EE02973B1 - Difenüülbutüül-piperasiinkarboksamiidi kasutamine narkomaaniavastase ravimi valmistamiseks ja farmatseutiline kompositsioon - Google Patents

Difenüülbutüül-piperasiinkarboksamiidi kasutamine narkomaaniavastase ravimi valmistamiseks ja farmatseutiline kompositsioon

Info

Publication number
EE02973B1
EE02973B1 EE9400358A EE9400358A EE02973B1 EE 02973 B1 EE02973 B1 EE 02973B1 EE 9400358 A EE9400358 A EE 9400358A EE 9400358 A EE9400358 A EE 9400358A EE 02973 B1 EE02973 B1 EE 02973B1
Authority
EE
Estonia
Prior art keywords
drug
diphenylbutyl
piperazinecarboxamide
manufacture
pharmaceutical composition
Prior art date
Application number
EE9400358A
Other languages
English (en)
Estonian (et)
Inventor
Bj�rk Anders
Christensson Erik
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Publication of EE02973B1 publication Critical patent/EE02973B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
EE9400358A 1991-03-22 1994-11-17 Difenüülbutüül-piperasiinkarboksamiidi kasutamine narkomaaniavastase ravimi valmistamiseks ja farmatseutiline kompositsioon EE02973B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100860A SE9100860D0 (sv) 1991-03-22 1991-03-22 New use

Publications (1)

Publication Number Publication Date
EE02973B1 true EE02973B1 (et) 1997-04-15

Family

ID=20382242

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400358A EE02973B1 (et) 1991-03-22 1994-11-17 Difenüülbutüül-piperasiinkarboksamiidi kasutamine narkomaaniavastase ravimi valmistamiseks ja farmatseutiline kompositsioon

Country Status (24)

Country Link
US (2) US5434156A (fr)
EP (1) EP0538422B1 (fr)
JP (1) JP3221611B2 (fr)
KR (1) KR100196674B1 (fr)
AT (1) ATE199057T1 (fr)
AU (1) AU653797B2 (fr)
BG (1) BG61829B1 (fr)
BR (1) BR9204969A (fr)
CA (1) CA2083505C (fr)
CZ (1) CZ282222B6 (fr)
DE (1) DE69231680T2 (fr)
DK (1) DK0538422T3 (fr)
EE (1) EE02973B1 (fr)
ES (1) ES2154261T3 (fr)
GR (1) GR3035805T3 (fr)
HU (2) HU217833B (fr)
IE (1) IE920920A1 (fr)
NO (1) NO301311B1 (fr)
PT (1) PT100279B (fr)
RO (1) RO109702B1 (fr)
RU (1) RU2095062C1 (fr)
SE (1) SE9100860D0 (fr)
SK (1) SK279237B6 (fr)
WO (1) WO1992016211A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100860D0 (sv) * 1991-03-22 1991-03-22 Kabi Pharmacia Ab New use
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
JP3571114B2 (ja) * 1995-07-11 2004-09-29 ポーラ化成工業株式会社 麻薬拮抗剤
US6265393B1 (en) 1998-08-07 2001-07-24 Heinrichs William Leroy Prevention of endometriosis signs or symptons
US6090780A (en) * 1999-04-07 2000-07-18 Chandon Prasad Histidyl-proline diketopiperazine and method of use
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
US20050192271A1 (en) * 2003-07-15 2005-09-01 Hythiam, Inc. Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse
ES2269661T3 (es) * 2001-01-17 2007-04-01 Hythiam, Inc. El uso de flumazenil en el desarrollo de un farmaco para el tratamiento de dependencia del alcohol.
US7183410B2 (en) * 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
UA78974C2 (en) * 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
US7482365B2 (en) 2002-02-08 2009-01-27 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
NZ551340A (en) * 2004-04-22 2010-10-29 Boehringer Ingelheim Int Pharmaceutical composition comprising flibanserin and a melanocortin agonist for the treatment of premenstrual disorder or sexual aversion disorder
US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
US20060025420A1 (en) * 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
CA2576812A1 (fr) * 2004-09-03 2006-03-09 Boehringer Ingelheim International Gmbh Methode de traitement du trouble de l'hyperactivite avec deficit de l'attention
JP2008538741A (ja) * 2005-03-04 2008-11-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 鬱病の治療用及び／又は予防用の医薬組成物
EP1858515A2 (fr) * 2005-03-04 2007-11-28 Boehringer Ingelheim International Gmbh Compositions pharmaceutiques permettant de traiter et/ou de prevenir les troubles de l'anxiete
WO2006096439A2 (fr) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Compositions pharmaceutiques destinees au traitement et/ou a la prevention de la schizophrenie et de maladies associees
EP1904182A2 (fr) * 2005-05-06 2008-04-02 Boehringer Ingelheim International GmbH Methode de traitement de la toxicomanie avec flibanserine
CA2608363A1 (fr) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Procede pour le traitement de dysfonctionnements sexuels d'origine medicamenteuse
WO2006125041A1 (fr) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Procede pour le traitement de dysfonctionnements sexuels dus a des etats pathologiques
PL1912650T3 (pl) 2005-08-03 2018-01-31 Sprout Pharmaceuticals Inc Zastosowanie flibanseryny w leczeniu otyłości
WO2007048803A1 (fr) * 2005-10-29 2007-05-03 Boehringer Ingelheim International Gmbh Derives de benzimidazolone utiles pour le traitement des troubles premenstruels et d'autres troubles sexuels chez la femme
US20070123540A1 (en) * 2005-10-29 2007-05-31 Angelo Ceci Sexual desire enhancing medicaments comprising benzimidazolone derivatives
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
PT2021006E (pt) * 2006-05-09 2015-11-12 Sprout Pharmaceuticals Inc Uso de flibanserina para o tratamento de distúrbios de desejo sexual pós-menopausa
US20090312242A1 (en) * 2006-06-30 2009-12-17 Ramiro Castro Flibanserin for the treatment of urinary incontinence and related diseases
JP2009543839A (ja) * 2006-07-14 2009-12-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 女性の性的障害を治療するためのフリバンセリンの使用
CL2007002214A1 (es) * 2006-08-14 2008-03-07 Boehringer Ingelheim Int Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp
WO2008019996A2 (fr) 2006-08-14 2008-02-21 Boehringer Ingelheim International Gmbh Formulations de flibansérine et leur procédé de fabrication
KR20090045945A (ko) * 2006-08-25 2009-05-08 베링거 인겔하임 인터내셔날 게엠베하 제어 방출 시스템 및 이의 제조방법
PE20091188A1 (es) * 2007-09-12 2009-08-31 Boehringer Ingelheim Int Compuesto 1-[2-(4-(3-trifluorometil-fenil)piperazin-1-il)etil]-2,3-dihidro-1h-benzimidazol-2-ona (flibanserina), sus sales de adicion y composiciones farmaceuticas que los contienen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154582C (no) * 1978-10-20 1986-11-05 Ferrosan Ab Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider.
SE9100860D0 (sv) * 1991-03-22 1991-03-22 Kabi Pharmacia Ab New use

