EP0158668A1 - Process for producing skin care preparations, particularly anti-inflammatory preparations - Google Patents

Process for producing skin care preparations, particularly anti-inflammatory preparations

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Publication number
EP0158668A1
EP0158668A1 EP84903716A EP84903716A EP0158668A1 EP 0158668 A1 EP0158668 A1 EP 0158668A1 EP 84903716 A EP84903716 A EP 84903716A EP 84903716 A EP84903716 A EP 84903716A EP 0158668 A1 EP0158668 A1 EP 0158668A1
Authority
EP
European Patent Office
Prior art keywords
preparations
cells
skin care
algae
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84903716A
Other languages
German (de)
French (fr)
Inventor
Beatrix Bodnarne Lovasi
János ZLINSZKY
Tünde SIMONNE ZAKONYI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIMONNE ZAKONYI TUNDE
Original Assignee
SIMONNE ZAKONYI TUNDE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SIMONNE ZAKONYI TUNDE filed Critical SIMONNE ZAKONYI TUNDE
Publication of EP0158668A1 publication Critical patent/EP0158668A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella

Definitions

  • the invention relates to the manufacture of skin care preparations, thus to the manufacture of medicinal preparations, but in particular to the manufacture of preparations with an anti-inflammatory effect.
  • GP-PS No. 1 392131 sets out cosmetic preparations which contain the nucleoplasm of the diatoms obtained from sea planks - Asterionella japonica, Ohaetoceros ceres.
  • DE-PS No. 2532 934 relates to such cosmetic preparations which contain cell-free plankton extracts. These are obtained from the mixed planks of thermal water with sulfur content.
  • DE-PS No. 294.0 411 recommends the dry matter extracts of the pure cultures of ßrün for medicinal purposes algae (Scenedesmus).
  • the object of the invention is thus a process for the production of skin care preparations, such as cosmetic and medicinal cosmetic preparations, where it is characteristic of the process that we use plant cells or tissue parts living as active ingredients, in particular the usual carriers and / or the other additives of the skin care preparations Add algae cells.
  • the subject of the invention is also those cosmetic preparations which contain the living plant cells or tissue parts mentioned, in particular algae cells.
  • the algae concentration of the preparations according to the invention can be selected between broad limits; the algae content is generally 0.3. 10 6 cells / ml, or 6.0. 10 cells / gram.
  • the algae cells are taken from pure algal cultures produced between sterile circumstances, advantageously from pure cultures of green algae.
  • the algae species Scenedesmus quadricauda, Selenastrum capricornutum, or Ghlamydomonas debaryna can be used particularly advantageously.
  • the algae reproduce in the usual way under sterile or aseptic conditions and are then - in the course of reaching the corresponding state of development - in the above-mentioned amounts added to the base material of the skin care product, which was produced from the usual carriers and / or additives .
  • the preparations produced in this way can be, for example, creams, jellies, solutions or body care liquids which are the usual pette or oils, solvents or diluents, emulsifiers, preservatives, water binders, fillers, colorants and / or fragrances, and also vitamins and / or others Contain substances with beneficial effects. These are made in a known manner.
  • the advantage of the preparations according to the invention is that they exert a very favorable effect on the skin, abolish or inhibit the inflammatory processes, improve the blood circulation, smooth out the epidermis tissue of the face and also exert a hydrating effect.
  • the invention will be further illustrated by the following example.
  • Example a Under aseptic conditions, we inoculate an inoculum derived from the sterile pure culture of Scenedesmus quadricauda into a nutrient solution "Zahnder 8" (Publication B-11/69, Norway Institute for Water Research, Blindem, 1972). The initial concentration is 1000 cells / ml. The production process takes 14 days and takes place under room temperature with 4000 lux lighting, and with alternating illuminated or dark periods of 12 hours. Between the seventh and the fourteenth day, half of the culture should be withdrawn daily, then, after weaning, topped up with the same nutrient solution to its original volume.
  • Zahnder 8 Publication B-11/69, Norway Institute for Water Research, Blindem, 1972.
  • the initial concentration is 1000 cells / ml.
  • the production process takes 14 days and takes place under room temperature with 4000 lux lighting, and with alternating illuminated or dark periods of 12 hours. Between the seventh and the fourteenth day, half of the culture should be withdrawn daily, then, after we
  • the algae cells deposited between the seventh and fourteenth days are added to the cream base material prepared according to point b).
  • the following ingredients are mixed under aseptic conditions:

