EP0261007A1 - Mikrowellenheizvorrichtung für Flüssigkeiten, insbesondere Blut - Google Patents

Mikrowellenheizvorrichtung für Flüssigkeiten, insbesondere Blut Download PDF

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Publication number
EP0261007A1
EP0261007A1 EP87401872A EP87401872A EP0261007A1 EP 0261007 A1 EP0261007 A1 EP 0261007A1 EP 87401872 A EP87401872 A EP 87401872A EP 87401872 A EP87401872 A EP 87401872A EP 0261007 A1 EP0261007 A1 EP 0261007A1
Authority
EP
European Patent Office
Prior art keywords
microwaves
enclosure
envelope
action
inert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87401872A
Other languages
English (en)
French (fr)
Inventor
Jean-Marie Jacomino
Jean-François Rochas
Jean-Paul Bernard
Alain Milhaud
Eric Lobjoie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SAIREM
Original Assignee
SAIREM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SAIREM filed Critical SAIREM
Publication of EP0261007A1 publication Critical patent/EP0261007A1/de
Withdrawn legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B6/00—Heating by electric, magnetic or electromagnetic fields
    • H05B6/64—Heating using microwaves
    • H05B6/80—Apparatus for specific applications

Definitions

  • the present invention relates to the heating by microwave of a liquid contained in an inert envelope in the microwave, for example a plastic bag. It relates more particularly to the heating of blood, globular concentrates and all the biological liquids preserved by refrigeration or by freezing and which must be brought before use to a precise temperature.
  • Human blood is generally packaged after collection from donors in flexible plastic bags. To block metabolisms harmful to its conservation, the blood must be either frozen or stored in a cold room. When transfused, this blood must be brought to a temperature close to that of the human body; it is generally accepted that the temperature of the blood injected during transfusions should be between 30 ° C and 35 ° C.
  • a device for microwave heating of a liquid contained in an inert envelope in the microwave for example a plastic bag, which ensures a homogeneous heating of said liquid while not having the aforementioned drawbacks.
  • the device of the invention allows heating of the blood, and more generally of any biological fluid in a few minutes without degrading the biochemical properties of the blood and without altering its metabolisms.
  • the microwave heating device is of the known type comprising a microwave energy generator and a metal enclosure of “resonant cavity” shape and into which a waveguide opens. It is characterized in that the lower part of the enclosure, which is intended to receive the envelope containing the liquid, is watertight and filled with water during the action of the microwaves, in that the enclosure is provided with an access door, situated above said lower part and impermeable to microwaves, and in that a mechanical means, known as immersion means, produced in a material which is inert or not microwave, is positioned inside the enclosure in two positions: the first where it keeps the envelope under the water level during the action of the microwaves, and the second where it allows to go out the envelope oppies from the enclosure after the action of the microwaves.
  • the envelope containing the liquid to be heated and which is itself inert to microwaves is kept under water by means of immersion.
  • the action of microwaves is homogeneous in all the liquid medium, constituted by the liquid to be heated, for example blood and by the water which surrounds it: in fact, the envelope surrounding the liquid to heating being inert to microwaves, does not disturb the action of these and there are no side effects leading to heterogeneous heating.
  • the immersion means consists of a grid inert or not to microwaves, with a locking system which has the effect of keeping the grid in the first position while the microwave generator is in operation and in the second position while the access door is opened.
  • a plate On the bottom of the lower part of the enclosure, a plate is made of a material inert to microwaves, on which the envelope containing the liquid to be heated is supported under the action of the immersion means.
  • the thickness of this plate is equal to a quarter of the wavelength of the microwaves generated in the enclosure.
  • the plate has the form of a grid.
  • a temperature sensor is placed in contact with or in the immediate vicinity of the envelope containing the liquid to be heated. This sensor controls the stopping of the microwave generator as soon as the water temperature reaches the predetermined set value.
  • the sensor is for example integral with the immersion means and fixed on the underside thereof.
  • the bags 7 for drawing blood from flexible plastic material which have been shown very diagrammatically in FIGS. 1 and 2 have the defect of generating extremely dangerous thermal shocks when they are introduced directly into a microwave field. Blood indeed has substantially the same dielectric characteristics as liquid water.
  • the electromagnetic field symbolized by the arrows shown in Figure 2 causes on the edges 1 of the pocket and inside the pipe 2 for supplying and discharging the liquid an immediate thermal runaway while the concentrated liquid mass in the middle of the bag only experiences a slight rise in temperature.
  • the device according to the invention consists of a metal enclosure 3 forming a resonant microwave cavity whose geometric characteristics have been calculated to obtain the best possible rate of standing waves at l inside the enclosure.
  • a waveguide 4 opens into the enclosure 3; this waveguide is itself connected to an electromagnetic wave generator, not shown.
  • a magnetron with a nominal power of 1,250 Watts can be used as the generator for the standardized frequency of 2,450 Megahertz.
  • the lower part of the enclosure consists of a watertight part, forming a tank 4.
  • a plate 5 of material inert to microwaves covers the entire bottom surface of the enclosure, the thickness of this plate is preferably a quarter of the length of wave in the material considered for a frequency of 2450 MHz.
  • the blood bags 7 are placed on the plate 5; a grid 8 blocked by a mechanical lock tightens the blood bags.
  • Water is introduced into the lower part 4 of the enclosure 3 through a supply pipe 9; a level sensor 11 controls the solenoid valve 10 which cuts off the water supply when it arrives at the predetermined level 12.
  • the water level above the blocking grid will advantageously be equal at a quarter of the wavelength in water for a frequency of 2450 MHz.
  • a temperature sensor 13 is placed on the underside of the grid 8, so that it is in contact with an envelope 7 during the action of the microwaves.
  • This sensor 13 is connected to the regulator 14.
  • the latter controls the stopping of the microwave generator as soon as the temperature detected by the sensor 13 reaches the set value which has been previously displayed.
  • the regulator 14 also controls the starting of the pump 16 for discharging the water.
  • the grid 8 for holding blood bags under the water level can take two extreme positions, in which it is blocked under the effect of the mechanical locking, not shown.
  • the first position corresponds to the introduction and evacuation of the blood bags 7 in the enclosure: the grid 8 is raised in the high position, to allow the placement of the pockets in the lower part 4 of the enclosure. In this case, the door can be freely opened, and the microwave generator is stopped.
  • the second position corresponds to the heating of the blood bags: the grid 8 is in the low position, bearing on the bags 7 so that they are kept below the level of the water contained in the lower part of the enclosure and that they are in contact with the plate 5 placed at the bottom of the enclosure. In this case the door is locked in the closed position, the microwave generator can be in operation.
  • Such a reheating cycle of two blood bags with a capacity of 300 to 400 milliliters generally requires no more than 3 minutes.
  • a heating obtained thanks to the device according to the invention is sufficiently homogeneous throughout the volume of the envelope containing the liquid to be heated to apply to blood, and in general to biological liquids and to all liquids which need be homogeneously heated to a given temperature.
  • the embodiment which has been described above is not exclusive of the invention.
  • the liquid envelope is placed under the water level at a certain distance to obtain the best possible homogeneity in the liquid with optimal efficiency of microwave energy.

