EP0189370A3 - Spirodioxolanes, -dithiolanes and -oxothiolanes - Google Patents

Spirodioxolanes, -dithiolanes and -oxothiolanes Download PDF

Info

Publication number
EP0189370A3
EP0189370A3 EP86810003A EP86810003A EP0189370A3 EP 0189370 A3 EP0189370 A3 EP 0189370A3 EP 86810003 A EP86810003 A EP 86810003A EP 86810003 A EP86810003 A EP 86810003A EP 0189370 A3 EP0189370 A3 EP 0189370A3
Authority
EP
European Patent Office
Prior art keywords
interrupted
carbocyclic ring
membered carbocyclic
spirodioxolanes
oxothiolanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86810003A
Other languages
German (de)
French (fr)
Other versions
EP0189370A2 (en
Inventor
Georg Bolliger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Sandoz AG
Original Assignee
Sandoz Erfindungen Verwaltungs GmbH
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853501225 external-priority patent/DE3501225A1/en
Priority claimed from DE19853504286 external-priority patent/DE3504286A1/en
Priority claimed from DE19853504281 external-priority patent/DE3504281A1/en
Priority claimed from DE19853504284 external-priority patent/DE3504284A1/en
Application filed by Sandoz Erfindungen Verwaltungs GmbH, Sandoz AG filed Critical Sandoz Erfindungen Verwaltungs GmbH
Publication of EP0189370A2 publication Critical patent/EP0189370A2/en
Publication of EP0189370A3 publication Critical patent/EP0189370A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Spiro-Verbindungen, enthaltend einen fünfgliedrigen, carbocyclischen Ring, der in den Stellungen 1 und 3 durch zwei Heteroatome aus der Reihe Sauerstoff und Schwefel unterbrochen ist und dessen Kohlenstoffatom in Stellung 4 mit einem 4- bis 8-gliedrigen, carbocyclischen Ring, der durch ein Stickstoffatom unterbrochen ist, gemeinsam ist, in Form der freien Basen oder von pharmazeutisch annehmba­ ren Säureadditionssalzen oder quaternären Ammonium-­ Salzen, ihre Herstellung und Anwendung als Therapeutika. Spiro compounds containing a five-membered carbocyclic ring, which is in positions 1 and 3 two heteroatoms from the series oxygen and sulfur is interrupted and its carbon atom in position 4 with a 4- to 8-membered carbocyclic ring which is interrupted by a nitrogen atom, is common in Form of free bases or pharmaceutically acceptable acid addition salts or quaternary ammonium Salts, their production and use as therapeutic agents.

EP86810003A 1985-01-16 1986-01-08 Spirodioxolanes, -dithiolanes and -oxothiolanes Withdrawn EP0189370A3 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE3501225 1985-01-16
DE19853501225 DE3501225A1 (en) 1985-01-16 1985-01-16 Spirodioxolanes, their preparation and use
DE3504284 1985-02-08
DE19853504286 DE3504286A1 (en) 1985-02-08 1985-02-08 Spiro-oxothiolanes, their preparation and use
DE19853504281 DE3504281A1 (en) 1985-02-08 1985-02-08 Spiro-oxothiolanes, their preparation and use
DE3504286 1985-02-08
DE3504281 1985-02-08
DE19853504284 DE3504284A1 (en) 1985-02-08 1985-02-08 Spiro-dithiolanes, their preparation and use

Publications (2)

Publication Number Publication Date
EP0189370A2 EP0189370A2 (en) 1986-07-30
EP0189370A3 true EP0189370A3 (en) 1988-01-27

Family

ID=27433274

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86810003A Withdrawn EP0189370A3 (en) 1985-01-16 1986-01-08 Spirodioxolanes, -dithiolanes and -oxothiolanes

Country Status (10)

Country Link
US (1) US4735944A (en)
EP (1) EP0189370A3 (en)
AU (1) AU586848B2 (en)
DK (1) DK17286A (en)
ES (1) ES8800948A1 (en)
FI (1) FI860186A (en)
GR (1) GR860078B (en)
HU (1) HU196073B (en)
NZ (1) NZ214821A (en)
PT (1) PT81835B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE122353T1 (en) * 1987-10-05 1995-05-15 Yamanouchi Pharma Co Ltd HETEROCYCLIC SPIR COMPOUNDS AND THEIR PRODUCTION.
US4900830A (en) * 1987-10-28 1990-02-13 Israel Institute For Biological Research Process for labelling sulfur-containing compounds
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
GB8816299D0 (en) * 1988-07-08 1988-08-10 Merck Sharp & Dohme Therapeutic agents
US5075317A (en) * 1989-06-21 1991-12-24 Fisons Corporation Spirofurane derivatives
US5594000A (en) * 1989-06-21 1997-01-14 Astra Ab Spirofurane derivatives
HU204530B (en) * 1989-08-10 1992-01-28 Richter Gedeon Vegyeszet Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5073560A (en) * 1990-07-20 1991-12-17 Fisons Corporation Spiro-isoxazolidine derivatives as cholinergic agents
AU736238B2 (en) * 1996-08-28 2001-07-26 Procter & Gamble Company, The Spirocyclic metalloprotease inhibitors
SE9701396D0 (en) * 1997-04-15 1997-04-15 Astra Pharma Prod Compounds
BR0013085A (en) * 1999-08-13 2002-04-23 Aventis Cropscience Gmbh Heterocyclic spiro compounds as pesticides
WO2010084499A2 (en) * 2009-01-26 2010-07-29 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2650845A1 (en) * 1975-11-11 1977-05-18 Mundipharma Ag NEW SPIRO- (1,3-DIOXOLAN-4,3 ') QUINUCLIDINE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2650845A1 (en) * 1975-11-11 1977-05-18 Mundipharma Ag NEW SPIRO- (1,3-DIOXOLAN-4,3 ') QUINUCLIDINE

