a mixing tube 1, the input 2 of which is connected to one or more storage containers 6 for distilled water via a pump 3 with pressure control, a temperature control device 4 and a volume or mass counter 5. It is advantageous to provide a ring line 7 with a further pump 8 for the storage container, to which the mixing tube is connected with a line 9 via the above-mentioned devices 3-5. With the help of the counter 5, the distilled water can be metered into the mixing tube via a control valve 10. Pressure control 3 and temperature control 4 prevent measurement errors and thus metering errors as a result of pressure fluctuations and thermally induced changes in volume. Furthermore, the optimal solution temperature can be set by the temperature control.
  • the device for this can be, for example, a heat exchanger through which a temperature control medium flows.
  • the ingredients are introduced into the mixing tube 1 by means of one or more nozzles 11 and mix therein with the flowing, distilled water as a result of the turbulence that arises. It is expedient to prepare all ingredients with distilled water in the form of a high-proof concentrate in a batch container 12 before introducing them into the mixing tube and to feed them to the nozzle 11 in the mixing tube 1 via a line 13.
  • a pump 14 with pressure control, a temperature control device 15 and a volume or mass counter 16 with a subsequent, controllable control valve 17 are inserted into the line for the exact metering of the ingredients.
  • the outlet of the mixing tube 1 is connected by means of a line 18 via a measuring and analysis device 19 to a buffer container 20 to which a filling fitting 21 is connected.
  • a safety valve 22 which can be controlled by the measuring and analysis device prevents the unusable solution from being filled.
  • Such devices are available in specialist shops, so that they do not need to be described further.
  • the buffer tank is connected to a nitrogen source 23 in order to compensate for changes in pressure and level caused by the filling.
  • line 9 can be switched to a nitrogen source 24 and a pure steam source 25.
  • control device 19 the characteristic data of the physiological solution to be produced as well as the optimal values of the operating temperatures and pressures are entered into the control device, so that the process sequence is monitored by the measurement and analysis device 19 in accordance with the measured value acquisition and, if necessary, the respective control valves are controlled via control lines 27 can be.
  • the continuous mode of operation created by the invention means that the effort both for the operating space and for the operation itself and for maintenance and analysis can be considerably reduced.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)

Abstract

Physiological solutions are prepared by adding a desired quantity of solid or liquid ingredients to an initial quantity of distilled water and mixing therewith. According to the invention, this is carried out continuously in a mixing tube (1), the inlets of which are each connected via metering devices (5, 16) to stock tanks (6, 12) for distilled water and for the ingredients. The outlet of the mixing tube is connected to a filling device (21).

Description

Die Erfindung betrifft ein Verfahren zur Herstellung von physiologischen Lösungen, bei dem einer vorgelegten Menge destillierten Wassers eine der gewünschten Konzentration der Lösung entsprechende Menge an festen oder flüssigen Inhaltsstoffen zugegeben und damit vermischt wird. Ferner betrifft die Erfindung eine verfahrenstechnische Anordnung zur Durchführung des Verfahrens.The invention relates to a method for producing physiological solutions, in which a quantity of solid or liquid ingredients corresponding to the desired concentration of the solution is added to a mixture of distilled water and mixed therewith. The invention further relates to a procedural arrangement for performing the method.

Bisher war es üblich, das destillierte Wasser in einem Rührwerkbehälter vorzulegen und in diesen die Inhaltsstoffe zuzugeben und mit dem destillierten Wasser zu vermischen. Danach wurde die Lösung temperiert und in Beutel abgefüllt. Der leere Behälter mußte dann gereinigt und mit Reidampf sterilisiert werden. Neben der dadurch und durch die Abfüllung verminderten Nutzung eines Behälters ist von Nachteil, daß ein großer Raum für notwendigerweise mehrere Behälter vorzusehen ist und die Betriebs- sowie Wartungskosten für das Rührwerk hoch sind.So far, it has been customary to place the distilled water in an agitator tank and to add the ingredients to it and mix it with the distilled water. The solution was then tempered and filled into bags. The empty container then had to be cleaned and sterilized with steam. In addition to the reduced use of a container as a result of this and the filling, it is disadvantageous that a large space must necessarily be provided for several containers and the operating and maintenance costs for the agitator are high.

