EP0032560A1 - Direct on-column injector and injection method - Google Patents
Direct on-column injector and injection method Download PDFInfo
- Publication number
- EP0032560A1 EP0032560A1 EP80107899A EP80107899A EP0032560A1 EP 0032560 A1 EP0032560 A1 EP 0032560A1 EP 80107899 A EP80107899 A EP 80107899A EP 80107899 A EP80107899 A EP 80107899A EP 0032560 A1 EP0032560 A1 EP 0032560A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- valve
- channel
- passage
- injection
- duct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/18—Injection using a septum or microsyringe
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
Definitions
- Valves of the mentioned type are applied to direct on column injectors as it is well known in the art.
- a sample liquid cap may occur in correspondence with the free end of the injection needle, specially when the capillary column is at low temperature in correspondence to the injection zone.
- This liquid cap formation depends on different factors, among wich solvent nature, column diameter and surface treatment of the glass forming the column itself, temperature of the injection zone, pressure and flow rate of carrier gas and amount of sample injected, of course together with infection speed.
- the introduction of carrier, wich is performed upstream the zone of cap formation, causes a breaking of same, but a portion of the sample still remains on the needle tip.
- This sample portion is then drawn with the siringe outside the column, or may possibly remain inside the injector body, but in any case said portion, which is usually richer in heavy compounds, causes a discrimination of the sample, as the volatile components thereof are vaporized more quickly than the heavy ones during the needle insertion.
- vapours of volatile compounds and small drops of sample are produced, which are discharged in the atmospere through the inlet passage for the syringe needle, as well as small drops which remain attached to the walls of the injector and of the initial section of the column together with condensed vapours, with loss of the sample portion entrapped inside the injector body.
- This exhaust is useful in some cases and Grob suggests to perform the same by keeping at least partially open the injection valve.
- this solution depends on the skill and sensibility of the operator, who not always proves to be up to the task.
- An object of this invention is to provide a new control valve for the injection passage in a direct on column injector, which jointly or alternatively allows, to solve said problems to perform an injection without sample loss and without sample discrimination even in case of quick injection, on one side, and on the other side, to perform an exhaust at the injection end, without the necessity of controlling said exhaust operation in its entity, by a particular position of the valve opening.
- Another object of the present invention is to provide a new quick-type injection method which can be carried-out even with columns at high temperature and allows to perform said injection without the sample loss and discrimination, as noticed in injections under the same conditions with known injectors, said method using a control valve according to the invention.
- Said valve according to the invention essentially comprises at least one channel leading to the insertion passage for the injection needle and pneumatically connected to the passage itself in at least one of the valve positions, said channel bein able to be connected, outside the injector, to a source of carrier gas or to the atmosphere.
- the,valve body shows at least one channel which may be connected to the outside in the shown way, namely to the carrier gas supply when the valve is open and/or to the atmosphere when the valve is closed.
- a valve for a direct on column injector which allows, under the operator's control and according to the existing work co conditions, to perform the mentioned exhaust with the valve in closed position and at the end of injection, as well as to carry out an introduction of carrier gas in correspondence to the valve during injection, these two operations being performed or excluded during one single injection, according to the requirements.
- the introduction of carrier gas in correspondence to the valve during injection allows when the flow rate and pressure features of this introduction are suitably controlled, to eliminate all the above mentioned disadvantages in case of quick injections, in that the carrier gas flow gives rise to counterpressure which prevents sample loss and sample discrimination which usually occur with quick injection, as previously described.
- the exhaust channel provided in correspondence of the valve allows to perform washing of the injector under the best possible conditions, in that said exhaust channel is positioned in the upper possible section.
- Figure 1 is an axial cross-sectional T iew of a direct on column injector of the type with control valve according to the invention, in the valve open position.
