EA202191958A1 - Способы и соединения - Google Patents
Способы и соединенияInfo
- Publication number
- EA202191958A1 EA202191958A1 EA202191958A EA202191958A EA202191958A1 EA 202191958 A1 EA202191958 A1 EA 202191958A1 EA 202191958 A EA202191958 A EA 202191958A EA 202191958 A EA202191958 A EA 202191958A EA 202191958 A1 EA202191958 A1 EA 202191958A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- connections
- preparation
- serd
- degrader
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 108010007005 Estrogen Receptor alpha Proteins 0.000 abstract 3
- 102100038595 Estrogen receptor Human genes 0.000 abstract 3
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940125904 compound 1 Drugs 0.000 abstract 1
- 239000001064 degrader Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229940125944 selective estrogen receptor degrader Drugs 0.000 abstract 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 abstract 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Описаны способы получения и промежуточные соединения, пригодные для получения соединения 1, селективного модулятора/деградатора рецептора эстрогена альфа (ER) (SERM/SERD), применимого для лечения ER+ раковых заболеваний, включая рак молочной железы.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962804391P | 2019-02-12 | 2019-02-12 | |
PCT/US2020/017777 WO2020167855A1 (en) | 2019-02-12 | 2020-02-11 | Processes and compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202191958A1 true EA202191958A1 (ru) | 2021-12-13 |
Family
ID=69784561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202191958A EA202191958A1 (ru) | 2019-02-12 | 2020-02-11 | Способы и соединения |
Country Status (15)
Country | Link |
---|---|
US (1) | US20220162233A1 (ru) |
EP (1) | EP3924328A1 (ru) |
JP (1) | JP2022523160A (ru) |
KR (1) | KR20210127961A (ru) |
CN (1) | CN113348163A (ru) |
AU (1) | AU2020223101A1 (ru) |
BR (1) | BR112021014126A2 (ru) |
CA (1) | CA3128510A1 (ru) |
EA (1) | EA202191958A1 (ru) |
IL (1) | IL285461A (ru) |
JO (1) | JOP20210218A1 (ru) |
MA (1) | MA54946A (ru) |
MX (1) | MX2021009569A (ru) |
SG (1) | SG11202108479UA (ru) |
WO (1) | WO2020167855A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023227029A1 (zh) * | 2022-05-25 | 2023-11-30 | 苏州科睿思制药有限公司 | 艾拉司群二盐酸盐的晶型及其制备方法和用途 |
WO2024104268A1 (zh) * | 2022-11-15 | 2024-05-23 | 苏州科睿思制药有限公司 | 艾拉司群二盐酸盐的共晶及其制备方法和用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003292625B2 (en) | 2002-12-26 | 2008-07-24 | Eisai R & D Management Co., Ltd. | Selective estrogen receptor modulators |
US9744177B2 (en) * | 2014-03-10 | 2017-08-29 | Endorecherche, Inc. | Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM |
-
2020
- 2020-02-11 AU AU2020223101A patent/AU2020223101A1/en active Pending
- 2020-02-11 SG SG11202108479UA patent/SG11202108479UA/en unknown
- 2020-02-11 EA EA202191958A patent/EA202191958A1/ru unknown
- 2020-02-11 US US17/430,248 patent/US20220162233A1/en active Pending
- 2020-02-11 EP EP20710682.4A patent/EP3924328A1/en active Pending
- 2020-02-11 WO PCT/US2020/017777 patent/WO2020167855A1/en active Application Filing
- 2020-02-11 JO JOP/2021/0218A patent/JOP20210218A1/ar unknown
- 2020-02-11 BR BR112021014126-0A patent/BR112021014126A2/pt unknown
- 2020-02-11 MX MX2021009569A patent/MX2021009569A/es unknown
- 2020-02-11 KR KR1020217028863A patent/KR20210127961A/ko unknown
- 2020-02-11 JP JP2021546691A patent/JP2022523160A/ja active Pending
- 2020-02-11 CA CA3128510A patent/CA3128510A1/en active Pending
- 2020-02-11 CN CN202080011109.9A patent/CN113348163A/zh active Pending
