EP0233418A1 - Impervious package in the form of a cellular block permitting exchanges of gas between the cells - Google Patents

Impervious package in the form of a cellular block permitting exchanges of gas between the cells Download PDF

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Publication number
EP0233418A1
EP0233418A1 EP86401152A EP86401152A EP0233418A1 EP 0233418 A1 EP0233418 A1 EP 0233418A1 EP 86401152 A EP86401152 A EP 86401152A EP 86401152 A EP86401152 A EP 86401152A EP 0233418 A1 EP0233418 A1 EP 0233418A1
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EP
European Patent Office
Prior art keywords
packaging according
tablets
cells
absorbent product
wafer
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Granted
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EP86401152A
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German (de)
French (fr)
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EP0233418B1 (en
Inventor
Jacques Dauphin
Alain Cuine
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ADIR SARL
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ADIR SARL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B65D75/328—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments the compartments being interconnected, e.g. by small channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56—Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Abstract

New impervious single packaging in the form of a card having compartments and permitting gaseous exchange between the compartments, of which one or more are designed to contain a gas absorber or generator and the others act as receptacles for the solid bodies to be stored; the said compartments being interconnected by small channels. This safety packaging is particularly suited to use in the storage of solid pharmaceutical bodies (tablets, capsules or others).

Description

Le présente invention a pour objet un conditionnement étanche sous forme de plaquette alvéolaire permettant des échanges gazeux entre les alvéoles.The present invention relates to a sealed package in the form of a blister card allowing gas exchanges between the cells.

Ce conditionnement utilisable pour tout produit néces­sitant pour sa conversation un emballage étanche, est parti­culièrement adapté à l'industrie pharmaceutique.This packaging, which can be used for any product requiring sealed packaging for its conversation, is particularly suitable for the pharmaceutical industry.

Le conditionnement, objet de la présente invention, se distingue des conditionnements déjà existants pour les formes pharmaceutiques et offre par rapport à ces derniers des avan­tages particulièrement intéressants.The packaging which is the subject of the present invention differs from the already existing packaging for the pharmaceutical forms and offers particularly advantageous advantages over the latter.

En effet, jusqu'à présent, les conditionnements qui permettent des échanges gazeux sont soit des flacons fermés avec un absorbeur ou un générateur de gaz, soit des plaquettes alvéolaires suremballées dans un second conditionnement étanche contenant un absorbeur ou un générateur de gaz. Le flacon ne constitue pas un condtionnement de sécurité, en ce sens où l'accès à l'ensemble du contenu est facilité. La plaquette alvéolaire suremballée nécessite la superposition de deux opérations de conditionnement. Le nouveau conditionnement proposé est un conditionnement unique réalisant une individualisation de chaque forme pharmaceutique tout en per­mettant des échanges gazeux. Il allie à la fois la stabilité de conservation des médicaments, garantie jusqu'alors par l'emploi de flacons à absorbeur, à la sécurité d'utilisation, présentée par les blisters classiques, et est de ce fait particulièrement intéressant.Indeed, until now, the packaging which allows gas exchanges are either closed bottles with an absorber or a gas generator, or blister packs overwrapped in a second sealed package containing an absorber or a gas generator. The bottle does not constitute security packaging, in the sense that access to all of the content is facilitated. The overwrapped blister pack requires the overlapping of two packaging operations. The new packaging offered is a unique packaging which individualizes each pharmaceutical form while allowing gas exchanges. It combines both the stability of medication storage, guaranteed until then by the use of absorbent bottles, with the safety of use, presented by conventional blisters, and is therefore particularly interesting.

La présente invention concerne particulièrement un conditionnement imperméable aux gaz se présentant sous la forme d'une plaquette constituée en sa partie supérieure d'un film étanche thermocollant et en sa partie inférieure d'un film étanche dans lequel des alvéoles reliés entre eux par des canalicules sont formés par emboutissage ou thermoformage, ou l'ensemble des deux techniques.The present invention relates particularly to gas-impermeable packaging in the form of a plate formed in its upper part by a waterproof fusible film and in its lower part a waterproof film in which cells connected together by canaliculi are formed by stamping or thermoforming, or all of the two techniques.

