EA202091057A2 - Способы и композиции для лечения нарушений, ассоциированных со старением - Google Patents
Способы и композиции для лечения нарушений, ассоциированных со старениемInfo
- Publication number
- EA202091057A2 EA202091057A2 EA202091057A EA202091057A EA202091057A2 EA 202091057 A2 EA202091057 A2 EA 202091057A2 EA 202091057 A EA202091057 A EA 202091057A EA 202091057 A EA202091057 A EA 202091057A EA 202091057 A2 EA202091057 A2 EA 202091057A2
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- aging
- methods
- compositions
- treatment
- disorders associated
- Prior art date
Links
- 230000032683 aging Effects 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 3
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/07—Proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
Abstract
Предлагаются способы лечения взрослого млекопитающего от нарушения, ассоциированного со старением. Аспекты способов включают в себя снижение уровня 2-микроглобулина (B2M) у млекопитающего в степени, достаточной для лечения млекопитающего от нарушения, ассоциированного со старением. Ряд нарушений, ассоциированных со старением, можно лечить посредством практического осуществления способов, причем данные нарушения включают в себя когнитивные нарушения.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562163222P | 2015-05-18 | 2015-05-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA202091057A2 true EA202091057A2 (ru) | 2020-12-30 |
EA202091057A3 EA202091057A3 (ru) | 2021-03-31 |
Family
ID=57320543
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792437A EA035799B1 (ru) | 2015-05-18 | 2016-05-17 | Способ лечения взрослого млекопитающего от когнитивного нарушения, ассоциированного со старением |
EA202091057A EA202091057A3 (ru) | 2015-05-18 | 2016-05-17 | Способы и композиции для лечения нарушений, ассоциированных со старением |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792437A EA035799B1 (ru) | 2015-05-18 | 2016-05-17 | Способ лечения взрослого млекопитающего от когнитивного нарушения, ассоциированного со старением |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP3892315A1 (ru) |
JP (2) | JP7134089B2 (ru) |
KR (1) | KR20180030965A (ru) |
CN (2) | CN107921188A (ru) |
AU (4) | AU2016265948B2 (ru) |
CA (1) | CA2984645C (ru) |
EA (2) | EA035799B1 (ru) |
HK (1) | HK1248153A1 (ru) |
IL (1) | IL255319B2 (ru) |
NZ (1) | NZ738184A (ru) |
WO (1) | WO2016187217A2 (ru) |
Families Citing this family (14)
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WO2017120461A1 (en) | 2016-01-08 | 2017-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
US10487148B2 (en) | 2010-01-28 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating aging-associated impairments |
US20160208011A1 (en) | 2010-01-28 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
US9161968B2 (en) | 2011-04-08 | 2015-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists |
US10905779B2 (en) | 2013-12-09 | 2021-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening human blood products comprising plasma using immunocompromised rodent models |
MX2016007492A (es) | 2013-12-09 | 2017-03-06 | Univ Leland Stanford Junior | Métodos y composiciones para el tratamiento de afecciones asociadas con el envejecimiento. |
JP6921006B2 (ja) | 2015-06-15 | 2021-08-18 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 老化関連症状を治療するための方法および組成物 |
DK3390367T3 (da) * | 2015-12-15 | 2020-10-26 | Univ Leland Stanford Junior | Fremgangsmåde til forebyggelse og/eller behandling af aldersrelateret kognitiv funktionsnedsættelse og neuroinflammation |
