EP0175760A1 - Dispositif de douche rectale prophylactique - Google Patents

Dispositif de douche rectale prophylactique

Info

Publication number
EP0175760A1
EP0175760A1 EP85901762A EP85901762A EP0175760A1 EP 0175760 A1 EP0175760 A1 EP 0175760A1 EP 85901762 A EP85901762 A EP 85901762A EP 85901762 A EP85901762 A EP 85901762A EP 0175760 A1 EP0175760 A1 EP 0175760A1
Authority
EP
European Patent Office
Prior art keywords
nozzle
cap
bottle
douching
nozzle means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP85901762A
Other languages
German (de)
English (en)
Inventor
Erick-Pierre Fournier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0175760A1 publication Critical patent/EP0175760A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/005—Medical syringes, e.g. enemata; Irrigators comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0201—Cassettes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/0254—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped
    • A61M3/0262—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped manually, e.g. by squeezing a bulb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/02—Enemata; Irrigators
    • A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/0245—Containers therefor, e.g. with heating means or with storage means for cannula

Definitions

  • This invention relates to douching devices and more particularly to convenient, safe and inexpensive means of rinsing out the rectal cavity known as the ampulla. While the present inventive products address themselves in general to patient's suffering from vari ⁇ ous enteric parasitic infections, they are primarily directed to people involved in anal sexual relations for routine, preventive hygiene and/or therapeutic treatment.
  • Oral-genital-anal sexual relations performed with- out regards to intimate cleanliness can lead any active partner to a variety of serious and debilitating dis ⁇ eases such as Amebiasis, Hepatitis A or Salmonella.
  • An infected active partner can transmit to any passive party some equally serious disorder such as Proctitis, Herpes, Hepatitis B or Gonorrhea.
  • frequent and/or careless anal intercourse can easily cause inter ⁇ nal damage to the fragile lining of the rectal cavity and sphincter muscles in the form of anal fissures, tears or bleeding hemorrhoids. Through these breaks in the lining, microscopic as they may be, infective agents carried along by the semen can enter into the bloodstream and create severe systemic conditions.
  • AIDS Acquired Immune Deficiency Syndrome
  • the stool is a source of parasitic infections and should be thoroughly cleansed out from the ampulla before sexual relations while the semen from the active partner should be flushed out right after intercourse as a possible carrier of diseases to the passive party. Accordingly, to effectively ac ⁇ complish this objective, the key design criteria of any appropriate rectal douching device should be as follows:
  • the nozzle should be safe, comfortable to insert and equipped with exit apertures situated in such a way that the pressure flow of the douching liquid is evenly distributed among the four cardinal points and oriented upward at a 30° to 50° angle in order to adequately drench the dome of the ampulla.
  • the structure of the device should allow the container of liquid to be easily and quickly refillable at least three times in fairly rapid succession.
  • the device should incorporate conveniently handable means of dispensing a variety of water-soluble medications.
  • U.S. Patent No. 1,602,215 features a water-soluble tablet of solid medication situated inside a reusable douche nozzle equipped with two separate rows of perforations: an upper series designed to allow the fluid to exit from the tip of the nozzle and a lower series at the base of the nozzle to channel the rinse-off flow out of the body cavity.
  • U.S. Patent No. 2,507,214 covers a vaginal syringe equipped with a water-pressure control screw-valve acting also as a dispenser of liquid medica ⁇ tion.
  • 2,596,597 relates to a syringe nozzle with manually rotatable spray orifices. While all of the foregoing devices are intended and designed for vaginal use, none incorporate the above-listed design criteria deemed essential for any effective rectal douching apparatus.
  • the present invention is designed to overcome the deficiencies of the prior art and to provide a device which accomplishes the objectives described above. This is achieved, according to the invention, by providing a prophylactic rectal douching device which includes a plastic squeeze bottle having a cap with an elongated nozzle mounted thereon and extending upwardly therefrom.
  • the cap is divided into an upper portion and a lower portion and includes a living hinge between the two which allows the upper cap portion and nozzle to pivot out of the way to expose the open top of the bottle for refilling the same with tap water. This is done without having to remove the entire cap and nozzle from the bottle.
  • a locking mechanism main ⁇ tains the upper cap portion and nozzle in their upright operable position during use.
  • the nozzle includes a plurality of spaced apertures which are designed to dispense liquid from the bottle at optimal angles. Flow splitters within the nozzle equalize the flow rate and pressure among the various apertures. The nozzle is also adapted to carry a supply of medication which is intended to be added to the douching fluid.