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Procédé de fabrication de préparations de soins de la peau, comme des préparations médicinales, en particulier des préparations qui ont une action anti-inflammatoire, en ajoutant aux éléments porteurs habituels et/ou aux autres additifs des préparations de soins de la peau des parties de tissus ou des cellules végétales vivantes, en particulier des cellules d'algues, pour servir d'éléments actifs.Process for the manufacture of skin care preparations, such as medicinal preparations, in particular preparations which have an anti-inflammatory action, by adding to the usual carrier elements and / or other additives skin care preparations living tissue or plant cells, especially algae cells, to serve as active ingredients.

Description

Verfahren zur Herstellung von Hautpflege-präparaten, insbesondere zur Herstellung solcher Präparate von entzündungshemmender Wirkung Process for the manufacture of skin care preparations, in particular for the manufacture of such preparations with an anti-inflammatory effect
Technisches Gebiet der Erfindung Die Erfindung bezieht sich auf die Herstellung von Hautpflegepräparaten, so auf die Herstellung von Heilpräparaten, insbesondere aber auf die Herstellung von Präparaten mit entzündungshemmender Wirkung.TECHNICAL FIELD OF THE INVENTION The invention relates to the manufacture of skin care preparations, thus to the manufacture of medicinal preparations, but in particular to the manufacture of preparations with an anti-inflammatory effect.
Kurze Beschreibung des Standes der Technik Es ist allbekannt, daß das Interesse für Heilund, kosmetische Präparate, die Naturstoffe als Wirkstoff enthalten, in aller Welt immer größer wird. Diese Gruppen der Kosmetikpräparate werden durch die sogenannten Phitokosmetika gebildet, welche die Extrakte verschiedener Pflanzen, so Heilpflanzen, Gemüsearten, oder Obstsorten, als Wirkstoff enthalten. Neuerlich werden auch Algenextrakte als Wirkstoff verwendet.Brief Description of the Prior Art It is well known that interest in medicinal and cosmetic preparations containing natural substances as active ingredients is increasing all over the world. These groups of cosmetic preparations are formed by the so-called phitocosmetics, which contain the extracts of various plants, such as medicinal plants, vegetables, or types of fruit, as active ingredients. Algae extracts have recently been used as an active ingredient.
Die GP-PS Nr. 1 392131, legt- solche Kosmetikpräparate dar, die das Nukleoplasma der aus Meeresplankten gewonnenen Kieselalgen - Asterionella japonica, Ohaetoceros ceres - enthalten.GP-PS No. 1 392131 sets out cosmetic preparations which contain the nucleoplasm of the diatoms obtained from sea planks - Asterionella japonica, Ohaetoceros ceres.
Die DE-PS Nr. 2532 934, bezieht sich auf solche kosmetische Präparate, die zellenfreie Planktonextrakte enthalten. Diese werden aus den gemischten Plankten der Thermalwasser mit Schwefelgehalt gewonnen.DE-PS No. 2532 934 relates to such cosmetic preparations which contain cell-free plankton extracts. These are obtained from the mixed planks of thermal water with sulfur content.
Die DE-PS Nr. 294.0 411, empfiehlt für Heilzwecke die Trockensubstanzextrakte der Reinkulturen von ßrün algen (Scenedesmus).DE-PS No. 294.0 411 recommends the dry matter extracts of the pure cultures of ßrün for medicinal purposes algae (Scenedesmus).
