EP0288488A4 - Dopamine- -hydroxylase inhibitors - Google Patents

Dopamine- -hydroxylase inhibitors

Info

Publication number
EP0288488A4
EP0288488A4 EP19870905838 EP87905838A EP0288488A4 EP 0288488 A4 EP0288488 A4 EP 0288488A4 EP 19870905838 EP19870905838 EP 19870905838 EP 87905838 A EP87905838 A EP 87905838A EP 0288488 A4 EP0288488 A4 EP 0288488A4
Authority
EP
European Patent Office
Prior art keywords
dopamine
hydroxylase inhibitors
inhibitors
dbh
hydroxylase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19870905838
Other languages
English (en)
Other versions
EP0288488A1 (en
Inventor
Joseph Alan Finkelstein
James Simpson Frazee
Carl Kaiser
Lawrence Ivan Kruse
Thomas Brent Leonard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0288488A1 publication Critical patent/EP0288488A1/en
Publication of EP0288488A4 publication Critical patent/EP0288488A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP19870905838 1986-08-18 1987-08-17 Dopamine- -hydroxylase inhibitors Pending EP0288488A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89816586A 1986-08-18 1986-08-18
US898165 1986-08-18

Publications (2)

Publication Number Publication Date
EP0288488A1 EP0288488A1 (en) 1988-11-02
EP0288488A4 true EP0288488A4 (en) 1990-09-12

Family

ID=25409053

Family Applications (2)

Application Number Title Priority Date Filing Date
EP87307259A Expired - Lifetime EP0260814B1 (en) 1986-08-18 1987-08-17 Dopamine-beta-hydroxylase inhibitors
EP19870905838 Pending EP0288488A4 (en) 1986-08-18 1987-08-17 Dopamine- -hydroxylase inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP87307259A Expired - Lifetime EP0260814B1 (en) 1986-08-18 1987-08-17 Dopamine-beta-hydroxylase inhibitors

Country Status (15)

Country Link
EP (2) EP0260814B1 (el)
CN (1) CN87105734A (el)
AT (1) ATE72430T1 (el)
AU (1) AU7910287A (el)
DE (1) DE3776613D1 (el)
DK (1) DK210488D0 (el)
ES (1) ES2038185T3 (el)
GR (1) GR3004345T3 (el)
HU (2) HU911945D0 (el)
NZ (1) NZ221427A (el)
PH (1) PH23530A (el)
PT (1) PT85547B (el)
WO (1) WO1988001267A1 (el)
ZA (1) ZA876073B (el)
ZW (1) ZW15387A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835154A (en) * 1987-06-01 1989-05-30 Smithkline Beckman Corporation 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors
US4882348A (en) * 1987-12-29 1989-11-21 Smithkline Beckman Corporation 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors
FR2928544A1 (fr) * 2008-03-17 2009-09-18 Oreal Utilisation d'inhibiteurs de la dopamine-beta hydroxylase pour la pigmentation capillaire.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125033A1 (en) * 1983-04-12 1984-11-14 Smithkline Beckman Corporation Dopamine-beta-hydroxylase inhibitors
EP0125783A1 (en) * 1983-04-12 1984-11-21 Smithkline Beckman Corporation Dopamine-beta-hydroxylase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125033A1 (en) * 1983-04-12 1984-11-14 Smithkline Beckman Corporation Dopamine-beta-hydroxylase inhibitors
EP0125783A1 (en) * 1983-04-12 1984-11-21 Smithkline Beckman Corporation Dopamine-beta-hydroxylase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 104, no.21, 26th May 1986, page 633, abstract no. 186409j, Columbus, Ohio, US; & ZA-A-84 02 962 (SMITHKLINE BECKMAN CORP.) 27-02-1985 *
See also references of WO8801267A1 *

Also Published As

Publication number Publication date
AU7910287A (en) 1988-03-08
PH23530A (en) 1989-08-25
HU204037B (en) 1991-11-28
HUT50461A (en) 1990-02-28
CN87105734A (zh) 1988-02-24
PT85547B (pt) 1995-03-01
ATE72430T1 (de) 1992-02-15
HU911945D0 (en) 1991-12-30
ES2038185T3 (es) 1993-07-16
WO1988001267A1 (en) 1988-02-25
ZA876073B (en) 1988-08-31
DK210488A (da) 1988-04-18
EP0288488A1 (en) 1988-11-02
NZ221427A (en) 1990-12-21
EP0260814B1 (en) 1992-02-05
DE3776613D1 (de) 1992-03-19
EP0260814A1 (en) 1988-03-23
ZW15387A1 (en) 1987-11-18
PT85547A (pt) 1988-08-17
DK210488D0 (da) 1988-04-18
GR3004345T3 (el) 1993-03-31

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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STAA Information on the status of an ep patent application or granted ep patent

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17P Request for examination filed

Effective date: 19880712

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

Effective date: 19900723

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XX Miscellaneous (additional remarks)

Free format text: VERFAHREN ABGESCHLOSSEN INFOLGE VERBINDUNG MIT 87307259.9/0260814 (EUROPAEISCHE ANMELDENUMMER/VEROEFFENTLICHUNGSNUMMER) VOM 13.03.91.