EA201991370A1 - Методы лечения поликистозной болезни почек - Google Patents
Методы лечения поликистозной болезни почекInfo
- Publication number
- EA201991370A1 EA201991370A1 EA201991370A EA201991370A EA201991370A1 EA 201991370 A1 EA201991370 A1 EA 201991370A1 EA 201991370 A EA201991370 A EA 201991370A EA 201991370 A EA201991370 A EA 201991370A EA 201991370 A1 EA201991370 A1 EA 201991370A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- kidney disease
- polycystic kidney
- methods
- treating polycystic
- treating
- Prior art date
Links
- 208000030761 polycystic kidney disease Diseases 0.000 title abstract 2
- 208000010061 Autosomal Dominant Polycystic Kidney Diseases 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 208000022185 autosomal dominant polycystic kidney disease Diseases 0.000 abstract 1
- 108091091751 miR-17 stem-loop Proteins 0.000 abstract 1
- 108091069239 miR-17-2 stem-loop Proteins 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/322—2'-R Modification
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- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430164P | 2016-12-05 | 2016-12-05 | |
| PCT/US2017/064432 WO2018106568A1 (en) | 2016-12-05 | 2017-12-04 | Methods for treatment of polycystic kidney disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201991370A1 true EA201991370A1 (ru) | 2019-12-30 |
Family
ID=61074503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201991370A EA201991370A1 (ru) | 2016-12-05 | 2017-12-04 | Методы лечения поликистозной болезни почек |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US20190345494A1 (https=) |
| EP (1) | EP3548011B1 (https=) |
| JP (1) | JP7105775B2 (https=) |
| KR (2) | KR20240148005A (https=) |
| CN (1) | CN110225747B (https=) |
| AU (1) | AU2017372695B2 (https=) |
| CA (1) | CA3045461A1 (https=) |
| CL (1) | CL2019001526A1 (https=) |
| EA (1) | EA201991370A1 (https=) |
| IL (1) | IL266989B2 (https=) |
| MA (1) | MA46970A (https=) |
| MX (1) | MX2019006337A (https=) |
| MY (1) | MY202466A (https=) |
| NZ (2) | NZ794203A (https=) |
| WO (1) | WO2018106568A1 (https=) |
| ZA (1) | ZA201903608B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6929269B2 (ja) | 2015-08-26 | 2021-09-01 | レグルス セラピューティクス インコーポレイテッド | 多発性嚢胞腎の処置のための方法 |
| CN112585280A (zh) | 2018-08-23 | 2021-03-30 | 罗氏创新中心哥本哈根有限公司 | 微小rna-134生物标志物 |
| WO2023060237A1 (en) | 2021-10-08 | 2023-04-13 | Regulus Therapeutics Inc. | Methods and compositions for treatment of polycystic kidney disease |
| WO2025193584A1 (en) * | 2024-03-11 | 2025-09-18 | Regulus Therapeutics Inc. | Compound for use in methods for treatment of polycystic kidney disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5417201A (en) * | 1996-05-24 | 2001-09-20 | Genzyme Corporation | Polycystic kidney disease gene |
| BRPI0509979A (pt) * | 2004-04-20 | 2007-10-16 | Genaco Biomedical Products Inc | método para detectar ncrna |
| GB0523659D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| CA2927045A1 (en) | 2006-10-03 | 2008-04-10 | Muthiah Manoharan | Lipid containing formulations |
| EP2714904B1 (en) * | 2007-06-14 | 2017-04-12 | Mirx Therapeutics ApS | Oligonucleotides for modulation of target rna activity |
| EP2623599B1 (en) * | 2007-10-04 | 2019-01-02 | Roche Innovation Center Copenhagen A/S | Micromirs |
| CA2717792A1 (en) * | 2008-03-07 | 2009-09-11 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| AU2010319555A1 (en) * | 2009-11-11 | 2012-06-14 | Sanford-Burnham Medical Research Institute | Method for generation and regulation of iPS cells and compositions thereof |
