CY1110446T1 - Χρηση (ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοϊκου οξεος-(4’-τριφθορομεθυλοφαινυλο)-αμιδης για τη θεραπεια πολλαπλης σκληρωσης - Google Patents

Χρηση (ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοϊκου οξεος-(4’-τριφθορομεθυλοφαινυλο)-αμιδης για τη θεραπεια πολλαπλης σκληρωσης

Info

Publication number
CY1110446T1
CY1110446T1 CY20081100822T CY081100822T CY1110446T1 CY 1110446 T1 CY1110446 T1 CY 1110446T1 CY 20081100822 T CY20081100822 T CY 20081100822T CY 081100822 T CY081100822 T CY 081100822T CY 1110446 T1 CY1110446 T1 CY 1110446T1
Authority
CY
Cyprus
Prior art keywords
multiple sclerosis
triffluoromethylphenyl
enochic
cyano
amide
Prior art date
Application number
CY20081100822T
Other languages
English (en)
Inventor
Joseph Wettstein
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23078354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1110446(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP02763962A external-priority patent/EP1381356B1/en
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of CY1110446T1 publication Critical patent/CY1110446T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αφορά τη χρήση μιας ένωσης του τύπου Ι για τη θεραπεία ασθενών που εκδηλώνουν τα συμπτώματα της πολλαπλής σκλήρωσης.
CY20081100822T 2001-04-05 2008-08-06 Χρηση (ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοϊκου οξεος-(4’-τριφθορομεθυλοφαινυλο)-αμιδης για τη θεραπεια πολλαπλης σκληρωσης CY1110446T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28168501P 2001-04-05 2001-04-05
GBGB0123571.2A GB0123571D0 (en) 2001-04-05 2001-10-02 Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
EP02763962A EP1381356B1 (en) 2001-04-05 2002-04-04 Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis

Publications (1)

Publication Number Publication Date
CY1110446T1 true CY1110446T1 (el) 2015-04-29

Family

ID=23078354

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100822T CY1110446T1 (el) 2001-04-05 2008-08-06 Χρηση (ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοϊκου οξεος-(4’-τριφθορομεθυλοφαινυλο)-αμιδης για τη θεραπεια πολλαπλης σκληρωσης

Country Status (6)

Country Link
US (2) US6794410B2 (el)
BE (1) BE2014C008I2 (el)
CY (1) CY1110446T1 (el)
EC (1) ECSP024244A (el)
GB (1) GB0123571D0 (el)
HN (1) HN2002000110A (el)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR245601A0 (en) 2001-01-10 2001-02-01 Silverbrook Research Pty Ltd An apparatus (WSM09)
CA2673398A1 (en) * 2006-12-19 2008-07-03 Merrimack Pharmaceuticals, Inc. Coadministration of alpha-fetoprotein and an immunomodulatory agent to treat multiple sclerosis
EP2277515A1 (en) 2009-07-10 2011-01-26 Sanofi-Aventis Use of the combination of teriflunomide and interferon beta for treating multiple sclerosis
PE20121478A1 (es) * 2009-09-18 2012-11-12 Sanofi Sa Formulaciones en comprimido de teriflunomida: "(4'-trifluorometilfenil) amida del acido (z)-2-ciano-3-hidroxibut-2-enoico con estabilidad mejorada
EP2314291A1 (en) 2009-10-22 2011-04-27 Sanofi-Aventis Use of the combination of teriflunomide and glatiramer acetate for treating multiple sclerosis
WO2011049792A1 (en) 2009-10-22 2011-04-28 Sanofi-Aventis U.S. Llc Use of the combination of teriflunomide and glatiramer acetate for treating multiple sclerosis
AR081220A1 (es) 2010-05-26 2012-07-04 Sanofi Aventis Us Llc Uso de teriflunomida para el tratamiento de la atrofia cerebral
AR081764A1 (es) 2010-05-26 2012-10-17 Sanofi Aventis Us Llc Uso de teriflunomida para mantener el nivel de fatiga de un paciente que tiene esclerosis multiple, articulo de fabricacion y envase
AR082436A1 (es) 2010-08-02 2012-12-05 Sanofi Aventis Us Llc Uso de teriflunomida para tratar la esclerosis multiple
ES2591355T3 (es) * 2010-08-24 2016-11-28 Algiax Pharmaceuticals Gmbh Uso novedoso de leflunomida y malononitrilamidas
WO2012061060A1 (en) 2010-10-25 2012-05-10 Sanofi-Aventis U.S. Llc Use of teriflunomide for treating brain atrophy
WO2012061062A1 (en) * 2010-10-25 2012-05-10 Sanofi-Aventis U.S. Llc Use of teriflunomide for improving motor function
LT2632451T (lt) 2010-10-29 2018-02-12 Algiax Pharmaceuticals Gmbh Malononitrilamidų panaudojimas esant neuropatiniam skausmui
AR085305A1 (es) 2011-02-24 2013-09-18 Sanofi Aventis Us Llc Uso de la teriflunomida para el tratamiento del deterioro cognitivo
WO2012162339A1 (en) 2011-05-24 2012-11-29 Sanofi-Aventis U.S. Llc Use of teriflunomide for reducing occurrence of relapses requiring healthcare resources
RU2471482C1 (ru) * 2011-10-27 2013-01-10 Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ" Композиция для лечения рассеянного склероза (варианты)
RU2493845C1 (ru) * 2012-06-07 2013-09-27 Общество с ограниченной ответственностью "ВАЛЕНТА ИНТЕЛЛЕКТ" Композиция для лечения рассеянного склероза (варианты)
EP2762135A1 (en) 2013-02-04 2014-08-06 Sanofi Methods for reducing the risk of an adverse teriflunomide and rosuvastatin interaction in multiple sclerosis patients
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
NL178596C (nl) * 1975-06-05 1986-04-16 Hoechst Ag Werkwijze voor het bereiden van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor het bereiden van daarin als geneeskrachtige verbindingen te gebruiken 5-methylisoxazool-4-carbonzuuraniliden.
DE2854439A1 (de) 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
US4284784A (en) * 1980-05-22 1981-08-18 Merck & Co., Inc. Process for the preparation of 4-methyl thiazole
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5268382A (en) 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
US4965278A (en) * 1989-04-21 1990-10-23 Warner-Lambert Company 7-(substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro[4,5]decanes as diuretics antiiflammatory, and cerebrovascular agents
US6133301A (en) 1991-08-22 2000-10-17 Aventis Pharma Deutschland Gmbh Pharmaceuticals for the treatment of rejection reactions in organ transplantations
IT1254519B (it) 1992-03-16 1995-09-25 Chiesi Farma Spa Associazioni di composti ad attivita' antivirale
WO1994024095A1 (en) 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
US5700823A (en) 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
DE19534649A1 (de) 1995-09-19 1997-03-20 Hoechst Ag 2-Cyano-3-mercaptocrotonsäureamide
DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
DE19610955A1 (de) 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
US5856330A (en) 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US6011051A (en) 1996-07-31 2000-01-04 Hoechst Aktiengesellschaft Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
US5981536A (en) 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
ATE207065T1 (de) 1997-08-08 2001-11-15 Aventis Pharma Gmbh Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid
DE19857009A1 (de) 1998-12-10 2000-06-15 Aventis Pharma Gmbh Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren
ATE292966T1 (de) * 2000-02-15 2005-04-15 Teva Pharma Methode zur synthetisierung von leflunomid

