EP0124970A2 - Magnetrührer und Rührverfahren - Google Patents

Magnetrührer und Rührverfahren Download PDF

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Publication number
EP0124970A2
EP0124970A2 EP84301536A EP84301536A EP0124970A2 EP 0124970 A2 EP0124970 A2 EP 0124970A2 EP 84301536 A EP84301536 A EP 84301536A EP 84301536 A EP84301536 A EP 84301536A EP 0124970 A2 EP0124970 A2 EP 0124970A2
Authority
EP
European Patent Office
Prior art keywords
impeller
chamber
fluid
buoyant
magnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84301536A
Other languages
English (en)
French (fr)
Other versions
EP0124970A3 (de
Inventor
William Hertl
William Scott Ramsey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corning Glass Works
Original Assignee
Corning Glass Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corning Glass Works filed Critical Corning Glass Works
Publication of EP0124970A2 publication Critical patent/EP0124970A2/de
Publication of EP0124970A3 publication Critical patent/EP0124970A3/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements

Definitions

  • the present invention relates to an apparatus and method for stirring fluids with a magnetic impeller, and more particularly, a novel buoyant magnetic impeller which can be used to stir fluids as well as suspended solids.
  • U.S. 4,310,253 to Sada et al. discloses magnetic particles which are covered with a material less dense than the fluid the particles are to stir, e.g., paraffin. The result is a mat of floating magnetic particles which stirs a fluid when subjected to a rotating magnetic field.
  • the present invention provides an improved magnetic stirring apparatus capable of suspending solids in a liquid medium with a minimum of shear force. It is particularly useful in suspended microcarrier cell culture, where low shear forces and low revolution per minute (RPM) operation are desirable.
  • RPM revolution per minute
  • a magnetic stirring apparatus capable of suspending solids in a liquid medium, comprising a vessel for containing fluids and solids, having walls, a bottom, and an opening; a magnetic impeller; and a means for rotating the magnetic impeller; characterized in that the impeller comprises a chamber which is buoyant with respect to the fluid contained by the vessel, and a magnet placed within the buoyancy chamber thereby forming a buoyant magentic impeller.
  • the invention provides an effective, yet inexpensive stirrer.
  • the need for a stirrer shaft and bearing is eliminated by the use of a buoyant magentic impeller wherein the magnet is placed inside a buoyant chamber.
  • This is different from the coated, comminuted magnetic particles in the prior art.
  • the present impeller has a space between the magnet and the chamber walls for buoyancy.
  • the magnet is not coated with a buoyant composition, and need not have a chamber made from buoyant materials.
  • buoyancy of the impeller can be adjusted by changing the density of fluid in the space between the magnet and the chamber walls. For example, if the chamber is filled with a liquid alkane it would be more buoyant in water than if it was filled with benzene. Thus, the depth of the impeller in the fluid to be stirred can be controlled.
  • the present invention comprises, as shown in Figure 1, with a buoyant magnetic impell'er 10 having a buoyancy chamber 12 and a magnet 14.
  • the chamber is dimensioned and configured to allow placement of the magnet within the chamber as well as to provide a buoyancy space 16 about the magnet.
  • impeller blade 20 Attached to the outside of the chamber wall adjacent to and extending away from the magnet is a optional impeller blade 20 (see Figure 3).
  • This blade has a negative buoyancy such that when the impeller is placed into a stirring vessel 22 containing a fluid 24, the blade extends downwardly into the fluid. Impeller movement arises from a conventional rotating means 26 which provides a rotating magnetic field.
  • the impeller-to-bottom-wall clearance can be adjusted without relying on bearings and shafts.
  • detachable impeller blades of varying weight can be used to compensate for fluids of diverse densities.
  • the chamber space can be filled with a material, which can be solid, liquid, or gas. In fact, the chamber space could even be evacuated.
  • Suspension cell culturing can put high demands on a stirrer, i.e., low speed operation, minimal fluid shearing, and adequate clearance to avoid cell grinding.
  • the present invention excels in all these areas. Without bearings and shafts, and correctly adjusted in height, cell abrasion is eliminated. When submerged in a suspension, preferably to about two thirds of the chamber height, low speed suspension without shear is a reality.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
EP84301536A 1983-05-09 1984-03-08 Magnetrührer und Rührverfahren Withdrawn EP0124970A3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49255983A 1983-05-09 1983-05-09
US492559 2000-01-27

Publications (2)

Publication Number Publication Date
EP0124970A2 true EP0124970A2 (de) 1984-11-14
EP0124970A3 EP0124970A3 (de) 1986-06-04

Family

ID=23956741

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84301536A Withdrawn EP0124970A3 (de) 1983-05-09 1984-03-08 Magnetrührer und Rührverfahren

Country Status (2)