- Figures 2, 2A, 3, 3A, 4, 4A, 5, 5A, 6 and 6A illustrate, in a sectional view in a plane perpendicular to the rotation axis of valve body, different possible solutions of a valve according to the invention, in the open and closed position respectively of the passage for the sirynge needle introduction.
- a direct on column injector of a type known in itself is essentially formed by an injector body 10 made of suitable metal material, inside which an injection passage 12 is provided having a jacket formed by a stainless steel tube, for instance with inner diameter of 0.28 mm, said injection passage 12 leading to a wider passage 14 forming a chamber to receive a carrier gas which is introduced through a duct 16 provided for in the injector body.
- a nut 18 threaded in 20 fits to the base section of the injector body 10 and keeps in position a cooling jacket 22 and a trapezoidal scaling gasket 24, said cooling jacket 22 showing a central passage 26 connected by means of fittings 28 to a chamber 30 formed in the lower section of the injector and connected, through a duct 32, to an inlet of cooling auxiliary air.
- the gasket 24 pneumatically adheres to 3 glass capillary column 34, having for istance an inner diameter of 0.3 mm, which penetrates with its free end into the chamber 14.
- the needle 36 of an injection syringe 38 is introduced through the injection passage 12 and the initial section of the gas chromatographic column 34 1 said needle having for istance an outer diameter of 0.23 mm.
- valve is positioned said valve, comprising a valve body 40 having a diametral through-channel 42, which is aligned with the injection passage in the valve open position.
- the valve body 40 is sealingly assembled, by means of gaskets.44, to the injector body 10, said gaskets, for instance made of polytetrafluoroethylene, being kept under pressure for instance by means of a series of bolts 46 acting on an upper section 10' of the injector body.
- the valve body 40 is controlled by means of a manual lever 48 which allows to perform a rotation of same around its own axis 50 until injection passage 12 is completely closed, in a substantially known way.
- the valve body 40 shows another channel, for instance an axial duct 52 wich, in at least one of the valve positions, is connected, through a passage 54 provided in the injector body 10, to the outside of the injector itself, where it can be connected, according to different cases and Choices, to a source for carrier gas introduction as well as directly to the atmosphere.
- said injection conditions in a valve according to the invention can be achieved by positioning the channel 52, always inside the valve body in a different way form the one illustrated in fig.1 or by providing for more than one channel, to be connected with the outside.
- FIGS 3 and 3A illustrate a valve to be used only to perform exhaust at the end of injection.
- the valve body 40 presents, besides the diametral through-channel 42, a radial duct 60 which, with the valve in its open position, as illustrated in fig.3, is closed by gaskets 44.
- the radial duct 60 is in connection with the downstream section of the injection passage 12 and said injection passage may exhaust towards the atmosphere through a passage 54' and through the diametral channel 42, which has been rotated of 90° so as to close the upper section of injection passage 12.
- the passage 54' is connected, outside the injector, to a T-fitting 64, the two branches of which lead, on one side, to a control valve 56 for introduction of carrier gas coming from a source 58, the valve 56 remaining open when the main valve 40 is open, as indicated in fig.4, and, on the other side, to a valve 66 which controls the connection to the atmosphere, said valve 66 being closed when the valve 40 is open.
- valve 56 In the closed position of valve 40 (fig. 4A), valve 56 is closed and valve 66 is open. In this case, it is possible to obtain both an introduction of carrier gas in the open position of valve 40, and an exhaust towards the atmosphere in the closed position of said valve 40.
- This double possibility of carrier gas introduction and exhaust towards the atmosphere may be achieved by means of two channels provided in the valve body 40, a duct 52 operating as in the case of figures 2 and 2A and a radial duct 60 respectively operating as in the case of figures 3and 3A, the configuration being then that shown in figures 5 ad 5A.
- figures 6 and 6A illustrate a further possible configuration, where the carrier gas introduction is performed by means of a channel 52 operating as in figures 2, 2A and 5, 5A, while the exhaust is carried out through a duct 60', parallel to the passage 42 and connecting the injection passage 12 to the exhaust channel 54' when the valve is closed, said valve closure occurring by a rotation of less than 90°, for . instance of 60° starting from the closure position.