  • FIG. 1 is a front elevational view of a pro ⁇ phylactic rectal douching device constructed in ac ⁇ cordance with the principles of the present invention
  • Figure 2 is a top plan view thereof
  • Figure 3 is a vertical sectional view with the nozzle shown in phantom in its open position
  • Figure 4 is a top plan view of the douching device with the nozzle in its open position
  • Figure 5 is a cross-sectional view similar to
  • Figure 3 but showing a modified form of the invention
  • Figure 6 is a top plan view of the embodiment shown in Figure 5 with the nozzle in its open position
  • Figure 7 is a cross-sectional view taken through the line 7-7 of Figure 5;
  • Figure 8 is a top plan view of the device prior to assembly for use
  • Figure 9 is a vertical cross-sectional view of the device prior to assembly for use
  • Figure 10 is a top plan view similar to Figure 8 but showing the same with a heat shrink film thereon for protection during shipping, and Figure 11 is a front elevational view of the device packaged for shipping.
  • FIG. 1 a prophylactic rectal douching device constructed in accordance with the principles of the present invention and designated generally as 10.
  • the douching device 10 is comprised essentially of three components: a squeezable plastic container 12, an an ⁇ atomically shaped nozzle 14 mounted on the container 12 and internal means (to be described more fully here ⁇ inafter) for storing and dispensing water-soluble med ⁇ ication into the douching solution.
  • the container 12 is a thin-walled, easily squeez ⁇ able, blow-molded plastic bottle typically made from low to medium density polyethylene and/or polypropylene.
  • a plastic unitary assembly comprised of the nozzle 14 and an internally threaded crown cap 16 which can be injection molded from polyvinylchloride, polystyrene, polypropylene, polyester or semi-flexible thermoplastic elastomers such as polyurethane.
  • the crown cap 16 is a split structure comprising an upper cap portion 16a and a lower cap portion 16b.
  • An integral living hinge 18 joins the upper and lower portions 16a and 16b along one side thereof.
  • the hinge 18 is located at a level which is substantially equal to the uppermost edge of the rim of the bottle 12.
  • the upper super structure that is, the upper cap portion 16a with the nozzle 14 attached thereto is able to tilt downwardly to expose the open mouth of the bottle 12 while the lower portion 16b of the cap 16 remains secured to the neck of the bottle 12. This is shown in phantom in Figure 3.
  • the nozzle 14 and upper cap portion 16a are main ⁇ tained in their upright position by a locking means carried by the cap 16 located at a position remote from the hinge 18.
  • the locking means is comprised of a ridge 20 which extends upwardly from the upper surface of the lower cap portion 16b.
  • a complementary mating groove 22 is located in the lower surface of the upper cap portion 16a. The ridge 20 and groove 22 frictionally interact with each other to form the locking means.
  • a simple pressure of the hand, however, opposite the hinge side of the nozzle 14 will quickly open access to the mouth of the container 12 for easily refilling the same with water.
  • the douching sprays should assume the pattern of an inverted cone and be directed upwardly around an arc of 30° to 50°.
  • the pressure of the liquid forced out of the nozzle should be diffused as evenly as pos ⁇ sible through a plurality of channels leading to lateral exit slits rather than holes. Too high a water pressure forced through one single circular opening has been known to cause minute punctures in the rectal mucous membrane providing virus and bacteria with possible entry points into the blood stream.
  • the nozzle 14 is designed in the following manner.
  • the upper portion 16a of the cap 16 is surmounted by a narrow, flat recess abutting a short circular ridge 24 forming therewith a shelf designed to keep the in ⁇ verted nozzle stabilized into the neck of the bottle during shipping as will be explained more fully here- inafter.
  • the circular ridge 24 progressively tapers inwardly and upwardly as shown at 26 into a substantial ⁇ ly cylindrical shape to form the nozzle 14.
  • the nozzle 14 should have an outer diameter of approximately one inch in order to constitute a plug- like arrangement against the anal sphincter muscles to thereby prevent seepage of the liquid during douching.
  • the nozzle diameter thins further down to about five-eighths to three-quarters of an inch in diameter to form a very soft shoulder 28 ringed with four exit slits 30 which are equidistant- ly arranged around the circumference of the nozzle.
  • the nozzle 14 terminates in a rounded tip 32 which is provided with three apertures 34 equally spaced therearound.
  • the internal arrangement of the nozzle 14 includes, adjacent its base, a flexible semi-spherical one-way valve 36 of unitary construction which prevents backflow and, to a degree, controls forward flow pressure.
  • the valve 36 incorporates one or more expand ⁇ able slits across its top which may either be lateral or cross shaped.
  • the valve is preferably made of such inert thermoplastic elastomeric materials as latex, neoprene or polyolefin rubber so that it can be heat- sealed or ultrasonically welded onto .the circular recess 38 provided therefor underneath the ridge 24.