| WO2014063080A1 (en) * | 2012-10-19 | 2014-04-24 | Synta Pharmaceuticals Corp. | Treating polycystic kidney disease with hsp90 inhibitory compounds |
| JP2017511694A (ja) * | 2014-02-12 | 2017-04-27 | トーマス・ジェファーソン・ユニバーシティ | マイクロｒｎａ阻害剤を使用するための組成物および方法 |
| JP6929269B2 (ja) * | 2015-08-26 | 2021-09-01 | レグルス セラピューティクス インコーポレイテッド | 多発性嚢胞腎の処置のための方法 |
| US11157828B2 (en) * | 2016-12-08 | 2021-10-26 | Microsoft Technology Licensing, Llc | Tomography and generative data modeling via quantum boltzmann training |
-
2017
- 2017-12-04 AU AU2017372695A patent/AU2017372695B2/en active Active
- 2017-12-04 EA EA201991370A patent/EA201991370A1/ru unknown
- 2017-12-04 WO PCT/US2017/064432 patent/WO2018106568A1/en not_active Ceased
- 2017-12-04 EP EP17835968.3A patent/EP3548011B1/en active Active
- 2017-12-04 IL IL266989A patent/IL266989B2/en unknown
- 2017-12-04 MA MA046970A patent/MA46970A/fr unknown
- 2017-12-04 MX MX2019006337A patent/MX2019006337A/es unknown
- 2017-12-04 CA CA3045461A patent/CA3045461A1/en active Pending
- 2017-12-04 KR KR1020247032150A patent/KR20240148005A/ko active Pending
- 2017-12-04 NZ NZ794203A patent/NZ794203A/en unknown
- 2017-12-04 CN CN201780083381.6A patent/CN110225747B/zh active Active
- 2017-12-04 KR KR1020197019107A patent/KR102780365B1/ko active Active
- 2017-12-04 NZ NZ753811A patent/NZ753811A/en unknown
- 2017-12-04 US US16/466,752 patent/US20190345494A1/en not_active Abandoned
- 2017-12-04 JP JP2019529914A patent/JP7105775B2/ja active Active
- 2017-12-04 MY MYPI2019003144A patent/MY202466A/en unknown
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2019
- 2019-06-05 CL CL2019001526A patent/CL2019001526A1/es unknown
- 2019-06-05 ZA ZA2019/03608A patent/ZA201903608B/en unknown
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2020
- 2020-08-27 US US17/004,975 patent/US20200392501A1/en not_active Abandoned
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2022
- 2022-03-21 US US17/700,339 patent/US20220213483A1/en not_active Abandoned
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2023
- 2023-11-30 US US18/524,302 patent/US20240141350A1/en not_active Abandoned
-
2025
- 2025-04-07 US US19/172,583 patent/US20260055406A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR102780365B1 (ko) | 2025-03-18 |
| CL2019001526A1 (es) | 2019-10-18 |
| US20220213483A1 (en) | 2022-07-07 |
| NZ753811A (en) | 2026-03-27 |
| JP2019536803A (ja) | 2019-12-19 |
| NZ794203A (en) | 2026-03-27 |
| WO2018106568A1 (en) | 2018-06-14 |
| US20260055406A1 (en) | 2026-02-26 |
| IL266989B2 (en) | 2024-12-01 |
| IL266989B1 (en) | 2024-08-01 |
| AU2017372695B2 (en) | 2023-07-20 |
| CA3045461A1 (en) | 2018-06-14 |
| IL266989A (en) | 2019-07-31 |
| MY202466A (en) | 2024-04-30 |
| CN110225747A (zh) | 2019-09-10 |
| CN110225747B (zh) | 2025-04-29 |
| KR20240148005A (ko) | 2024-10-10 |
| EP3548011B1 (en) | 2023-06-14 |
| MA46970A (fr) | 2019-10-09 |
| AU2017372695A1 (en) | 2019-06-13 |
| BR112019011597A2 (pt) | 2019-10-22 |
| EP3548011A1 (en) | 2019-10-09 |
| US20190345494A1 (en) | 2019-11-14 |
| ZA201903608B (en) | 2021-10-27 |
| US20240141350A1 (en) | 2024-05-02 |
| JP7105775B2 (ja) | 2022-07-25 |
| US20200392501A1 (en) | 2020-12-17 |
| MX2019006337A (es) | 2019-09-26 |
| KR20190093207A (ko) | 2019-08-08 |
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