EP0068443A3 - Method for the selective analysis of traces of individual components in gases and liquids - Google Patents

Method for the selective analysis of traces of individual components in gases and liquids Download PDF

Info

Publication number
EP0068443A3
EP0068443A3 EP82105550A EP82105550A EP0068443A3 EP 0068443 A3 EP0068443 A3 EP 0068443A3 EP 82105550 A EP82105550 A EP 82105550A EP 82105550 A EP82105550 A EP 82105550A EP 0068443 A3 EP0068443 A3 EP 0068443A3
Authority
EP
European Patent Office
Prior art keywords
component
vacuum chamber
mass spectrometer
given component
sample holder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP82105550A
Other languages
German (de)
Other versions
EP0068443B1 (en
EP0068443A2 (en
Inventor
Alfred Prof. Dr. Benninghoven
Gunther Prof. Dr. Kampf
Reimer Dr. Holm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AT82105550T priority Critical patent/ATE22368T1/en
Publication of EP0068443A2 publication Critical patent/EP0068443A2/en
Publication of EP0068443A3 publication Critical patent/EP0068443A3/en
Application granted granted Critical
Publication of EP0068443B1 publication Critical patent/EP0068443B1/en
Expired legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Electron Tubes For Measurement (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A laser activated mass spectrometer having a sample holder for holding a given component to be investigated, a laser source for producing a laser beam to evaporate the given component and a vacuum chamber in which the evaporated component is analyzed, has the sample holder and the given component mounted outside the vacuum chamber of the mass spectrometer under atmospheric pressure or in an inert gas atmosphere. The sample holder comprises a polymer carrier film for depositing the component thereon with the carrier film forming part of a wall of the vacuum chamber of the mass spectrometer. The laser beam is directed onto the deposited component for evaporating the given component and simultaneously forming a hole in the carrier film through which the given component is transferred into the vacuum chamber of the mass spectrometer simultaneously with evaporation.
EP82105550A 1981-06-27 1982-06-24 Method for the selective analysis of traces of individual components in gases and liquids Expired EP0068443B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82105550T ATE22368T1 (en) 1981-06-27 1982-06-24 METHODS FOR THE SELECTIVE ANALYSIS OF INDIVIDUAL TRACE-FORM COMPONENTS IN GASES AND LIQUIDS.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813125335 DE3125335A1 (en) 1981-06-27 1981-06-27 METHOD FOR ANALYZING GASES AND LIQUIDS
DE3125335 1981-06-27

Publications (3)

Publication Number Publication Date
EP0068443A2 EP0068443A2 (en) 1983-01-05
EP0068443A3 true EP0068443A3 (en) 1984-07-04
EP0068443B1 EP0068443B1 (en) 1986-09-17

Family

ID=6135517

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82105550A Expired EP0068443B1 (en) 1981-06-27 1982-06-24 Method for the selective analysis of traces of individual components in gases and liquids

Country Status (6)

Country Link
US (2) US4468468A (en)
EP (1) EP0068443B1 (en)
JP (1) JPS589040A (en)
AT (1) ATE22368T1 (en)
CA (1) CA1195013A (en)
DE (2) DE3125335A1 (en)

