EP0290516A4 - Proteines associees a des agents tensioactifs hydrophobes pulmonaires. - Google Patents

Proteines associees a des agents tensioactifs hydrophobes pulmonaires.

Info

Publication number
EP0290516A4
EP0290516A4 EP19870907365 EP87907365A EP0290516A4 EP 0290516 A4 EP0290516 A4 EP 0290516A4 EP 19870907365 EP19870907365 EP 19870907365 EP 87907365 A EP87907365 A EP 87907365A EP 0290516 A4 EP0290516 A4 EP 0290516A4
Authority
EP
European Patent Office
Prior art keywords
pulmonary
associated proteins
hydrophobic surfactant
hydrophobic
surfactant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19870907365
Other languages
German (de)
English (en)
Other versions
EP0290516A1 (fr
Inventor
Jeffrey A Whitsett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1986/002258 external-priority patent/WO1987006943A1/fr
Application filed by Individual filed Critical Individual
Publication of EP0290516A1 publication Critical patent/EP0290516A1/fr
Publication of EP0290516A4 publication Critical patent/EP0290516A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Peptides Or Proteins (AREA)
EP19870907365 1986-10-24 1987-10-02 Proteines associees a des agents tensioactifs hydrophobes pulmonaires. Withdrawn EP0290516A4 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
PCT/US1986/002258 WO1987006943A1 (fr) 1986-05-06 1986-10-24 Proteine associee a un agent tensio-actif hydrophobe pulmonaire d'un poids moleculaire de 6000 daltons, et ses multimeres
WOPCT/US86/02258 1986-10-24
US93920686A 1986-12-08 1986-12-08
US939206 1986-12-08
US6071987A 1987-06-10 1987-06-10
US60719 1987-06-10
US10168087A 1987-10-01 1987-10-01
US101680 1987-10-01

Publications (2)

Publication Number Publication Date
EP0290516A1 EP0290516A1 (fr) 1988-11-17
EP0290516A4 true EP0290516A4 (fr) 1989-11-14

Family

ID=27490143

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19870907365 Withdrawn EP0290516A4 (fr) 1986-10-24 1987-10-02 Proteines associees a des agents tensioactifs hydrophobes pulmonaires.

Country Status (2)

Country Link
EP (1) EP0290516A4 (fr)
WO (1) WO1988003170A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989000167A1 (fr) * 1987-07-01 1989-01-12 Kabigen Ab Proteines, compositions de proteines et leurs utilisations
KR960010558B1 (ko) * 1987-11-04 1996-08-02 캘리포니아 바이오테크놀로지 인코오퍼레이티드 폐포계면활성 단백질
US6613734B2 (en) 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5124255A (en) * 1988-03-11 1992-06-23 Abbott Laboratories CKS method of protein synthesis
WO1990001540A1 (fr) * 1988-08-11 1990-02-22 California Biotechnology Inc. Procede et vecteurs de stabilisation de l'expression de proteines heterologues
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5238920A (en) * 1989-08-22 1993-08-24 Abbott Laboratories Pulmonary surfactant protein fragments
DE69125750D1 (de) * 1990-05-21 1997-05-28 Abbott Lab Fettsäure-Oberflächenaktives-Lungenprotein Konjate
KR920004577A (ko) * 1990-08-24 1992-03-27 원본미기재 단백질 합성의 cks 방법
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
DE69332654T2 (de) * 1992-04-10 2003-09-25 Abbott Lab Fragmente eines oberflächenaktiven lungenproteins
JP3644035B2 (ja) * 1993-12-08 2005-04-27 三菱ウェルファーマ株式会社 新規な合成ペプチド，それを含有する肺サーファクタント及び呼吸窮迫症候群治療剤
US6372720B1 (en) * 1998-02-05 2002-04-16 Kenneth J. Longmuir Liposome fusion and delivery vehicle
JP4559731B2 (ja) 2001-10-11 2010-10-13 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺サーファクタントの新規使用
US8236750B2 (en) 2004-08-06 2012-08-07 Nycomed Gmbh Composition comprising a pulmonary surfactant and a TNF-derived peptide
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
CA2744940A1 (fr) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Procedes et compositions pour la delivrance de medicaments aux poumons
WO2010087771A1 (fr) * 2009-01-30 2010-08-05 Alphabeta Ab Composé et procédé de traitement de la maladie d'alzheimer
AU2010356144B2 (en) 2010-06-24 2015-06-04 Alphabeta Ab Compound and method for treatment of Alzheimer's disease and familial dementia
WO2012130731A1 (fr) * 2011-03-25 2012-10-04 Roche Diagnostics Gmbh Mesure de c-terminal prosp-b
EP2694977B1 (fr) 2011-04-05 2016-06-29 Alphabeta AB Cible d'amyloïdose utile dans des méthodes pour le criblage de composés

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986003408A1 (fr) * 1984-12-11 1986-06-19 California Biotechnology Inc. Proteine tensio-active alveolaire recombinante
WO1987002037A1 (fr) * 1985-09-26 1987-04-09 Genetics Institute, Inc. Proteines tensio-actives pulmonaires

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016258A (en) * 1975-08-05 1977-04-05 Said Sami I Vasoactive intestinal peptide from fowl

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986003408A1 (fr) * 1984-12-11 1986-06-19 California Biotechnology Inc. Proteine tensio-active alveolaire recombinante
WO1987002037A1 (fr) * 1985-09-26 1987-04-09 Genetics Institute, Inc. Proteines tensio-actives pulmonaires

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PEDIATRIC RESEARCH, vol. 20, no. 8, August 1986, pages 744-749, International Pediatric Research Foundation, Inc., US; J.A. WHITSETT et al.: "Immunologic identification of a pulmonary surfactant-associated protein of molecular weight = 6000 daltons" *
See also references of WO8803170A1 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 262, no. 20, 15th July 1987, pages 9808-9811, The American Society of Biological Chemists, Inc., US; K.A. JACOBS et al.: "Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein" *

Also Published As

Publication number Publication date
EP0290516A1 (fr) 1988-11-17
WO1988003170A1 (fr) 1988-05-05

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19881026

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Effective date: 19891114

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Effective date: 19920508

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