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Band 75, Nr. 7, 16. August 1971, Columbus, Ohio, USA KATRITZKY, A.R.; JONES, R.A.Y.; LEHMANN, P.G.; RECORD, K.A.F.; SHAPIRO, MRS. B.B. "Conformational analysis of saturated heterocycles. XXXI. 1-tert-Butyl-spiro(piperidine-4,4'-(1',3'-dioxolane)) and spiro(1,3-dioxane-5,4'-(1',3'-dioxolane))" Seite 299, Spalte 2, Zusammenfassung-Nr. 48 294z * J. Chem. Soc. ,B 1971, (6), 1302-7 *
CHEMICAL ABSTRACTS, Band 78, Nr. 19, 14. Mai 1973, Columbus, Ohio, USA JONES, R.A.Y.; KATRITZKY, A.R.; NICOL, D.L.; SCATTER GOOD, R. "Conformational analysis of saturated heterocycles. LI. Spirodioxolanes" Seite 424, Spalte 2, Zusammenfassung-Nr. 123 867f & J. Chem. Soc. , Perkin Trans. 2, 1973, (4), 337-8 *

Also Published As

Publication number Publication date
PT81835A (en) 1986-02-01
FI860186A0 (en) 1986-01-15
PT81835B (en) 1987-11-19
EP0189370A2 (en) 1986-07-30
AU586848B2 (en) 1989-07-27
DK17286D0 (en) 1986-01-14
ES8800948A1 (en) 1987-12-01
HU196073B (en) 1988-09-28
HUT42774A (en) 1987-08-28
US4735944A (en) 1988-04-05
AU5224286A (en) 1986-07-24
NZ214821A (en) 1989-03-29
FI860186A (en) 1986-07-17
ES550896A0 (en) 1987-12-01
GR860078B (en) 1986-04-30
DK17286A (en) 1986-07-17

Similar Documents

Publication Publication Date Title
EP0189370A3 (en) Spirodioxolanes, -dithiolanes and -oxothiolanes
EP0577847A4 (en) Morphinan derivative and medicinal use.
MX173358B (en) ANTIBACTERIAL COMPOUNDS AND PROCEDURE TO OBTAIN THEM
FI935675A (en) pyrazolopyrimidines
ATE145914T1 (en) ANTICONVULSIVE FRUCTOPYRANOSE CYCLIC SULFATES AND SULFITES
EP0775487A4 (en) Triazine derivative and medicine
ATE49749T1 (en) AMINO ACID DERIVATIVES WITH ANTITUMORIC ACTIVITY AND COMPOSITIONS CONTAINING THESE DERIVATIVES.
FI941863A (en) Oksatsolidonijohdannainen
DK472387A (en) NAPHTHALINE AND INHANDER DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING SUCH COMPOUNDS
GB1397645A (en) Aza-benzimidazoles
ATE88091T1 (en) 2-ALKOXY-N-(1-AZABICYCLO(2.2.2)-OCT-3-YL) BENZAMIDES AND THIOBENZAMIDES WITH ANTSCHIZOPHRENIC ACTIVITIES.
AT338234B (en) PROCESS FOR THE PREPARATION OF 2,5-DISUBSTITUTED BENZAMIDES AND THEIR ACID ADDITION AND QUARTAR AMMONIUM SALTS
DK0554794T3 (en) aminobenzoic
ES2063126T3 (en) SOLID-BASED ALKID PAINTS.
JO1041B1 (en) N- (1-methyl-2-pyrrolidinylmethyl) -2,3-dimethoxy -5- methylsulfamoyl benzamide and its derivatives, their preparations processes and their use in the treatment of disorders of the lower urinary apparatus
ES517779A0 (en) PROCEDURE FOR THE PREPARATION OF NEW 2-PHENYLMORFOLINE DERIVATIVES.
ATE115586T1 (en) NAPHTHALENE AND TETRAHYDRONAPHTHALENE GEM-DIPHOSPHONATE DERIVATIVES.
AT330741B (en) PROCESS FOR THE PREPARATION OF 2,5 DISUBSTITUTED BENZAMIDES AND THEIR ACID ADDITION SALTS AND QUARTAR AMMONIUM SALTS
IE800900L (en) Pyrrolidinyl-benzoic acid derivatives.
AT338235B (en) PROCESS FOR THE PREPARATION OF 2,5-DISUBSTITUTED BENZAMIDES AND THEIR ACID ADDITION AND QUARTAR AMMONIUM SALTS
EP0264928A3 (en) Vinylogous porphyrines
FR2361874A1 (en) Analgesic propoxyphene compns. - of d or l-isomers potentiated with benzodiazepines
AT338236B (en) PROCESS FOR THE PREPARATION OF 2,5-DISUBSTITUTED BENZAMIDES AND THEIR ACID ADDITION AND QUARTAR AMMONIUM SALTS
USD239280S (en)
GB1178724A (en) Novel Quaternary Compounds

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19860110

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19891208

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19900419

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BOLLIGER, GEORG