EA202190162A2 - Способы лечения заболеваний, при которых активность il-13 оказывает негативное влияние, с применением антител против il-13 - Google Patents

Способы лечения заболеваний, при которых активность il-13 оказывает негативное влияние, с применением антител против il-13

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Publication number
EA202190162A2
EA202190162A2 EA202190162A EA202190162A EA202190162A2 EA 202190162 A2 EA202190162 A2 EA 202190162A2 EA 202190162 A EA202190162 A EA 202190162A EA 202190162 A EA202190162 A EA 202190162A EA 202190162 A2 EA202190162 A2 EA 202190162A2
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Eurasian Patent Office
Prior art keywords
activity
treatment
methods
diseases
antibodies against
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EA202190162A
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English (en)
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EA202190162A3 (ru
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Грегг Тимони
Шейла Гуджратхи
Роберт Пич
Аллан Олсон
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Эббви Инк.
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Publication of EA202190162A2 publication Critical patent/EA202190162A2/ru
Publication of EA202190162A3 publication Critical patent/EA202190162A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

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Abstract

Настоящее изобретение направлено на способы лечения заболеваний, при которых активность IL-13 оказывает негативное влияние, включающих эозинофильный эзофагит (ЭоЭ) и бронхиальную астму, путем введения субъекту, нуждающемуся в таком лечении, композиции, содержащей антитело к интерлейкину-13 (IL-13) или его антигенсвязывающий фрагмент.
EA202190162A 2016-04-27 2017-04-27 Способы лечения заболеваний, при которых активность il-13 оказывает негативное влияние, с применением антител против il-13 EA202190162A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662328539P 2016-04-27 2016-04-27

Publications (2)

Publication Number Publication Date
EA202190162A2 true EA202190162A2 (ru) 2021-04-30
EA202190162A3 EA202190162A3 (ru) 2021-11-30

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ID=60160091

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Application Number Title Priority Date Filing Date
EA201892409A EA037960B1 (ru) 2016-04-27 2017-04-27 Способ лечения эозинофильного эзофагита с применением антитела против il-13
EA202190162A EA202190162A3 (ru) 2016-04-27 2017-04-27 Способы лечения заболеваний, при которых активность il-13 оказывает негативное влияние, с применением антител против il-13

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EA201892409A EA037960B1 (ru) 2016-04-27 2017-04-27 Способ лечения эозинофильного эзофагита с применением антитела против il-13

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US (3) US11390669B2 (ru)
EP (2) EP4276108A3 (ru)
JP (4) JP6871948B2 (ru)
KR (3) KR102460040B1 (ru)
CN (2) CN109562115A (ru)
AU (4) AU2017258097B2 (ru)
BR (1) BR112018072263A2 (ru)
CA (1) CA3021334C (ru)
EA (2) EA037960B1 (ru)
FI (1) FI3448391T3 (ru)
IL (2) IL297519B2 (ru)
MX (2) MX2018013172A (ru)
SG (1) SG11201809253RA (ru)
WO (1) WO2017189805A1 (ru)
ZA (2) ZA201807174B (ru)

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EP4276108A3 (en) 2024-01-24
AU2017258097B2 (en) 2019-10-24
US20220281968A1 (en) 2022-09-08
JP7124040B2 (ja) 2022-08-23
US20230220061A1 (en) 2023-07-13
AU2021203358A1 (en) 2021-06-24
IL297519B2 (en) 2024-06-01
CA3021334A1 (en) 2017-11-02
AU2017258097A1 (en) 2018-11-15
AU2019275659A1 (en) 2020-01-02
US20210380674A1 (en) 2021-12-09
SG11201809253RA (en) 2018-11-29
EA202190162A3 (ru) 2021-11-30
ZA202000478B (en) 2021-10-27
JP2019514919A (ja) 2019-06-06
BR112018072263A2 (pt) 2019-02-12
IL297519A (en) 2022-12-01
IL262441B2 (en) 2023-06-01
CN109562115A (zh) 2019-04-02
KR20240052871A (ko) 2024-04-23
EP3448391A1 (en) 2019-03-06
EP4276108A2 (en) 2023-11-15
AU2022268294A1 (en) 2022-12-15
KR20220147722A (ko) 2022-11-03
IL297519B1 (en) 2024-02-01
CN114617962A (zh) 2022-06-14
IL262441A (en) 2018-12-31
ZA201807174B (en) 2021-06-30
MX2022008255A (es) 2022-08-04
CA3021334C (en) 2022-11-29
AU2019275659B2 (en) 2021-04-22
EP3448391A4 (en) 2019-12-18
JP2024054237A (ja) 2024-04-16
JP2021050204A (ja) 2021-04-01
KR20190002607A (ko) 2019-01-08
JP7434456B2 (ja) 2024-02-20
EA037960B1 (ru) 2021-06-15
EA201892409A1 (ru) 2019-03-29
FI3448391T3 (fi) 2024-06-19
AU2021203358B2 (en) 2022-12-01
JP6871948B2 (ja) 2021-05-19
EP3448391B1 (en) 2024-05-29
WO2017189805A1 (en) 2017-11-02
US11390669B2 (en) 2022-07-19
JP2022160627A (ja) 2022-10-19
MX2018013172A (es) 2019-02-21
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