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  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Constitution Of High-Frequency Heating (AREA)
  • External Artificial Organs (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
EP87401872A 1986-08-28 1987-08-12 Mikrowellenheizvorrichtung für Flüssigkeiten, insbesondere Blut Withdrawn EP0261007A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8612301A FR2603444B1 (fr) 1986-08-28 1986-08-28 Dispositif de chauffage de liquide par micro-ondes notamment du sang
FR8612301 1986-08-28

Publications (1)

Publication Number Publication Date
EP0261007A1 true EP0261007A1 (de) 1988-03-23

Family

ID=9338623

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87401872A Withdrawn EP0261007A1 (de) 1986-08-28 1987-08-12 Mikrowellenheizvorrichtung für Flüssigkeiten, insbesondere Blut

Country Status (2)

Country Link
EP (1) EP0261007A1 (de)
FR (1) FR2603444B1 (de)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329732A1 (de) * 1987-09-03 1989-08-30 The Vanderbilt University Vorrichtung und verfahren zum aufwärmen von blut mit mikrowellen
WO1990007854A1 (en) * 1988-12-30 1990-07-12 Lifeblood Advanced Blood Bank Systems, Inc. Method and apparatus for the rapid thawing of cryopreserved blood, blood components, and tissue
US4954679A (en) * 1988-12-30 1990-09-04 Lifeblood Advanced Blood Bank Systems, Inc. Method for the rapid thawing of cryopreserved blood, blood components, and tissue
WO1991012888A1 (en) * 1990-02-28 1991-09-05 Kreatech Biotechnology B.V. Apparatus for automatically performing a biotechnological process at different desired temperatures
WO2002054833A1 (en) 2001-01-08 2002-07-11 Lars Ekemar tN APPLIANCE FOR THE EQUALISATION OF HEAT IN A DIELECTRIC LOAD HEATED BY AN OSCILLATING ELECTRIC/ELECTROMAGNETIC FIELD
WO2003083926A2 (en) * 2002-04-02 2003-10-09 Politechnika Wroclawska The microwave enhanced method of silicon etching and the system for microwave enhanced semiconductors etching
WO2015190974A1 (en) * 2014-06-10 2015-12-17 Antrad Medical Ab Detecting leakage when heating a perishable dielectric load
WO2017123145A1 (en) * 2016-01-12 2017-07-20 Antrad Medical Ab Heater and method for thawing/warming a perishable dielectric load

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10763814B2 (en) 2016-08-09 2020-09-01 John Bean Technologies Corporation Radio frequency processing apparatus and method