Bezeichnend ist für all diese Lösungen, daß sie die Extrakte der abgestorbenen, desintegrierten Zellen, bzw. ihre spezifischen Zellenkernfraktionen verwenden. Der Grund der Erfindung wird durch die Erkenntnis gebildet, daß wenn man statt den abgestorbenen Pflanzenzellen intakte, leb.ende Pflanzenzellen, - so Algenzellen als Wirkstoff der Heil- und Kosmetikpräparate verwendet, werden die so hergestellten Hautpflegepräparate eine entzündungshemmende, hydratierende und die Blutzirkulation verbessernde Wirkung haben und werden das Oberhautgewebe (Epithelialgewebe) des Gesichtes glattstreichen.It is characteristic of all these solutions that they use the extracts of the dead, disintegrated cells or their specific nucleus fractions. The reason for the invention is formed by the knowledge that if, instead of the dead plant cells, intact, living plant cells, such as algae cells, are used as active ingredients of the medicinal and cosmetic preparations, the skin care preparations thus produced have an anti-inflammatory, hydrating and blood circulation-improving effect have and will smoothen the epidermal tissue of the face.
Zusammenfassung der ErfindungSummary of the invention
Der Gegenstand der Erfindung ist also ein Verfahren zur Herstellung von Hautpflegepräparaten, so von kosmetischen und heilkosmetischen Präparaten, wo für das Verfahren charakteristisch ist, daß wir den gewöhnlichen Trägerstoffen und/oder zu den anderen Zuschlagstoffen der Hautpflegepräparate, als Wirkstoff lebende Pflanzenzellen oder Gewebeteile, insbesondere Algenzellen zugeben.The object of the invention is thus a process for the production of skin care preparations, such as cosmetic and medicinal cosmetic preparations, where it is characteristic of the process that we use plant cells or tissue parts living as active ingredients, in particular the usual carriers and / or the other additives of the skin care preparations Add algae cells.
Den Gegenstand der Erfindung bilden auch diejenigen kosmetischen Präparate, die die erwähnten lebenden Pflanzenzellen, oder Gewebeteile, so insbesondere Algenzellen, enthalten. Die Algenkonzentration der erfindungsgemäßen Präparate kann zwischen breiten Grenzen ausgewählt werden; der Algengehalt macht im allgemeinen 0,3 . 106 Zellen/ml, bzw. 6,0 . 10 Zellen/Gramm aus.The subject of the invention is also those cosmetic preparations which contain the living plant cells or tissue parts mentioned, in particular algae cells. The algae concentration of the preparations according to the invention can be selected between broad limits; the algae content is generally 0.3. 10 6 cells / ml, or 6.0. 10 cells / gram.
Man nimmt die Δlgenzellen aus zwischen sterilen Umständen hergestellten reinen Algenkulturen, vorteilhaft aus Reinkulturen von Grünalgen. Die Algenarten Scenedesmus quadricauda, Selenastrum capricornutum, oder Ghlamydomonas debaryna können besonders vorteilhaft verwendet werden.The algae cells are taken from pure algal cultures produced between sterile circumstances, advantageously from pure cultures of green algae. The algae species Scenedesmus quadricauda, Selenastrum capricornutum, or Ghlamydomonas debaryna can be used particularly advantageously.
Die Algen vermehren sich auf übliche Weise unter sterilen oder aseptischen Bedingungen und werden dann - im Laufe der Erreichung des entsprechenden Entwicklungszu- Standes - in den oben erwähnten Mengen dem Grundstoff des Hautpflegemittels, der aus den üblichen Träger- und/oder Zuschlagstoffen hergestellt wurde, beigemengt.The algae reproduce in the usual way under sterile or aseptic conditions and are then - in the course of reaching the corresponding state of development - in the above-mentioned amounts added to the base material of the skin care product, which was produced from the usual carriers and / or additives .
