EE03871B1 - Tsüanoguanidiinid kui rakkude paljunemise inhibiitorid - Google Patents
Tsüanoguanidiinid kui rakkude paljunemise inhibiitoridInfo
- Publication number
- EE03871B1 EE03871B1 EEP199900551A EEP9900551A EE03871B1 EE 03871 B1 EE03871 B1 EE 03871B1 EE P199900551 A EEP199900551 A EE P199900551A EE P9900551 A EEP9900551 A EE P9900551A EE 03871 B1 EE03871 B1 EE 03871B1
- Authority
- EE
- Estonia
- Prior art keywords
- cyanoguanidines
- inhibitors
- cell proliferation
- proliferation
- cell
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title 1
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical class NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9711119.9A GB9711119D0 (en) | 1997-05-29 | 1997-05-29 | Novel cyanoguanidines |
| PCT/DK1998/000195 WO1998054143A1 (en) | 1997-05-29 | 1998-05-15 | Cyanoguanidines as cell proliferation inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9900551A EE9900551A (et) | 2000-06-15 |
| EE03871B1 true EE03871B1 (et) | 2002-10-15 |
Family
ID=10813249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP199900551A EE03871B1 (et) | 1997-05-29 | 1998-05-15 | Tsüanoguanidiinid kui rakkude paljunemise inhibiitorid |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6121297A (ja) |
| EP (1) | EP0984937A1 (ja) |
| JP (1) | JP2001526693A (ja) |
| KR (1) | KR20010013158A (ja) |
| CN (1) | CN1314890A (ja) |
| AU (1) | AU733093B2 (ja) |
| BG (1) | BG103867A (ja) |
| BR (1) | BR9809496A (ja) |
| CA (1) | CA2291489A1 (ja) |
| EA (1) | EA002037B1 (ja) |
| EE (1) | EE03871B1 (ja) |
| GB (1) | GB9711119D0 (ja) |
| HK (1) | HK1039116A1 (ja) |
| HU (1) | HUP0003150A3 (ja) |
| IS (1) | IS5229A (ja) |
| NZ (1) | NZ500702A (ja) |
| PL (1) | PL337091A1 (ja) |
| SK (1) | SK161199A3 (ja) |
| WO (1) | WO1998054143A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061561A1 (en) | 1999-04-09 | 2000-10-19 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
| AU1494702A (en) | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| WO2002094265A1 (en) * | 2001-05-24 | 2002-11-28 | Leo Pharma A/S | A method of modulating nf-$g(k)b activity |
| IL158574A0 (en) | 2001-05-24 | 2004-05-12 | Leo Pharma As | Novel pyridyl cyanoguanidine compounds |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| US6642215B2 (en) | 2001-05-24 | 2003-11-04 | Leo Pharma A/S | Method of modulating NF-kB activity |
| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| EP1838696B1 (en) | 2004-12-22 | 2016-03-09 | Leo Pharma A/S | Novel cyanoguanidine compounds |
| US8173677B2 (en) | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| WO2009072004A2 (en) | 2007-09-26 | 2009-06-11 | Gemin X Pharmaceuticals Canada, Inc. | Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| WO2010088842A1 (zh) | 2009-02-06 | 2010-08-12 | 天津和美生物技术有限公司 | 含有吡啶基氰基胍的药物组合物及其制备和应用 |
| US9676721B2 (en) | 2010-09-03 | 2017-06-13 | Forma Tm, Llc | Compounds and compositions for the inhibition of NAMPT |
| EP2634173A4 (en) | 2010-10-26 | 2014-04-02 | Tianjin Hemay Bio Tech Co Ltd | POLYMORPH OF N- (6- (4-CHLOROPHENOXY) HEXYL-) N'-CYANO-N '' - (4-PYRIDYL-) GUANIDINE, PREPARATION THEREOF AND USE THEREOF |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9219472D0 (en) * | 1992-09-15 | 1992-10-28 | Leo Pharm Prod Ltd | Chemical compounds |
-
1997
- 1997-05-29 GB GBGB9711119.9A patent/GB9711119D0/en active Pending
-
1998
- 1998-05-15 SK SK1611-99A patent/SK161199A3/sk unknown
- 1998-05-15 CA CA002291489A patent/CA2291489A1/en not_active Abandoned
- 1998-05-15 EP EP98924054A patent/EP0984937A1/en not_active Withdrawn
- 1998-05-15 EE EEP199900551A patent/EE03871B1/xx not_active IP Right Cessation
- 1998-05-15 AU AU76385/98A patent/AU733093B2/en not_active Ceased