US10245285B2 (en) | 2016-04-28 | 2019-04-02 | Alkahest, Inc. | Blood plasma and plasma fractions as therapy for tumor growth and progression |
EA039316B1 (ru) | 2016-10-24 | 2022-01-12 | Алкахест, Инк. | Фракции плазмы крови в качестве лечения когнитивных расстройств, связанных со старением |
US11040068B2 (en) | 2017-04-26 | 2021-06-22 | Alkahest, Inc. | Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products |
EP4299129A3 (en) | 2017-04-26 | 2024-03-20 | Alkahest, Inc. | Dosing regimen for treatment of cognitive impairments with blood plasma products |
AU2019364271A1 (en) | 2018-10-26 | 2021-06-03 | Alkahest, Inc. | Use of plasma and plasma fractions for improvement of pain, wound healing, and postoperative recovery |
CN113081079B (zh) * | 2021-03-30 | 2022-04-22 | 中国科学院生态环境研究中心 | 血桥限位器 |
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2016
- 2016-05-17 EP EP21162695.7A patent/EP3892315A1/en active Pending
- 2016-05-17 CN CN201680028881.5A patent/CN107921188A/zh active Pending
- 2016-05-17 EA EA201792437A patent/EA035799B1/ru unknown
- 2016-05-17 CA CA2984645A patent/CA2984645C/en active Active
- 2016-05-17 NZ NZ73818416A patent/NZ738184A/en unknown
- 2016-05-17 CN CN202310374205.5A patent/CN116687969A/zh active Pending
- 2016-05-17 AU AU2016265948A patent/AU2016265948B2/en active Active
- 2016-05-17 EA EA202091057A patent/EA202091057A3/ru unknown
- 2016-05-17 WO PCT/US2016/032907 patent/WO2016187217A2/en active Application Filing
- 2016-05-17 EP EP16797159.7A patent/EP3297702A4/en not_active Withdrawn
- 2016-05-17 JP JP2018512817A patent/JP7134089B2/ja active Active
- 2016-05-17 KR KR1020177035957A patent/KR20180030965A/ko not_active Application Discontinuation
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2017
- 2017-10-30 IL IL255319A patent/IL255319B2/en unknown
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2018
- 2018-06-15 HK HK18107779.2A patent/HK1248153A1/zh unknown
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2019
- 2019-02-26 AU AU2019201337A patent/AU2019201337B9/en active Active
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2020
- 2020-07-28 AU AU2020210181A patent/AU2020210181B2/en active Active
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2021
- 2021-01-29 JP JP2021013639A patent/JP7323561B2/ja active Active
-
2022
- 2022-08-25 AU AU2022221494A patent/AU2022221494A1/en active Pending
Also Published As
Publication number | Publication date |
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NZ738184A (en) | 2019-09-27 |
AU2016265948A1 (en) | 2018-01-04 |
HK1248153A1 (zh) | 2018-10-12 |
IL255319B (en) | 2022-11-01 |
EA201792437A1 (ru) | 2018-04-30 |
AU2016265948B2 (en) | 2018-12-06 |
EP3297702A4 (en) | 2019-01-16 |
CN107921188A (zh) | 2018-04-17 |
EP3892315A1 (en) | 2021-10-13 |
JP7323561B2 (ja) | 2023-08-08 |
AU2022221494A1 (en) | 2022-09-29 |
CA2984645A1 (en) | 2016-11-24 |
IL255319B2 (en) | 2023-03-01 |
JP7134089B2 (ja) | 2022-09-09 |
EA035799B1 (ru) | 2020-08-12 |
AU2020210181B2 (en) | 2022-05-26 |
EP3297702A2 (en) | 2018-03-28 |
JP2021073264A (ja) | 2021-05-13 |
WO2016187217A3 (en) | 2017-01-05 |
AU2020210181A1 (en) | 2020-08-13 |
CA2984645C (en) | 2023-01-10 |
JP2018518530A (ja) | 2018-07-12 |
WO2016187217A2 (en) | 2016-11-24 |
AU2019201337A1 (en) | 2019-03-21 |
AU2019201337B2 (en) | 2020-05-14 |
EA202091057A3 (ru) | 2021-03-31 |
IL255319A0 (en) | 2017-12-31 |
AU2019201337B9 (en) | 2020-05-21 |
CN116687969A (zh) | 2023-09-05 |
KR20180030965A (ko) | 2018-03-27 |
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