ECSP12011627A - Otamixaban para el tratamiento de pacientes con alteración renal y de edad avanzada con infarto de miocardio sin elevación del st - Google Patents

Otamixaban para el tratamiento de pacientes con alteración renal y de edad avanzada con infarto de miocardio sin elevación del st

Info

Publication number
ECSP12011627A
ECSP12011627A EC2012011627A ECSP12011627A ECSP12011627A EC SP12011627 A ECSP12011627 A EC SP12011627A EC 2012011627 A EC2012011627 A EC 2012011627A EC SP12011627 A ECSP12011627 A EC SP12011627A EC SP12011627 A ECSP12011627 A EC SP12011627A
Authority
EC
Ecuador
Prior art keywords
elevation
treatment
otamixaban
alteration
renal
Prior art date
Application number
EC2012011627A
Other languages
English (en)
Inventor
Christophe Gaudin
Jens Stechl
Angele Moryusef
Moury Pascale Ythier
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ECSP12011627A publication Critical patent/ECSP12011627A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere al uso de éster metílico del ácido (2R,3R)-2-(3-carbamimidoil-bencil)-3-[4-(1-oxi-piridin-4-il)benzoilamino]-butírico o una sal farmacéuticamente aceptable del mismo, para la preparación de un medicamento para su uso en el infarto de miocardio sin elevación del ST, comprendiendo dicho tratamiento administrar una cantidad terapéuticamente eficaz de éster metílico del ácido (2R,3R)-2-(3-carbamimidoil-bencil)-3-[4-(1-oxi-piridin-4-il)benzoilamino]-butírico o una sal farmacéuticamente aceptable del mismo a un paciente humano, de edad avanzada y/o que muestra insuficiencia renal y/o tiene un bajo peso corporal.
EC2012011627A 2009-07-29 2012-01-26 Otamixaban para el tratamiento de pacientes con alteración renal y de edad avanzada con infarto de miocardio sin elevación del st ECSP12011627A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09290601 2009-07-29
EP10305192 2010-02-26

Publications (1)

Publication Number Publication Date
ECSP12011627A true ECSP12011627A (es) 2012-02-29

Family

ID=42542846

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2012011627A ECSP12011627A (es) 2009-07-29 2012-01-26 Otamixaban para el tratamiento de pacientes con alteración renal y de edad avanzada con infarto de miocardio sin elevación del st

Country Status (25)

Country Link
US (1) US9492437B2 (es)
EP (1) EP2459193A1 (es)
JP (1) JP2013500298A (es)
KR (1) KR20120038982A (es)
CN (1) CN102470128A (es)
AR (1) AR077427A1 (es)
AU (1) AU2010277725B2 (es)
BR (1) BR112012001900A2 (es)
CA (1) CA2766533A1 (es)
CL (1) CL2012000196A1 (es)
CO (1) CO6491041A2 (es)
CR (1) CR20110674A (es)
DO (1) DOP2012000012A (es)
EC (1) ECSP12011627A (es)
IL (1) IL217612A (es)
MA (1) MA33455B1 (es)
MX (1) MX2012000457A (es)
NI (1) NI201200008A (es)
NZ (1) NZ597957A (es)
PE (1) PE20121401A1 (es)
RU (1) RU2542455C2 (es)
SG (1) SG177772A1 (es)
TW (1) TWI463982B (es)
UY (1) UY32807A (es)
WO (1) WO2011012527A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI551289B (zh) * 2011-03-29 2016-10-01 賽諾菲公司 具有改良之安定性之奧米沙班調配物
EA025572B1 (ru) 2011-03-29 2017-01-30 Санофи Лекарственные формы отамиксабана с улучшенной стабильностью
CN103562183B (zh) 2011-03-29 2015-12-23 赛诺菲 奥米沙班的苯甲酸盐
US9597322B2 (en) 2012-08-31 2017-03-21 Sanofi Otamixaban for use in the treatment of non-ST elevation acute coronary syndrome in patients planned to undergo coronary artery bypass grafting

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9612423B1 (pt) * 1996-01-02 2010-11-30 composto de n-[(amino-imino-metil ou amino-metil) fenil] propil amidas substituìdas, e, composição farmacêutica.
RU2225617C1 (ru) * 2002-12-16 2004-03-10 Научно-исследовательский институт кардиологии Томского научного центра СО РАМН Способ определения дифференцированного назначения гепаринов больным с острым коронарным синдромом без подъема сегмента st

Also Published As

Publication number Publication date
NZ597957A (en) 2014-05-30
UY32807A (es) 2011-02-28
RU2542455C2 (ru) 2015-02-20
US20120238605A1 (en) 2012-09-20
JP2013500298A (ja) 2013-01-07
WO2011012527A1 (en) 2011-02-03
CN102470128A (zh) 2012-05-23
BR112012001900A2 (pt) 2016-03-15
RU2012107483A (ru) 2013-09-10
CA2766533A1 (en) 2011-02-03
SG177772A1 (en) 2012-03-29
AU2010277725A1 (en) 2012-02-16
EP2459193A1 (en) 2012-06-06
CR20110674A (es) 2012-04-17
KR20120038982A (ko) 2012-04-24
AU2010277725B2 (en) 2016-08-18
CO6491041A2 (es) 2012-07-31
CL2012000196A1 (es) 2012-10-05
TW201119655A (en) 2011-06-16
NI201200008A (es) 2012-05-29
MX2012000457A (es) 2012-01-27
IL217612A (en) 2014-08-31
PE20121401A1 (es) 2012-10-25
AR077427A1 (es) 2011-08-24
DOP2012000012A (es) 2012-02-15
TWI463982B (zh) 2014-12-11
MA33455B1 (fr) 2012-07-03
US9492437B2 (en) 2016-11-15

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