EA202091199A1 - Лекарственное средство для предотвращения или лечения риновирусной инфекции - Google Patents
Лекарственное средство для предотвращения или лечения риновирусной инфекцииInfo
- Publication number
- EA202091199A1 EA202091199A1 EA202091199A EA202091199A EA202091199A1 EA 202091199 A1 EA202091199 A1 EA 202091199A1 EA 202091199 A EA202091199 A EA 202091199A EA 202091199 A EA202091199 A EA 202091199A EA 202091199 A1 EA202091199 A1 EA 202091199A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- prevention
- treatment
- drug
- aldohexose
- composition
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title abstract 2
- 206010039105 Rhinoviral infections Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- GZCGUPFRVQAUEE-UHFFFAOYSA-N 2,3,4,5,6-pentahydroxyhexanal Chemical compound OCC(O)C(O)C(O)C(O)C=O GZCGUPFRVQAUEE-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- VRYALKFFQXWPIH-PBXRRBTRSA-N (3r,4s,5r)-3,4,5,6-tetrahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)CC=O VRYALKFFQXWPIH-PBXRRBTRSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract 1
- 241000430519 Human rhinovirus sp. Species 0.000 abstract 1
- 206010061494 Rhinovirus infection Diseases 0.000 abstract 1
- PMMURAAUARKVCB-UHFFFAOYSA-N alpha-D-ara-dHexp Natural products OCC1OC(O)CC(O)C1O PMMURAAUARKVCB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229940112141 dry powder inhaler Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229940071648 metered dose inhaler Drugs 0.000 abstract 1
- 229940097496 nasal spray Drugs 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 239000006199 nebulizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к фармацевтической композиции для применения при предотвращении или лечении риновирусной инфекции человека (HRV). Композиция содержит альдогексозу, где гидроксильная группа при углероде 2 альдогексозы заменена любым из H, F, Cl, Br, I, SH, Me, OMe и SMe, такую как 2-дезокси-D-глюкозу. Кроме того, предложен дозатор для интраназального введения, такой как назальный спрей или аппликатор для закапывания в нос, содержащий указанную фармацевтическую композицию. Дополнительно, предложено ингаляционное устройство, такое как дозирующий ингалятор, ингалятор сухого порошка или небулайзер, содержащее указанную композицию.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18154088.1A EP3517117A1 (en) | 2018-01-30 | 2018-01-30 | Medicament for prevention or treatment of rhinovirus infection |
| PCT/EP2018/097060 WO2019149436A1 (en) | 2018-01-30 | 2018-12-28 | Medicament for prevention or treatment of rhinovirus infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202091199A1 true EA202091199A1 (ru) | 2020-10-19 |
Family
ID=61094293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202091199A EA202091199A1 (ru) | 2018-01-30 | 2018-12-28 | Лекарственное средство для предотвращения или лечения риновирусной инфекции |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11413298B2 (ru) |
| EP (3) | EP3517117A1 (ru) |
| JP (3) | JP7359519B2 (ru) |
| CN (3) | CN111655267B (ru) |
| AU (1) | AU2018406914A1 (ru) |
| BR (1) | BR112020012869A2 (ru) |
| CA (1) | CA3086085A1 (ru) |
| EA (1) | EA202091199A1 (ru) |
| ES (1) | ES2907138T3 (ru) |
| HU (1) | HUE058250T2 (ru) |
| PL (1) | PL3634428T3 (ru) |
| PT (1) | PT3634428T (ru) |
| WO (1) | WO2019149436A1 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220166800A (ko) * | 2020-03-16 | 2022-12-19 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 헥소스형 모노사카라이드 및 이의 유사체를 이용한 바이러스성 감염 치료의 방법 |
| WO2021205412A1 (en) * | 2020-04-11 | 2021-10-14 | Exploration Invest Pte Ltd | 2-deoxy-d-glucose for prevention and treatment of a viral disease, in particular of covid-19 |
| EP4188984A1 (en) | 2020-07-30 | 2023-06-07 | Ecole Polytechnique Federale De Lausanne (Epfl) | Virucidal compositions and use thereof |
| WO2023062516A1 (en) * | 2021-10-11 | 2023-04-20 | Exploration Invest Pte Ltd | 2-deoxy-d-glucose for use in disease therapy |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2577321A (en) | 1949-10-29 | 1951-12-04 | Joseph B Filger | Nose drop dispenser |
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| US4603122A (en) * | 1979-08-17 | 1986-07-29 | Blough Herbert A | Antiviral agent against herpes virus infections |
| EP0169146A3 (en) * | 1984-07-20 | 1988-07-20 | Merck & Co. Inc. | Monoclonal antibodies directed against the cellular receptor of human rhinovirus |