Les alvéoles d'une même plaquette peuvent être de taille différente. Un ou plusieurs alvéoles contiennent un absorbeur ou un générateur de gaz, les autres alvéoles contiennent des formes pharmaceutiques solides divisées (comprimés, capsules, lyocs...).The cells of the same wafer can be of different size. One or more cells contain a gas absorber or generator, the other cells contain divided solid pharmaceutical forms (tablets, capsules, lyocs ...).

Les échanges gazeux à l'intérieur de la plaquette se font par des canalicules reliant les alvéoles entre eux. Ils peuvent être de taille variable suivant les échanges gazeux souhaités.The gas exchanges inside the wafer are made by canaliculi connecting the alveoli together. They can be of variable size according to the desired gas exchanges.

Les matériaux constituant une barrière aux gaz utilisés pour la fabrication de la plaquette sont :
. Les complexes aluminium thermocollants : polyéthylène-­aluminium-polyéthylène,
. les matières plastiques thermoformables :
chlorure de polyvinyle (PVC) + chlorure de polyvinylidène ; chlorure de polyvinyle + polyéthylène + chlorure de polyvinylidène.The materials constituting a gas barrier used for the manufacture of the wafer are:
. The fusible aluminum complexes: polyethylene-aluminum-polyethylene,
. thermoformable plastics:
polyvinyl chloride (PVC) + polyvinylidene chloride; polyvinyl chloride + polyethylene + polyvinylidene chloride.

D'autres matériaux "barrière", tels que par exemple le polypropylène ou les co-extrudés à base de résine d'alcools polyvinyliques, peuvent également être utilisés.Other "barrier" materials, such as for example polypropylene or co-extrudates based on polyvinyl alcohol resin, can also be used.

Les produits absorbants ou générateurs de gaz sont :
. les tamis moléculaires seuls ou contenant de l'azote
. les gels de silice
. les carbonates de potassium
. l'oxyde de magnesium
. les argiles réactivées.The absorbent products or gas generators are:
. molecular sieves alone or containing nitrogen
. silica gels
. potassium carbonates
. magnesium oxide
. reactivated clays.

Les exemples suivants, donnés à titre non limitatif, illustrent la présente invention.The following examples, given without limitation, illustrate the present invention.

EXEMPLE 1EXAMPLE 1 Plaquette alvéolaire pour conditionnement de comprimés à base d'un produit sensible à l'humidité.Blister for packaging tablets based on a product sensitive to humidity. Exemple 1.AExample 1.A a) formule du comprimé :a) tablet formula:

(N-dicyclopropylméthyl) amino-2 oxazoline phosphate 1 mg
Lactose 70 mg
Cellulose microcristalline 28 mg
Stéarate de magnésium 1 mg(N-dicyclopropylmethyl) 2-amino oxazoline phosphate 1 mg
Lactose 70 mg
28 mg microcrystalline cellulose
Magnesium stearate 1 mg

b) produit absorbant :b) absorbent product:

gel de silicesilica gel

c) type de plaquette alvéolaire :c) type of blister:

Il correspond à la figure annexée 1/2. La face inférieure est formée par un complexe polyéthylène-aluminium-polyéthylène ; la face supérieure par une pellicule d'aluminium thermocollant.It corresponds to the attached figure 1/2. The underside is formed by a polyethylene-aluminum-polyethylene complex; the upper side with a fusible aluminum film.

Une telle plaquette comprend en sa partie supérieure un alvéole (A), réceptacle du produit absorbant, auquel est reliée une double rangée d'alvéoles (C) destinés à recevoir les comprimés.Such a plate comprises in its upper part a cell (A), receptacle for the absorbent product, to which is connected a double row of cells (C) intended to receive the tablets.

Dans chacune de ces rangées, les alvéoles (C) sont groupés par couple de part et d'autre d'un canalicule les reliant entre eux et à l'alvéole (A) contenant le produit absorbant.In each of these rows, the cells (C) are grouped in pairs on either side of a canaliculus connecting them to each other and to the cell (A) containing the absorbent product.

