ECSP024244A - Uso de (z)-2-cyano-3-hydroxy-but-2-enoic acid(4´-trifluoromethylphenyl)-amide para el tratamiento de la esclerosis múltiple - Google Patents

Uso de (z)-2-cyano-3-hydroxy-but-2-enoic acid(4´-trifluoromethylphenyl)-amide para el tratamiento de la esclerosis múltiple

Info

Publication number
ECSP024244A
ECSP024244A EC2002004244A ECSP024244A ECSP024244A EC SP024244 A ECSP024244 A EC SP024244A EC 2002004244 A EC2002004244 A EC 2002004244A EC SP024244 A ECSP024244 A EC SP024244A EC SP024244 A ECSP024244 A EC SP024244A
Authority
EC
Ecuador
Prior art keywords
multiple sclerosis
trifluoromethylphenyl
cyano
amide
hydroxy
Prior art date
Application number
EC2002004244A
Other languages
English (en)
Spanish (es)
Inventor
Joseph G Wettstein
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23078354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP024244(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of ECSP024244A publication Critical patent/ECSP024244A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EC2002004244A 2001-04-05 2002-04-04 Uso de (z)-2-cyano-3-hydroxy-but-2-enoic acid(4´-trifluoromethylphenyl)-amide para el tratamiento de la esclerosis múltiple ECSP024244A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28168501P 2001-04-05 2001-04-05

Publications (1)

Publication Number Publication Date
ECSP024244A true ECSP024244A (es) 2002-08-01

Family

ID=23078354

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2002004244A ECSP024244A (es) 2001-04-05 2002-04-04 Uso de (z)-2-cyano-3-hydroxy-but-2-enoic acid(4´-trifluoromethylphenyl)-amide para el tratamiento de la esclerosis múltiple

Country Status (6)

Country Link
US (2) US6794410B2 (en:Method)
BE (1) BE2014C008I2 (en:Method)
CY (1) CY1110446T1 (en:Method)
EC (1) ECSP024244A (en:Method)
GB (1) GB0123571D0 (en:Method)
HN (1) HN2002000110A (en:Method)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR245601A0 (en) 2001-01-10 2001-02-01 Silverbrook Research Pty Ltd An apparatus (WSM09)
KR20090104041A (ko) * 2006-12-19 2009-10-05 메리맥 파마슈티컬즈, 인크. 다발성 경화증을 치료하기 위한 α페토프로테인 및 면역조절제의 병용투여
EP2277515A1 (en) 2009-07-10 2011-01-26 Sanofi-Aventis Use of the combination of teriflunomide and interferon beta for treating multiple sclerosis
PE20152031A1 (es) * 2009-09-18 2016-01-14 Sanofi Sa Formulaciones en comprimido de la (4'-trifluorometilfenil)amida del acido (z)-2-ciano-3-hidroxibut-2-enoico con estabilidad mejorada
WO2011049792A1 (en) 2009-10-22 2011-04-28 Sanofi-Aventis U.S. Llc Use of the combination of teriflunomide and glatiramer acetate for treating multiple sclerosis
EP2314291A1 (en) 2009-10-22 2011-04-27 Sanofi-Aventis Use of the combination of teriflunomide and glatiramer acetate for treating multiple sclerosis
AR081220A1 (es) 2010-05-26 2012-07-04 Sanofi Aventis Us Llc Uso de teriflunomida para el tratamiento de la atrofia cerebral
AR081764A1 (es) 2010-05-26 2012-10-17 Sanofi Aventis Us Llc Uso de teriflunomida para mantener el nivel de fatiga de un paciente que tiene esclerosis multiple, articulo de fabricacion y envase
AR082436A1 (es) 2010-08-02 2012-12-05 Sanofi Aventis Us Llc Uso de teriflunomida para tratar la esclerosis multiple
WO2012025217A1 (en) * 2010-08-24 2012-03-01 Algiax Pharmaceuticals Gmbh Novel use of leflunomide and malononitrilamides
WO2012061060A1 (en) 2010-10-25 2012-05-10 Sanofi-Aventis U.S. Llc Use of teriflunomide for treating brain atrophy
WO2012061062A1 (en) 2010-10-25 2012-05-10 Sanofi-Aventis U.S. Llc Use of teriflunomide for improving motor function
DK2632451T3 (en) 2010-10-29 2017-12-18 Algiax Pharmaceuticals Gmbh USE OF MALONNITRILAMIDS IN NEUROPATHIC PAIN
AR085305A1 (es) 2011-02-24 2013-09-18 Sanofi Aventis Us Llc Uso de la teriflunomida para el tratamiento del deterioro cognitivo
WO2012162339A1 (en) 2011-05-24 2012-11-29 Sanofi-Aventis U.S. Llc Use of teriflunomide for reducing occurrence of relapses requiring healthcare resources
RU2471482C1 (ru) * 2011-10-27 2013-01-10 Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ" Композиция для лечения рассеянного склероза (варианты)
RU2493845C1 (ru) * 2012-06-07 2013-09-27 Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ" Композиция для лечения рассеянного склероза (варианты)
EP2762135A1 (en) 2013-02-04 2014-08-06 Sanofi Methods for reducing the risk of an adverse teriflunomide and rosuvastatin interaction in multiple sclerosis patients
JOP20190207A1 (ar) * 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
ES448386A1 (es) * 1975-06-05 1978-04-16 Hoechst Ag Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.
DE2854439A1 (de) 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
US4284784A (en) * 1980-05-22 1981-08-18 Merck & Co., Inc. Process for the preparation of 4-methyl thiazole
US5268382A (en) 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US4965278A (en) * 1989-04-21 1990-10-23 Warner-Lambert Company 7-(substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro[4,5]decanes as diuretics antiiflammatory, and cerebrovascular agents
US6133301A (en) 1991-08-22 2000-10-17 Aventis Pharma Deutschland Gmbh Pharmaceuticals for the treatment of rejection reactions in organ transplantations
IT1254519B (it) 1992-03-16 1995-09-25 Chiesi Farma Spa Associazioni di composti ad attivita' antivirale
WO1994024095A1 (en) 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
DE19534649A1 (de) 1995-09-19 1997-03-20 Hoechst Ag 2-Cyano-3-mercaptocrotonsäureamide
DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
DE19610955A1 (de) 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
US5856330A (en) 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US6011051A (en) 1996-07-31 2000-01-04 Hoechst Aktiengesellschaft Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
US5981536A (en) 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
DE59801792D1 (de) 1997-08-08 2001-11-22 Aventis Pharma Gmbh Kristallform von N-(4-Trifluormethylphenyl)-5-methylisoxazol-4-carbonsäureamid
DE19857009A1 (de) 1998-12-10 2000-06-15 Aventis Pharma Gmbh Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren
PL366088A1 (en) * 2000-02-15 2005-01-24 Teva Pharmaceutical Industries Ltd. A method for synthesizing leflunomide