Also Published As

Publication number Publication date
CA2083505C (fr) 2003-06-10
JP3221611B2 (ja) 2001-10-22
KR100196674B1 (ko) 1999-06-15
HU9203632D0 (en) 1993-03-29
JPH05507731A (ja) 1993-11-04
GR3035805T3 (en) 2001-07-31
DE69231680D1 (de) 2001-03-15
CZ344992A3 (en) 1994-02-16
EP0538422B1 (fr) 2001-02-07
NO301311B1 (no) 1997-10-13
BG97108A (bg) 1994-03-24
PT100279B (pt) 1999-06-30
ES2154261T3 (es) 2001-04-01
BG61829B1 (bg) 1998-07-31
SK279237B6 (sk) 1998-08-05
HUT64696A (en) 1994-02-28
CA2083505A1 (fr) 1992-09-23
AU1428092A (en) 1992-10-21
NO924502D0 (no) 1992-11-23
RO109702B1 (ro) 1995-05-30
PT100279A (pt) 1993-07-30
AU653797B2 (en) 1994-10-13
IE920920A1 (en) 1992-09-23
SK344992A3 (en) 1995-11-08
EP0538422A1 (fr) 1993-04-28
HU217833B (hu) 2000-04-28
US5618817A (en) 1997-04-08
DK0538422T3 (da) 2001-05-07
DE69231680T2 (de) 2001-06-07
US5434156A (en) 1995-07-18
WO1992016211A1 (fr) 1992-10-01
KR930700108A (ko) 1993-03-13
SE9100860D0 (sv) 1991-03-22
ATE199057T1 (de) 2001-02-15
RU2095062C1 (ru) 1997-11-10
NO924502L (no) 1992-11-23
CZ282222B6 (cs) 1997-06-11
BR9204969A (pt) 1993-07-27

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

MM4A Lapsed by not paying the annual fees

Effective date: 20061117