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Abstract
Description
- This invention relates to a control valve for controlling injection passage of a direct on column injector, of the type having a valve body capable of rotating in a seat, to respecti vely open and close on injector passage for the injection needle insertion by meansof a diametral through-channel, provided inside the valve body
- Valves of the mentioned type are applied to direct on column injectors as it is well known in the art. However in some cases, the use of direct injectors equipped with vafives of the mentioned type, wich are, open during injection and closed at the end there-of leads to drawbacks, specially due to sample discrimination and loss of a sample portion.
- In particular, when a so-called slow injection is carried-out, i.e. when the siringe piston is slowly lowered after the needle introduction into the injector, with open valve, the formation of a sample liquid cap may occur in correspondence with the free end of the injection needle, specially when the capillary column is at low temperature in correspondence to the injection zone. This liquid cap formation depends on different factors, among wich solvent nature, column diameter and surface treatment of the glass forming the column itself, temperature of the injection zone, pressure and flow rate of carrier gas and amount of sample injected, of course together with infection speed. The introduction of carrier, wich is performed upstream the zone of cap formation, causes a breaking of same, but a portion of the sample still remains on the needle tip. This sample portion is then drawn with the siringe outside the column, or may possibly remain inside the injector body, but in any case said portion, which is usually richer in heavy compounds, causes a discrimination of the sample, as the volatile components thereof are vaporized more quickly than the heavy ones during the needle insertion.
- To overcome this drawback, it has been proposed to perform a quick injection, during which the syringe piston is quickly lowered. In this case, specially if the upstream end section of the column is heated, a vaporization zone in expansion and at high pressure is immediately formed downstream the needle tip, said zone tending to backwardly push the injected sample, inside the needle and above all into the passage between the needle and the column internal surface as well as into the injector passage. This involves, on one side, a backward ejection of small drops and vapour and, on the other side, a discrimination of heavy compounds inside the needle. Actually, vapours of volatile compounds and small drops of sample are produced, which are discharged in the atmospere through the inlet passage for the syringe needle, as well as small drops which remain attached to the walls of the injector and of the initial section of the column together with condensed vapours, with loss of the sample portion entrapped inside the injector body.
- Another problem arising in the case of a direct on column injection, specially using certain solvents, is the problem of improving the work conditions at the injection end, by maintaining a certain exhaust to the atmosphere, in order to perform washing of the column and injector upper sections, as suggested by Grob. This exhaust is useful in some cases and Grob suggests to perform the same by keeping at least partially open the injection valve. However, this solution depends on the skill and sensibility of the operator, who not always proves to be up to the task.
- An objet of this invention is to provide a new control valve for the injection passage in a direct on column injector, which jointly or alternatively allows, to solve said problems to perform an injection without sample loss and without sample discrimination even in case of quick injection, on one side, and on the other side, to perform an exhaust at the injection end, without the necessity of controlling said exhaust operation in its entity, by a particular position of the valve opening.
- Another object of the present invention is to provide a new quick-type injection method which can be carried-out even with columns at high temperature and allows to perform said injection without the sample loss and discrimination, as noticed in injections under the same conditions with known injectors, said method using a control valve according to the invention.
- Said valve according to the invention essentially comprises at least one channel leading to the insertion passage for the injection needle and pneumatically connected to the passage itself in at least one of the valve positions, said channel bein able to be connected, outside the injector, to a source of carrier gas or to the atmosphere. In particular, the,valve body shows at least one channel which may be connected to the outside in the shown way, namely to the carrier gas supply when the valve is open and/or to the atmosphere when the valve is closed.
