EP3732294A4 - Compositions for the management of hyperglycemia and related conditions - Google Patents

Compositions for the management of hyperglycemia and related conditions Download PDF

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Publication number
EP3732294A4
EP3732294A4 EP18897769.8A EP18897769A EP3732294A4 EP 3732294 A4 EP3732294 A4 EP 3732294A4 EP 18897769 A EP18897769 A EP 18897769A EP 3732294 A4 EP3732294 A4 EP 3732294A4
Authority
EP
European Patent Office
Prior art keywords
hyperglycemia
compositions
management
related conditions
conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18897769.8A
Other languages
German (de)
French (fr)
Other versions
EP3732294A1 (en
Inventor
Muhammed Majeed
Kalyanam Nagabhushanam
Lakshmi MUNDKUR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sami Sabinsa Group Ltd
Original Assignee
Sami Chemicals and Extracts Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sami Chemicals and Extracts Ltd filed Critical Sami Chemicals and Extracts Ltd
Publication of EP3732294A1 publication Critical patent/EP3732294A1/en
Publication of EP3732294A4 publication Critical patent/EP3732294A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0211—Solvent extraction of solids in combination with an electric or magnetic field
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0292—Treatment of the solvent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Botany (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Toxicology (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
EP18897769.8A 2017-12-27 2018-12-26 Compositions for the management of hyperglycemia and related conditions Pending EP3732294A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762610565P 2017-12-27 2017-12-27
PCT/US2018/067480 WO2019133588A1 (en) 2017-12-27 2018-12-26 Compositions for the management of hyperglycemia and related conditions

Publications (2)

Publication Number Publication Date
EP3732294A1 EP3732294A1 (en) 2020-11-04
EP3732294A4 true EP3732294A4 (en) 2021-08-18

Family

ID=66949194

Family Applications (2)

Application Number Title Priority Date Filing Date
EP18897769.8A Pending EP3732294A4 (en) 2017-12-27 2018-12-26 Compositions for the management of hyperglycemia and related conditions
EP18893434.3A Pending EP3731833A4 (en) 2017-12-27 2018-12-26 Compositions containing thymohydroquinone and their method of preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18893434.3A Pending EP3731833A4 (en) 2017-12-27 2018-12-26 Compositions containing thymohydroquinone and their method of preparation

Country Status (11)

Country Link
US (2) US10881623B2 (en)
EP (2) EP3732294A4 (en)
JP (2) JP7012857B2 (en)
KR (2) KR102577863B1 (en)
CN (2) CN111542313B (en)
AU (2) AU2018397667B2 (en)
BR (2) BR112020012949A2 (en)
CA (2) CA3087050C (en)
EA (2) EA202091205A1 (en)
WO (2) WO2019133587A1 (en)
ZA (2) ZA202004532B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3965586A1 (en) * 2019-05-07 2022-03-16 Lynxit Sport Nutrition AS Omega-3 beverage
CN111214514B (en) * 2020-03-10 2022-03-22 上海中医药大学 Application of teasel roots and active components in teasel roots in blood sugar reduction
WO2022132844A1 (en) * 2020-12-15 2022-06-23 Muhammed Majeed Anti-viral compositions
KR20230119160A (en) * 2020-12-17 2023-08-16 새미-사빈사 그룹 리미티드 Compositions targeting advanced glycation end product receptor (RAGE) in chronic inflammatory conditions
CN114948915B (en) * 2022-07-18 2023-10-24 广东省农业科学院动物卫生研究所 Application of bailiquinone in preparation of anti-haemophilus parasuis drug
WO2024073699A1 (en) * 2022-09-29 2024-04-04 Muhammed Majeed Compositions for the management of hirsutism

