EP0066587A1 - Ciment osseux - Google Patents

Ciment osseux

Info

Publication number
EP0066587A1
EP0066587A1 EP81903273A EP81903273A EP0066587A1 EP 0066587 A1 EP0066587 A1 EP 0066587A1 EP 81903273 A EP81903273 A EP 81903273A EP 81903273 A EP81903273 A EP 81903273A EP 0066587 A1 EP0066587 A1 EP 0066587A1
Authority
EP
European Patent Office
Prior art keywords
silver
bone cement
volume
polymethylmethacrylate
cement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP81903273A
Other languages
German (de)
English (en)
Inventor
Tor Christiansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHRISTIANSEN Karen-Sofie
Original Assignee
CHRISTIANSEN Karen-Sofie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHRISTIANSEN Karen-Sofie filed Critical CHRISTIANSEN Karen-Sofie
Publication of EP0066587A1 publication Critical patent/EP0066587A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the invention relates to bone cement especially for cementing protheses, in particular protheses components for joint caps and bone marrow canals.
  • the invention relates to a bone cement which is characterized by comprising polymethylmethacrylate, a filler material and a silver ion-releasing material.
  • the new cement is substantially stronger than the cement used previously, as may be seen from the table found below.
  • the increased strength is obtained by the addition of filler in the form of particles of glass fiber or quartz having a particle size of 4 - 8 microns.
  • a silver ion-releasing material is also added to the cement, preferably in the form of colloidal silver having an express germicidal and anti-bacterial effect.
  • Colloidal silver solutions are combinations of insoluble forms, of silver such as iodides, chlorides, oxides, etc., with protective colloids, usually organic.
  • the insoluble forms of silver are precipitated in the presence of the protective colloids (for example, gelatins) in such manner that the particle size is very small and the particles do not settle but remain in suspension, and the resulting Liquid has many of the advantages of an actual solution.
  • the protective colloids for example, gelatins
  • These small particles of silver compounds act as reservoirs which release silver ions in a controlle manner and in small amounts; the actual concentration of silver ions will vary according to the nature of the silver compound present.
  • this colloidal silver has a so-called oligodynamic effect, in that silver ions are continuously released over a long period of time.
  • the silver ions will pass through the membrane of the bacteria and into the DNA molecule, in this way preventing propagation of the bacteria.
  • the ratio of the three components of the bone cement mixture can vary as may be seen from the table founl below, which shows the results of tests carried out by Det Norske Veritas.
  • the curing time is about 6 - 7 minutes and the curing temperature rises to about 90°C for a 10-mm thick layer.
  • the curing time is 12-14 minutes under similar conditions.
  • the curing time is 20-25 minutes, and. the curing temperature about 45°C. Since a curing time of as long as 20-25 minutes is impractical, the preferred bone cement comprises 65% polymethylmethacrylate with an addition of 30% quartz particles and 5% colloidal silver.
  • the quartz particles are more irregular and thus provide a larger surface area, than glass fiber particles.
  • the particle size for either quartz or glass fiber is between 4 and 8 microns.
  • the larger surface area of the quartz particles may possibly help to make the cement less toxic by absorbing monomers, and one thereby also avoids the harmful high curing temperature. Bending tests were carried out at Det Norske Veritas on test rods made of polymethylmethacrylate alone and on test rods made of the bone cement of the invention. The results were as follows;
  • A pure cement (polymethylmethacrylate).
  • the bone cement of the invention should preferably be used for the cementing of protheses, especially protheses components in joint caps and bone marrow canals, and the results obtained up to now have been very satisfactory.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Dental Preparations (AREA)
  • Catalysts (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Ciment osseux destine a etre utilise dans l'assemblage de protheses, en particulier de composants de protheses pour des articulations et des canaux medullaires. Le ciment osseux comprend un polymethylmethacrylate, un materiau de remplissage sous la forme de particules de fibre de verre ou de quartz possedant des dimensions de 4 a 8 microns, et un materiau liberant des ions argent sous la forme d'argent colloidal (sel-d'argent).
EP81903273A 1980-12-09 1981-12-08 Ciment osseux Withdrawn EP0066587A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO803713A NO146306C (no) 1980-12-09 1980-12-09 Bensement og anvendelse derav.
NO803713 1980-12-09

Publications (1)

Publication Number Publication Date
EP0066587A1 true EP0066587A1 (fr) 1982-12-15

Family

ID=19885784

Family Applications (1)

Application Number Title Priority Date Filing Date
EP81903273A Withdrawn EP0066587A1 (fr) 1980-12-09 1981-12-08 Ciment osseux

Country Status (5)

Country Link
EP (1) EP0066587A1 (fr)
BE (1) BE891374A (fr)
DK (1) DK352882A (fr)
NO (1) NO146306C (fr)
WO (1) WO1982001990A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE88324T1 (de) * 1984-12-28 1993-05-15 Johnson Matthey Plc Antimikrobielle zusammensetzungen.
DE3536076A1 (de) * 1985-10-09 1987-04-09 Muehlbauer Ernst Kg Polymerisierbare zementmischungen
DE10043151A1 (de) * 2000-08-31 2002-03-28 Peter Steinruecke Knochenzement mit antimikrobieller Wirksamkeit
DE10146050B4 (de) 2001-09-18 2007-11-29 Bio-Gate Ag Verfahren zur Herstellung eines antimikrobiellen Kleb- und Beschichtungsstoffes
DE102007043311B4 (de) 2007-09-12 2010-02-25 Trovotech Gmbh Zusammensetzung mit antimikrobieller Wirkung, Verfahren zu deren Herstellung und deren Verwendung
US20090092538A1 (en) 2007-10-08 2009-04-09 Amit Khanolkar Methods for forming stabilized metal salt particles
IT1394800B1 (it) 2009-07-10 2012-07-13 Univ Degli Studi Torino Cementi ossei compositi a matrice di pmma, contenenti vetri e vetroceramici bioattivi ed antibatterici
DE102012022419A1 (de) 2012-11-16 2014-05-22 Heraeus Medical Gmbh Antiseptischer Polymethylmethacrylat-Knochenzement
DE102016212091A1 (de) 2016-07-04 2018-01-04 Heraeus Medical Gmbh Antiseptischer Polymethylmethacrylat-Knochenzement

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2347567A (en) * 1943-03-11 1944-04-25 Edward J Kresse Dental implant
US3932627A (en) * 1974-02-04 1976-01-13 Rescue Products, Inc. Siver-heparin-allantoin complex
DE2724814C3 (de) * 1977-06-02 1980-03-27 Kulzer & Co Gmbh, 6380 Bad Homburg Vorprodukt fur die Zubereitung von Knochenzement
FR2418253A1 (fr) * 1978-02-22 1979-09-21 Sepc Nouveau ciment applicable en chirurgie osseuse et en stomatologie
WO1981002667A1 (fr) * 1980-03-27 1981-10-01 Nat Res Dev Implants chirurgicaux antimicrobiens

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8201990A1 *

Also Published As

Publication number Publication date
DK352882A (da) 1982-08-06
BE891374A (fr) 1982-03-31
NO146306C (no) 1982-09-08
NO803713L (no) 1982-06-01
NO146306B (no) 1982-06-01
WO1982001990A1 (fr) 1982-06-24

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): AT CH DE FR GB LI NL SE

17P Request for examination filed

Effective date: 19821101

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 19840727

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CHRISTIANSEN, TOR