Die so hergestellten Präparate können zum Beispiel Cremes, Gelees, Lösungen oder Kδrperpflegeflüssigkeiten sein, die die gewöhnlichen Pette oder Öle, Lösungs- oder Verdünnungsmittel, Emulgeatore, Konservierungsmittel, Wasserabbindmittel, Füll-, Pärbungs- und/oder Duftstoffe, sowie Vitamine und/oder andere Stoffe von günstiger Wirkung enthalten. Diese werden auf bekannte Art und Weise hergestellt.The preparations produced in this way can be, for example, creams, jellies, solutions or body care liquids which are the usual pette or oils, solvents or diluents, emulsifiers, preservatives, water binders, fillers, colorants and / or fragrances, and also vitamins and / or others Contain substances with beneficial effects. These are made in a known manner.
Der Vorteil der erfindungsgemäßen Präparate ist, daß sie eine sehr günstige Wirkung auf die Haut ausüben, die Entzündungsprozesse aufheben oder hemmen, die Blutzirkulation verbessern, das Oberhautgewebe des Gesichtes glattstreichen und außerdem eine hydratierende Wirkung ausüben. Die Erfindung wird durch das folgende Beispiel näher bekannt gegeben werden.The advantage of the preparations according to the invention is that they exert a very favorable effect on the skin, abolish or inhibit the inflammatory processes, improve the blood circulation, smooth out the epidermis tissue of the face and also exert a hydrating effect. The invention will be further illustrated by the following example.
Beispiel a.) Unter aseptischen Bedingungen impfen wir ein aus der sterilen Reinkultur von Scenedesmus quadricauda stammendes Inokulum in eine Nährlösung "Zahnder 8" ein (Publication B-11/69, Norwegien Institute für Water Research, Blindem, 1972). Die anfängliche Konzentration macht 1000 Zellen/ml aus. Der Produktionsprozeß dauert 14 Tage lang und findet unter Raumtemperatur mit einer Beleuchtung von 4000 Lux statt, und zwar mit wechselnden beleuchteten, bzw. dunklen Perioden von 12 Stunden. Zwischen dem siebenten und dem vierzehnten Tag soll die Hälfte der Kultur täglich abgezogen, dann nach Absetzen mit der gleichen Nährlösung wieder auf ihr ursprüngliches Volumen aufgefüllt werden.Example a.) Under aseptic conditions, we inoculate an inoculum derived from the sterile pure culture of Scenedesmus quadricauda into a nutrient solution "Zahnder 8" (Publication B-11/69, Norway Institute for Water Research, Blindem, 1972). The initial concentration is 1000 cells / ml. The production process takes 14 days and takes place under room temperature with 4000 lux lighting, and with alternating illuminated or dark periods of 12 hours. Between the seventh and the fourteenth day, half of the culture should be withdrawn daily, then, after weaning, topped up with the same nutrient solution to its original volume.
Die zwischen den siebenten und vierzehnten Tagen abgesetzten Algenzellen werden dem gemäß dem Punkt b) hergestellten Cremegrundstoff beigemengt. Die folgenden Bestandteile werden unter aseptischen Bedingungen vermischt:The algae cells deposited between the seventh and fourteenth days are added to the cream base material prepared according to point b). The following ingredients are mixed under aseptic conditions:
Lanolcolum 60 gLanolcolum 60 g
Vaselinum album ophtalmicum 120 gVaselineum album ophtalmicum 120 g
Vaselinum album 790 g Alcohol cetylstearilicus 30 gVaselinum album 790 g Alcohol cetylstearilicus 30 g
Nachher soll noch 600 ml destilliertes Wasser zugesetzt werden und zuletzt diejenige Menge der gemäß dem Punkt a) hergestellten Algenkultur, die einehydratierende Creme mit einer Algenkonzentration von 0,5 . 10 Zellen/Gramm ergibt. Afterwards, 600 ml of distilled water should be added and finally the amount of algae culture prepared according to point a), the hydrating cream with an algae concentration of 0.5. 10 cells / gram results.