Une telle plaquette contient la médication valable pour un traitement de 10 jours à raison de 2 comprimés /jour.Such a pack contains the medication valid for a 10-day treatment at the rate of 2 tablets / day.

d) avantages :d) advantages:

Le mode de conditionnement ci-dessus décrit assure la stabilité des comprimés lors d'un stockage de longue durée, chez le fabricant ou le grossiste par exemple.The packaging method described above ensures the stability of the tablets during long-term storage, at the manufacturer or the wholesaler for example.

En effet, selon le mode de conditionnement, le titre des comprimés, en pourcentage par rapport au titre initial, après trois mois à 37°C et 75 % d'humidité relative, est le suivant :

Figure imgb0001
Indeed, according to the packaging method, the title of the tablets, in percentage compared to the initial title, after three months at 37 ° C and 75% relative humidity, is as follows:
Figure imgb0001

La plaquette alvéolaire schématisée dans l'annexe 1/2 assure donc aux comprimés conditionnés une stabilité supérieure à celle assurée par les blisters classiques même suremballés. Elle offre la même garantie de stabilité des comprimés que le pilulier avec absorbeur, mais présente par rapport à ce dernier les avantages d'une présentation pour un traitement séquenciel particulièrement apprécié dans le traitement de patients à haut risque.The blister pack shown schematically in Annex 1/2 therefore provides the packaged tablets with greater stability than that provided by conventional blisters, even overpackaged. It offers the same guarantee of stability of the tablets as the pillbox with absorber, but has compared to the latter the advantages of a presentation for a sequential treatment particularly appreciated in the treatment of patients at high risk.

Exemple 1.BExample 1.B

Des résultats analogues ont été obtenus en utilisant le même type de plaquette alvéolaire et le même produit absorbant que dans l'exemple 1.A, pour des comprimés dont la formule unitaire est :
(N-dicyclopropylméthyl) amino-2 oxazoline phosphate (correspondant à 0,001 g de base) 0,001544 g
Carboxyméthylamidon sodique 0,0045 g
Cellulose microcristalline 0,03367 g
Cire blanche q.s.
Lactose 0,047 g
Paraffine 0,00015 g
Silice colloïdale 0,00023 g
Stéarate de magnesium 0,0009 g
Talc 0,002 g
pour un comprimé terminé à 0,090 gSimilar results have been obtained using the same type of blister and the same absorbent product as in Example 1.A, for tablets whose unit formula is:
(N-dicyclopropylmethyl) 2-amino oxazoline phosphate (corresponding to 0.001 g of base) 0.001544 g
Carboxymethyl sodium starch 0.0045 g
Microcrystalline cellulose 0.03367 g
White wax qs
Lactose 0.047 g
Paraffin 0.00015 g
Colloidal silica 0.00023 g
Magnesium stearate 0.0009 g
Talc 0.002 g
for a tablet finished at 0.090 g

Selon le mode de conditionnement, le titre des comprimés, en pourcentage par rapport au titre initial, après trois mois à 37° C et 75 % d'humidité relative, est le suivant :

Figure imgb0002
According to the packaging method, the title of the tablets, in percentage compared to the initial title, after three months at 37 ° C and 75% relative humidity, is as follows:
Figure imgb0002

Les résultats comparatifs ci-dessus permettent d'établir la même conclusion que dans l'exemple 1.A.The comparative results above make it possible to establish the same conclusion as in Example 1.A.

EXEMPLE 2 EXAMPLE 2 Plaquette alvéolaire pour conditionnement de comprimés effervescents :Blister for packaging of effervescent tablets: a) formule du comprimé :a) tablet formula:

Acide ascorbique 100 mg
Inositocalcium 20 mg
Acide tartrique 100 mg
Bicarbonate de sodium 100 mg
Chlorure de sodium 3 mg
Cyclamate de sodium 9 mg
Extrait sec d'orange 12,7 mg
Jaune orangé S 0,3 mg
Polyoxyéthylène glycol 6000 5 mg
Saccharose 100 mgAscorbic acid 100 mg
Inositocalcium 20 mg
Tartaric acid 100 mg
Sodium bicarbonate 100 mg
Sodium chloride 3 mg
Sodium cyclamate 9 mg
Dry orange extract 12.7 mg
Orange yellow S 0.3 mg
Polyoxyethylene glycol 6000 5 mg
Sucrose 100 mg

b) produit absorbant :b) absorbent product:

Un tamis moléculaireA molecular sieve

c) type de plaquette alvéolaire :c) type of blister:

Il correspond au schéma, objet de la figure annexée 2/2.La face inférieure est formée par l'ensemble chlorure de polyvinyle + polyéthylène + chlorure de polyvinylidène ; la face supérieure par une pellicule d'aluminium thermocollant.It corresponds to the diagram, which is the subject of the attached figure 2/2. The underside is formed by the polyvinyl chloride + polyethylene + polyvinylidene chloride assembly; the upper side with a fusible aluminum film.

