EA037291B8 - Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома sars-cov-2 (варианты) - Google Patents

Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома sars-cov-2 (варианты)

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Publication number
EA037291B8
EA037291B8 EA202000369A EA202000369A EA037291B8 EA 037291 B8 EA037291 B8 EA 037291B8 EA 202000369 A EA202000369 A EA 202000369A EA 202000369 A EA202000369 A EA 202000369A EA 037291 B8 EA037291 B8 EA 037291B8
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seq
serotype
expression vector
cov
virus
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EA202000369A
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English (en)
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EA202000369A1 (ru
EA037291B1 (ru
EA037291B9 (ru
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Ольга Вадимовна ЗУБКОВА
Татьяна Андреевна Ожаровская
Инна Вадимовна ДОЛЖИКОВА
Ольга Попова
Дмитрий Викторович ЩЕБЛЯКОВ
Дарья Михайловна Гроусова
Алина Шахмировна ДЖАРУЛЛАЕВА
Амир Ильдарович ТУХВАТУЛИН
Наталья Михайловна Тухватулина
Дмитрий Николаевич ЩЕРБИНИН
Ильяс Булатович Есмагамбетов
Елизавета Александровна ТОКАРСКАЯ
Андрей Геннадьевич Ботиков
Алина Сергеевна Ерохова
Наталья Анатольевна Никитенко
Александр Сергеевич Семихин
Сергей Владимирович БОРИСЕВИЧ
Борис Савельевич НАРОДИЦКИЙ
Денис Юрьевич ЛОГУНОВ
Александр Леонидович ГИНЦБУРГ
Original Assignee
федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации
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Priority claimed from RU2020127979A external-priority patent/RU2731356C9/ru
Application filed by федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации filed Critical федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации
Publication of EA202000369A1 publication Critical patent/EA202000369A1/ru
Publication of EA037291B1 publication Critical patent/EA037291B1/ru
Publication of EA037291B8 publication Critical patent/EA037291B8/ru
Publication of EA037291B9 publication Critical patent/EA037291B9/ru

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Abstract

Изобретение относится к биотехнологии, иммунологии и вирусологии. Оно касается рекомбинантных векторов, которые могут быть использованы в фармацевтической промышленности для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2. Создан экспрессионный вектор, содержащий геном рекомбинантного штамма human adenovirus 26-го серотипа, в котором делетированы E1 и E3 области, а область ORF6-Ad26 заменена на ORF6-Ad5, со встроенной экспрессионной кассетой, выбранной из SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 (вариант 1). При этом в качестве материнской последовательности human adenovirus 26-го серотипа использована последовательность SEQ ID NO: 5. Кроме того, создан экспрессионный вектор, содержащий геном рекомбинантного штамма simian adenovirus 25-го серотипа, в котором делетированы E1 и E3 области, со встроенной экспрессионной кассетой, выбранной из SEQ ID NO: 4, SEQ ID NO: 2, SEQ ID NO: 3 (вариант 2). При этом в качестве материнской последовательности simian adenovirus 25-го серотипа использована последовательность SEQ ID NO: 6. Кроме того, создан экспрессионный вектор содержащего геном рекомбинантного штамма human adenovirus 5-го серотипа, в котором делетированы E1 и E3 области, со встроенной экспрессионной кассетой, выбранной из SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 (вариант 3). При этом в качестве материнской последовательности human adenovirus 5-го серотипа использована последовательность SEQ ID NO: 7. Разработан также способ применения разработанного экспрессионного вектора для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2. Изобретение позволяет получать устойчивый иммунный ответ к гликопротеину SARS-Cov-2.
EA202000369A 2020-08-22 2020-11-06 Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома sars-cov-2 (варианты) EA037291B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2020127979A RU2731356C9 (ru) 2020-08-22 2020-08-22 Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты)
PCT/RU2020/000589 WO2021076009A1 (en) 2020-08-22 2020-11-06 Expression vector against severe acute respiratory syndrome virus sars-cov-2

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EA202000369A1 EA202000369A1 (ru) 2021-03-02
EA037291B1 EA037291B1 (ru) 2021-03-05
EA037291B8 true EA037291B8 (ru) 2021-04-26
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BR112022003581A2 (pt) 2022-08-16
US20220235376A1 (en) 2022-07-28
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KR20230088301A (ko) 2023-06-19
IL291022A (en) 2022-05-01
EA202000369A1 (ru) 2021-03-02
EA037291B1 (ru) 2021-03-05
JP2023505920A (ja) 2023-02-14
CA3152658A1 (en) 2021-04-22
EP4010018A1 (en) 2022-06-15
EA037291B9 (ru) 2021-11-24
ZA202202322B (en) 2023-12-20
CN114845733A (zh) 2022-08-02
MX2022002609A (es) 2022-06-08

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