- 2020-02-11 MA MA054946A patent/MA54946A/fr unknown
-
2021
- 2021-08-09 IL IL285461A patent/IL285461A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3128510A1 (en) | 2020-08-20 |
US20220162233A1 (en) | 2022-05-26 |
WO2020167855A1 (en) | 2020-08-20 |
SG11202108479UA (en) | 2021-09-29 |
IL285461A (en) | 2021-09-30 |
CN113348163A (zh) | 2021-09-03 |
JP2022523160A (ja) | 2022-04-21 |
MX2021009569A (es) | 2021-09-08 |
EP3924328A1 (en) | 2021-12-22 |
AU2020223101A1 (en) | 2021-09-02 |
BR112021014126A2 (pt) | 2021-09-21 |
KR20210127961A (ko) | 2021-10-25 |
MA54946A (fr) | 2021-12-22 |
JOP20210218A1 (ar) | 2023-01-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2020012797A (es) | Anticuerpos biespecificos anti-pvrig/anti-tigit y métodos de uso. | |
MX2020010458A (es) | Conjugados de camptotecina-peptido. | |
NO2017019I2 (no) | Enzalutamid eller et farmasøytisk akseptabelt salt derav | |
EA202092907A1 (ru) | Мультиспецифические связывающие белки и их усовершенствования | |
BR112019010356A2 (pt) | molécula de carboidrato, conjugado fármaco-anticorpo (adc), composição, método para preparar a composição, método para tratar câncer em um indivíduo, método para induzir ou melhorar a reação imune em um indivíduo necessitando do mesmo, composto conjugado de fármaco-anticorpo, uso de um composto conjungado anticorpo-fáramco, método para determinar a eficácia terapêutica de células de câncer ao adcc e método para fazer imagem de um indivíduo | |
MX2019010156A (es) | Proteínas multiespecíficas de unión de direccionamiento a anhidrasa carbónica 9 (caix), anoctamina-1 (ano1), mesotelina, antígeno de superficie celular de trofoblasto (trop2), antígeno carcinoembrionario (cea) o claudina-18.2. | |
MX2022003930A (es) | Conjugados de péptido de camptotecina. | |
MD3313884T2 (ro) | Anticorpi anti-CD123 şi conjugaţi şi derivaţi ai acestora | |
EP4286008A3 (en) | Method of treatment of neuroendocrine tumors that over-express somatostatatin receptors | |
MX2021005075A (es) | Metodos para el tratamiento de cancer de prostata resistente a la castracion y sensible a la castracion. | |
EA202191958A1 (ru) | Способы и соединения | |
IL284645A (en) | Therapeutic RNA and Anti PD1 antibodies for the treatment of solid cancer tumors in advanced stages | |
MX2019010382A (es) | Metodo de tratamiento de tumor inmunoterapeutico utilizando un agonista alfa,beta-selectivo del receptor de interleuquina-2 en combinacion con terapia de transferencia celular adoptiva. | |
MX2021009138A (es) | Anticuerpos anti-cd228 y conjugados de anticuerpo-farmaco. | |
EA202090387A1 (ru) | Белки, связывающие nkg2d, cd16 и flt3 | |
MX2021008958A (es) | Proteínas de unión a antígeno del receptor gamma anti-il2. | |
MX2020000673A (es) | Composiciones que contienen conjugados análogos de cannabinoides y métodos de uso. | |
MX2020005640A (es) | Anticuerpos anti-liv1 humanizados para el tratamiento de cancer de mama. | |
CL2021000316A1 (es) | Proteínas de unión multiespecíficas que se unen a bcma, nkg2d y cd16 y métodos de uso | |
MX2022008099A (es) | Tratamiento para el cancer con inhibidores de cdk12/13. | |
EA202190862A1 (ru) | Способы лечения | |
EA202092861A1 (ru) | Специфичные в отношении злокачественной опухоли t-клеточные рецепторы | |
MX2021007687A (es) | Sales novedosas de degradadores selectivos de receptores de estrogeno. | |
ECSP20082970A (es) | Conjugados de fármaco y anticuerpo anti-sez6 y métodos de uso | |
MX2022006289A (es) | Tratamiento de canceres con conjugados anticuerpo-farmaco (adc) que se unen a las proteinas 191p4d12. |