Also Published As

Publication number Publication date
US6794410B2 (en) 2004-09-21
US20020177623A1 (en) 2002-11-28
ECSP024244A (es) 2002-08-01
GB0123571D0 (en) 2001-11-21
BE2014C008I2 (el) 2021-02-04
HN2002000110A (es) 2002-07-04
US20030223960A1 (en) 2003-12-04

Similar Documents

Publication Publication Date Title
CY1110446T1 (el) Χρηση (ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοϊκου οξεος-(4’-τριφθορομεθυλοφαινυλο)-αμιδης για τη θεραπεια πολλαπλης σκληρωσης
CY1107853T1 (el) Χρησεις αντισπασμωδικων αμινοξεων για τη θεραπευτικη αγωγη διπολικων διαταραχων
HRP20090281T1 (en) 1,2,3,4-tetrasubstituted indole for the treatment of respiratory diseases
CY2014004I2 (el) Χρηση (ζ)-2-κυανο-3-υδροξυ-βουτ-2-ενοικου οξεος-(4΄-τριφθορομεθυλοφαινυλο)-αμιδης για τη θεραπεια της πολλαπλης σκληρωσης
CY1108738T1 (el) Θεραπευτικοι παραγοντες χρησιμοι για την αγωγη του πονου
CY1109886T1 (el) Καινοφανεις ενωσεις ως αντι-φλεγμονωδεις, ανοσοτροποποιητικοι και αντι υπερπλαστικοι παραγοντες
CY1106247T1 (el) Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες
CY1109497T1 (el) Παραγωγα θειοφενιου ως αντιβιοτικοι παραγοντες για λοιμωξη/μολυνση φλαβοϊου (flavivirus)
CY1105386T1 (el) Βενζοϋλοσουλφοναμιδια και σουλφονυλβενζαμιδινες για χρηση σαν παραγοντες κατα του ογκου
ATE307810T1 (de) Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
EA200401114A2 (ru) Замещённые гидроксиэтиламины
NO20052907D0 (no) Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
ATE389395T1 (de) Substituierte 2-aminotetraline zur vorbeugenden behandlung von morbus parkinson
NO20014925L (no) Farmasöytiske forbindelser
IT1319202B1 (it) Farmaci per le malattie a base infiammatoria.
SE9802794D0 (sv) New compounds
SE9802793D0 (sv) New compounds
CY1105345T1 (el) Φαινυλαλκινια
SE0101082D0 (sv) Novel use
SE0002739D0 (sv) New use
SE0004827D0 (sv) Therapeutic compounds
ATE308513T1 (de) Naphthamid-neurokinin antagonisten zur verwendung als medikamente
PL403800A1 (pl) Kompozycja farmaceutyczna
NO20033049D0 (no) Fremgangsmåte for fremstilling av (+/-) trans-4-p-fluorfenyl- 3-hydroksymetyl-1
EA200200682A1 (ru) Новые соединения n-бензилпиперазина, способ их получения и фармацевтические композиции, их содержащие