EA037291B8 - Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома sars-cov-2 (варианты) - Google Patents
Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома sars-cov-2 (варианты)Info
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- EA037291B8 EA037291B8 EA202000369A EA202000369A EA037291B8 EA 037291 B8 EA037291 B8 EA 037291B8 EA 202000369 A EA202000369 A EA 202000369A EA 202000369 A EA202000369 A EA 202000369A EA 037291 B8 EA037291 B8 EA 037291B8
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Abstract
Изобретение относится к биотехнологии, иммунологии и вирусологии. Оно касается рекомбинантных векторов, которые могут быть использованы в фармацевтической промышленности для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2. Создан экспрессионный вектор, содержащий геном рекомбинантного штамма human adenovirus 26-го серотипа, в котором делетированы E1 и E3 области, а область ORF6-Ad26 заменена на ORF6-Ad5, со встроенной экспрессионной кассетой, выбранной из SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 (вариант 1). При этом в качестве материнской последовательности human adenovirus 26-го серотипа использована последовательность SEQ ID NO: 5. Кроме того, создан экспрессионный вектор, содержащий геном рекомбинантного штамма simian adenovirus 25-го серотипа, в котором делетированы E1 и E3 области, со встроенной экспрессионной кассетой, выбранной из SEQ ID NO: 4, SEQ ID NO: 2, SEQ ID NO: 3 (вариант 2). При этом в качестве материнской последовательности simian adenovirus 25-го серотипа использована последовательность SEQ ID NO: 6. Кроме того, создан экспрессионный вектор содержащего геном рекомбинантного штамма human adenovirus 5-го серотипа, в котором делетированы E1 и E3 области, со встроенной экспрессионной кассетой, выбранной из SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 (вариант 3). При этом в качестве материнской последовательности human adenovirus 5-го серотипа использована последовательность SEQ ID NO: 7. Разработан также способ применения разработанного экспрессионного вектора для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2. Изобретение позволяет получать устойчивый иммунный ответ к гликопротеину SARS-Cov-2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2020127979A RU2731356C9 (ru) | 2020-08-22 | 2020-08-22 | Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома SARS-CoV-2 (варианты) |
PCT/RU2020/000589 WO2021076009A1 (en) | 2020-08-22 | 2020-11-06 | Expression vector against severe acute respiratory syndrome virus sars-cov-2 |
Publications (4)
Publication Number | Publication Date |
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EA202000369A1 EA202000369A1 (ru) | 2021-03-02 |
EA037291B1 EA037291B1 (ru) | 2021-03-05 |
EA037291B8 true EA037291B8 (ru) | 2021-04-26 |
EA037291B9 EA037291B9 (ru) | 2021-11-24 |
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EA202000369A EA037291B9 (ru) | 2020-08-22 | 2020-11-06 | Экспрессионный вектор для создания иммунобиологического средства для индукции специфического иммунитета против вируса тяжелого острого респираторного синдрома sars-cov-2 (варианты) |
Country Status (11)
Country | Link |
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US (1) | US20220235376A1 (ru) |
EP (1) | EP4010018A4 (ru) |
JP (1) | JP7369276B2 (ru) |
KR (1) | KR20230088301A (ru) |
CN (1) | CN114845733A (ru) |
BR (1) | BR112022003581A2 (ru) |
CA (1) | CA3152658A1 (ru) |
EA (1) | EA037291B9 (ru) |
IL (1) | IL291022A (ru) |
MX (1) | MX2022002609A (ru) |
ZA (1) | ZA202202322B (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113308493A (zh) * | 2021-03-18 | 2021-08-27 | 广州恩宝生物医药科技有限公司 | 新型冠状病毒Ad26腺病毒载体疫苗及其制备方法与应用 |
CN117511968B (zh) * | 2023-11-06 | 2024-07-05 | 军事科学院军事医学研究院军事兽医研究所 | 表达SARS-CoV-2的S、E和M蛋白的重组金丝雀痘病毒及其构建方法和应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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US6251677B1 (en) * | 1997-08-25 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Hybrid adenovirus-AAV virus and methods of use thereof |
AU764686B2 (en) * | 1998-08-28 | 2003-08-28 | Duke University | Adenoviruses deleted in the IVa2, 100K, polymerase and/or preterminal protein sequences |
US20100143302A1 (en) * | 2006-03-16 | 2010-06-10 | Crucell Holland B.V. | Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof |
WO2010037027A2 (en) * | 2008-09-26 | 2010-04-01 | Auburn University | Immunization of avians by mucosal administration of non-replicating vectored vaccines |
US10183069B2 (en) * | 2011-03-21 | 2019-01-22 | Altimmune Inc. | Rapid and prolonged immunologic-therapeutic |
GB201108879D0 (en) * | 2011-05-25 | 2011-07-06 | Isis Innovation | Vector |
KR102050616B1 (ko) * | 2012-03-22 | 2019-12-03 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv에 대한 백신 |
GB2549809C (en) * | 2016-06-23 | 2022-11-30 | Univ Oxford Innovation Ltd | Vector |
CN111218459B (zh) * | 2020-03-18 | 2020-09-11 | 中国人民解放军军事科学院军事医学研究院 | 一种以人复制缺陷腺病毒为载体的重组新型冠状病毒疫苗 |
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2020
- 2020-11-06 CN CN202080061936.9A patent/CN114845733A/zh active Pending
- 2020-11-06 CA CA3152658A patent/CA3152658A1/en not_active Abandoned
- 2020-11-06 KR KR1020227006931A patent/KR20230088301A/ko not_active Application Discontinuation
- 2020-11-06 EA EA202000369A patent/EA037291B9/ru unknown
- 2020-11-06 EP EP20877055.2A patent/EP4010018A4/en active Pending
- 2020-11-06 JP JP2022513579A patent/JP7369276B2/ja active Active
- 2020-11-06 BR BR112022003581A patent/BR112022003581A2/pt unknown
- 2020-11-06 MX MX2022002609A patent/MX2022002609A/es unknown
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2022
- 2022-02-23 ZA ZA2022/02322A patent/ZA202202322B/en unknown
- 2022-03-01 IL IL291022A patent/IL291022A/en unknown
- 2022-03-31 US US17/711,012 patent/US20220235376A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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JP7369276B2 (ja) | 2023-10-25 |
KR20230088301A (ko) | 2023-06-19 |
CN114845733A (zh) | 2022-08-02 |
ZA202202322B (en) | 2023-12-20 |
CA3152658A1 (en) | 2021-04-22 |
EP4010018A4 (en) | 2022-11-09 |
EP4010018A1 (en) | 2022-06-15 |
BR112022003581A2 (pt) | 2022-08-16 |
IL291022A (en) | 2022-05-01 |
EA037291B1 (ru) | 2021-03-05 |
EA037291B9 (ru) | 2021-11-24 |
MX2022002609A (es) | 2022-06-08 |
US20220235376A1 (en) | 2022-07-28 |
JP2023505920A (ja) | 2023-02-14 |
EA202000369A1 (ru) | 2021-03-02 |
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