  • the internal walls of the nozzle 14 extend upwardly from the circular recess 38 in a substantially cylindri ⁇ cal manner up to the level of the constriction created by the shoulder 28. At that point, the internal walls of the upper portion of the nozzle 14 thicken as shown at 40 to create, in effect, a circular sluice-like arrangement 42 having its base and the four cardinal exit slits 30 angulated at approximately 45° from the normal. As a result, the douching fluid forced out of the bottle is not only apportioned according to the diameter of the ducts in the lower and upper nozzle portions but is sprayed out at the desired angle. The same principle applies for the uppermost internal ar ⁇ rangement of the nozzle which incorporates an inverted cone 44 fanning the fluid out at the chosen angle through the apertures 34.
  • the circular inner edge of the sluice wall 42 extends downwardly to form a substantial- ly cylindrical tube 46.
  • This feature is designed to accomplish three primary functions. Firstly, in combina ⁇ tion with the four radially extending support walls 48, five separate channels are formed to equalize the douching fluid in the desired volumes. The five channels are comprised of the four channels 50 formed between the walls 48 and the " cylindrical wall 46 and the central duct or channel 52 within the cylindrical wall 46. Secondly, the wall 46 tends to diffuse the hydraulic pressure and lastly, it acts as a spacer for the car- tridge of medication 54.
  • the cylindrical wall 46 and radial support walls 48 are, of course, only one method for maintaining the cartridge 54 of medication in its proper position inside the base of the nozzle 14.
  • the inside walls of the nozzle could also be provided with a plurality of short radially inwardly extending fins which would be positioned around the inside wall of the nozzle in a manner very similar to the radial support walls 48.
  • the present invention also provides a means for storing and dispensing unit-dose medications.
  • Two dif- ferent methods are proposed according to the invention depending on the precision of the dosage required.
  • the first method which is the more precise one, is shown most clearly in Figures 8 and 9.
  • the apparatus is provided with a small con- tainer 56 comprised of a thermoformed plastic material and which is filled with a liquid, solid or powdered concentrate 58 of any appropriate medicated solution to be diluted or dissolved into the water contents of the bottle 12 prior to use.
  • the size and shape of the container 56 are chosen so that the container is designed to fit snuggly into the empty cavity available at the base of the nozzle 14 in the area substantially surrounded by the cap 16.
  • the "piggy-back" container 56 of medication .58 can also be shaped to provide two or more separate cavities. Each cavity could be filled with a separate medication which can either be mixed together in one application or which may be intended to be used in sequence.
  • FIG. 5 A more convenient but less precise delivery mode for a medication is shown in Figure 5.
  • a cartridge 54 of medication can be inserted into the base of the nozzle.
  • the cartridge 54 is prefer- ably cylindrically shaped and may be made of a plastic cellular material such as polyurethane foam impregnated with a variety of partially dehydrated, water soluble ingredients in various concentrations.
  • These ingre ⁇ washers, deposited in film form around the cells of the foam structure, are designed to allow the fluid to flow through and to spontaneously dissolve on contact with water or any other aqueous substances.
  • the dissolution of the ingredients from the car ⁇ tridge 54 can be speeded up by increasing the surface exposure of the cellular carrier to the liquid medium by providing the cartridge with a plurality of longi- tudinal channels 60 and 62. As shown most clearly in Figures 5 and 7, these channels can assume various depths, widths or cross-sectional shapes and can be situated laterally or internally or both.
  • the length of the cartridge 54 can vary according to cell sizes, concentration and solubility rate of the additives and release requirements of the ingredients in the exiting douching fluid.
  • foamable polymers and co-polymers can be utilized to produce the cellular foam cartridge 54.
  • material such as foam rubber, polyvinylchloride, poly- vinylacetate, polypropylene, polyethylene, polyester polyurethane and polyether polyurethane can be used. Of these materials, the latter is the preferred material in view of its good hydrophilic properties combined with flexibility in cell size formation and high- addi ⁇ tive-handling capacity.
  • the foam density should range from about 1 to 1.8 pounds per cubic foot (excluding the weight of the additives) with average cell sizes ranging from 3.5 to 8 millimeters.
  • the car ⁇ tridge 54 of cellular foam can be manufactured and impregnated with medicated additives in at least two different ways.
  • a grooved cylinder of appropriate diameter can be machined from a block of cured, reticulated polyurethane foam utilizing a hot knife.
  • the cylinder can then be dipped into a bath containing the liquid medications for saturation and subsequently dried out.
  • the cylinder can then be cut into appropriate lengths unless it had been precut.