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US8535740B2 (en) * 2002-11-22 2013-09-17 Bionexus, Ltd. Compositions from Nigella sativa
US8029831B2 (en) * 2008-07-29 2011-10-04 Bionexus, Ltd. Formulations containing thymoquinone for urinary health
WO2005009332A2 (en) * 2003-07-31 2005-02-03 Palsamed (P.B.S.) Ltd. Compositions-of-matter for lowering serum cholesterol and/or triglyceride level and methods of producing and using same
GB0505909D0 (en) * 2005-03-23 2005-04-27 Univ Leeds Formulations
CN105106301A (en) * 2006-08-09 2015-12-02 帝斯曼知识产权资产管理有限公司 Novel agents for the treatment of disorders connected to impaired neurotransmission
CN101781604A (en) * 2010-03-11 2010-07-21 南京农业大学 Method for extracting semen nigellae oil by using supercritical carbon dioxide
US20160213727A1 (en) * 2012-01-26 2016-07-28 William G. Rohlfsen Methods and Uses of High Thymoquinone and Thymohydroquinone Essential Oil of Monarda
CN103948604A (en) * 2014-05-20 2014-07-30 天津理工大学 Application of hederagenin compound serving as medicament for treating liver cancer and preparation of hederagenin compound
PL412214A1 (en) * 2015-05-04 2016-11-07 Biovico Spółka Z Ograniczoną Odpowiedzialnością Composition of plants with anti-inflammatory, antiallergic and/or antiasthmatic properties and its applications

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AFTAB AHMAD ET AL: "A review on therapeutic potential of Nigella sativa: A miracle herb", ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE, vol. 3, no. 5, 1 May 2013 (2013-05-01), China, pages 337 - 352, XP055559274, ISSN: 2221-1691, DOI: 10.1016/S2221-1691(13)60075-1 *
HAWSAWI ZUBAIDA A ET AL: "EFFECT OF NIGELLA SATIVA (BLACK SEED) AND THYMOQUINONE ON BLOOD GLUCOSE IN ALBINO RATS", 1 July 2001 (2001-07-01), pages 242 - 244, XP055818581, Retrieved from the Internet <URL:https://www.annsaudimed.net/doi/pdf/10.5144/0256-4947.2001.242> [retrieved on 20210628] *
MEDDAH B ET AL: "Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, vol. 121, no. 3, 30 January 2009 (2009-01-30), pages 419 - 424, XP025768162, ISSN: 0378-8741, [retrieved on 20081117], DOI: 10.1016/J.JEP.2008.10.040 *
RAZAVI B. M. ET AL: "A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome", JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 37, no. 11, 15 August 2014 (2014-08-15), pages 1031 - 1040, XP055818575, Retrieved from the Internet <URL:http://link.springer.com/article/10.1007/s40618-014-0150-1/fulltext.html> DOI: 10.1007/s40618-014-0150-1 *

Also Published As

Publication number Publication date
US20190192448A1 (en) 2019-06-27
AU2018397668A1 (en) 2020-07-09
AU2018397667B2 (en) 2021-11-11
WO2019133587A1 (en) 2019-07-04
CA3087050A1 (en) 2019-07-04
CN111566218A (en) 2020-08-21
EP3732294A1 (en) 2020-11-04
CN111542313A (en) 2020-08-14
EA202091184A1 (en) 2020-09-23
JP7012857B2 (en) 2022-01-28
JP2021508480A (en) 2021-03-11
US10945969B2 (en) 2021-03-16
CN111566218B (en) 2023-11-21
EA202091205A1 (en) 2020-12-14
CA3087042C (en) 2023-08-01
ZA202004532B (en) 2021-08-25
JP2021508718A (en) 2021-03-11
AU2018397668B2 (en) 2022-07-14
EP3731833A1 (en) 2020-11-04
CA3087042A1 (en) 2019-07-04
KR20200100772A (en) 2020-08-26
KR102539298B1 (en) 2023-06-02
BR112020012333A2 (en) 2020-11-24
WO2019133588A1 (en) 2019-07-04
US10881623B2 (en) 2021-01-05
CN111542313B (en) 2023-11-21
KR102577863B1 (en) 2023-09-15
CA3087050C (en) 2023-09-19
ZA202004531B (en) 2022-12-21
KR20200098616A (en) 2020-08-20
BR112020012949A2 (en) 2021-01-05
JP7089033B2 (en) 2022-06-21
EP3731833A4 (en) 2021-11-24
US20190192447A1 (en) 2019-06-27
AU2018397667A1 (en) 2020-07-09

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