EP0287565A1 - Transfer device for serological diagnosis - Google Patents
Transfer device for serological diagnosisInfo
- Publication number
- EP0287565A1 EP0287565A1 EP87900254A EP87900254A EP0287565A1 EP 0287565 A1 EP0287565 A1 EP 0287565A1 EP 87900254 A EP87900254 A EP 87900254A EP 87900254 A EP87900254 A EP 87900254A EP 0287565 A1 EP0287565 A1 EP 0287565A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- vessels
- transfer device
- plate
- duct
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
Definitions
- the present invention provides a transfer device for serological diagnosis, to be used in particular in the diagnostic processes for HTLV III virus infections.
- the transfer device allows to interconnect a plurality of opposite vessels, con ⁇ taining each a small ball coated with antigens, so as to allow, by a single operation, to shift the serum under examination from a vessel to the other so quickly that the liquid temperature has no time to diminish, and absolutely avoiding any contaminations and/or possi ⁇ bility of mistakes.
- the taken sample is introduced in a vessel in contact with a solid substrate, for instance a polystyrene ball covered with antibodies, to which immunoglobulins adhere that are then detected by means of conjugated anti-antibodies .
- a solid substrate for instance a polystyrene ball covered with antibodies, to which immunoglobulins adhere that are then detected by means of conjugated anti-antibodies .
- the colouring of the ball indicates the presence in blood of the sought for immunoglobulins and, accordingly, the infection state.
- the critical phase of this new process is the elution, that takes place at a temperature oscillating between 50° and 58°C, necessary to cause the specific immunoglo ⁇ bulins of the various classes - caught by the antigens secured to the first substrate - to detach therefrom, which enables the production of an eluate of specific antibodies of the various classes, with few non-speci- fie antibodies .
- the transfer of the eluate from the first to the second vessel takes l ce via suction and force-pumps.
- the present invention provides a transfer device consisting substa tially of a plurality of con ⁇ necting elements, fastened to a common support, and arranged in such a manner as to fit, from either side, to the plates carrying the vessels used at present in laboratories for serological diagnosis.
- a characteristic of the invention is the special shap ⁇ ing of its parts that allows to arrange a pair of opposi ' te plates, so that each vessel of one of these plates communicates with the corresponding vessel of the other plate, the whole being watertight; it is thus possible, by a single operation, to shift serum from the vessels in one plate to those in the second plate, without any decrease in temperature taking place.
- FIG. 1 shows the plane view of the transfer device according to the invention
- FIG. 2 shows the side, partly section view, of a transfer device according to the invention
- FIG. 3 shows a view from above of a detail of the transfer device according to the invention.
- a plate or support 1 comprises a plurality of elements, each of which is referenced as a whole with No. 2, each of them being suitable to allow connection between a pair of opposite vessels.
- elements 2 are located at the vertexes of a square link grid.
- Each element 2 is substantially a hollow cylinder defin ⁇ ed by side walls 3, inside which passes the serum, that shifts from one vessel to the other.
- each element 2 is not of constant size but has a narrowing at the central zone.
- the upper inner part of element 2 comprises a first, substantially cylindrical section 4, linked to a frusto-conical section 5 and to a lower duct 6, of lesser diameter.
- the sizes of the frusto-conical section 5 too are inferior to those of the upper cylindrical section 4, so as to define, on the bottom of the latter, a flat peripheral edge 7.
- the lower duct 6 extends downwards to a certain extent
- Plate 1 comprises further a number of stif ening ribs 12. The utilization takes place as follows:
- the samples of serum to be examined are inside as many vessels 13 (Fig.2) , present on a support plate and arranged in the same way as the elements 2.
- Each of these vessels contains, in addition to serum, a small
- the transfer device according to the invention is put on top o the essels, so that their ' edge fits the
- the transfer device can be inserted between a pair of opposite twin plates, provided each with a plurality of vessels, in such a way as to ensure a continuous link between each vessel of one plate and the corresponding vessel of the other, the said link being direct and watertight.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2418085U | 1985-12-17 | ||
IT8524180U IT209360Z2 (it) | 1985-12-17 | 1985-12-17 | Trasportatore per diagnosi sierologiche. |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0287565A1 true EP0287565A1 (en) | 1988-10-26 |
Family
ID=11212401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP87900254A Withdrawn EP0287565A1 (en) | 1985-12-17 | 1986-12-16 | Transfer device for serological diagnosis |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0287565A1 (it) |
JP (1) | JPS63502774A (it) |
AU (1) | AU6838987A (it) |
DK (1) | DK424287A (it) |
ES (1) | ES1001194Y (it) |
IT (1) | IT209360Z2 (it) |
NO (1) | NO873401L (it) |
PT (1) | PT83950A (it) |
WO (1) | WO1987003825A1 (it) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2829709B1 (fr) * | 2001-09-14 | 2004-01-02 | In Cyto Tox | Dispositif de transfert de fluide pour essais in vitro |
US11382185B2 (en) * | 2016-01-08 | 2022-07-05 | Siemens Healthcare Diagnostics Inc. | Heating element for sensor array |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4111754A (en) * | 1976-11-29 | 1978-09-05 | Hydow Park | Immunological testing devices and methods |
DE2802495A1 (de) * | 1977-01-21 | 1978-07-27 | Searle & Co | Vorrichtung zur durchfuehrung immunologischer untersuchungen |
FR2404466A1 (fr) * | 1977-10-03 | 1979-04-27 | Manudo | Support servant de receptacles pour analyses, notamment medicales et biochimiques et son procede de fabrication |
DE3382430D1 (de) * | 1982-03-03 | 1991-11-14 | Becton Dickinson Co | Trageplatte und anordnung mit mehreren bechern fuer immunologische untersuchungen. |
-
1985
- 1985-12-17 IT IT8524180U patent/IT209360Z2/it active
-
1986
- 1986-12-16 WO PCT/IT1986/000092 patent/WO1987003825A1/en not_active Application Discontinuation
- 1986-12-16 EP EP87900254A patent/EP0287565A1/en not_active Withdrawn
- 1986-12-16 AU AU68389/87A patent/AU6838987A/en not_active Abandoned
- 1986-12-16 JP JP62500401A patent/JPS63502774A/ja active Pending
- 1986-12-17 ES ES19868601661U patent/ES1001194Y/es not_active Expired
- 1986-12-17 PT PT83950A patent/PT83950A/pt not_active Application Discontinuation
-
1987
- 1987-08-13 NO NO873401A patent/NO873401L/no unknown
- 1987-08-14 DK DK424287A patent/DK424287A/da not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO8703825A1 * |
Also Published As
Publication number | Publication date |
---|---|
DK424287D0 (da) | 1987-08-14 |
DK424287A (da) | 1987-08-14 |
IT209360Z2 (it) | 1988-10-05 |
AU6838987A (en) | 1987-07-15 |
IT8524180V0 (it) | 1985-12-17 |
PT83950A (pt) | 1987-08-19 |
NO873401D0 (no) | 1987-08-13 |
ES1001194Y (es) | 1988-11-16 |
ES1001194U (es) | 1988-04-16 |
WO1987003825A1 (en) | 1987-07-02 |
JPS63502774A (ja) | 1988-10-13 |
NO873401L (no) | 1987-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB LI LU NL SE |
|
17P | Request for examination filed |
Effective date: 19880426 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19900703 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: BEDARIDA, GUGLIELMO |