EA202192229A1 - Селективное оптическое обнаружение органических анализируемых веществ в жидкостях - Google Patents

Селективное оптическое обнаружение органических анализируемых веществ в жидкостях

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Publication number
EA202192229A1
EA202192229A1 EA202192229A EA202192229A EA202192229A1 EA 202192229 A1 EA202192229 A1 EA 202192229A1 EA 202192229 A EA202192229 A EA 202192229A EA 202192229 A EA202192229 A EA 202192229A EA 202192229 A1 EA202192229 A1 EA 202192229A1
Authority
EA
Eurasian Patent Office
Prior art keywords
organic
liquids
optical detection
analyzed
selective optical
Prior art date
Application number
EA202192229A
Other languages
English (en)
Inventor
Сергей Бабиченко
Яак Ярв
Алексей Кузнецов
Антон Маститски
Original Assignee
Куаникдикс Ою
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Куаникдикс Ою filed Critical Куаникдикс Ою
Publication of EA202192229A1 publication Critical patent/EA202192229A1/ru

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Изобретение относится к способу и устройству для обнаружения и количественного определения разнообразных анализируемых органических веществ в жидком образце, а также к аналитической подложке для обеспечения измерений анализируемых веществ. Указанный способ осуществлен посредством применения специфического взаимодействия органических анализируемых веществ с селективными связывающими центрами, иммобилизованными на многослойной аналитической подложке, с дальнейшим обнаружением такого взаимодействия посредством применения устройства на основе индуцирования и регистрации флуоресценции такой подложки для биохимических, генетических и экологических анализов.
EA202192229A 2019-02-11 2020-01-20 Селективное оптическое обнаружение органических анализируемых веществ в жидкостях EA202192229A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EEU201900011U EE01561U1 (et) 2019-02-11 2019-02-11 Meetod vedelas proovis vähemalt ühe orgaanilise analüüdi tuvastamiseks ja kvantifitseerimiseks.
PCT/EP2020/051268 WO2020164863A1 (en) 2019-02-11 2020-01-20 Selective optical detection of organic analytes in liquids

Publications (1)

Publication Number Publication Date
EA202192229A1 true EA202192229A1 (ru) 2021-12-20

Family

ID=69467499

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192229A EA202192229A1 (ru) 2019-02-11 2020-01-20 Селективное оптическое обнаружение органических анализируемых веществ в жидкостях

Country Status (7)

Country Link
US (3) US11650205B2 (ru)
EP (1) EP3924734A1 (ru)
AU (1) AU2020220593A1 (ru)
CA (1) CA3129896A1 (ru)
EA (1) EA202192229A1 (ru)
EE (1) EE01561U1 (ru)
WO (1) WO2020164863A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE01561U1 (et) * 2019-02-11 2022-03-15 Qanikdx Oü Meetod vedelas proovis vähemalt ühe orgaanilise analüüdi tuvastamiseks ja kvantifitseerimiseks.
CN114674900B (zh) * 2022-04-02 2023-09-22 湖北大学 基于小分子探针的光电化学微传感器及其制备方法与应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0111459D0 (en) * 2001-05-10 2001-07-04 Isis Innovation Universal fluorescent sensors
KR100650162B1 (ko) * 2003-08-05 2006-11-27 주식회사 진인 품질 관리 프로브 및 음성 조절 프로브를 함유하는 약제내성 ｂ형 간염 바이러스 검출용 마이크로어레이 및 이를이용한 약제 내성 ｂ형 간염 바이러스의 검출 방법
US7572640B2 (en) 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
CA2616404A1 (en) * 2005-07-26 2007-02-01 Oregon Health & Science University Nanoparticle probes for capture, sorting and placement of targets
WO2007016665A2 (en) * 2005-07-29 2007-02-08 Dominion Diagnostics, Llc Single use fluorescent assays for determination of analytes
US20140349873A1 (en) 2006-05-12 2014-11-27 John Bruno Methods of Producing Competitive Aptamer FRET Reagents and Assays
US20090186342A1 (en) 2006-05-12 2009-07-23 Pronucleotein Biotechnologies, Llc Methods of producing competitive aptamer fret reagents and assays
US8158444B2 (en) 2006-10-06 2012-04-17 Sirigen, Inc. Fluorescent methods and materials for directed biomarker signal amplification
WO2008046029A2 (en) 2006-10-12 2008-04-17 The Board Of Trustees Of The University Of Illinois Detectio n of specific binding reactions using magnetic labels
KR100883547B1 (ko) * 2007-03-08 2009-02-13 한국과학기술원 양자점 기반의 바이오칩 및 이를 이용한 가수분해 단백질의활성 분석 방법
WO2009105583A1 (en) * 2008-02-19 2009-08-27 Anstron Technologies Company Fluorescence resonance energy transfer (fret) binding assays that are surface-based
KR100970584B1 (ko) * 2008-02-28 2010-07-16 한국과학기술원 당단백질 분석용 바이오칩 세트
US8940506B2 (en) 2008-03-21 2015-01-27 The Regents Of The University Of California High-sensitive fluorescent energy transfer assay using fluoresent amino acids and fluorescent proteins
WO2010033249A2 (en) 2008-09-22 2010-03-25 Massachusetts Institute Of Technology Compositions of and methods using ligand dimers
JP5720248B2 (ja) 2008-12-24 2015-05-20 コニカミノルタ株式会社 表面プラズモンおよび蛍光共鳴エネルギー転移を利用した免疫アッセイ
WO2010127980A1 (en) 2009-05-05 2010-11-11 F. Hoffmann-La Roche Ag Fret-based binding assay
WO2011154918A2 (en) * 2010-06-09 2011-12-15 Medisensor Gh, Inc. Diagnostic apparatus for immunoassay and diagnostic method for immunoassay using the same
KR101631581B1 (ko) 2010-06-11 2016-06-17 한국생명공학연구원 나노입자가 융합된 ｆｒｅｔ 센서 및 이를 이용한 파이토에스트로겐을 고감도로 검출하는 방법
WO2012092489A1 (en) 2010-12-30 2012-07-05 Quantum Dynamics, Ltd. Portable detection devices and methods for detection of biomarkers or other analytes
US9120820B2 (en) 2011-05-18 2015-09-01 Cayman Chemical Company, Incorporated Fluorescent molecular probes for use in assays that measure test compound competitive binding with SAM-utilizing proteins
US20180188243A1 (en) 2015-06-22 2018-07-05 The Regents Of The University Of California Quantitative fret-based interaction assay
GB201515693D0 (en) 2015-09-04 2015-10-21 Univ Birmingham Method for antigen detection
IL261734B2 (en) 2016-03-15 2023-04-01 Mipsalus Aps A method for detection and means for it
US20170341077A1 (en) * 2016-05-31 2017-11-30 University Of Guelph Microfluidic biosensor for allergen detection
EE01561U1 (et) * 2019-02-11 2022-03-15 Qanikdx Oü Meetod vedelas proovis vähemalt ühe orgaanilise analüüdi tuvastamiseks ja kvantifitseerimiseks.

Also Published As

Publication number Publication date
AU2020220593A1 (en) 2021-10-07
US11650205B2 (en) 2023-05-16
US11899011B2 (en) 2024-02-13
EE01561U1 (et) 2022-03-15
WO2020164863A1 (en) 2020-08-20
US20230258631A1 (en) 2023-08-17
US20240192203A1 (en) 2024-06-13
EP3924734A1 (en) 2021-12-22
US20210356463A1 (en) 2021-11-18
CA3129896A1 (en) 2020-08-20

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