EP0066587A1 - Knochenzement - Google Patents
KnochenzementInfo
- Publication number
- EP0066587A1 EP0066587A1 EP81903273A EP81903273A EP0066587A1 EP 0066587 A1 EP0066587 A1 EP 0066587A1 EP 81903273 A EP81903273 A EP 81903273A EP 81903273 A EP81903273 A EP 81903273A EP 0066587 A1 EP0066587 A1 EP 0066587A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- silver
- bone cement
- volume
- polymethylmethacrylate
- cement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Definitions
- the invention relates to bone cement especially for cementing protheses, in particular protheses components for joint caps and bone marrow canals.
- the invention relates to a bone cement which is characterized by comprising polymethylmethacrylate, a filler material and a silver ion-releasing material.
- the new cement is substantially stronger than the cement used previously, as may be seen from the table found below.
- the increased strength is obtained by the addition of filler in the form of particles of glass fiber or quartz having a particle size of 4 - 8 microns.
- a silver ion-releasing material is also added to the cement, preferably in the form of colloidal silver having an express germicidal and anti-bacterial effect.
- Colloidal silver solutions are combinations of insoluble forms, of silver such as iodides, chlorides, oxides, etc., with protective colloids, usually organic.
- the insoluble forms of silver are precipitated in the presence of the protective colloids (for example, gelatins) in such manner that the particle size is very small and the particles do not settle but remain in suspension, and the resulting Liquid has many of the advantages of an actual solution.
- the protective colloids for example, gelatins
- These small particles of silver compounds act as reservoirs which release silver ions in a controlle manner and in small amounts; the actual concentration of silver ions will vary according to the nature of the silver compound present.
- this colloidal silver has a so-called oligodynamic effect, in that silver ions are continuously released over a long period of time.
- the silver ions will pass through the membrane of the bacteria and into the DNA molecule, in this way preventing propagation of the bacteria.
- the ratio of the three components of the bone cement mixture can vary as may be seen from the table founl below, which shows the results of tests carried out by Det Norske Veritas.
- the curing time is about 6 - 7 minutes and the curing temperature rises to about 90°C for a 10-mm thick layer.
- the curing time is 12-14 minutes under similar conditions.
- the curing time is 20-25 minutes, and. the curing temperature about 45°C. Since a curing time of as long as 20-25 minutes is impractical, the preferred bone cement comprises 65% polymethylmethacrylate with an addition of 30% quartz particles and 5% colloidal silver.
- the quartz particles are more irregular and thus provide a larger surface area, than glass fiber particles.
- the particle size for either quartz or glass fiber is between 4 and 8 microns.
- the larger surface area of the quartz particles may possibly help to make the cement less toxic by absorbing monomers, and one thereby also avoids the harmful high curing temperature. Bending tests were carried out at Det Norske Veritas on test rods made of polymethylmethacrylate alone and on test rods made of the bone cement of the invention. The results were as follows;
- A pure cement (polymethylmethacrylate).
- the bone cement of the invention should preferably be used for the cementing of protheses, especially protheses components in joint caps and bone marrow canals, and the results obtained up to now have been very satisfactory.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Dental Preparations (AREA)
- Catalysts (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO803713 | 1980-12-09 | ||
NO803713A NO146306C (no) | 1980-12-09 | 1980-12-09 | Bensement og anvendelse derav. |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0066587A1 true EP0066587A1 (de) | 1982-12-15 |
Family
ID=19885784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP81903273A Withdrawn EP0066587A1 (de) | 1980-12-09 | 1981-12-08 | Knochenzement |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0066587A1 (de) |
BE (1) | BE891374A (de) |
DK (1) | DK352882A (de) |
NO (1) | NO146306C (de) |
WO (1) | WO1982001990A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0190504B1 (de) * | 1984-12-28 | 1993-04-21 | Johnson Matthey Public Limited Company | Antimikrobielle Zusammensetzungen |
DE3536076A1 (de) * | 1985-10-09 | 1987-04-09 | Muehlbauer Ernst Kg | Polymerisierbare zementmischungen |
DE10043151A1 (de) | 2000-08-31 | 2002-03-28 | Peter Steinruecke | Knochenzement mit antimikrobieller Wirksamkeit |
DE10146050B4 (de) | 2001-09-18 | 2007-11-29 | Bio-Gate Ag | Verfahren zur Herstellung eines antimikrobiellen Kleb- und Beschichtungsstoffes |
DE102007043311B4 (de) | 2007-09-12 | 2010-02-25 | Trovotech Gmbh | Zusammensetzung mit antimikrobieller Wirkung, Verfahren zu deren Herstellung und deren Verwendung |
US20090092538A1 (en) | 2007-10-08 | 2009-04-09 | Amit Khanolkar | Methods for forming stabilized metal salt particles |
IT1394800B1 (it) | 2009-07-10 | 2012-07-13 | Univ Degli Studi Torino | Cementi ossei compositi a matrice di pmma, contenenti vetri e vetroceramici bioattivi ed antibatterici |
DE102012022419A1 (de) | 2012-11-16 | 2014-05-22 | Heraeus Medical Gmbh | Antiseptischer Polymethylmethacrylat-Knochenzement |
DE102016212091A1 (de) | 2016-07-04 | 2018-01-04 | Heraeus Medical Gmbh | Antiseptischer Polymethylmethacrylat-Knochenzement |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2347567A (en) * | 1943-03-11 | 1944-04-25 | Edward J Kresse | Dental implant |
US3932627A (en) * | 1974-02-04 | 1976-01-13 | Rescue Products, Inc. | Siver-heparin-allantoin complex |
DE2724814C3 (de) * | 1977-06-02 | 1980-03-27 | Kulzer & Co Gmbh, 6380 Bad Homburg | Vorprodukt fur die Zubereitung von Knochenzement |
FR2418253A1 (fr) * | 1978-02-22 | 1979-09-21 | Sepc | Nouveau ciment applicable en chirurgie osseuse et en stomatologie |
IE51564B1 (en) * | 1980-03-27 | 1987-01-21 | Nat Res Dev | Antimicrobial surgical implants |
-
1980
- 1980-12-09 NO NO803713A patent/NO146306C/no unknown
-
1981
- 1981-12-07 BE BE0/206755A patent/BE891374A/fr not_active IP Right Cessation
- 1981-12-08 EP EP81903273A patent/EP0066587A1/de not_active Withdrawn
- 1981-12-08 WO PCT/NO1981/000044 patent/WO1982001990A1/en not_active Application Discontinuation
-
1982
- 1982-08-06 DK DK352882A patent/DK352882A/da unknown
Non-Patent Citations (1)
Title |
---|
See references of WO8201990A1 * |
Also Published As
Publication number | Publication date |
---|---|
NO146306B (no) | 1982-06-01 |
DK352882A (da) | 1982-08-06 |
NO803713L (no) | 1982-06-01 |
BE891374A (fr) | 1982-03-31 |
WO1982001990A1 (en) | 1982-06-24 |
NO146306C (no) | 1982-09-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Designated state(s): AT CH DE FR GB LI NL SE |
|
17P | Request for examination filed |
Effective date: 19821101 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 19840727 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: CHRISTIANSEN, TOR |