Une telle plaquette comprend cinq groupes alvéolaires formés chacun d'un alvéole central (A) destiné à contenir le produit absorbant relié, de part et d'autre, par un canalicule à deux alvéoles réceptacles des comprimés.Such a wafer comprises five alveolar groups each formed by a central alveolus (A) intended to contain the absorbent product connected, on both sides, by a canaliculus to two alveoli receptacles for the tablets.

Une telle plaquette contient la médication valable pour un traitement de 5 jours à la dose de 2 comprimés/jour.Such a pack contains the medication valid for a 5-day treatment at a dose of 2 tablets / day.

d) avantages :d) advantages:

Une détermination de l'effervescence des comprimés, après un stockage de trois mois à 37° C et 75 % d'humidité relative, a été effectuée pour différents conditionnements. Les résultats sont regroupés dans le tableau ci-après :

Figure imgb0003
A determination of the effervescence of the tablets, after storage for three months at 37 ° C. and 75% relative humidity, was carried out for various packages. The results are grouped in the table below:
Figure imgb0003

La plaquette alvéolaire schématisée dans l'annexe 2/2 assure outre l'intérêt d'une individualisation de chaque comprimé, une parfaite conservation des dits comprimés lors du stockage puisque ceux-ci conservent leur effervescence originelle.The blister card shown schematically in Annex 2/2 ensures, in addition to the advantage of individualizing each tablet, perfect preservation of said tablets during storage since they retain their original effervescence.

Claims (15)

