EA202091203A1 - Конъюгаты лиганда-лекарственного средства в качестве субстратов для селективного расщепления под действием экзопептидазной активности катепсина b - Google Patents

Конъюгаты лиганда-лекарственного средства в качестве субстратов для селективного расщепления под действием экзопептидазной активности катепсина b

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Publication number
EA202091203A1
EA202091203A1 EA202091203A EA202091203A EA202091203A1 EA 202091203 A1 EA202091203 A1 EA 202091203A1 EA 202091203 A EA202091203 A EA 202091203A EA 202091203 A EA202091203 A EA 202091203A EA 202091203 A1 EA202091203 A1 EA 202091203A1
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EA
Eurasian Patent Office
Prior art keywords
ligand
drug conjugates
catepsin
substrates
action
Prior art date
Application number
EA202091203A
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English (en)
Inventor
Манфред Муттер
Натали Беллок
Даниэль Биасс
Ален Разанам
Лео Маркс
Кристоф Шардонен
Патрик Гарруст
Original Assignee
Дебиофарм Рисёрч Энд Маньюфэкчеринг С.А.
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Application filed by Дебиофарм Рисёрч Энд Маньюфэкчеринг С.А. filed Critical Дебиофарм Рисёрч Энд Маньюфэкчеринг С.А.
Publication of EA202091203A1 publication Critical patent/EA202091203A1/ru

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Abstract

Настоящее изобретение относится к конъюгатам лиганда-лекарственного средства для лечения заболевания. В частности, настоящее изобретение относится к конъюгатам лиганда-лекарственного средства, включающим линкерную систему, которая селективно распознается и расщепляется экзопептидазной (т.е. карбоксидипептидазной) активностью катепсина В, что обеспечивает улучшенную внутриклеточную доставку лекарственного средства в клетку-мишень. Настоящее изобретение также относится к конъюгатам лиганда-лекарственного средства для внутриклеточной доставки цитотоксических средств в опухолевые клетки.
EA202091203A 2017-11-14 2018-11-14 Конъюгаты лиганда-лекарственного средства в качестве субстратов для селективного расщепления под действием экзопептидазной активности катепсина b EA202091203A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17201589 2017-11-14
PCT/EP2018/081269 WO2019096867A1 (en) 2017-11-14 2018-11-14 Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin b

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EA202091203A1 true EA202091203A1 (ru) 2020-08-03

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US (1) US20220062371A1 (ru)
EP (1) EP3710064A1 (ru)
KR (1) KR20200088402A (ru)
CN (1) CN111655294A (ru)
AU (1) AU2018368520A1 (ru)
BR (1) BR112020008974A2 (ru)
CA (1) CA3082271A1 (ru)
EA (1) EA202091203A1 (ru)
IL (1) IL274549A (ru)
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US20230046947A1 (en) 2019-12-03 2023-02-16 Debiopharm Research & Manufacturing S.A. Reactive conjugates
WO2022078566A1 (en) 2020-10-12 2022-04-21 Debiopharm Research & Manufacturing S.A. Reactive conjugates
WO2023098691A1 (zh) * 2021-12-01 2023-06-08 上海生物制品研究所有限责任公司 抗体药物偶联物及其用途
AR128023A1 (es) 2021-12-17 2024-03-20 3B Pharmaceuticals Gmbh Ligandos de anhidrasa carbónica ix
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