EP0057700A1 - Dérivés de nitroso-urées possédant une activité antitumorale et compositions pharmaceutiques les contenant - Google Patents

Dérivés de nitroso-urées possédant une activité antitumorale et compositions pharmaceutiques les contenant

Info

Publication number
EP0057700A1
EP0057700A1 EP81902235A EP81902235A EP0057700A1 EP 0057700 A1 EP0057700 A1 EP 0057700A1 EP 81902235 A EP81902235 A EP 81902235A EP 81902235 A EP81902235 A EP 81902235A EP 0057700 A1 EP0057700 A1 EP 0057700A1
Authority
EP
European Patent Office
Prior art keywords
compounds
groups
compound according
activity
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP81902235A
Other languages
German (de)
English (en)
Other versions
EP0057700A4 (fr
Inventor
Andrew Welebir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NATIONAL FOUNDATION FOR CANCER RESEARCH, INC.
Original Assignee
NATIONAL FOUNDATION FOR CANCER RESEARCH Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NATIONAL FOUNDATION FOR CANCER RESEARCH Inc filed Critical NATIONAL FOUNDATION FOR CANCER RESEARCH Inc
Publication of EP0057700A1 publication Critical patent/EP0057700A1/fr
Publication of EP0057700A4 publication Critical patent/EP0057700A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Nitroso-urees nouvelles et hautement efficaces utiles dans le traitement de tumeurs chez les mammiferes. Le degre eleve de selective des composes est attribue au positionnement de certains groupes electronegatifs sur le carbone (Beta) sur l'extremite non nitrosee de la molecule. Par hypothese, ceci pourrait influencer favorablement la liaison de l'hydrogene sur certains sites presentant une activite enzymatiques, en eliminant ainsi de maniere plus selective le maintien enzymatique de proteines, masquant les antigenes des surfaces des cellules tumorales, ce qui a son tour empeche la destruction par le systeme immunitaire normal du tissu neoplastique. L'activite de ces composes apparait en outre comme etant superieure a celle du MeCCNU(1-(4-trans-methylcyclohexyle)-3-(2-chloroethyle)-3-nitroso-uree), un compose tres actif utilise couramment dans la chimiotherapie du cancer. Les composes selon la formule generale suivante sont decrits: (FORMULE) ainsi que les sels derives pharmaceutiquement acceptables, ou hal represente du chlore ou du fluor; R est un groupe hydroxy, halogene, acide carboxylique ou des derives de ceux-ci; n varie entre 4 et 7, le groupe cycycloalkyle pouvant etre facultativement substitue avec un ou plusieurs groupes methyle ou groupes hydroxyle.
EP19810902235 1980-08-14 1981-08-14 Dérivés de nitroso-urées possédant une activité antitumorale et compositions pharmaceutiques les contenant. Ceased EP0057700A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17794080A 1980-08-14 1980-08-14
US177940 2002-06-21

Publications (2)

Publication Number Publication Date
EP0057700A1 true EP0057700A1 (fr) 1982-08-18
EP0057700A4 EP0057700A4 (fr) 1982-11-17

Family

ID=22650546

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19810902235 Ceased EP0057700A4 (fr) 1980-08-14 1981-08-14 Dérivés de nitroso-urées possédant une activité antitumorale et compositions pharmaceutiques les contenant.
EP19810902234 Withdrawn EP0057699A4 (fr) 1980-08-14 1981-08-14 Derives d'acide 5,6-o-isoalkylidene ascorbique.

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19810902234 Withdrawn EP0057699A4 (fr) 1980-08-14 1981-08-14 Derives d'acide 5,6-o-isoalkylidene ascorbique.

Country Status (6)

Country Link
EP (2) EP0057700A4 (fr)
JP (2) JPS57501580A (fr)
DK (2) DK167182A (fr)
HU (1) HU185969B (fr)
NO (2) NO821220L (fr)
WO (2) WO1982000642A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405412A (en) * 1994-04-13 1995-04-11 The Procter & Gamble Company Bleaching compounds comprising N-acyl caprolactam and alkanoyloxybenzene sulfonate bleach activators

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60130582A (ja) * 1983-12-19 1985-07-12 Takeda Chem Ind Ltd 食品用酸化防止剤，アスコルビン酸誘導体およびその製造法
JPS60139619A (ja) * 1983-12-27 1985-07-24 Mutsuyuki Kochi Ｏ−ベンジリデン−アスコルビン酸又はその塩よりなる抗腫瘍剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2539483A (en) * 1945-03-28 1951-01-30 Simon L Ruskin Urea ascorbate and complexes containing the same and process for their manufacture
US3074998A (en) * 1959-12-10 1963-01-22 Shell Oil Co Enol carbamates
CH495980A (de) * 1967-02-25 1970-09-15 Bayer Ag Verfahren zur Herstellung von Benzodioxan-N-methylcarbamaten
DE2346305A1 (de) * 1973-09-14 1975-04-03 Basf Ag Neue carbamate und ihre verwendung als arzneimittel
US4111958A (en) * 1977-06-03 1978-09-05 Pfizer Inc. Ascorbic acid synthesis
US4148921A (en) * 1977-07-13 1979-04-10 Suami T Antitumor agents
NL7904249A (nl) * 1978-06-20 1979-12-27 Cancer Res Nat Found Nieuwe cyclische acetalen met cytostatische, bloed- drukverlagende en pijnstillende werking, werkwijze ter bereiding van deze verbindingen alsmede farmaceu- tische preparaten die een dergelijke verbinding bevat- ten.
JPS554324A (en) * 1978-06-26 1980-01-12 Kaken Pharmaceut Co Ltd Novel glycopyranosidoamine derivative, its preparation, and antitumor agent comprising it as active constituent
JP2811964B2 (ja) * 1990-12-20 1998-10-15 富士通株式会社 接続相手指定方式

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8200642A1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405412A (en) * 1994-04-13 1995-04-11 The Procter & Gamble Company Bleaching compounds comprising N-acyl caprolactam and alkanoyloxybenzene sulfonate bleach activators

Also Published As

Publication number Publication date
WO1982000642A1 (fr) 1982-03-04
DK167182A (da) 1982-04-14
EP0057699A1 (fr) 1982-08-18
WO1982000644A1 (fr) 1982-03-04
NO821220L (no) 1982-04-14
EP0057699A4 (fr) 1982-11-08
JPS57501580A (fr) 1982-09-02
DK167282A (da) 1982-04-14
NO821221L (no) 1982-04-14
EP0057700A4 (fr) 1982-11-17
JPS57501581A (fr) 1982-09-02
HU185969B (en) 1985-04-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19820419

AK Designated contracting states

Designated state(s): AT CH DE FR GB LI LU NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NATIONAL FOUNDATION FOR CANCER RESEARCH, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19850201

RIN1 Information on inventor provided before grant (corrected)

Inventor name: WELEBIR, ANDREW