Country Link
EP (1) EP0124970A3 (de)
JP (1) JPS59206034A (de)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2178971A (en) * 1985-08-08 1987-02-25 Techne Inc Floating magnetic stirrer for culture medium
EP0259002A2 (de) * 1986-09-04 1988-03-09 Techne, Inc. Magnetmischer mit verbesserter Mischung
US6733171B2 (en) * 2000-09-13 2004-05-11 Levitronix Llc Magnetic stirring apparatus and an agitating device
EP1539335A2 (de) * 2002-07-03 2005-06-15 Bio/Data Corporation VORRICHTUNG UND VERFAHREN ZUR VERWENDUNG VON VERTIKALEM MAGNETISCHEM R HREN ZUR ERZEUGUNG VON TURBULENTEM UND CHAOTISCHEM MISCHEN IN VERSCHIEDENEN STADIEN OHNE BEEINTRûCHTIGUNG VON KOMPONENTEN
KR100747935B1 (ko) * 2004-12-22 2007-08-08 지이 메디컬 시스템즈 글로발 테크놀러지 캄파니 엘엘씨 코일 소자 선택 방법 및 자기 공명 촬영 장치
CN110665412A (zh) * 2019-11-20 2020-01-10 武汉医尔特科技有限公司 一种用于液体混匀的搅拌保温装置
CN114377599A (zh) * 2022-01-13 2022-04-22 青岛花帝食品配料有限公司 一种用于甜味香精制备的配料装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2444328A1 (de) * 1974-09-17 1976-03-25 Wolfgang Gruhn Verfahren zur bewegung von fluessigkeiten, gasen, granulaten oder staeuben, sowie zum antrieb leistungsarmer geraete mittels elektromagnetisch fererregter rotationsoder schwingkoerper
US4162855A (en) * 1974-11-18 1979-07-31 Spectroderm International, Inc. Magnetic stirrer apparatus
FR2449473A1 (fr) * 1979-01-25 1980-09-19 Jeanmougin Michel Dispositif permettant l'agitation d'un milieu fluide
EP0105574A2 (de) * 1982-06-09 1984-04-18 Techne Incorporated Schwimmender Magnetrührer für Kulturen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2444328A1 (de) * 1974-09-17 1976-03-25 Wolfgang Gruhn Verfahren zur bewegung von fluessigkeiten, gasen, granulaten oder staeuben, sowie zum antrieb leistungsarmer geraete mittels elektromagnetisch fererregter rotationsoder schwingkoerper
US4162855A (en) * 1974-11-18 1979-07-31 Spectroderm International, Inc. Magnetic stirrer apparatus
FR2449473A1 (fr) * 1979-01-25 1980-09-19 Jeanmougin Michel Dispositif permettant l'agitation d'un milieu fluide
EP0105574A2 (de) * 1982-06-09 1984-04-18 Techne Incorporated Schwimmender Magnetrührer für Kulturen

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2178971A (en) * 1985-08-08 1987-02-25 Techne Inc Floating magnetic stirrer for culture medium
EP0259002A2 (de) * 1986-09-04 1988-03-09 Techne, Inc. Magnetmischer mit verbesserter Mischung
EP0259002A3 (de) * 1986-09-04 1989-09-20 Techne, Inc. Magnetmischer mit verbesserter Mischung
US6733171B2 (en) * 2000-09-13 2004-05-11 Levitronix Llc Magnetic stirring apparatus and an agitating device
EP1539335A2 (de) * 2002-07-03 2005-06-15 Bio/Data Corporation VORRICHTUNG UND VERFAHREN ZUR VERWENDUNG VON VERTIKALEM MAGNETISCHEM R HREN ZUR ERZEUGUNG VON TURBULENTEM UND CHAOTISCHEM MISCHEN IN VERSCHIEDENEN STADIEN OHNE BEEINTRûCHTIGUNG VON KOMPONENTEN
EP1539335A4 (de) * 2002-07-03 2007-04-04 Bio Data Corp VORRICHTUNG UND VERFAHREN ZUR VERWENDUNG VON VERTIKALEM MAGNETISCHEM R HREN ZUR ERZEUGUNG VON TURBULENTEM UND CHAOTISCHEM MISCHEN IN VERSCHIEDENEN STADIEN OHNE BEEINTRûCHTIGUNG VON KOMPONENTEN
US7364350B2 (en) 2002-07-03 2008-04-29 Bio/Data Corporation Method and apparatus for using vertical magnetic stirring to produce turbulent and chaotic mixing in various states, without compromising components
KR100747935B1 (ko) * 2004-12-22 2007-08-08 지이 메디컬 시스템즈 글로발 테크놀러지 캄파니 엘엘씨 코일 소자 선택 방법 및 자기 공명 촬영 장치
CN110665412A (zh) * 2019-11-20 2020-01-10 武汉医尔特科技有限公司 一种用于液体混匀的搅拌保温装置
CN114377599A (zh) * 2022-01-13 2022-04-22 青岛花帝食品配料有限公司 一种用于甜味香精制备的配料装置
CN114377599B (zh) * 2022-01-13 2023-03-03 青岛花帝食品配料有限公司 一种用于甜味香精制备的配料装置

Also Published As

Publication number Publication date
EP0124970A3 (de) 1986-06-04
JPS59206034A (ja) 1984-11-21

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Inventor name: RAMSEY, WILLIAM SCOTT

Inventor name: HERTL, WILLIAM