  • the percentage of additives for release can usually amount only to a practical maximum of about 15 percent by weight of foam.
  • a second method for manufacturing and impregnating the cartridge 54 consists of admixing with the partially foamed polymers the various medicated additives to be released in the douching liquid.
  • This single step process has the advantage of bypassing the time-consum ⁇ ing machining steps by delivering straight from the mold a finished, ready-to-use preimpregnated cartridge with a porous membranous skin.
  • the use of this tech ⁇ nology based upon the teachings of Patent 4,271,272, allows the cellular cartridge to hold up to about 60 percent by weight of water soluble additives for release.
  • the medicated additives contained in the cartridge 54 or the container 56 should desirably contain a com ⁇ bination of non-irritating ingredients, not only for the effective removal of the stool but also to help restore to normal the very delicate membrane of - the ampulla.
  • the composition of the medicated douching solution should combine the following six generic ingredients:
  • An emollient such as mineral oil, vegetable glycerin or lanolin.
  • a mild surfactant such as cocoa-tallow "baby soap."
  • Healing agents such as vitamins C and E in combination with Zinc or extracts from any nu ber of appropriate medicinal herbs such as Hypericum (Hypericum Perforatum) , Arnica (Arnica Montana), Aesculus (Aesculus Hippo- castanum) , Comfrey (Symphytum Officinale) , Balsam (Graphalium Polycephalum) or Marigold
  • Astringents derived from any of the following herbs Aloe Vera (Trillium Purpureum) , Balmony (Chelone Glabra) , Shepherd's Purse (Capsella Bursa-Pastoris) , Witch Hazel (Hammanelis Vir- ginica) ' or Alum Root (Geranium Maculatum) .
  • the structure of the lower portion of the nozzle 16 is so designed that it can fit snuggly upside down into the bottle 12 as shown in Figures 9 and 10. It can be seen that the shape of the ridge 24 is selected so that it fits into the opening at the top of the bottle with the top edge of the bottle contacting the cap 16.
  • the base of the inverted cap 16 including the container 56 with medication 58 therein and the upper end of the bottle 12 are shielded during shipping and handling by means of a tamper-proof thermo-plastic heat shrinkable film 64.
  • the film 64 also maintains the cap 16 and nozzle 14 into proper orientation with the bottle 12.
  • the tear strip 66 of the shrink film 64 is used to rip open the protective film 64 and free the nozzle 14 for assembly onto the bottle 12.
  • the container 56 of medication 58 may also be provided with its own cover in the form of a peel-off seal 68. Prior to fill ⁇ ing the bottle 12 with water, the contents from the container 56 may be poured therein to be mixed therewith and the container 56 can then be disposed of.
  • the tip 32 of the nozzle 14 is also provided with its own supply of lubricant 70 which is held in place by a thin, flexible tubular mating plastic sleeve 72 press fitted or otherwise attached thereon during shipping.
  • a coating of lubrication 70 will be left on the tip of the nozzle. This process can be repeated prior to reinsertion by redipping the nozzle back into the sleeve of lubricant.
  • Desirable properties of the vegetable oil based lubricant 70 should primarily be high viscosity, re ⁇ sistant to body temperature and water solubility.
  • the lubricant may be medicated and incorporate a number of appropriate topical wound healing agents and astringents such as those listed above for the douching solutions as well as a mild topical anesthetic such as Procaine, Benzocaine or Lidocaine.
  • the anes ⁇ thetic should be chosen to selectively desensitize to some degree the pain conductive nerve endings of the anal sphincter without unduly affecting those which transmit sensations.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Un dispositif de douche rectale prophylactique (10) comporte une bouteille à presser en plastique (12) comportant un capuchon (16) avec un bec allongé (14) monté sur celui-ci et s'étendant vers le haut à partir de celui-ci. Le capuchon (10) est divisé en une partie supérieure (16a) et une partie inférieure (16b); il comporte une articulation tournante (18) entre les deux parties, qui permet à la partie supérieure du capuchon et au bec de pivoter vers l'extérieur pour exposer le sommet ouvert de la bouteille afin de remplir cette dernière avec de l'eau du robinet. A cet effet, on n'a pas besoin de retirer tout le capuchon et le bec de la bouteille. Un mécanisme de verrouillage (20, 22) mantient la partie supérieure du capuchon (16a) et le bec (14) dans leur position verticale de fonctionnement pendant l'utilisation. Le bec (14) comporte une pluralité d'ouvertures espacées (30, 34) conçues pour répartir le liquide provenant de la bouteille (12) à des angles optimaux. Des séparateurs d'écoulement (50, 52) placés dans le bec répartissent la pression et la vitesse d'écoulement entre les diverses ouvertures. Le bec est également conçu pour porter une alimentation de médication (58) prévue pour être ajoutée au liquide de douche.
EP85901762A 1984-03-19 1985-03-18 Dispositif de douche rectale prophylactique Withdrawn EP0175760A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59090984A 1984-03-19 1984-03-19
US590909 1984-03-19