1. Conditionnement étanche unique caractérisé en ce qu'il se présente sous forme de plaquette alvéolaire permettant des échanges gazeux entre les alvéoles.1. Unique sealed packaging, characterized in that it is in the form of a cellular wafer allowing gas exchanges between the cells. 2. Conditionnement selon la revendication 1 caractérisé en ce qu'il est utilisé pour des formes pharmaceutiques solides divisées.2. Packaging according to claim 1 characterized in that it is used for divided solid pharmaceutical forms. 3. Conditionnement selon les revendications 1 et 2 caractérisé en ce qu'il se présente sous la forme d'une plaquette constituée en sa partie supérieure d'un film étanche thermocollant et en sa partie inférieure d'un film étanche dans lequel des alvéoles reliés entre eux par des canalicules, ont été formés par emboutissage, thermoformage ou l'ensemble des deux techniques.3. Packaging according to claims 1 and 2 characterized in that it is in the form of a wafer consisting in its upper part of a waterproof fusible film and in its lower part of a waterproof film in which connected cells between them by canaliculi, were formed by stamping, thermoforming or all of the two techniques. 4. Conditionnement selon les revendications 1 à 3 caractérisé en ce que un ou plusieurs alvéoles sont destinés à contenir un absorbeur ou un générateur de gaz, les autres servant de réceptacles aux formes solides à stocker.4. Packaging according to claims 1 to 3 characterized in that one or more cells are intended to contain an absorber or a gas generator, the others serving as receptacles for the solid forms to be stored. 5. Conditionnement selon les revendications 1 à 4 caractérisé en ce que les matériaux constituant une barrière aux gaz utilisés pour la fabrication de la plaquette sont choisis parmi les complexes aluminium thermocollants, les matières plastiques thermoformables, le polypropylène et les co-extrudés à base de résine d'alcools polyvinyliques.5. Packaging according to claims 1 to 4 characterized in that the materials constituting a gas barrier used for the manufacture of the wafer are chosen from aluminum fusible complexes, thermoformable plastics, polypropylene and co-extrudates based on polyvinyl alcohol resin. 6. Conditionnement selon les revendications 1 à 5 caractérisé en ce que le produit absorbant ou le générateur de gaz utilisé est choisi parmi le group constitué par : les tamis moléculaires seuls et contenant de l'azote, les gels de silice, les carbonates de potassium, l'oxyde de magnésium et les argiles suractivées.6. Packaging according to claims 1 to 5 characterized in that the absorbent product or the gas generator used is chosen from the group consisting of: molecular sieves alone and containing nitrogen, silica gels, potassium carbonates , magnesium oxide and over-activated clays. 7. Un conditionnement selon les revendications 1 à 6, pour comprimés à base produit sensible à l'humidité, caractérisé en ce qu'il se présente sous forme de plaquette comprenant en sa partie supérieure un alvéole (A), réceptacle du produit absorbant, auquel est reliée une double rangée d'alvéoles (C) destinés à recevoir les comprimés ; dans chacune de ces rangées, les alvéoles (C) étant groupés par couple de part et d'autre d'un canalicule les reliant entre eux et à l'alvéole (A) contenant le produit absorbant.7. A packaging according to claims 1 to 6, for tablets based on a product sensitive to humidity, characterized in that it is in the form of a wafer comprising in its upper part a cell (A), receptacle for the absorbent product, to which is connected a double row of cells (C) intended to receive the tablets; in each of these rows, the cells (C) being grouped in pairs on either side of a canaliculus connecting them to each other and to the cell (A) containing the absorbent product. 8. Un conditionnement selon la revendication7, caractérisé en ce que la face inférieure de la plaquette alvéolaire est formée par un complexe polyéthylène - aluminium polyéthylène, et la face supérieure par une péllicule d'aluminium thermocollant.8. A packaging according to claim 7, characterized in that the lower face of the blister card is formed by a polyethylene - polyethylene aluminum complex, and the upper face by a fusible aluminum film. 9. Un conditionnement selon la revendication 8 caractérisé en ce que le produit absorbant est due gel de silice.9. A packaging according to claim 8 characterized in that the absorbent product is due to silica gel. 10. Un conditionnement selon la revendication 9 caractérisé en ce que les comprimés conditionnés renferment comme principe actif le (N-dicyclopropylméthyl) amino-2 oxazoline phosphate.10. A packaging according to claim 9 characterized in that the conditioned tablets contain as active ingredient (N-dicyclopropylmethyl) 2-amino-oxazoline phosphate. 11. Un conditionnement selon la revendication 10 caractérisé en ce que les comprimés conditionnés renferment chacun 0,001544 g de (N-dicyclopropylméthyl) amino-2 oxazoline phosphate correspondant à 0,001 g de base.11. A packaging according to claim 10 characterized in that the conditioned tablets each contain 0.001544 g of (N-dicyclopropylmethyl) 2-amino-oxazoline phosphate corresponding to 0.001 g of base. 12. Un conditionnement selon les revendications 1 à 6, pour comprimés effervescents, caractérisé en ce qu'il se présente sous forme de plaquette comprenant cinq groupes alvéolaires formés chacun d'un alvéole central (A) destiné à contenir le produit absorbant relié, de part et d'autre, par un canalicule à deux alvéoles réceptacles des comprimés.12. A packaging according to claims 1 to 6, for effervescent tablets, characterized in that it is in the form of a wafer comprising five cellular groups each formed by a central cell (A) intended to contain the absorbent product connected, on both sides, by a canaliculus with two receptacles for the tablets. 13. Un conditionnement selon la revendication 12 caractérisé en ce que la face inférieure de la plaquette alvéolaire est formée par l'ensemble chlorure de polyvinyle + polyéthylène + chlorure de polyvinylidène, et la face supérieure par une pellicule d'aluminium thermocollant.13. A packaging according to claim 12 characterized in that the lower face of the blister card is formed by the polyvinyl chloride + polyethylene + polyvinylidene chloride assembly, and the upper face by a thermo-adhesive aluminum film. 14. Un conditionnement selon la revendication 13 caractérisé en ce que le produit absorbant est un tamis moléculaire.14. A packaging according to claim 13 characterized in that the absorbent product is a molecular sieve. 15. Un conditionnement selon la revendication 14 caractérisé en ce que les comprimés conditionnés renferment comme principe actif l'acide ascorbique.15. A packaging according to claim 14 characterized in that the conditioned tablets contain as active ingredient ascorbic acid.
EP86401152A 1986-01-22 1986-05-30 Impervious package in the form of a cellular block permitting exchanges of gas between the cells Expired EP0233418B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT86401152T ATE39905T1 (en) 1986-01-22 1986-05-30 TIGHT CELLULAR SHELL PACKAGING THAT ALLOWS GAS EXCHANGE BETWEEN CELLS.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8600837 1986-01-22
FR8600837A FR2593152B1 (en) 1986-01-22 1986-01-22 WATERPROOF PACKAGING IN THE FORM OF ALVEOLAR PLATES ALLOWING FOR GAS EXCHANGES BETWEEN THE ALVEOLES.