| DE8422872U1 (de) | 1984-08-01 | 1984-10-25 | Anasco GmbH, 6200 Wiesbaden | Spender zur intranasalen applikation von fluessigkeiten in form von sprays oder tropfen |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US6000580A (en) | 1992-06-03 | 1999-12-14 | Astra Aktielbolag | Device for dispensing preservative-free nasal sprays and similar preparations |
| DE19706489C2 (de) * | 1997-02-19 | 2000-08-31 | Deutsches Krebsforsch | Verwendung von 2-Desoxyglucose zur Behandlung von Human-Papilloma-Virus-assoziierten Läsionen und/oder Neoplasien |
| CA2238460A1 (en) * | 1997-05-23 | 1998-11-23 | Imutec Pharma Inc. | Immunomodulating compositions for the treatment of viral disorders |
| US6260549B1 (en) | 1998-06-18 | 2001-07-17 | Clavius Devices, Inc. | Breath-activated metered-dose inhaler |
| AU2003261475B2 (en) * | 1998-11-05 | 2006-10-26 | Centre National De La Recherche Scientifique | Beta-L-2'-deoxy-nucleosides for the treatment of HIV infection |
| WO2002074370A2 (en) | 2001-03-20 | 2002-09-26 | Trudell Medical International | Nebulizer apparatus and method |
| US8957031B2 (en) * | 2007-10-23 | 2015-02-17 | Regents Of The University Of Colorado, A Body Corporate | Competitive inhibitors of invariant chain expression and/or ectopic clip binding |
| EP2633864A1 (en) * | 2008-07-25 | 2013-09-04 | The Regents of the University of Colorado | Clip inhibitors and methods of modulating immune function |
| US20100034839A1 (en) * | 2008-07-25 | 2010-02-11 | Martha Karen Newell | Methods for treating viral disorders |
| CN102639145B (zh) | 2009-10-22 | 2017-09-26 | 普罗潘克股份有限公司 | 包含胰蛋白酶原和/或糜蛋白酶原和选自硒化合物，类香兰素化合物和细胞质糖酵解减少剂的活性剂的用于治疗癌的药物组合物 |
| CN102178686B (zh) * | 2010-01-07 | 2016-01-13 | 王慧茹 | 多糖相关疾病的药物和疫苗及免疫测定产品 |
| US8633165B2 (en) * | 2010-08-04 | 2014-01-21 | Wisconsin Alumni Research Foundation | Neuroprotective effects of 2DG in traumatic brain injury |
| WO2012077828A1 (ja) * | 2010-12-08 | 2012-06-14 | 学校法人日本医科大学 | 炎症性サイトカインの機能を抑制する炎症性疾患治療剤 |
| WO2013077881A1 (en) * | 2011-11-23 | 2013-05-30 | 3B Pharmaceuticals, Inc. | Antiviral formulations |
| EP3328376A4 (en) * | 2015-07-31 | 2019-03-13 | The Johns Hopkins University | METHODS AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC REPROGRAMMING DISORDERS |
| US10813893B2 (en) * | 2017-02-24 | 2020-10-27 | Cellular Sciences, Inc. | Compositions and methods for the treatment and prevention of chronic hypoxemia and dyspnea |
-
2018
- 2018-01-30 EP EP18154088.1A patent/EP3517117A1/en not_active Withdrawn
- 2018-12-28 JP JP2020542122A patent/JP7359519B2/ja active Active
- 2018-12-28 PT PT188330690T patent/PT3634428T/pt unknown
- 2018-12-28 EP EP18833069.0A patent/EP3634428B1/en active Active
- 2018-12-28 WO PCT/EP2018/097060 patent/WO2019149436A1/en active Application Filing
- 2018-12-28 PL PL18833069T patent/PL3634428T3/pl unknown
- 2018-12-28 HU HUE18833069A patent/HUE058250T2/hu unknown
- 2018-12-28 EP EP21214874.6A patent/EP3988102A1/en active Pending
- 2018-12-28 EA EA202091199A patent/EA202091199A1/ru unknown
- 2018-12-28 US US16/770,482 patent/US11413298B2/en active Active
- 2018-12-28 AU AU2018406914A patent/AU2018406914A1/en active Pending
- 2018-12-28 CN CN201880087524.5A patent/CN111655267B/zh active Active
- 2018-12-28 CA CA3086085A patent/CA3086085A1/en active Pending
- 2018-12-28 ES ES18833069T patent/ES2907138T3/es active Active
- 2018-12-28 CN CN202310646048.9A patent/CN116473982A/zh active Pending
- 2018-12-28 CN CN202310646037.0A patent/CN116459265A/zh active Pending
- 2018-12-28 BR BR112020012869-4A patent/BR112020012869A2/pt unknown
-
2022
- 2022-07-08 US US17/811,488 patent/US12011453B2/en active Active
-
2023
- 2023-07-07 JP JP2023112485A patent/JP2023134593A/ja active Pending
- 2023-07-07 JP JP2023112484A patent/JP2023134592A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HUE058250T2 (hu) | 2022-07-28 |
| PL3634428T3 (pl) | 2022-03-14 |
| EP3634428A1 (en) | 2020-04-15 |
| EP3634428B1 (en) | 2022-01-26 |
| US11413298B2 (en) | 2022-08-16 |
| CN116473982A (zh) | 2023-07-25 |
| US20220362272A1 (en) | 2022-11-17 |
| CN111655267B (zh) | 2023-06-20 |
| JP2021516219A (ja) | 2021-07-01 |
| CN111655267A (zh) | 2020-09-11 |
| BR112020012869A2 (pt) | 2020-12-29 |
| CN116459265A (zh) | 2023-07-21 |
| US12011453B2 (en) | 2024-06-18 |
| ES2907138T3 (es) | 2022-04-22 |
| WO2019149436A1 (en) | 2019-08-08 |
| AU2018406914A1 (en) | 2020-07-02 |
| JP2023134592A (ja) | 2023-09-27 |
| CA3086085A1 (en) | 2019-08-08 |
| US20200397805A1 (en) | 2020-12-24 |
| EP3517117A1 (en) | 2019-07-31 |
| JP7359519B2 (ja) | 2023-10-11 |
| PT3634428T (pt) | 2022-03-22 |
| JP2023134593A (ja) | 2023-09-27 |
| EP3988102A1 (en) | 2022-04-27 |
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