- 1998-05-15 KR KR19997011141A patent/KR20010013158A/ko not_active Application Discontinuation
- 1998-05-15 NZ NZ500702A patent/NZ500702A/en unknown
- 1998-05-15 US US09/424,655 patent/US6121297A/en not_active Expired - Fee Related
- 1998-05-15 BR BR9809496-3A patent/BR9809496A/pt not_active IP Right Cessation
- 1998-05-15 JP JP50011399A patent/JP2001526693A/ja active Pending
- 1998-05-15 WO PCT/DK1998/000195 patent/WO1998054143A1/en not_active Application Discontinuation
- 1998-05-15 HU HU0003150A patent/HUP0003150A3/hu unknown
- 1998-05-15 PL PL98337091A patent/PL337091A1/xx unknown
- 1998-05-15 EA EA199901096A patent/EA002037B1/ru not_active IP Right Cessation
- 1998-05-15 CN CN98805480A patent/CN1314890A/zh active Pending
-
1999
- 1999-10-26 IS IS5229A patent/IS5229A/is unknown
- 1999-11-09 BG BG103867A patent/BG103867A/xx unknown
-
2002
- 2002-01-16 HK HK02100324.5A patent/HK1039116A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL337091A1 (en) | 2000-07-31 |
| AU7638598A (en) | 1998-12-30 |
| BG103867A (en) | 2001-05-31 |
| EA002037B1 (ru) | 2001-12-24 |
| BR9809496A (pt) | 2000-06-20 |
| EA199901096A1 (ru) | 2000-08-28 |
| IS5229A (is) | 1999-10-26 |
| GB9711119D0 (en) | 1997-07-23 |
| SK161199A3 (en) | 2000-06-12 |
| HUP0003150A2 (en) | 2001-03-28 |
| AU733093B2 (en) | 2001-05-03 |
| EE9900551A (et) | 2000-06-15 |
| CA2291489A1 (en) | 1998-12-03 |
| NZ500702A (en) | 2001-07-27 |
| US6121297A (en) | 2000-09-19 |
| KR20010013158A (ko) | 2001-02-26 |
| CN1314890A (zh) | 2001-09-26 |
| EP0984937A1 (en) | 2000-03-15 |
| JP2001526693A (ja) | 2001-12-18 |
| WO1998054143A1 (en) | 1998-12-03 |
| HK1039116A1 (zh) | 2002-04-12 |
| HUP0003150A3 (en) | 2002-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE200000706A (et) | Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid | |
| DK1114051T3 (da) | Inhibitorer for p38 | |
| DE69940115D1 (de) | Heterocyclische inhibitoren von p38 | |
| ID22982A (id) | PIRAZOL-PIRAZOL TERSUBSTITUSI SEBAGAI INHIBITOR KINASE p38 | |
| DE69716615D1 (de) | Heterozyklische metalloproteaseinhibitoren | |
| NO20002121D0 (no) | Benzotiazol-protein-tyrosin-kinaseinhibitorer | |
| DK1027332T3 (da) | Hidtil ukendte lactametalloproteaseinhibitorer | |
| EE200200140A (et) | Pteridinoonid kui kinaasi inhibiitorid | |
| ATE260248T1 (de) | Zellproliferation inhibitoren | |
| PL334846A1 (en) | Sulphamidic inhibitors of metaloproteases | |
| FI972701A (fi) | Menetelmä päätelaitteiden käytön rajoittamiseksi | |
| EE9900510A (et) | Leptiin kui tuumorirakkude proliferatsiooni inhibiitor | |
| PT927183E (pt) | Inibidores espirociclicos de metaloproteases | |
| EE9900551A (et) | Tsüanoguanidiinid kui rakkude paljunemise inhibiitorid | |
| PL337331A1 (en) | Cyanoguanidines as cell proliferation inhibitors | |
| NO20004579L (no) | Substituerte bisindolymaleimider for inhibering av celle- proliferering | |
| DE69531048D1 (de) | Verwendung von steroidsulphatase-hemmern | |
| ZA983065B (en) | Inhibitors of protein farnesyltranferase | |
| KR950703064A (ko) | 세포증식의 저해물질, 그의 제조방법 및 이용방법 | |
| PL337031A1 (en) | Cyanoguanidines as inhibitors of cell proliferation | |
| AU7638498A (en) | Cyanoguanidines as cell proliferation inhibitors | |
| HK1020944A1 (en) | Substituted heterocyclic benzocycloalkenes and their use as analgesically active compounds | |
| GB9706652D0 (en) | Inhibitors of FPT as anti-inflammatories | |
| PL336896A1 (en) | Cyanoamidines as inhibitors of cell proliferation | |
| PL343872A1 (en) | (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
|
| MA4A | Abandonment or withdrawal |
Effective date: 20040515 |
|
| MA4A | Abandonment or withdrawal |
Effective date: 20031015 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20030412 |