ECSP067050A - Forma de dosificacion solida de heparina humeda - Google Patents
Forma de dosificacion solida de heparina humedaInfo
- Publication number
- ECSP067050A ECSP067050A EC2006007050A ECSP067050A ECSP067050A EC SP067050 A ECSP067050 A EC SP067050A EC 2006007050 A EC2006007050 A EC 2006007050A EC SP067050 A ECSP067050 A EC SP067050A EC SP067050 A ECSP067050 A EC SP067050A
- Authority
- EC
- Ecuador
- Prior art keywords
- heparin
- wet
- dosage form
- solid dosage
- humeda
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/609—Amides, e.g. salicylamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica sólida (tal como una forma de dosificación sólida) que comprende un agente de suministro y heparina húmeda. La inclusión de heparina húmeda en lugar de la heparina no húmeda en la composición farmacéutica sólida resulta en la liberación aumentada de heparina. Sin vincularse por cualquier teoría particular, los solicitantes creen que debido a que la cadena de polímero de la heparina húmeda ya está en forma "abierta", mientras que la heparina no húmeda no lo está, menos de la heparina húmeda se disuelve en el aparato gastrointestinal y se absorbe más fácilmente en el estómago.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56947504P | 2004-05-06 | 2004-05-06 | |
US57267904P | 2004-05-19 | 2004-05-19 | |
US59897804P | 2004-08-04 | 2004-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP067050A true ECSP067050A (es) | 2007-02-28 |
Family
ID=35320730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006007050A ECSP067050A (es) | 2004-05-06 | 2006-12-07 | Forma de dosificacion solida de heparina humeda |
Country Status (14)
Country | Link |
---|---|
US (1) | US8039018B2 (es) |
EP (1) | EP1750729A2 (es) |
JP (1) | JP2007536268A (es) |
KR (1) | KR20070008720A (es) |
AU (1) | AU2005240206B2 (es) |
BR (1) | BRPI0510226A (es) |
CA (1) | CA2564866A1 (es) |
EC (1) | ECSP067050A (es) |
IL (1) | IL178846A0 (es) |
MA (1) | MA28774B1 (es) |
MX (1) | MXPA06012841A (es) |
NZ (1) | NZ550894A (es) |
RU (1) | RU2006138703A (es) |
WO (1) | WO2005107773A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ597499A (en) * | 2004-05-14 | 2013-04-26 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
AU2008316634B2 (en) * | 2007-10-24 | 2014-02-27 | Mannkind Corporation | Method of preventing adverse effects by GLP-1 |
WO2011097148A2 (en) * | 2010-02-04 | 2011-08-11 | Parsons Lowell C | Use of oral heparin preparations to treat urinary tract diseases and conditions |
SI2651398T1 (en) | 2010-12-16 | 2018-04-30 | Novo Nordisk A/S | SOLID COMPOSITIONS CONTAINING GLP-1 AGONIST AND SOL N- (8- (2-HYDROXYBENZOIL) AMINO) CAPRICULATE ACIDS |
DK2696687T3 (en) | 2011-04-12 | 2017-02-06 | Novo Nordisk As | Double-acylated GLP-1 derivatives |
HUE042757T2 (hu) | 2012-03-22 | 2019-07-29 | Novo Nordisk As | Szállító szert tartalmazó készítmények és elõállításuk |
EP2827845B1 (en) | 2012-03-22 | 2018-12-26 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
ES2690553T3 (es) | 2012-03-22 | 2018-11-21 | Novo Nordisk A/S | Composiciones de péptidos GLP-1 y preparación de estas |
US9993430B2 (en) | 2012-06-20 | 2018-06-12 | Novo Nordisk A/S | Tablet formulation comprising semaglutide and a delivery agent |
ES2960687T3 (es) | 2018-02-02 | 2024-03-06 | Novo Nordisk As | Composiciones sólidas que comprenden un agonista del GLP-1 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico y un lubricante |
TWI829687B (zh) * | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
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US3510561A (en) | 1965-05-20 | 1970-05-05 | Canada Packers Ltd | Sulfone-enhanced heparin absorption through mucous membranes |
US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
US5693338A (en) | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
US5578323A (en) | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US5629020A (en) | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
