SG11202003995PA - Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin b - Google Patents
Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin bInfo
- Publication number
- SG11202003995PA SG11202003995PA SG11202003995PA SG11202003995PA SG11202003995PA SG 11202003995P A SG11202003995P A SG 11202003995PA SG 11202003995P A SG11202003995P A SG 11202003995PA SG 11202003995P A SG11202003995P A SG 11202003995PA SG 11202003995P A SG11202003995P A SG 11202003995PA
- Authority
- SG
- Singapore
- Prior art keywords
- cathepsin
- conjugates
- ligand
- substrates
- drug
- Prior art date
Links
- 102000005600 Cathepsins Human genes 0.000 title 1
- 108010084457 Cathepsins Proteins 0.000 title 1
- 102000018389 Exopeptidases Human genes 0.000 title 1
- 108010091443 Exopeptidases Proteins 0.000 title 1
- 238000003776 cleavage reaction Methods 0.000 title 1
- 230000007017 scission Effects 0.000 title 1
- 239000000758 substrate Substances 0.000 title 1
Classifications
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- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17201589 | 2017-11-14 | ||
PCT/EP2018/081269 WO2019096867A1 (en) | 2017-11-14 | 2018-11-14 | Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin b |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202003995PA true SG11202003995PA (en) | 2020-05-28 |
Family
ID=60569563
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202003995PA SG11202003995PA (en) | 2017-11-14 | 2018-11-14 | Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin b |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220062371A1 (ru) |
EP (1) | EP3710064A1 (ru) |
KR (1) | KR20200088402A (ru) |
CN (1) | CN111655294A (ru) |
AU (1) | AU2018368520A1 (ru) |
BR (1) | BR112020008974A2 (ru) |
CA (1) | CA3082271A1 (ru) |
EA (1) | EA202091203A1 (ru) |
IL (1) | IL274549A (ru) |
SG (1) | SG11202003995PA (ru) |
WO (1) | WO2019096867A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4069311A1 (en) | 2019-12-03 | 2022-10-12 | Debiopharm Research & Manufacturing SA | Reactive conjugates |
WO2022078566A1 (en) | 2020-10-12 | 2022-04-21 | Debiopharm Research & Manufacturing S.A. | Reactive conjugates |
EP4431521A1 (en) * | 2021-12-01 | 2024-09-18 | Shanghai Institute of Biological Products Co., Ltd. | Antibody-drug conjugate and use thereof |
AU2022410422A1 (en) | 2021-12-17 | 2024-07-04 | 3B Pharmaceuticals Gmbh | Carbonic anhydrase ix ligands |
WO2023161291A1 (en) * | 2022-02-22 | 2023-08-31 | Araris Biotech Ag | Peptide linkers comprising two or more payloads |
WO2023198884A1 (en) | 2022-04-14 | 2023-10-19 | Debiopharm Research & Manufacturing S.A. | Ligand-drug-conjugates with improved pharmacokinetic and drug release properties |
WO2024013724A1 (en) * | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | Antibody-drug conjugates |
WO2024107014A1 (en) * | 2022-11-18 | 2024-05-23 | Genome And Company | Anti-basal cell adhesion molecule antibody-drug conjugate |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
EP2131866B1 (en) * | 2007-02-16 | 2015-08-26 | KTB Tumorforschungsgesellschaft mbH | Dual acting prodrugs |
PL2265283T3 (pl) * | 2008-03-18 | 2015-03-31 | Seattle Genetics Inc | Koniugaty aurystatyny lek łącznik |
EP3027224B1 (en) * | 2013-07-31 | 2020-06-03 | Rinat Neuroscience Corp. | Engineered polypeptide conjugates using transglutaminase |
HUE051389T2 (hu) * | 2013-10-15 | 2021-03-01 | Seagen Inc | Pegilezett gyógyszer-linkerek ligandum-gyógyszer konjugátum javított farmakokinetikájához |
IL309933A (en) | 2014-02-17 | 2024-03-01 | Seagen Inc | Hydrophilic antibody-drug conjugates |
KR20160145790A (ko) * | 2014-04-25 | 2016-12-20 | 리나트 뉴로사이언스 코프. | 약물이 고도로 로딩된 항체-약물 접합체 |
EP3185908B1 (en) * | 2014-08-28 | 2020-04-15 | Pfizer Inc | Stability-modulating linkers for use with antibody drug conjugates |
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2018
- 2018-11-14 CA CA3082271A patent/CA3082271A1/en active Pending
- 2018-11-14 WO PCT/EP2018/081269 patent/WO2019096867A1/en active Search and Examination
- 2018-11-14 EP EP18799568.3A patent/EP3710064A1/en active Pending
- 2018-11-14 CN CN201880086253.1A patent/CN111655294A/zh active Pending
- 2018-11-14 AU AU2018368520A patent/AU2018368520A1/en active Pending
- 2018-11-14 US US16/764,343 patent/US20220062371A1/en active Pending
- 2018-11-14 SG SG11202003995PA patent/SG11202003995PA/en unknown
- 2018-11-14 EA EA202091203A patent/EA202091203A1/ru unknown
- 2018-11-14 KR KR1020207017057A patent/KR20200088402A/ko not_active Application Discontinuation
- 2018-11-14 BR BR112020008974-5A patent/BR112020008974A2/pt unknown
-
2020
- 2020-05-10 IL IL274549A patent/IL274549A/en unknown
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CA3082271A1 (en) | 2019-05-23 |
AU2018368520A1 (en) | 2020-05-14 |
EP3710064A1 (en) | 2020-09-23 |
IL274549A (en) | 2020-06-30 |
US20220062371A1 (en) | 2022-03-03 |
KR20200088402A (ko) | 2020-07-22 |
EA202091203A1 (ru) | 2020-08-03 |
WO2019096867A1 (en) | 2019-05-23 |
CN111655294A (zh) | 2020-09-11 |
BR112020008974A2 (pt) | 2020-11-17 |
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