EP0061167A1 - Moyen de diagnostic immunologique et son procédé de préparation - Google Patents
Moyen de diagnostic immunologique et son procédé de préparation Download PDFInfo
- Publication number
- EP0061167A1 EP0061167A1 EP82102257A EP82102257A EP0061167A1 EP 0061167 A1 EP0061167 A1 EP 0061167A1 EP 82102257 A EP82102257 A EP 82102257A EP 82102257 A EP82102257 A EP 82102257A EP 0061167 A1 EP0061167 A1 EP 0061167A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- carrier
- partner
- immunological reaction
- irradiated
- determination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0023—Agression treatment or altering
Definitions
- the invention relates to a means for the detection and determination of a part in a liquid. ners an immunological reaction, in which the associated partner is on the surface of a carrier, characterized in that the carrier is irradiated.
- test methods based on this principle can have defects.
- this object can be achieved by irradiating the carrier material, preferably microtiter plates made therefrom, with, preferably 0.1 to 100, particularly 0.5 to 10 megarads, gamma rays, preferably cobalt rays.
- the invention thus relates to a method for the detection and determination of a partner of an immunological reaction, in which the corresponding partner is on the surface of a carrier, characterized in that the carrier is irradiated before or after its surface has been coated with this partner.
- Carrier materials that can be used in this process are in principle all plastics, but in particular polystyrene and polyvinyl chloride.
- Irradiated carriers can advantageously be used in known immunoassay systems, for example based on an antigen-antibody reaction, for example ELISA systems (enzyme linked sorbent) Assay systems), wherein a binding partner is bound to the irradiated carrier.
- ELISA systems enzyme linked sorbent Assay systems
- binding partners can be, for example, proteins such as immunoglobulins, antimicrobial antibodies, plasma proteins, for example C1q or antigenic materials, for example allergens or microbial antigens.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT82102257T ATE14353T1 (de) | 1981-03-24 | 1982-03-19 | Mittel zur immunologischen diagnose sowie verfahren zu seiner herstellung. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3111474 | 1981-03-24 | ||
DE19813111474 DE3111474A1 (de) | 1981-03-24 | 1981-03-24 | "mittel zur immunologischen diagnose sowie verfahren zu seiner herstellung" |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0061167A1 true EP0061167A1 (fr) | 1982-09-29 |
EP0061167B1 EP0061167B1 (fr) | 1985-07-17 |
Family
ID=6128118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP82102257A Expired EP0061167B1 (fr) | 1981-03-24 | 1982-03-19 | Moyen de diagnostic immunologique et son procédé de préparation |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0061167B1 (fr) |
JP (1) | JPS57169675A (fr) |
AT (1) | ATE14353T1 (fr) |
AU (1) | AU553464B2 (fr) |
CA (1) | CA1187786A (fr) |
DE (2) | DE3111474A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2629916A1 (fr) * | 1988-04-08 | 1989-10-13 | Hoechst Behring Applic Pharmac | Support solide pour diagnostic immunologique, son procede de traitement et application au diagnostic immunologique |
EP0469445A1 (fr) * | 1990-08-02 | 1992-02-05 | Roche Diagnostics GmbH | Dispositif d'épreuve et procédé de fabrication |
US5424220A (en) * | 1992-01-31 | 1995-06-13 | Boehringer Mannheim Gmbh | Analysis element and method for determination of an analyte in a liquid sample |
US6632682B1 (en) | 1987-05-23 | 2003-10-14 | Dade Behring Marburg Gmbh | One-step immunoassay for the determination of antigen-specific antibodies of one of the immunoglobulin classes A, M, D, or E, and an agent suitable for this purpose |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60260857A (ja) * | 1984-06-08 | 1985-12-24 | Sumitomo Bakelite Co Ltd | 固相免疫測定法用成形品 |
AU605746B2 (en) * | 1985-08-19 | 1991-01-24 | Royal Melbourne Institute Of Technology Limited | Method of attaching biological substances to solid substrates |
BR8606830A (pt) * | 1985-08-19 | 1987-10-27 | Melbourne Inst Tech | Processo para ligacao de substancias biologicas a substratos solidos |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1238280A (fr) * | 1968-11-06 | 1971-07-07 |
-
1981
- 1981-03-24 DE DE19813111474 patent/DE3111474A1/de not_active Withdrawn
-
1982
- 1982-03-19 EP EP82102257A patent/EP0061167B1/fr not_active Expired
- 1982-03-19 AT AT82102257T patent/ATE14353T1/de not_active IP Right Cessation
- 1982-03-19 DE DE8282102257T patent/DE3264726D1/de not_active Expired
- 1982-03-23 JP JP57044778A patent/JPS57169675A/ja active Pending
- 1982-03-23 CA CA000399130A patent/CA1187786A/fr not_active Expired
- 1982-03-23 AU AU81818/82A patent/AU553464B2/en not_active Ceased
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1238280A (fr) * | 1968-11-06 | 1971-07-07 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6632682B1 (en) | 1987-05-23 | 2003-10-14 | Dade Behring Marburg Gmbh | One-step immunoassay for the determination of antigen-specific antibodies of one of the immunoglobulin classes A, M, D, or E, and an agent suitable for this purpose |
FR2629916A1 (fr) * | 1988-04-08 | 1989-10-13 | Hoechst Behring Applic Pharmac | Support solide pour diagnostic immunologique, son procede de traitement et application au diagnostic immunologique |
EP0342068A1 (fr) * | 1988-04-08 | 1989-11-15 | Societe D'applications Pharmaceutiques Et Biologiques Hoechst-Behring | Support solide pour diagnostic immunologique, son procédé de traitement et application au diagnostic immunologique |
EP0469445A1 (fr) * | 1990-08-02 | 1992-02-05 | Roche Diagnostics GmbH | Dispositif d'épreuve et procédé de fabrication |
US5378638A (en) * | 1990-08-02 | 1995-01-03 | Boehringer Mannheim Gmbh | Analysis element and process for its manufacture |
US5424220A (en) * | 1992-01-31 | 1995-06-13 | Boehringer Mannheim Gmbh | Analysis element and method for determination of an analyte in a liquid sample |
Also Published As
Publication number | Publication date |
---|---|
DE3264726D1 (en) | 1985-08-22 |
ATE14353T1 (de) | 1985-08-15 |
AU553464B2 (en) | 1986-07-17 |
EP0061167B1 (fr) | 1985-07-17 |
DE3111474A1 (de) | 1982-10-07 |
AU8181882A (en) | 1982-09-30 |
JPS57169675A (en) | 1982-10-19 |
CA1187786A (fr) | 1985-05-28 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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AK | Designated contracting states |
Designated state(s): AT BE CH DE FR GB IT LU NL SE |
|
17P | Request for examination filed |
Effective date: 19830307 |
|
ITF | It: translation for a ep patent filed |
Owner name: ING. C. GREGORJ S.P.A. |
|
GRAA | (expected) grant |
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AK | Designated contracting states |
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NLR1 | Nl: opposition has been filed with the epo |
Opponent name: C.A. GREINER & SOEHNE GMBH & CO. KG Opponent name: A/S NUNC |
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