Publications (1)

Publication Number Publication Date
EP0175760A1 true EP0175760A1 (fr) 1986-04-02

Family

ID=24364231

Family Applications (1)

Application Number Title Priority Date Filing Date
EP85901762A Withdrawn EP0175760A1 (fr) 1984-03-19 1985-03-18 Dispositif de douche rectale prophylactique

Country Status (3)

Country Link
EP (1) EP0175760A1 (fr)
AU (1) AU4151285A (fr)
WO (1) WO1985004108A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311657A4 (en) * 1987-04-21 1991-09-18 Chattan Nominees Pty. Ltd. Vaginal douche
IT1297538B1 (it) * 1997-08-01 1999-12-17 Francesco Vicidomini Enteroclisma di lattulosio/lattitolo con o senza aggiunta di neomicina per la cura della encefalopatia portosistemica acuta
GB2351444B (en) * 1998-04-08 2003-09-10 Peter James Brian Lamb Substance applicator
US8147445B2 (en) * 2005-06-14 2012-04-03 C.B. Fleet Company Inc. Enema dispenser
FR2997874B1 (fr) * 2012-11-14 2020-01-31 Antoine Patte Dispositif d'aspersion pour asperger une partie d'un corps humain
US11654229B2 (en) * 2016-03-18 2023-05-23 Indiana University Research And Technology Corporation Wound irrigation device
JP7165808B2 (ja) * 2018-04-06 2022-11-04 レヴィ，フランク 医療用濃縮懸濁液を生成するための装置及び方法
DE102019109956B4 (de) 2018-04-19 2023-01-05 Philip Großkord Vorrichtung zur Dosierung von flüssigen Stoffen in Körperöffnungen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US758643A (en) * 1903-12-17 1904-05-03 Mcpike Drug Company Portable syringe.
US2254636A (en) * 1938-05-11 1941-09-02 Verl D Vangunten Medicinal product
US2241331A (en) * 1939-01-27 1941-05-06 Wm S Merrell Co Suppository
US2470293A (en) * 1946-02-14 1949-05-17 Angelo Joseph B D Nozzle
US2649398A (en) * 1949-04-01 1953-08-18 Tampax Inc Douche composition
US2869545A (en) * 1957-04-11 1959-01-20 Cb Fleet Co Inc Package
US3048174A (en) * 1960-01-07 1962-08-07 Frank E Charles Holder for medicated cartridge for douche bag
US3802435A (en) * 1971-01-25 1974-04-09 A Claasen Device for introducing a medicinal medium into the body through the anus
US4331653A (en) * 1977-08-18 1982-05-25 Robert Brown Composition for a topical cream for curtailing bleeding and treating skin disorders
US4274555A (en) * 1978-12-07 1981-06-23 Sneider Vincent R Flexible syringe with nozzle closure
US4487336A (en) * 1982-06-01 1984-12-11 Sneider Vincent R Syringe closure assembly with attachable nozzle

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8504108A1 *

Also Published As

Publication number Publication date
AU4151285A (en) 1985-10-11
WO1985004108A1 (fr) 1985-09-26

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