- In other words, according to the invention, a valve for a direct on column injector is proposed, which allows, under the operator's control and according to the existing work co conditions, to perform the mentioned exhaust with the valve in closed position and at the end of injection, as well as to carry out an introduction of carrier gas in correspondence to the valve during injection, these two operations being performed or excluded during one single injection, according to the requirements.
- The introduction of carrier gas in correspondence to the valve during injection allows when the flow rate and pressure features of this introduction are suitably controlled, to eliminate all the above mentioned disadvantages in case of quick injections, in that the carrier gas flow gives rise to counterpressure which prevents sample loss and sample discrimination which usually occur with quick injection, as previously described. In the same way, the exhaust channel provided in correspondence of the valve allows to perform washing of the injector under the best possible conditions, in that said exhaust channel is positioned in the upper possible section.
- Figure 1 is an axial cross-sectional Tiew of a direct on column injector of the type with control valve according to the invention, in the valve open position.
Figures 2, 2A, 3, 3A, 4, 4A, 5, 5A, 6 and 6A illustrate, in a sectional view in a plane perpendicular to the rotation axis of valve body, different possible solutions of a valve according to the invention, in the open and closed position respectively of the passage for the sirynge needle introduction. - With reference to figure 1, a direct on column injector of a type known in itself is essentially formed by an
injector body 10 made of suitable metal material, inside which aninjection passage 12 is provided having a jacket formed by a stainless steel tube, for instance with inner diameter of 0.28 mm, saidinjection passage 12 leading to awider passage 14 forming a chamber to receive a carrier gas which is introduced through aduct 16 provided for in the injector body. - A
nut 18 threaded in 20 fits to the base section of theinjector body 10 and keeps in position acooling jacket 22 and atrapezoidal scaling gasket 24, saidcooling jacket 22 showing acentral passage 26 connected by means offittings 28 to achamber 30 formed in the lower section of the injector and connected, through aduct 32, to an inlet of cooling auxiliary air. Thegasket 24 pneumatically adheres to 3 glasscapillary column 34, having for istance an inner diameter of 0.3 mm, which penetrates with its free end into thechamber 14. - The
needle 36 of aninjection syringe 38 is introduced through theinjection passage 12 and the initial section of the gaschromatographic column 341 said needle having for istance an outer diameter of 0.23 mm. - Along the injection passage 12 a valve is positioned said valve, comprising a
valve body 40 having a diametral through-channel 42, which is aligned with the injection passage in the valve open position. Thevalve body 40 is sealingly assembled, by means of gaskets.44, to theinjector body 10, said gaskets, for instance made of polytetrafluoroethylene, being kept under pressure for instance by means of a series ofbolts 46 acting on an upper section 10' of the injector body. Thevalve body 40 is controlled by means of amanual lever 48 which allows to perform a rotation of same around itsown axis 50 untilinjection passage 12 is completely closed, in a substantially known way. - According to the invention, the
valve body 40 shows another channel, for instance anaxial duct 52 wich, in at least one of the valve positions, is connected, through apassage 54 provided in theinjector body 10, to the outside of the injector itself, where it can be connected, according to different cases and Choices, to a source for carrier gas introduction as well as directly to the atmosphere. - For the application of the method of quick injection according to the invention, said
