EA202000369A1 - ЭКСПРЕССИОННЫЙ ВЕКТОР ДЛЯ СОЗДАНИЯ ИММУНОБИОЛОГИЧЕСКОГО СРЕДСТВА ДЛЯ ИНДУКЦИИ СПЕЦИФИЧЕСКОГО ИММУНИТЕТА ПРОТИВ ВИРУСА ТЯЖЕЛОГО ОСТРОГО РЕСПИРАТОРНОГО СИНДРОМА SARS-CoV-2 (ВАРИАНТЫ) - Google Patents

ЭКСПРЕССИОННЫЙ ВЕКТОР ДЛЯ СОЗДАНИЯ ИММУНОБИОЛОГИЧЕСКОГО СРЕДСТВА ДЛЯ ИНДУКЦИИ СПЕЦИФИЧЕСКОГО ИММУНИТЕТА ПРОТИВ ВИРУСА ТЯЖЕЛОГО ОСТРОГО РЕСПИРАТОРНОГО СИНДРОМА SARS-CoV-2 (ВАРИАНТЫ)

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EA202000369A1
EA202000369A1 EA202000369A EA202000369A EA202000369A1 EA 202000369 A1 EA202000369 A1 EA 202000369A1 EA 202000369 A EA202000369 A EA 202000369A EA 202000369 A EA202000369 A EA 202000369A EA 202000369 A1 EA202000369 A1 EA 202000369A1
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seq
expression vector
serotype
cov
induction
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EA202000369A
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English (en)
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EA037291B8 (ru
EA037291B1 (ru
EA037291B9 (ru
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Ольга Вадимовна ЗУБКОВА
Татьяна Андреевна Ожаровская
Инна Ваимовна Должикова
Ольга Попова
Дмитрий Викторович ЩЕБЛЯКОВ
Дарья Михайловна Гроусова
Алина Шахмировна ДЖАРУЛЛАЕВА
Амир Ильдарович ТУХВАТУЛИН
Наталья Михайловна Тухватулина
Дмитрий Николаевич ЩЕРБИНИН
Илья Булатович Есмагамбетов
Елизавета Александровна ТОКАРСКАЯ
Андрей Геннадьевич Ботиков
Алина Сергеевна Ерохова
Наталья Анатольевна Никитенко
Андрей Геннадьевич Семихин
Сергей Владимирович БОРИСЕВИЧ
Борис Савельевич НАРОДИЦКИЙ
Денис Юрьевич ЛОГУНОВ
Александр Леонидович ГИНЦБУРГ
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федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации
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Priority claimed from RU2020127979A external-priority patent/RU2731356C9/ru
Application filed by федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации filed Critical федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации
Publication of EA202000369A1 publication Critical patent/EA202000369A1/ru
Publication of EA037291B1 publication Critical patent/EA037291B1/ru
Publication of EA037291B8 publication Critical patent/EA037291B8/ru
Publication of EA037291B9 publication Critical patent/EA037291B9/ru

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Abstract

Изобретение относится к биотехнологии, иммунологии и вирусологии. Оно касается рекомбинантных векторов, которые могут быть использованы в фармацевтической промышленности для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2. Создан экспрессионный вектор, содержащий геном рекомбинантного штамма human adenovirus 26-го серотипа, в котором делетированы E1 и E3 области, а область ORF6-Ad26 заменена на ORF6-Ad5, со встроенной экспрессионной кассетой, выбранной из SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 (вариант 1). При этом в качестве материнской последовательности human adenovirus 26-го серотипа использована последовательность SEQ ID NO: 5. Кроме того, создан экспрессионный вектор, содержащий геном рекомбинантного штамма simian adenovirus 25-го серотипа, в котором делетированы E1 и E3 области, со встроенной экспрессионной кассетой, выбранной из SEQ ID NO: 4, SEQ ID NO: 2, SEQ ID NO: 3 (вариант 2). При этом в качестве материнской последовательности simian adenovirus 25-го серотипа использована последовательность SEQ ID NO: 6. Кроме того, создан экспрессионный вектор содержащего геном рекомбинантного штамма human adenovirus 5-го серотипа, в котором делетированы E1 и E3 области, со встроенной экспрессионной кассетой, выбранной из SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 (вариант 3). При этом в качестве материнской последовательности human adenovirus 5-го серотипа использована последовательность SEQ ID NO: 7. Разработан также способ применения разработанного экспрессионного вектора для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2. Изобретение позволяет получать устойчивый иммунный ответ к гликопротеину SARS-Cov-2.
EA202000369A 2020-08-22 2020-11-06 Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома sars-cov-2 (варианты) EA037291B9 (ru)

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RU2020127979A RU2731356C9 (ru) 2020-08-22 2020-08-22 Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты)
PCT/RU2020/000589 WO2021076009A1 (en) 2020-08-22 2020-11-06 Expression vector against severe acute respiratory syndrome virus sars-cov-2

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