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US4988879A (en) * 1987-02-24 1991-01-29 The Board Of Trustees Of The Leland Stanford Junior College Apparatus and method for laser desorption of molecules for quantitation
US4988628A (en) * 1989-02-28 1991-01-29 New England Deaconess Hospital Corporation Method of drug detection
DE4017805C2 (en) * 1989-08-22 1998-03-26 Finnigan Mat Gmbh Method, preparation and device for providing an analyte for an examination
GB2236186B (en) * 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) * 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
GB2269934B (en) * 1992-08-19 1996-03-27 Toshiba Cambridge Res Center Spectrometer
DE69432791T2 (en) * 1993-05-28 2004-06-03 Baylor College Of Medicine, Houston METHOD AND MASS SPECTROMETER FOR DESORPTION AND IONIZATION OF ANALYZES
US20020037517A1 (en) * 1993-05-28 2002-03-28 Hutchens T. William Methods for sequencing biopolymers
US6071610A (en) * 1993-11-12 2000-06-06 Waters Investments Limited Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
USRE39353E1 (en) 1994-07-21 2006-10-17 Applera Corporation Mass spectrometer system and method for matrix-assisted laser desorption measurements
DE19608963C2 (en) * 1995-03-28 2001-03-22 Bruker Daltonik Gmbh Process for ionizing heavy molecules at atmospheric pressure
WO1996037777A1 (en) * 1995-05-23 1996-11-28 Nelson Randall W Mass spectrometric immunoassay
DE19617011C2 (en) * 1996-04-27 2000-11-02 Bruker Daltonik Gmbh Matrix component mixture for matrix-assisted laser desorption and ionization and method for preparing a matrix component mixture
DE19641981C2 (en) * 1996-10-11 2000-12-07 A Benninghoven Procedure for the determination of depth profiles in the thin film area
DE19642261A1 (en) * 1996-10-11 1998-04-16 Hoechst Ag Method and device for detecting the catalytic activity of solids
EP1387390B1 (en) 1997-06-20 2009-02-18 Bio - Rad Laboratories, Inc. Retentate chromatography and protein chip arrays with applications in biology and medicine
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6265715B1 (en) * 1998-02-02 2001-07-24 Helene Perreault Non-porous membrane for MALDI-TOFMS
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
DE19934242A1 (en) * 1999-07-21 2001-01-25 Clariant Gmbh Method for the detection of organic compounds on surfaces in humans
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CA2301451A1 (en) * 2000-03-20 2001-09-21 Thang T. Pham Method for analysis of analytes by mass spectrometry
US7375319B1 (en) 2000-06-09 2008-05-20 Willoughby Ross C Laser desorption ion source
US7087898B2 (en) * 2000-06-09 2006-08-08 Willoughby Ross C Laser desorption ion source
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JP4015992B2 (en) * 2001-05-25 2007-11-28 ウォーターズ・インヴェストメンツ・リミテッド Sample concentration MALDI plate for MALDI mass spectrometer
JP4194370B2 (en) 2001-05-25 2008-12-10 ウォーターズ・インヴェストメンツ・リミテッド Desalting plate for MALDI mass spectrometry
US7063264B2 (en) 2001-12-24 2006-06-20 Digimarc Corporation Covert variable information on identification documents and methods of making same
US7728048B2 (en) 2002-12-20 2010-06-01 L-1 Secure Credentialing, Inc. Increasing thermal conductivity of host polymer used with laser engraving methods and compositions
US7694887B2 (en) 2001-12-24 2010-04-13 L-1 Secure Credentialing, Inc. Optically variable personalized indicia for identification documents
ATE435757T1 (en) * 2001-12-24 2009-07-15 Digimarc Id Systems Llc LASER ENGRAVING PROCESSES AND ITEMS WITH LASER ENGRAVING
CA2470600C (en) 2001-12-24 2009-12-22 Digimarc Id Systems, Llc Systems, compositions, and methods for full color laser engraving of id documents
EP1467834A4 (en) 2001-12-24 2005-04-06 Digimarc Id Systems Llc Laser etched security features for identification documents and methods of making same
AU2003221894A1 (en) 2002-04-09 2003-10-27 Digimarc Id Systems, Llc Image processing techniques for printing identification cards and documents
US7824029B2 (en) 2002-05-10 2010-11-02 L-1 Secure Credentialing, Inc. Identification card printer-assembler for over the counter card issuing
US7687276B2 (en) * 2002-05-30 2010-03-30 Massachusetts Institute Of Technology Method of detecting analyte vaporized from sample with low-power UV radiation
US7095019B1 (en) 2003-05-30 2006-08-22 Chem-Space Associates, Inc. Remote reagent chemical ionization source
US7109038B2 (en) * 2002-06-13 2006-09-19 The Johns Hopkins University Occult blood detection in biological samples by laser desorption and matrix-assisted laser desorption/ionization mass spectrometry for biomedical applications
JP4241006B2 (en) * 2002-11-11 2009-03-18 株式会社島津製作所 Laser desorption ionization mass spectrometry method and sample plate used therefor
US7105809B2 (en) * 2002-11-18 2006-09-12 3M Innovative Properties Company Microstructured polymeric substrate
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US6639217B1 (en) * 2002-12-20 2003-10-28 Agilent Technologies, Inc. In-line matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) systems and methods of use
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CA2480549A1 (en) * 2004-09-15 2006-03-15 Phytronix Technologies Inc. Ionization source for mass spectrometer
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US8123396B1 (en) 2007-05-16 2012-02-28 Science Applications International Corporation Method and means for precision mixing
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US8071957B1 (en) 2009-03-10 2011-12-06 Science Applications International Corporation Soft chemical ionization source
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Citations (3)

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Publication number Priority date Publication date Assignee Title
FR1450511A (en) * 1965-04-29 1966-06-24 Selective chromatographic separation
US3567927A (en) * 1969-04-11 1971-03-02 Nasa Ion microprobe mass spectrometer for analyzing fluid materials
FR2406823A1 (en) * 1977-10-20 1979-05-18 Shionogi & Co SAMPLE SUPPORT ELEMENT FOR MASS SPECTROMETER

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CA1039649A (en) * 1973-08-30 1978-10-03 General Electric Company Method of forming multilayer immunologically complexed films
DE2442346C3 (en) * 1974-09-04 1978-09-21 Bayer Ag, 5090 Leverkusen Method and device for determining traces of mercury in liquids
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FR2454635A1 (en) * 1979-04-18 1980-11-14 Commissariat Energie Atomique METHOD AND DEVICE FOR ADJUSTING THE IMPACT ON A TARGET OF A MONOCHROMATIC LIGHT BEAM EMITTED BY A LASER SOURCE
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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
FR1450511A (en) * 1965-04-29 1966-06-24 Selective chromatographic separation
US3567927A (en) * 1969-04-11 1971-03-02 Nasa Ion microprobe mass spectrometer for analyzing fluid materials
FR2406823A1 (en) * 1977-10-20 1979-05-18 Shionogi & Co SAMPLE SUPPORT ELEMENT FOR MASS SPECTROMETER

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Title
ANALYTICAL CHEMISTRY, Band 52, Nr. 4, April 1980, Seiten 557a-572a, Columbus, Ohio, US *
APPLIED PHYSICS, Band 8, Nr. 4, Dezember 1975, Seiten 341-348, Springer-Verlag, Heidelberg, DE *

Also Published As

Publication number Publication date
JPS589040A (en) 1983-01-19
US4468468A (en) 1984-08-28
CA1195013A (en) 1985-10-08
DE3125335A1 (en) 1983-01-13
DE3273325D1 (en) 1986-10-23
EP0068443B1 (en) 1986-09-17
ATE22368T1 (en) 1986-10-15
US4527059A (en) 1985-07-02
EP0068443A2 (en) 1983-01-05

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