Dementsprechend bestand die Aufgabe, die vorstehend aufgezeigten, für ein diskontinuierliches Herstellverfahren charakteristischen Nachteile bei einem neuen Herstellverfahren zu vermeiden, wobei insbesondere auf einen möglischst geringen Platzbedarf und niedrige Betriebskosten geachtet werden sollte.Accordingly, the task was to avoid the disadvantages, which are characteristic of a discontinuous production process, of a new production process, with particular attention being given to the smallest possible space requirement and low operating costs.

Verfahrenstechnisch wurde die Aufgabe dadurch gelöst, daß das destillierte Wasser und die Inhaltsstoffe in einer Apparatur zum kontinuierlichen Mischen zusammengeführt und dabei vermischt werden.In terms of process technology, the object was achieved in that the distilled water and the ingredients are combined in an apparatus for continuous mixing and mixed in the process.

Die erfindungsgemäße Anordnung zur Durchführung des Herstellverfahrens besteht aus einem Mischrohr, dessen Eingänge über Dosiereinrichtungen jeweils an Vorratsbehälter für destilliertes Wasser und für die Inhaltsstoffe angeschlossen sind und dessen Ausgang mit einer Abfülleinrichtung in Verbindung steht.The arrangement according to the invention for carrying out the manufacturing process consists of a mixing tube, the inputs of which are connected via metering devices to storage containers for distilled water and for the ingredients, and the output of which is connected to a filling device.

Die Erfindung ist anhand eines in der Zeichnung schematisch dargestellten Ausführungsbeispiels nachfolgend näher beschrieben.The invention is described below with reference to an embodiment shown schematically in the drawing.

Zentrales Teil für das neue Verfahren zur Herstellung von physiologischen Lösungen ist ein Mischrohr 1, dessen Eingang 2 über eine Pumpe 3 mit Druckregelung, eine Temperiereinrichtung 4 und einen Volumen- oder Massezähler 5 mit einem oder mehreren Vorratsbehältern 6 für destilliertes Wasser verbunden ist. Es ist dabei vorteilhaft, für die Vorratsbehälter eine Ringleitung 7 mit einer weiteren Pumpe 8 vorzusehen, an die das Mischrohr mit einer Leitung 9 über die vorstehend erwähnten Einrichtungen 3-5 angeschlossen ist. Mit Hilfe des Zählers 5 kann das destillierte Wasser über ein Regelventil 10 in das Mischrohr dosiert werden. Durch die Druckregelung 3 und die Temperierung 4 werden Meßfehler und damit Dosierfehler infolge von Druckschwankungen und thermisch bedingten Volumenänderungen vermieden. Ferner kann durch die Temperierung die jeweils optimale Lösungstemperatur eingestellt werden. Die Einrichtung hiefür kann beispielsweise ein von einem Temperiermedium durchströmter Wärmetauscher sein.The central part for the new process for the production of physiological solutions is a mixing tube 1, the input 2 of which is connected to one or more storage containers 6 for distilled water via a pump 3 with pressure control, a temperature control device 4 and a volume or mass counter 5. It is advantageous to provide a ring line 7 with a further pump 8 for the storage container, to which the mixing tube is connected with a line 9 via the above-mentioned devices 3-5. With the help of the counter 5, the distilled water can be metered into the mixing tube via a control valve 10. Pressure control 3 and temperature control 4 prevent measurement errors and thus metering errors as a result of pressure fluctuations and thermally induced changes in volume. Furthermore, the optimal solution temperature can be set by the temperature control. The device for this can be, for example, a heat exchanger through which a temperature control medium flows.

Die Inhaltsstoffe werden mittels einer oder mehrerer Düsen 11 in das Mischrohr 1 eingeführt und vermischen sich darin mit dem durchfließenden, destillierten Wasser infolge der dabei entstehenden Turbulenzen. Es zweckmäßig, alle Inhaltsstoffe vor dem Einbringen in das Mischrohr mit destilliertem Wasser in Form eines hochprozentigen Konzentrats in einem Ansatzbehälter 12 aufzubereiten und über eine Leitung 13 der Düse 11 im Mischrohr 1 zuzuführen. Auch hier sind zur genauen Dosierung der Inhaltsstoffe eine Pumpe 14 mit Druckregelung, eine Temperier­einrichtung 15 sowie ein Volumen- oder Massezähler 16 mit nachfolgendem, ansteuerbarem Regelventil 17 in die Leitung eingefügt.The ingredients are introduced into the mixing tube 1 by means of one or more nozzles 11 and mix therein with the flowing, distilled water as a result of the turbulence that arises. It is expedient to prepare all ingredients with distilled water in the form of a high-proof concentrate in a batch container 12 before introducing them into the mixing tube and to feed them to the nozzle 11 in the mixing tube 1 via a line 13. Here too, a pump 14 with pressure control, a temperature control device 15 and a volume or mass counter 16 with a subsequent, controllable control valve 17 are inserted into the line for the exact metering of the ingredients.