Claims

Patentansprüche Claims
1. Verfahren zur Herstellung von Hautpflegepräparaten, so Heilpräparaten, insbesondere aber solcher Präparate, die eine entzündungsnemmende Wirkung haben, dadurch g e k e n n z e i c h n e t , daß man zu den üblichen Träger- und/oder anderen Zuschlagstoffen der Hautpflegepräparate als Wirkstoff lebende Pflanzenzellen oder Gewebeteile, so insbesondere Algenzellen, vorteilhaft in einer Konzentration von 0,3 . 106 Zellen/ml, bzw. 6,0 . 106 Zellen/Gramm beimengt.1. A process for the production of skin care preparations, such as medicinal preparations, but especially those preparations which have an anti-inflammatory effect, characterized in that plant cells or tissue parts, in particular algae cells, are used as active ingredients in addition to the usual carriers and / or other additives of the skin care preparations. advantageous in a concentration of 0.3. 10 6 cells / ml, or 6.0. 10 6 cells / gram added.
2. Verfahren nach Anspruch 1, dadurch g e k e n n z e i c h n e t , daß die Algen der grünen Algenarten, vorteilhaft Scenedesmus quadricauda, Selenestrum capricornutum oder Chlamydomonas deberyna verwendet werden. 2. The method according to claim 1, characterized in that the algae of the green algae species, advantageously Scenedesmus quadricauda, Selenestrum capricornutum or Chlamydomonas deberyna are used.
3. Kosmetische Präparate,dadurch g e k e n n z e i c h n e t , daß sie außer den in solchen Präparaten gewöhnlichen Träger- und/oder anderen Zuschlagstoffen, noch intakte, lebende, oder im lebenden Zustand beigemengte Pflanzenzellen oder Gewebeteile, insbesondere Algenzellen enthalten. 3. Cosmetic preparations, characterized by the fact that, in addition to the usual carriers and / or other additives in such preparations, they also contain intact, living, or in the living state admixed plant cells or tissue parts, in particular algae cells.
4. Kosmetische Präparate nach Anspruch 3, dadurch g e k e n n z e i c hn e t , daß sie die Pflanzenzellen oder Gewebeteile in einer Konzentration von 0,3 . 106 Zellen/ml., bzw. 6,0 . 106 Zellen/Gramm, enthalten. 4. Cosmetic preparations according to claim 3, characterized gekennzeic hn et that the plant cells or tissue parts in a concentration of 0.3. 10 6 cells / ml. Or 6.0. 10 6 cells / gram.
EP84903716A 1983-10-12 1984-10-12 Process for producing skin care preparations, particularly anti-inflammatory preparations Withdrawn EP0158668A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU833523A HU191489B (en) 1983-10-12 1983-10-12 Cosmetic containing living unicellular alga
HU352383 1983-10-12

Publications (1)

Publication Number Publication Date
EP0158668A1 true EP0158668A1 (en) 1985-10-23

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ID=10964384

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84903716A Withdrawn EP0158668A1 (en) 1983-10-12 1984-10-12 Process for producing skin care preparations, particularly anti-inflammatory preparations

Country Status (7)

Country Link
EP (1) EP0158668A1 (en)
JP (1) JPS61500314A (en)
DK (1) DK261485A (en)
FI (1) FI852274L (en)
HU (1) HU191489B (en)
NO (1) NO852353L (en)
WO (1) WO1985001655A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19608563C2 (en) * 1996-03-06 1999-08-05 Greenpower International Natuu Manufacture of preparations for orally administered drugs and / or nutritional supplements
JP3142245B2 (en) * 1996-06-28 2001-03-07 株式会社資生堂 External preparation for skin
GB9702130D0 (en) 1997-02-03 1997-03-26 Zorma Ltd Calcareous material
KR20000028547A (en) * 1998-10-24 2000-05-25 손경식 Cosmetic composition containing useful component recovered from plant
CH701253A1 (en) * 2009-06-12 2010-12-15 Mibelle Ag Use of an extract from snow algae in cosmetic or dermatological formulations.
WO2012069073A1 (en) * 2010-11-12 2012-05-31 La Prairie Group Ag Cosmetic and/or dermatological preparations containing extracts of snow algae

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1073787A (en) * 1911-05-17 1913-09-23 Reginald C Thomas Cosmetic cream.
FR1106017A (en) * 1954-06-10 1955-12-12 Fr Des Cosmetiques Biolog Soc Plankton Culture and Harvesting Process
FR1125342A (en) * 1955-05-27 1956-10-29 Docteur Robert Maurin Use of freshwater algae cultures (more particularly of the chlorella type) for cosmetic uses
FR84159E (en) * 1960-06-07 1964-12-04 Nutrient product and its manufacturing process
FR1320958A (en) * 1962-02-16 1963-03-15 Esthetique Et De Produits De B Block incorporating seaweed for beauty treatments
AU3548368A (en) * 1969-03-25 1970-10-01 Svorinich Giovanna Cosmetic preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8501655A1 *

Also Published As

Publication number Publication date
FI852274A0 (en) 1985-06-06
HU191489B (en) 1987-02-27
FI852274L (en) 1985-06-06
WO1985001655A1 (en) 1985-04-25
NO852353L (en) 1985-06-11
JPS61500314A (en) 1986-02-27
DK261485D0 (en) 1985-06-11
DK261485A (en) 1985-06-11

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