Also Published As

Publication number Publication date
BE2014C008I2 (en:Method) 2021-02-04
US20020177623A1 (en) 2002-11-28
US6794410B2 (en) 2004-09-21
US20030223960A1 (en) 2003-12-04
CY1110446T1 (el) 2015-04-29
GB0123571D0 (en) 2001-11-21
HN2002000110A (es) 2002-07-04

Similar Documents

Publication Publication Date Title
ECSP024244A (es) Uso de (z)-2-cyano-3-hydroxy-but-2-enoic acid(4´-trifluoromethylphenyl)-amide para el tratamiento de la esclerosis múltiple
ECSP044992A (es) Inhibidores de la alquín-aril fosfodiesterasa-4
UY27244A1 (es) Uso del acido- (4´-trifluormetilfenil) - amida (z) -2- ciano-3- hidroxi-but-2-enoico para el tratamiento de la esclerosis multiple
IS8485A (is) Notkun á setnum 2-amínótetralínum í fyrirbyggjandi meðferð á Parkinsons-veiki
ECSP055609A (es) "Uso de inhibidores de la IkB-quinasa para el tratamiento del dolor"
CR10190A (es) INHIBIDORES DEL FACTOR Xa Y DE OTRAS PROTEASAS DE SERINA IMPLICADAS EN LA CASCADA DE LA COAGULACION (SOLICITUD DIVISIONAL EXP. 7332)
ATE365720T1 (de) Agonisten von beta-adrenorezeptoren
MXPA04004301A (es) Bencimidazoles sustituidos utiles como inhibidores de la proteina cinasa.
ECSP034811A (es) Derivados heterocicliloxi-, -tioxi - y - aminobenzazole tales como ligandos 5-hidroxitriptamina-6
BR0306922A (pt) N-pirazinil-fenilsulfonamidas e seu uso no tratamento de doenças mediadas por quimocina
PL376324A1 (en) Piperazinyl and diazapanyl benzamides and benzthioamides
NO20033959D0 (no) Benzimidazoler som er nyttige i behandling av seksuell dysfunksjon
SE9802794D0 (sv) New compounds
BR0305708A (pt) Derivados de benzimidazol para o tratamento de disfunção sexual
SE9802793D0 (sv) New compounds
SE0004101D0 (sv) New use
SE0002739D0 (sv) New use
BRPI0509667B8 (pt) composto, processo para a preparação de um composto de fórmula (i), medicamento e uso de um composto
SE0102641D0 (sv) Novel compounds
ATE265423T1 (de) Neue phenylheteroalkylamin-derivate
UY27372A1 (es) Derivados de bencimidazol 1-aril-2-n, s u o-sustituidos, su uso para la obtención de medicamentos y preparados farmacéuticos que contienen estos derivados
SE0102639D0 (sv) Novel compounds
SE0102640D0 (sv) Novel compounds
BR0317445A (pt) Composto, composição farmacêutica, método para o tratamento de doenças, e, uso de um composto
BR0317413A (pt) Uso de tiazolobenzoheterociclos para o tratamento de esclerose múltipla