passage 54 is connected to the carrier gas source in the open position ofvalve 40 and the conditions for carrier gas introduction are such as to create a counterpressure sufficient to avoid sample loss and sample discrimination by return on the outside of theinjection needle 36. Alternatively or jointly, theduct 54 may be connected to the atmosphere when thevalve 40 is closed, in order to perform said exhaust as suggested by Grob. - Obviously, said injection conditions in a valve according to the invention can be achieved by positioning the
channel 52, always inside the valve body in a different way form the one illustrated in fig.1 or by providing for more than one channel, to be connected with the outside. - For example, in fig.2, the
valve body 40 shows, besides theinjection channel 42, anaxial duct 52 similar tc the one illustrated in fig.1, which is permanently in communication with apassage 54 connected by means of avalve 56 to acarrier gas source 58. In the condition of fig.2, thevalve 40 is open and thechannel 42 allows the passage of the injection syringe needle, and thevalve 56 is correspondingly open to perform a simultaneous introduction of carrier gas under suitable conditions of pressure and flow rate. In figure 2A, thevalve body 40 has been rotated by 90° and theinjection passage 12 is closed, while simultaneously thevalve 56 is closed, and therefore theduct 52 is no longer connected with the outside. Obviously in this case no exhaust occurs at the end of injection. - Figures 3 and 3A illustrate a valve to be used only to perform exhaust at the end of injection. In this case, the
valve body 40 presents, besides the diametral through-channel 42, aradial duct 60 which, with the valve in its open position, as illustrated in fig.3, is closed bygaskets 44. When the valve is closed, as illustrated in fig.3A, theradial duct 60 is in connection with the downstream section of theinjection passage 12 and said injection passage may exhaust towards the atmosphere through a passage 54' and through thediametral channel 42, which has been rotated of 90° so as to close the upper section ofinjection passage 12. - The embodiment of figs. 4 and 4A too, only uses one
radial channel 62, 1800 oriented with respect to theradial channel 60 of the previous figures and in connection to the passage 54' when the valve is in its open position (fig. 4), while when the valve is in its closed position, saidradial channel 62 connects the downstream section ofinjection passage 12 to the passage 54' through thediametral channel 42. The passage 54' is connected, outside the injector, to a T-fitting 64, the two branches of which lead, on one side, to acontrol valve 56 for introduction of carrier gas coming from asource 58, thevalve 56 remaining open when themain valve 40 is open, as indicated in fig.4, and, on the other side, to avalve 66 which controls the connection to the atmosphere, saidvalve 66 being closed when thevalve 40 is open. In the closed position of valve 40 (fig. 4A),valve 56 is closed andvalve 66 is open. In this case, it is possible to obtain both an introduction of carrier gas in the open position ofvalve 40, and an exhaust towards the atmosphere in the closed position of saidvalve 40. - This double possibility of carrier gas introduction and exhaust towards the atmosphere may be achieved by means of two channels provided in the
valve body 40, aduct 52 operating as in the case of figures 2 and 2A and aradial duct 60 respectively operating as in the case of figures 3and 3A, the configuration being then that shown in figures 5 ad 5A. - Finally, figures 6 and 6A illustrate a further possible configuration, where the carrier gas introduction is performed by means of a
channel 52 operating as in figures 2, 2A and 5, 5A, while the exhaust is carried out through a duct 60', parallel to thepassage 42 and connecting theinjection passage 12 to the exhaust channel 54' when the valve is closed, said valve closure occurring by a rotation of less than 90°, for . instance of 60° starting from the closure position. - Obviously the invention must not be considered as limited to the described and shown embodiments, but it may undergo to numerous modifications without departing from the spirit and scope of the present invention.
