EA202091184A1 - Композиции, содержащие тимогидрохинон, и способ их получения - Google Patents

Композиции, содержащие тимогидрохинон, и способ их получения

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Publication number
EA202091184A1
EA202091184A1 EA202091184A EA202091184A EA202091184A1 EA 202091184 A1 EA202091184 A1 EA 202091184A1 EA 202091184 A EA202091184 A EA 202091184A EA 202091184 A EA202091184 A EA 202091184A EA 202091184 A1 EA202091184 A1 EA 202091184A1
Authority
EA
Eurasian Patent Office
Prior art keywords
thymohydroquinone
disclosed
preparation
compositions containing
nigella sativa
Prior art date
Application number
EA202091184A
Other languages
English (en)
Inventor
Мухаммед Маджид
Кальянам Нагабхушанам
Беена Бхат
Original Assignee
Сами Лабс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сами Лабс Лимитед filed Critical Сами Лабс Лимитед
Publication of EA202091184A1 publication Critical patent/EA202091184A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0211—Solvent extraction of solids in combination with an electric or magnetic field
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0292—Treatment of the solvent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Abstract

Раскрыты композиции, обогащенные тимогидрохиноном, дополнительно включающие тимохинон, гедерагенин и/или -гедерин, приготовленные путем смешивания активных молекул, выделенных из семян Nigella sativa. Также раскрыты новые способы выделения биологически активных компонентов тимогидрохинона, тимохинона из семян Nigella sativa. Также раскрыт способ выделения -гедерина и гедерагенина из отработанного материала Nigella sativa.
EA202091184A 2017-12-27 2018-12-26 Композиции, содержащие тимогидрохинон, и способ их получения EA202091184A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762610565P 2017-12-27 2017-12-27
PCT/US2018/067478 WO2019133587A1 (en) 2017-12-27 2018-12-26 Compositions containing thymohydroquinone and their method of preparation

Publications (1)

Publication Number Publication Date
EA202091184A1 true EA202091184A1 (ru) 2020-09-23

Family

ID=66949194

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202091205A EA202091205A1 (ru) 2017-12-27 2018-12-26 Композиции для терапии гипергликемии и сопутствующих состояний
EA202091184A EA202091184A1 (ru) 2017-12-27 2018-12-26 Композиции, содержащие тимогидрохинон, и способ их получения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA202091205A EA202091205A1 (ru) 2017-12-27 2018-12-26 Композиции для терапии гипергликемии и сопутствующих состояний

Country Status (11)

Country Link
US (2) US10881623B2 (ru)
EP (2) EP3731833A4 (ru)
JP (2) JP7012857B2 (ru)
KR (2) KR102577863B1 (ru)
CN (2) CN111566218B (ru)
AU (2) AU2018397668B2 (ru)
BR (2) BR112020012333A2 (ru)
CA (2) CA3087050C (ru)
EA (2) EA202091205A1 (ru)
WO (2) WO2019133588A1 (ru)
ZA (2) ZA202004531B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111214514B (zh) * 2020-03-10 2022-03-22 上海中医药大学 续断及续断中活性组分在降糖中的应用
WO2022132844A1 (en) * 2020-12-15 2022-06-23 Muhammed Majeed Anti-viral compositions
JP2023554640A (ja) * 2020-12-17 2023-12-28 サミ－サビンサ グループ リミテッド 慢性炎症状態において終末糖化産物受容体（ｒａｇｅ）を標的とするための組成物
CN114948915B (zh) * 2022-07-18 2023-10-24 广东省农业科学院动物卫生研究所 百里醌在制备抗副猪嗜血杆菌药物中的应用
WO2024073699A1 (en) * 2022-09-29 2024-04-04 Muhammed Majeed Compositions for the management of hirsutism

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8029831B2 (en) * 2008-07-29 2011-10-04 Bionexus, Ltd. Formulations containing thymoquinone for urinary health
US8535740B2 (en) * 2002-11-22 2013-09-17 Bionexus, Ltd. Compositions from Nigella sativa
WO2005009332A2 (en) * 2003-07-31 2005-02-03 Palsamed (P.B.S.) Ltd. Compositions-of-matter for lowering serum cholesterol and/or triglyceride level and methods of producing and using same
GB0505909D0 (en) * 2005-03-23 2005-04-27 Univ Leeds Formulations
CN101500588A (zh) * 2006-08-09 2009-08-05 帝斯曼知识产权资产管理有限公司 用于治疗与受损的神经传递相关的病症的新颖试剂
CN101781604A (zh) * 2010-03-11 2010-07-21 南京农业大学 超临界二氧化碳萃取黑种草子油的方法
US20160213727A1 (en) * 2012-01-26 2016-07-28 William G. Rohlfsen Methods and Uses of High Thymoquinone and Thymohydroquinone Essential Oil of Monarda
CN103948604A (zh) * 2014-05-20 2014-07-30 天津理工大学 常春藤皂苷元类化合物作为治疗肝癌药品的应用及其制备
PL412214A1 (pl) * 2015-05-04 2016-11-07 Biovico Spółka Z Ograniczoną Odpowiedzialnością Kompozycja roślinna o właściwościach przeciwzapalnych, przeciwalergicznych i/lub przeciwastmatycznych oraz jej zastosowanie

Also Published As

Publication number Publication date
US10881623B2 (en) 2021-01-05
AU2018397668A1 (en) 2020-07-09
KR102577863B1 (ko) 2023-09-15
CA3087050A1 (en) 2019-07-04
US20190192447A1 (en) 2019-06-27
WO2019133587A1 (en) 2019-07-04
EP3732294A1 (en) 2020-11-04
BR112020012333A2 (pt) 2020-11-24
CA3087042C (en) 2023-08-01
JP2021508718A (ja) 2021-03-11
JP2021508480A (ja) 2021-03-11
US10945969B2 (en) 2021-03-16
EA202091205A1 (ru) 2020-12-14
KR102539298B1 (ko) 2023-06-02
AU2018397668B2 (en) 2022-07-14
CN111566218B (zh) 2023-11-21
ZA202004532B (en) 2021-08-25
KR20200098616A (ko) 2020-08-20
CN111566218A (zh) 2020-08-21
EP3731833A1 (en) 2020-11-04
JP7012857B2 (ja) 2022-01-28
EP3731833A4 (en) 2021-11-24
ZA202004531B (en) 2022-12-21
CN111542313B (zh) 2023-11-21
KR20200100772A (ko) 2020-08-26
CA3087042A1 (en) 2019-07-04
EP3732294A4 (en) 2021-08-18
AU2018397667B2 (en) 2021-11-11
CN111542313A (zh) 2020-08-14
AU2018397667A1 (en) 2020-07-09
JP7089033B2 (ja) 2022-06-21
WO2019133588A1 (en) 2019-07-04
BR112020012949A2 (pt) 2021-01-05
US20190192448A1 (en) 2019-06-27
CA3087050C (en) 2023-09-19

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