Der Ausgang des Mischrohr 1 steht mittels einer Leitung 18 über eine Meß- und Analyseeinrichtung 19 mit einem Pufferbehälter 20 in Verbindung, an den eine Abfüllarmatur 21 angeschlossen ist. Durch ein von der Meß- und Analyseeinrichtung ansteuerbares Sicherheitsventil 22 wird verhindert, daß unbrauchbare Lösung zur Abfüllung gelangt. Derartige Einrichtungen stehen im Fachhandel zur Verfügung, so daß sie nicht weiteres beschrieben zu werden brauchen. Der Pufferbehälter ist an eine Stickstoffquelle 23 angeschlossen, um durch die Abfüllung bedingter Druck- und Füllstandsänderungen zu kompensieren.The outlet of the mixing tube 1 is connected by means of a line 18 via a measuring and analysis device 19 to a buffer container 20 to which a filling fitting 21 is connected. A safety valve 22 which can be controlled by the measuring and analysis device prevents the unusable solution from being filled. Such devices are available in specialist shops, so that they do not need to be described further. The buffer tank is connected to a nitrogen source 23 in order to compensate for changes in pressure and level caused by the filling.

Zur Sterilisierung des Systems ist die Leitung 9 an eine Stickstoffquelle 24 und eine Reindampfquelle 25 schaltbar.To sterilize the system, line 9 can be switched to a nitrogen source 24 and a pure steam source 25.

Mit Hilfe eines handelsüblichen Steuergerätes 26 kann die vorstehend beschriebene, verfahrenstechnische Anordnung automatisch betrieben und überwacht werden.With the help of a commercially available control unit 26, the procedural arrangement described above can be operated and monitored automatically.

Hierzu werden die charakteristischen Daten der herzustellenden, physiologischen Lösung sowie die optimalen Werte der Betriebstemperaturen und -drucke in das Steuergerät eingegeben, so daß von diesem entsprechend der Meßwerterfassung durch die Meß- und Analyseeinrichtung 19 der Verfahrensablauf überwacht und über Steuerleitungen 27 gegebenenfalls die jeweiligen Regelventile angesteuert werden können.For this purpose, the characteristic data of the physiological solution to be produced as well as the optimal values of the operating temperatures and pressures are entered into the control device, so that the process sequence is monitored by the measurement and analysis device 19 in accordance with the measured value acquisition and, if necessary, the respective control valves are controlled via control lines 27 can be.

Durch die mit der Erfindung geschaffene kontinuierliche Arbeitsweise ist erreicht, daß der Aufwand sowohl für Betriebsraum als auch für den Betrieb selbst sowie für Wartung und Analyse erheblich reduziert werden kann.The continuous mode of operation created by the invention means that the effort both for the operating space and for the operation itself and for maintenance and analysis can be considerably reduced.

Claims (6)