Publications (2)

Publication Number Publication Date
EP0233418A1 true EP0233418A1 (en) 1987-08-26
EP0233418B1 EP0233418B1 (en) 1989-01-11

Family

ID=9331356

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86401152A Expired EP0233418B1 (en) 1986-01-22 1986-05-30 Impervious package in the form of a cellular block permitting exchanges of gas between the cells

Country Status (15)

Country Link
US (1) US4753352A (en)
EP (1) EP0233418B1 (en)
JP (1) JPS62182073A (en)
AT (1) ATE39905T1 (en)
AU (1) AU597254B2 (en)
DE (1) DE3661717D1 (en)
DK (1) DK163050C (en)
ES (1) ES2000557A6 (en)
FR (1) FR2593152B1 (en)
GR (1) GR861400B (en)
IE (1) IE57511B1 (en)
NZ (1) NZ216349A (en)
OA (1) OA08333A (en)
PT (1) PT82687B (en)
ZA (1) ZA864013B (en)

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FR2660634A1 (en) * 1990-04-06 1991-10-11 Airsec Ind Sa Package for products requiring the use of a desiccant
US5231521A (en) * 1989-10-30 1993-07-27 The University Of Colorado Foundation, Inc. Chiral smectic liquid crystal polarization interference filters
US5243455A (en) * 1990-05-11 1993-09-07 The University Of Colorado Foundation, Inc. Chiral smectic liquid crystal polarization interference filters

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JPH0471560A (en) * 1990-07-10 1992-03-06 Mect Corp Packing body
US5293996A (en) * 1992-05-14 1994-03-15 Motorola, Inc. Container having an observation window
GB9401893D0 (en) * 1994-02-01 1994-03-30 Aquasol Ltd New packages
US6499597B2 (en) 1994-02-01 2002-12-31 Aquasol Limited Skin package
CH687615A5 (en) * 1994-09-07 1997-01-15 R W Johnson Pharmaceutical Res Tropical packaging.
US6279736B1 (en) * 1995-04-19 2001-08-28 Capitol Specialty Plastics, Inc. Barrier pack having an absorbing agent applied to the interior of the pack
US6112888A (en) * 1996-06-28 2000-09-05 W. R. Grace & Co.-Conn. Non-reclosable packages containing desiccant matrix
US6180708B1 (en) 1996-06-28 2001-01-30 W. R. Grace & Co.-Conn. Thermoplastic adsorbent compositions containing wax and insulating glass units containing such compositions
PT1015352E (en) * 1997-04-01 2007-09-24 Cima Labs Inc Blister package and packaged tablets
US6131738A (en) * 1999-01-22 2000-10-17 Valley Design Inc. Breakage prevention device for blister packs
US6905016B2 (en) * 2000-03-14 2005-06-14 Noven Pharmaceuticals, Inc. Packaging system for transdermal drug delivery systems
WO2001093859A1 (en) † 2000-06-09 2001-12-13 Lek Pharmaceuticals D.D. Stable pharmaceutical product and formulation
US7077130B2 (en) 2000-12-22 2006-07-18 Chrysalis Technologies Incorporated Disposable inhaler system
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
AU779458B2 (en) 2000-12-28 2005-01-27 Manrex Pty. Limited Improvements in blister sheets
EP1243524A3 (en) * 2001-03-16 2004-04-07 Pfizer Products Inc. Pharmaceutical kit for oxygen-sensitive drugs
JP2004534571A (en) * 2001-05-15 2004-11-18 イー−メディケーション・アンパルトセルスカブ Medicine dispensing machine
SE0401654D0 (en) * 2004-06-24 2004-06-24 Astrazeneca Ab A support structure for a drug
JP2009545343A (en) * 2006-08-03 2009-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Pack containing pharmaceutical preparation
DK200601302A (en) * 2006-10-06 2008-04-07 O2 Tabs Gmbh Blister pack for tablets
CA2691451C (en) 2007-06-21 2015-03-24 Sara H. Fan Instrument and receptacles for performing processes
SI2098249T1 (en) * 2008-03-05 2013-02-28 Rivopharm Sa Nicorandil carriers with enhanced stability
EP2127628A1 (en) * 2008-05-27 2009-12-02 Ranbaxy Laboratories Limited Unit dose pack
WO2010068527A1 (en) * 2008-12-10 2010-06-17 Merck Sharp & Dohme Corp. Package for oxygen-sensitive pharmaceutical products
AU2009100522A4 (en) * 2009-05-28 2009-08-06 Manrex Pty. Ltd. Blister Package Stiffening
ATE546387T1 (en) * 2009-05-30 2012-03-15 Bayer Innovation Gmbh PRODUCT WITH BIORESORBABLE CARRIER MATERIALS AND PACKAGING
EP2637933B1 (en) * 2010-11-10 2014-09-10 Boehringer Ingelheim Microparts GmbH Method for filling a blister packaging with liquid
JP6040940B2 (en) * 2010-12-16 2016-12-07 ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツングＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ ｍｉｃｒｏＰａｒｔｓ ＧｍｂＨ Method for filling cavities, especially blisters in blister packaging, with liquid and semi-finished product used in such a method
US20170304150A1 (en) * 2016-04-19 2017-10-26 Ascent Pharmaceuticals, Inc. Stable packaging system for moisture and oxygen sensitive pharmaceutical dosage forms
WO2020092651A1 (en) 2018-10-30 2020-05-07 Verinetics An integrated device and system for drug dispensing