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT80107899T ATE14243T1 (en) | 1980-01-02 | 1980-12-15 | ON-COLUMN INJECTOR AND INJECTION PROCEDURE. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8019005A IT1209297B (en) | 1980-01-02 | 1980-01-02 | INJECTION PASSAGE CONTROL VALVE FOR A DIRECT INJECTOR IN GAS-CHROMATOGRAPH COLUMN AND INJECTION PROCEDURE USING SUCH VALVE. |
IT1900580 | 1980-01-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0032560A1 true EP0032560A1 (en) | 1981-07-29 |
EP0032560B1 EP0032560B1 (en) | 1985-07-10 |
Family
ID=11153776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP80107899A Expired EP0032560B1 (en) | 1980-01-02 | 1980-12-15 | Direct on-column injector and injection method |
Country Status (6)
Country | Link |
---|---|
US (1) | US4403520A (en) |
EP (1) | EP0032560B1 (en) |
JP (1) | JPS56101550A (en) |
AT (1) | ATE14243T1 (en) |
DE (1) | DE3070871D1 (en) |
IT (1) | IT1209297B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0141148A1 (en) * | 1983-09-14 | 1985-05-15 | CARLO ERBA STRUMENTAZIONE S.p.A. | Automatic sample apparatus and sampling method |
WO1999031480A1 (en) * | 1997-12-18 | 1999-06-24 | Varian, Inc. | Improved method and device for solid phase microextraction |
WO2009040224A1 (en) * | 2007-09-27 | 2009-04-02 | Dani Instruments S.P.A. | Method for directly injecting a liquid sample into a capillary chromatography column and apparatus for implementing the method. |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5752663A (en) * | 1996-01-26 | 1998-05-19 | Hewlett-Packard Company | Micro concentric tube nebulizer for coupling liquid devices to chemical analysis devices |
US5868322A (en) * | 1996-01-31 | 1999-02-09 | Hewlett-Packard Company | Apparatus for forming liquid droplets having a mechanically fixed inner microtube |
DE102007036612A1 (en) * | 2007-08-02 | 2009-02-05 | Dimatec Analysentechnik Gmbh | Injection port for analyzers, arrangement for actuating an injection port and analyzer with an injection port |
Citations (10)
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FR1388466A (en) * | 1964-04-09 | 1965-02-05 | Micro Tek Instr | Sample injector in gas chromatography |
US3220246A (en) * | 1961-07-13 | 1965-11-30 | Technicon Chromatography Corp | Apparatus and devices, especially for chromatography analysis |
US3458699A (en) * | 1966-10-12 | 1969-07-29 | Universal Oil Prod Co | Sample introduction apparatus |
DE1698191A1 (en) * | 1967-06-14 | 1971-12-23 | Becker Delft Nv | Device for introducing samples into a chromatography column |
FR2138486A1 (en) * | 1971-05-27 | 1973-01-05 | Kodak Pathe | Gas chromatography - pyrolysis attachment locates sample filament in chromatograph's vapoarisation chamber |
DE2211744A1 (en) * | 1972-03-10 | 1973-09-13 | Jurij Nikolajewit Golowistikow | Gas chromatograph sample injector - hermetically sealed from ambient atmos |
DE2400983A1 (en) * | 1973-01-12 | 1974-07-18 | Stephen Z Turney | MULTI-HOLE DISTRIBUTION PIECE |
GB1427821A (en) * | 1973-09-24 | 1976-03-10 | Medex Inc | Valve |
US4128008A (en) * | 1977-05-04 | 1978-12-05 | Xonics, Inc. | Concentration valve for a gas detecting apparatus, or the like |
DD135419A1 (en) * | 1978-03-08 | 1979-05-02 | Langrock Ernst Juergen | DOSING |
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DE135419C (en) * | 1901-03-13 | 1902-10-10 | ||
US3253455A (en) * | 1962-10-18 | 1966-05-31 | Nat Tank Co | Sample system for gas chromatography |
US3327520A (en) * | 1964-02-28 | 1967-06-27 | Beckman Instruments Inc | Heated sample injection port |
US3985016A (en) * | 1969-12-10 | 1976-10-12 | Shimadzu Seisakusho Ltd. | Chromatograph |