1. Verfahren zur Herstellung von physiologischen Lösungen, bei dem einer vorgelegten Menge destillierten Wassers eine der gewünschten Konzentration der Lösung entsprechende Menge an festen oder flüssigen Inhaltsstoffen zugegeben und damit vermischt wird, dadurch gekennzeichnet, daß das destillierte Wasser und die Inhaltsstoffe in einer Apparatur zum kontinuierlichen Mischen zusammengeführt und dabei vermischt werden.1. A process for the preparation of physiological solutions, in which a quantity of solid or liquid constituents corresponding to the desired concentration of the solution is added to and mixed with a quantity of distilled water, characterized in that the distilled water and the constituents are in an apparatus for continuous Mix together and be mixed in the process. 2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß die Inhaltsstoffe in einer hochkonzentrierten Lösung der Apparatur zugeführt werden.2. The method according to claim 1, characterized in that the ingredients are supplied to the apparatus in a highly concentrated solution. 3. Anordnung zur Herstellung von physiologischen Lösungen zur Durchführung des Verfahrens nach den Ansprüchen 1 und 2, bestehend aus einem Mischrohr (1), dessen Eingänge über Dosiereinrichtungen (5, 16) jeweils an Vorratsbehälter (6, 12) für destilliertes Wasser und für die Inhaltsstoffe angeschlossen sind und dessen Ausgang mit einer Abfülleinrichtung (21) in Verbindung steht.3. Arrangement for the production of physiological solutions for performing the method according to claims 1 and 2, consisting of a mixing tube (1), the inputs of which via metering devices (5, 16) each to storage containers (6, 12) for distilled water and for Ingredients are connected and the output of which is connected to a filling device (21). 4. Anordnung nach Anspruch 3, dadurch gekennzeichnet, daß der Eingang für die Inhaltsstoffe mit einer Düse (11) ausgestattet ist.4. Arrangement according to claim 3, characterized in that the input for the ingredients is equipped with a nozzle (11). 5. Anordnung nach Anspruch 3 und 4, dadurch gekennzeichnet, daß zur Sterilisierung der Anordnung mindestens eine der Zuleitungen (9) zum Mischrohr (1) an eine Stickstoff- und Dampfquelle (24, 25) schaltbar ist.5. Arrangement according to claim 3 and 4, characterized in that for sterilizing the arrangement at least one of the feed lines (9) to the mixing tube (1) to a nitrogen and steam source (24, 25) is switchable. 6. Anordnung nach Anspruch 3 bis 5, dadurch gekennzeichnet, daß die Verbindungsleitung (18) zwischen dem Mischrohrausgang und der Abfülleinichtung (21) über eine Meß- und Analyseeinrichtung (19) geführt ist.6. Arrangement according to claim 3 to 5, characterized in that the connecting line (18) between the mixing tube outlet and the filling device (21) is guided via a measuring and analysis device (19).
EP88108081A 1987-05-27 1988-05-20 Process and apparatus for producing physiological solutions Withdrawn EP0292887A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873717883 DE3717883A1 (en) 1987-05-27 1987-05-27 METHOD AND ARRANGEMENT FOR PRODUCING PHYSIOLOGICAL SOLUTIONS
DE3717883 1987-05-27

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EP0292887A1 true EP0292887A1 (en) 1988-11-30

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861546A1 (en) * 2003-10-31 2005-05-06 Bruno Eto Producing and preserving physiological media, especially oral rehydration solutions, comprises mixing the constituents in powder form and compressing the mixture

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208084B (en) * 1991-10-31 1993-08-30 Hyd Kutato Fejlesztoe Kft Process for producing compositions suitable for curing tumorous diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001803A1 (en) * 1979-12-27 1981-07-09 Imo Industri Ab A method and apparatus for mixing liquids
DE3132994A1 (en) * 1980-09-02 1982-05-19 Vito 11743 Huntington N.Y. Agosta Method and appliance for mixing liquids
EP0143294A2 (en) * 1983-10-29 1985-06-05 Weber Apparatebau GmbH Apparatus for dosing a component to a solvent or diluent
DE3409341A1 (en) * 1984-03-14 1985-09-19 Laboratoires Boiron, Sainte Foy les Lyon, Rhone Apparatus for diluting mother tinctures according to the Korsakov method
WO1986000797A1 (en) * 1984-07-25 1986-02-13 Green Cross Corporation Infusion solution mixing apparatus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001803A1 (en) * 1979-12-27 1981-07-09 Imo Industri Ab A method and apparatus for mixing liquids
DE3132994A1 (en) * 1980-09-02 1982-05-19 Vito 11743 Huntington N.Y. Agosta Method and appliance for mixing liquids
EP0143294A2 (en) * 1983-10-29 1985-06-05 Weber Apparatebau GmbH Apparatus for dosing a component to a solvent or diluent
DE3409341A1 (en) * 1984-03-14 1985-09-19 Laboratoires Boiron, Sainte Foy les Lyon, Rhone Apparatus for diluting mother tinctures according to the Korsakov method
WO1986000797A1 (en) * 1984-07-25 1986-02-13 Green Cross Corporation Infusion solution mixing apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861546A1 (en) * 2003-10-31 2005-05-06 Bruno Eto Producing and preserving physiological media, especially oral rehydration solutions, comprises mixing the constituents in powder form and compressing the mixture

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DE3717883A1 (en) 1988-12-15

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