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997566A (en) * 1959-04-14 1961-08-22 Raytheon Co Microwave apparatus
CH398831A (de) * 1963-02-11 1966-03-15 Patelhold Patentverwertung Mikrowellenbehandlungsgerät mit Generator, Hohlleiter und Mikrowellenarbeitsraum zur raschen Erwärmung von Flüssigkeiten
US3629552A (en) * 1969-06-25 1971-12-21 John D Edging Heating device for parenteral fluid
FR2492210A1 (fr) * 1980-10-09 1982-04-16 Applic Micro Ondes Ste Fse Procede et appareil de chauffage d'un produit par micro-ondes, notamment a des fins de decongelation, et application au plasma sanguin
US4439656A (en) * 1981-04-06 1984-03-27 The Stouffer Corporation Apparatus and method for the reconstitution of frozen foods in a microwave oven
US4503307A (en) * 1983-06-20 1985-03-05 The United States Of America As Represented By The Secretary Of The Navy Shielding apparatus for microwave thawing
FR2571918A1 (fr) * 1984-08-03 1986-04-18 Pellissier Jean Pierre Appareil micro-ondes a decongeler ou rechauffer un liquide biologique

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997566A (en) * 1959-04-14 1961-08-22 Raytheon Co Microwave apparatus
CH398831A (de) * 1963-02-11 1966-03-15 Patelhold Patentverwertung Mikrowellenbehandlungsgerät mit Generator, Hohlleiter und Mikrowellenarbeitsraum zur raschen Erwärmung von Flüssigkeiten
US3629552A (en) * 1969-06-25 1971-12-21 John D Edging Heating device for parenteral fluid
FR2492210A1 (fr) * 1980-10-09 1982-04-16 Applic Micro Ondes Ste Fse Procede et appareil de chauffage d'un produit par micro-ondes, notamment a des fins de decongelation, et application au plasma sanguin
US4439656A (en) * 1981-04-06 1984-03-27 The Stouffer Corporation Apparatus and method for the reconstitution of frozen foods in a microwave oven
US4503307A (en) * 1983-06-20 1985-03-05 The United States Of America As Represented By The Secretary Of The Navy Shielding apparatus for microwave thawing
FR2571918A1 (fr) * 1984-08-03 1986-04-18 Pellissier Jean Pierre Appareil micro-ondes a decongeler ou rechauffer un liquide biologique

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329732A1 (de) * 1987-09-03 1989-08-30 The Vanderbilt University Vorrichtung und verfahren zum aufwärmen von blut mit mikrowellen
EP0329732A4 (de) * 1987-09-03 1989-12-28 Univ Vanderbilt Vorrichtung und verfahren zum aufwärmen von blut mit mikrowellen.
AU593751B1 (en) * 1987-09-03 1990-02-15 Vanderbilt University Microwave energy blood rewarming method and apparatus
WO1990007854A1 (en) * 1988-12-30 1990-07-12 Lifeblood Advanced Blood Bank Systems, Inc. Method and apparatus for the rapid thawing of cryopreserved blood, blood components, and tissue
US4954679A (en) * 1988-12-30 1990-09-04 Lifeblood Advanced Blood Bank Systems, Inc. Method for the rapid thawing of cryopreserved blood, blood components, and tissue
US5302347A (en) * 1990-02-28 1994-04-12 Kreatech Biotechnology B.V. Apparatus for cyclincial temperature process with automatic monitoring and adjusting of the temperature of a water bath
WO1991012888A1 (en) * 1990-02-28 1991-09-05 Kreatech Biotechnology B.V. Apparatus for automatically performing a biotechnological process at different desired temperatures
WO2002054833A1 (en) 2001-01-08 2002-07-11 Lars Ekemar tN APPLIANCE FOR THE EQUALISATION OF HEAT IN A DIELECTRIC LOAD HEATED BY AN OSCILLATING ELECTRIC/ELECTROMAGNETIC FIELD
WO2003083926A2 (en) * 2002-04-02 2003-10-09 Politechnika Wroclawska The microwave enhanced method of silicon etching and the system for microwave enhanced semiconductors etching
WO2003083926A3 (en) * 2002-04-02 2004-04-29 Politechnika Wroclawska The microwave enhanced method of silicon etching and the system for microwave enhanced semiconductors etching
WO2015190974A1 (en) * 2014-06-10 2015-12-17 Antrad Medical Ab Detecting leakage when heating a perishable dielectric load
US10299318B2 (en) 2014-06-10 2019-05-21 Antrad Medical Ab Detecting leakage when heating a perishable dielectric load
WO2017123145A1 (en) * 2016-01-12 2017-07-20 Antrad Medical Ab Heater and method for thawing/warming a perishable dielectric load
US10798788B2 (en) 2016-01-12 2020-10-06 Antrad Medical Ab Heater and method for thawing/warming a perishable dielectric load

Also Published As

Publication number Publication date
FR2603444A1 (fr) 1988-03-04
FR2603444B1 (fr) 1988-12-09

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Inventor name: MILHAUD, ALAIN

Inventor name: BERNARD, JEAN-PAUL

Inventor name: LOBJOIE, ERIC

Inventor name: ROCHAS, JEAN-FRANCOIS

Inventor name: JACOMINO, JEAN-MARIE