EP0024393A1 - Imino-alkyle et amino-nitrile cyano-guanidines - Google Patents

Imino-alkyle et amino-nitrile cyano-guanidines

Info

Publication number
EP0024393A1
EP0024393A1 EP80900296A EP80900296A EP0024393A1 EP 0024393 A1 EP0024393 A1 EP 0024393A1 EP 80900296 A EP80900296 A EP 80900296A EP 80900296 A EP80900296 A EP 80900296A EP 0024393 A1 EP0024393 A1 EP 0024393A1
Authority
EP
European Patent Office
Prior art keywords
par
dans
est
formule
imino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP80900296A
Other languages
German (de)
English (en)
Inventor
Pierre Baudet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recherches Et De Syntheses Organiques SA Ste
Original Assignee
Recherches Et De Syntheses Organiques SA Ste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recherches Et De Syntheses Organiques SA Ste filed Critical Recherches Et De Syntheses Organiques SA Ste
Publication of EP0024393A1 publication Critical patent/EP0024393A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Definitions

  • F.120-122 ° Vietnamesep.IR (nujol): 3300, 3200, 3100, 2700, 2650, 1700, 1665 1590, 1410, 1400, 1360, 13.15, 1290, 1260, 1245, 1210, 1165, (doublet) 1100 , 1025,935,870,780,700 cm -1 .
  • IR (nujol): 3200.3080, 1710, 1644, 1605.1570, 1480.1395, 1340, 1305 1230, 1150, (doublet), 1.080, 1065, 1040, 1010, 1005, 960, 845.780 (doublet), 690 , 660 cm -1 .

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cyano - guanidines de formule: (FORMULE) dans quelle: R1 est (a) le reste HS - CH2 - CH2-, (b) le reste HO - CH2 - CH2-, (c) le reste (FORMULE) (d) le reste (FORMULE) et plusieurs procedes de leur preparation respective. Le compose I(c) possede une activite antihistaminique.
EP80900296A 1979-02-14 1980-08-25 Imino-alkyle et amino-nitrile cyano-guanidines Withdrawn EP0024393A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH140479 1979-02-14
CH1404/79 1979-02-14

Publications (1)

Publication Number Publication Date
EP0024393A1 true EP0024393A1 (fr) 1981-03-11

Family

ID=4209638

Family Applications (1)

Application Number Title Priority Date Filing Date
EP80900296A Withdrawn EP0024393A1 (fr) 1979-02-14 1980-08-25 Imino-alkyle et amino-nitrile cyano-guanidines

Country Status (5)

Country Link
US (2) US4383115A (fr)
EP (1) EP0024393A1 (fr)
JP (1) JPS56500174A (fr)
BE (1) BE884820A (fr)
WO (1) WO1980001694A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8710091A8 (en) * 1987-01-23 1996-06-30 Lek Tovarna Farmacevtskih Process for obtaining crystalline cimetadine (n-cyano-n'-methyl-n"- (2/(5-methyl-1h-imidazole-4-yl)methylthio/ethyl)-guanidine
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4093621A (en) * 1974-09-02 1978-06-06 Smith Kline & French Laboratories Limited Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
IL56265A (en) * 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8001694A1 *

Also Published As

Publication number Publication date
US4383115A (en) 1983-05-10
US4443613A (en) 1984-04-17
WO1980001694A1 (fr) 1980-08-21
JPS56500174A (fr) 1981-02-19
BE884820A (fr) 1980-12-16

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): AT DE FR GB NL SE

17P Request for examination filed

Effective date: 19810211

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19830915

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BAUDET, PIERRE