EA202091032A1 - Составы, содержащие глюкоцереброзидазу и изофагомин - Google Patents
Составы, содержащие глюкоцереброзидазу и изофагоминInfo
- Publication number
- EA202091032A1 EA202091032A1 EA202091032A EA202091032A EA202091032A1 EA 202091032 A1 EA202091032 A1 EA 202091032A1 EA 202091032 A EA202091032 A EA 202091032A EA 202091032 A EA202091032 A EA 202091032A EA 202091032 A1 EA202091032 A1 EA 202091032A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- disease
- glucocerebrosidase
- composition
- isophagomin
- disorder
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 102000004547 Glucosylceramidase Human genes 0.000 title abstract 4
- 108010017544 Glucosylceramidase Proteins 0.000 title abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010003694 Atrophy Diseases 0.000 abstract 1
- 208000024720 Fabry Disease Diseases 0.000 abstract 1
- 208000015872 Gaucher disease Diseases 0.000 abstract 1
- 208000032007 Glycogen storage disease due to acid maltase deficiency Diseases 0.000 abstract 1
- 206010053185 Glycogen storage disease type II Diseases 0.000 abstract 1
- 208000009829 Lewy Body Disease Diseases 0.000 abstract 1
- 201000002832 Lewy body dementia Diseases 0.000 abstract 1
- 102100033448 Lysosomal alpha-glucosidase Human genes 0.000 abstract 1
- 208000015439 Lysosomal storage disease Diseases 0.000 abstract 1
- 208000002678 Mucopolysaccharidoses Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000037444 atrophy Effects 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 201000004502 glycogen storage disease II Diseases 0.000 abstract 1
- 206010028093 mucopolysaccharidosis Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 229960004406 velaglucerase alfa Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение представляет композицию глюкоцереброзидазы, такой как велаглюцераза альфа, и изофагомина в молярном соотношении по меньшей мере приблизительно 1:2,5. Также предоставлено применение композиции для лечения расстройства, связанного с дисфункцией в пути GCазы. Нарушение может представлять собой лизосомальную болезнь накопления, такую как болезнь Гоше, болезнь Фабри, болезнь Помпе, мукополисахаридозы или множественная системная атрофия. Расстройство также может представлять собой нейродегенеративное расстройство, такое как болезнь Паркинсона, болезнь Альцгеймера или деменция с тельцами Леви. Композиция может содержать от 0,5 до 5,0 мг/кг глюкоцереброзидазы и изофагомин по меньшей мере примерно в 3-кратном молярном избытке по отношению к глюкоцереброзидазе. Композицию можно вводить внутривенно или подкожно.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762577429P | 2017-10-26 | 2017-10-26 | |
PCT/US2018/057575 WO2019084309A1 (en) | 2017-10-26 | 2018-10-25 | FORMULATIONS COMPRISING GLUCOCEREBROSIDASE AND ISOFAGOMIN |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202091032A1 true EA202091032A1 (ru) | 2020-07-17 |
Family
ID=66246719
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202091032A EA202091032A1 (ru) | 2017-10-26 | 2018-10-25 | Составы, содержащие глюкоцереброзидазу и изофагомин |
Country Status (13)
Country | Link |
---|---|
US (2) | US20200316178A1 (ru) |
EP (1) | EP3700526A4 (ru) |
JP (2) | JP2021501135A (ru) |
KR (1) | KR20200079280A (ru) |
CN (1) | CN111278439A (ru) |
AR (1) | AR113797A1 (ru) |
AU (1) | AU2018354318A1 (ru) |
BR (1) | BR112020007820A2 (ru) |
CA (1) | CA3078463A1 (ru) |
EA (1) | EA202091032A1 (ru) |
IL (1) | IL273773A (ru) |