US5541155A (en) | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
US6916489B2 (en) | 1992-06-15 | 2005-07-12 | Emisphere Technologies, Inc. | Active agent transport systems |
US20040062773A1 (en) | 1993-04-22 | 2004-04-01 | Emisphere Technologies Inc. | Compositions for the delivery of antigens |
US6461643B2 (en) | 1993-04-22 | 2002-10-08 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
US20010003001A1 (en) | 1993-04-22 | 2001-06-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
SE9302135D0 (sv) | 1993-06-18 | 1993-06-18 | Kabi Pharmacia Ab | New pharmaceutical composition |
US5965121A (en) | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
WO1997036480A1 (en) | 1996-03-29 | 1997-10-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
CN1151836C (zh) | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
US5989539A (en) | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5820881A (en) | 1995-04-28 | 1998-10-13 | Emisphere Technologies, Inc. | Microspheres of diamide-dicarboxylic acids |
US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
JP2000512671A (ja) | 1996-06-14 | 2000-09-26 | エミスフェアー テクノロジーズ インク | マイクロカプセル化香料及び調製方法 |
WO1998021951A1 (en) | 1996-11-18 | 1998-05-28 | Emisphere Technologies, Inc. | Methods and compositions for inducing oral tolerance in mammals |
US6313088B1 (en) | 1997-02-07 | 2001-11-06 | Emisphere Technologies, Inc. | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents |
US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
IN186245B (es) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
WO1999044642A1 (en) | 1998-03-05 | 1999-09-10 | Phares Pharmaceutical Research Nv | Pharmaceutical compositions and their use |
US6949816B2 (en) * | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
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TR200100922T2 (tr) | 1998-07-27 | 2001-09-21 | Emisphere Technologies Inc. | Aktif maddelerin akciğerler yolu ile tatbik edilmesi. |
PL212652B1 (pl) | 1998-08-07 | 2012-11-30 | Emisphere Tech Inc | Zwiazki, zawierajace je kompozycje farmaceutyczne oraz postacie dawki jednostkowej |
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US20030225300A1 (en) | 2001-04-19 | 2003-12-04 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
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-
2005
- 2005-05-06 NZ NZ550894A patent/NZ550894A/en not_active IP Right Cessation
- 2005-05-06 KR KR1020067025727A patent/KR20070008720A/ko not_active Application Discontinuation
- 2005-05-06 JP JP2007511670A patent/JP2007536268A/ja active Pending
- 2005-05-06 WO PCT/US2005/016012 patent/WO2005107773A2/en active Application Filing
- 2005-05-06 CA CA002564866A patent/CA2564866A1/en not_active Abandoned
- 2005-05-06 US US11/568,749 patent/US8039018B2/en not_active Expired - Fee Related
- 2005-05-06 RU RU2006138703/15A patent/RU2006138703A/ru unknown
- 2005-05-06 BR BRPI0510226-0A patent/BRPI0510226A/pt not_active IP Right Cessation
- 2005-05-06 MX MXPA06012841A patent/MXPA06012841A/es not_active Application Discontinuation
- 2005-05-06 AU AU2005240206A patent/AU2005240206B2/en not_active Ceased
- 2005-05-06 EP EP05744023A patent/EP1750729A2/en not_active Withdrawn
-
2006
- 2006-10-24 IL IL178846A patent/IL178846A0/en unknown
- 2006-12-04 MA MA29506A patent/MA28774B1/fr unknown
- 2006-12-07 EC EC2006007050A patent/ECSP067050A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2005240206A1 (en) | 2005-11-17 |
US20070224262A1 (en) | 2007-09-27 |
BRPI0510226A (pt) | 2007-10-23 |
CA2564866A1 (en) | 2005-11-17 |
MXPA06012841A (es) | 2007-02-15 |
IL178846A0 (en) | 2007-05-15 |
AU2005240206B2 (en) | 2011-04-07 |
WO2005107773A3 (en) | 2006-01-05 |
WO2005107773A8 (en) | 2006-12-21 |
MA28774B1 (fr) | 2007-08-01 |
RU2006138703A (ru) | 2008-06-20 |
US8039018B2 (en) | 2011-10-18 |
KR20070008720A (ko) | 2007-01-17 |
WO2005107773A2 (en) | 2005-11-17 |
EP1750729A2 (en) | 2007-02-14 |
NZ550894A (en) | 2011-02-25 |
JP2007536268A (ja) | 2007-12-13 |
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