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GB1249050A (en) * 1969-12-09 1971-10-06 Grace W R & Co Improvements relating to desiccant packages
US4211326A (en) * 1978-10-10 1980-07-08 American Can Company Blister package
EP0148020A2 (en) * 1983-12-24 1985-07-10 Proprietary Association Of Great Britain Strip packaging

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US4444316A (en) * 1982-09-03 1984-04-24 Olin Corporation Gas scavenger agents for containers of solid chloroisocyanurates

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GB1249050A (en) * 1969-12-09 1971-10-06 Grace W R & Co Improvements relating to desiccant packages
US4211326A (en) * 1978-10-10 1980-07-08 American Can Company Blister package
EP0148020A2 (en) * 1983-12-24 1985-07-10 Proprietary Association Of Great Britain Strip packaging

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231521A (en) * 1989-10-30 1993-07-27 The University Of Colorado Foundation, Inc. Chiral smectic liquid crystal polarization interference filters
FR2660634A1 (en) * 1990-04-06 1991-10-11 Airsec Ind Sa Package for products requiring the use of a desiccant
US5243455A (en) * 1990-05-11 1993-09-07 The University Of Colorado Foundation, Inc. Chiral smectic liquid crystal polarization interference filters

Also Published As

Publication number Publication date
ES2000557A6 (en) 1988-03-01
DK252686A (en) 1987-07-23
DK252686D0 (en) 1986-05-29
AU5809686A (en) 1987-07-23
ATE39905T1 (en) 1989-01-15
ZA864013B (en) 1987-01-28
DK163050B (en) 1992-01-13
AU597254B2 (en) 1990-05-31
PT82687A (en) 1986-11-28
GR861400B (en) 1986-10-02
PT82687B (en) 1992-11-30
NZ216349A (en) 1988-04-29
IE57511B1 (en) 1992-10-07
US4753352A (en) 1988-06-28
EP0233418B1 (en) 1989-01-11
FR2593152B1 (en) 1988-12-23
JPS62182073A (en) 1987-08-10
IE861433L (en) 1987-07-22
DK163050C (en) 1992-06-09
OA08333A (en) 1988-02-29
FR2593152A1 (en) 1987-07-24
DE3661717D1 (en) 1989-02-16

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