TW (1) | TW201922248A (ru) |
WO (1) | WO2019084309A1 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2022530017A (ja) * | 2019-04-25 | 2022-06-27 | 武田薬品工業株式会社 | イソファゴミン塩、その使用方法および製剤 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2857036B1 (en) * | 2003-01-31 | 2016-12-21 | Mount Sinai School of Medicine of New York University | Combination therapy for treating protein deficiency disorders |
US7501439B2 (en) * | 2006-05-24 | 2009-03-10 | Amicus Therapeutics, Inc. | Tartrate salt of isofagomine and methods of use |
PT2040548E (pt) * | 2006-06-23 | 2012-08-02 | Amicus Therapeutics Inc | Método para o tratamento de distúrbios neurológicos através do aumento da atividade da -glucocerebrosidase |
US9206457B2 (en) * | 2009-05-26 | 2015-12-08 | Amicus Therapeutics, Inc. | Utilization of pharmacological chaperones to improve manufacturing and purification of biologics |
CN105126086B (zh) * | 2009-07-28 | 2019-05-14 | 夏尔人类遗传性治疗公司 | 用于治疗戈谢病的组合物和方法 |
CN103153344A (zh) * | 2010-04-30 | 2013-06-12 | 阿莱克森国际制药有限公司 | 用于治疗基质矿化障碍的方法、组合物、和试剂盒 |
EP2595651B1 (en) * | 2010-07-19 | 2017-03-29 | Shire Human Genetic Therapies, Inc. | Mannose receptor c type 1 (mrc1) codon optimized cell line and uses thereof |
AU2013225816B2 (en) * | 2012-03-02 | 2017-10-26 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating Type III Gaucher Disease |
WO2013148333A1 (en) * | 2012-03-28 | 2013-10-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Salicylic acid derivatives useful as glucocerebrosidase activators |
SG11201502989XA (en) * | 2012-11-05 | 2015-05-28 | Genzyme Corp | Compositions and methods for treating proteinopathies |
EP3087056A4 (en) * | 2013-12-23 | 2017-07-19 | Alectos Therapeutics Inc. | Glucocerebrosidase modulators and uses thereof |
-
2018
- 2018-10-25 CA CA3078463A patent/CA3078463A1/en active Pending
- 2018-10-25 EP EP18870565.1A patent/EP3700526A4/en active Pending
- 2018-10-25 CN CN201880069548.8A patent/CN111278439A/zh active Pending
- 2018-10-25 JP JP2020521515A patent/JP2021501135A/ja active Pending
- 2018-10-25 BR BR112020007820-4A patent/BR112020007820A2/pt unknown
- 2018-10-25 WO PCT/US2018/057575 patent/WO2019084309A1/en unknown
- 2018-10-25 EA EA202091032A patent/EA202091032A1/ru unknown
- 2018-10-25 US US16/759,201 patent/US20200316178A1/en not_active Abandoned
- 2018-10-25 KR KR1020207014990A patent/KR20200079280A/ko not_active Application Discontinuation
- 2018-10-25 AU AU2018354318A patent/AU2018354318A1/en active Pending
- 2018-10-25 AR ARP180103113A patent/AR113797A1/es unknown
- 2018-10-26 TW TW107138053A patent/TW201922248A/zh unknown
-
2020
- 2020-04-02 IL IL273773A patent/IL273773A/en unknown
-
2023
- 2023-02-22 JP JP2023025853A patent/JP2023062160A/ja active Pending
- 2023-08-09 US US18/231,982 patent/US20230381287A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2021501135A (ja) | 2021-01-14 |
AR113797A1 (es) | 2020-06-10 |
EP3700526A4 (en) | 2021-09-08 |
WO2019084309A1 (en) | 2019-05-02 |
RU2020115430A3 (ru) | 2021-11-26 |
US20200316178A1 (en) | 2020-10-08 |
JP2023062160A (ja) | 2023-05-02 |
CA3078463A1 (en) | 2019-05-02 |
RU2020115430A (ru) | 2021-11-26 |
BR112020007820A2 (pt) | 2020-10-20 |
IL273773A (en) | 2020-05-31 |
TW201922248A (zh) | 2019-06-16 |
AU2018354318A1 (en) | 2020-04-23 |
KR20200079280A (ko) | 2020-07-02 |
EP3700526A1 (en) | 2020-09-02 |
US20230381287A1 (en) | 2023-11-30 |
CN111278439A (zh) | 2020-06-12 |
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