EA202190001A1 - Низкомолекулярные инициаторы аутофагии - Google Patents

Низкомолекулярные инициаторы аутофагии

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Publication number
EA202190001A1
EA202190001A1 EA202190001A EA202190001A EA202190001A1 EA 202190001 A1 EA202190001 A1 EA 202190001A1 EA 202190001 A EA202190001 A EA 202190001A EA 202190001 A EA202190001 A EA 202190001A EA 202190001 A1 EA202190001 A1 EA 202190001A1
Authority
EA
Eurasian Patent Office
Prior art keywords
autophagy
initiators
low molecular
protein
molecular
Prior art date
Application number
EA202190001A
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English (en)
Inventor
Джеф Дебрабандер
Цижэнь Лян
Бет Левин
Вэй-Чун Чиан
Original Assignee
Борд Оф Реджентс, Зе Юниверсити Оф Техас Систем
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Борд Оф Реджентс, Зе Юниверсити Оф Техас Систем filed Critical Борд Оф Реджентс, Зе Юниверсити Оф Техас Систем
Publication of EA202190001A1 publication Critical patent/EA202190001A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
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Abstract

Предложены низкомолекулярные соединения, нарушающие белок-белковое взаимодействие Beclin-1/Bcl-2, которые вызывают аутофагию и, следовательно, подходят для лечения различных показаний, в которых терапевтически целесообразно стимулирование (инициация) аутофагии, включая рак, иммунитет к инфекциям (в том числе Зика), нейродегенерацию, увеличение продолжительности жизни.
EA202190001A 2018-06-04 2019-06-02 Низкомолекулярные инициаторы аутофагии EA202190001A1 (ru)

Applications Claiming Priority (2)

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US201862680578P 2018-06-04 2018-06-04
PCT/US2019/035099 WO2019236433A1 (en) 2018-06-04 2019-06-02 Small molecule inducers of autophagy

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EA202190001A1 true EA202190001A1 (ru) 2021-06-10

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US (3) US11325898B2 (ru)
EP (1) EP3801488A4 (ru)
JP (1) JP2021527067A (ru)
KR (1) KR20210031869A (ru)
CN (1) CN112543632A (ru)
AU (1) AU2019281966A1 (ru)
CA (1) CA3102828A1 (ru)
EA (1) EA202190001A1 (ru)
WO (1) WO2019236433A1 (ru)

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JP2021527067A (ja) * 2018-06-04 2021-10-11 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System オートファジーの低分子誘導物質
WO2023081312A1 (en) * 2021-11-04 2023-05-11 Vir Biotechnology, Inc. Small molecule inducers of autophagy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032173A1 (fr) * 1999-10-29 2001-05-10 Yamanouchi Pharmaceutical Co., Ltd. Inhibiteurs de neurocytotoxicite de l'acide kainique
US20130202646A1 (en) * 2010-02-25 2013-08-08 San Diego State University (Sdsu) Foundation Compositions and methods for modulating autophagy
WO2012160447A1 (en) * 2011-05-25 2012-11-29 Dynamix Pharmaceuticals Ltd. 3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases
JP2021527067A (ja) * 2018-06-04 2021-10-11 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System オートファジーの低分子誘導物質

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