US3675466A (en) * | 1970-08-19 | 1972-07-11 | Hydronautics | Sampling valve and system for the detection of predetermined compounds in air |
JPS4890591A (en) * | 1972-03-02 | 1973-11-26 | ||
US3733909A (en) * | 1972-03-10 | 1973-05-22 | J Nikolaevich | Apparatus for injecting a sample into a gas chromatograph |
US3985066A (en) * | 1975-05-15 | 1976-10-12 | S&S Corrugated Paper Machinery Co., Inc. | Single point means for slotter adjustment |
US3961534A (en) * | 1975-09-02 | 1976-06-08 | Richard Gundelfinger | Two position rotary valve for injecting sample liquids into an analysis system |
US4068528A (en) * | 1976-01-19 | 1978-01-17 | Rheodyne Incorporated | Two position rotary valve for injecting sample liquids into an analysis system |
DE2716013A1 (en) * | 1977-04-09 | 1978-10-19 | Bayer Ag | DEVICE FOR DOSING IN SAMPLES INTO HIGH PRESSURE GAS OR LIQUID CHROMATOGRAPHS |
US4182184A (en) * | 1978-12-14 | 1980-01-08 | Rheodyne Incorporated | Sample injector |
NL8000240A (en) * | 1979-01-17 | 1980-07-21 | Erba Strumentazione | EVAPORATIVE INJECTOR FOR GAS CHROMATOGRAPHIC COLUMNS. |
-
1980
- 1980-01-02 IT IT8019005A patent/IT1209297B/en active
- 1980-12-15 DE DE8080107899T patent/DE3070871D1/en not_active Expired
- 1980-12-15 EP EP80107899A patent/EP0032560B1/en not_active Expired
- 1980-12-15 AT AT80107899T patent/ATE14243T1/en not_active IP Right Cessation
- 1980-12-27 JP JP18514680A patent/JPS56101550A/en active Pending
- 1980-12-30 US US06/221,304 patent/US4403520A/en not_active Expired - Fee Related
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3220246A (en) * | 1961-07-13 | 1965-11-30 | Technicon Chromatography Corp | Apparatus and devices, especially for chromatography analysis |
FR1388466A (en) * | 1964-04-09 | 1965-02-05 | Micro Tek Instr | Sample injector in gas chromatography |
US3458699A (en) * | 1966-10-12 | 1969-07-29 | Universal Oil Prod Co | Sample introduction apparatus |
DE1698191A1 (en) * | 1967-06-14 | 1971-12-23 | Becker Delft Nv | Device for introducing samples into a chromatography column |
FR2138486A1 (en) * | 1971-05-27 | 1973-01-05 | Kodak Pathe | Gas chromatography - pyrolysis attachment locates sample filament in chromatograph's vapoarisation chamber |
DE2211744A1 (en) * | 1972-03-10 | 1973-09-13 | Jurij Nikolajewit Golowistikow | Gas chromatograph sample injector - hermetically sealed from ambient atmos |
DE2400983A1 (en) * | 1973-01-12 | 1974-07-18 | Stephen Z Turney | MULTI-HOLE DISTRIBUTION PIECE |
GB1427821A (en) * | 1973-09-24 | 1976-03-10 | Medex Inc | Valve |
US4128008A (en) * | 1977-05-04 | 1978-12-05 | Xonics, Inc. | Concentration valve for a gas detecting apparatus, or the like |
DD135419A1 (en) * | 1978-03-08 | 1979-05-02 | Langrock Ernst Juergen | DOSING |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0141148A1 (en) * | 1983-09-14 | 1985-05-15 | CARLO ERBA STRUMENTAZIONE S.p.A. | Automatic sample apparatus and sampling method |
WO1999031480A1 (en) * | 1997-12-18 | 1999-06-24 | Varian, Inc. | Improved method and device for solid phase microextraction |
WO2009040224A1 (en) * | 2007-09-27 | 2009-04-02 | Dani Instruments S.P.A. | Method for directly injecting a liquid sample into a capillary chromatography column and apparatus for implementing the method. |
Also Published As
Publication number | Publication date |
---|---|
IT1209297B (en) | 1989-07-16 |
ATE14243T1 (en) | 1985-07-15 |
US4403520A (en) | 1983-09-13 |
IT8019005A0 (en) | 1980-01-02 |
JPS56101550A (en) | 1981-08-14 |
DE3070871D1 (en) | 1985-08-14 |
EP0032560B1 (en) | 1985-07-10 |
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