CN110225747B - 用于治疗多囊肾病的方法 - Google Patents

用于治疗多囊肾病的方法 Download PDF

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Publication number
CN110225747B
CN110225747B CN201780083381.6A CN201780083381A CN110225747B CN 110225747 B CN110225747 B CN 110225747B CN 201780083381 A CN201780083381 A CN 201780083381A CN 110225747 B CN110225747 B CN 110225747B
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kidney disease
polycystic kidney
nucleoside
compound
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Chinese (zh)
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CN110225747A (zh
Inventor
C·R·艾勒森
V·D·帕特尔
B·N·周
J·R·安德罗萨维奇
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Regulus Therapeutics Inc
University of Texas System
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Regulus Therapeutics Inc
University of Texas System
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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CN201780083381.6A 2016-12-05 2017-12-04 用于治疗多囊肾病的方法 Active CN110225747B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662430164P 2016-12-05 2016-12-05
US62/430,164 2016-12-05
PCT/US2017/064432 WO2018106568A1 (en) 2016-12-05 2017-12-04 Methods for treatment of polycystic kidney disease

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CN110225747A CN110225747A (zh) 2019-09-10
CN110225747B true CN110225747B (zh) 2025-04-29

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US (5) US20190345494A1 (https=)
EP (1) EP3548011B1 (https=)
JP (1) JP7105775B2 (https=)
KR (2) KR20240148005A (https=)
CN (1) CN110225747B (https=)
AU (1) AU2017372695B2 (https=)
CA (1) CA3045461A1 (https=)
CL (1) CL2019001526A1 (https=)
EA (1) EA201991370A1 (https=)
IL (1) IL266989B2 (https=)
MA (1) MA46970A (https=)
MX (1) MX2019006337A (https=)
MY (1) MY202466A (https=)
NZ (2) NZ753811A (https=)
WO (1) WO2018106568A1 (https=)
ZA (1) ZA201903608B (https=)

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DK3340993T5 (da) 2015-08-26 2024-10-07 Regulus Therapeutics Inc Forbindelse til anvendelse i fremgangsmåder til behandling af polycystisk nyresygdom
EP3841220A1 (en) 2018-08-23 2021-06-30 Roche Innovation Center Copenhagen A/S Microrna-134 biomarker
CA3234547A1 (en) 2021-10-08 2023-04-13 Regulus Therapeutics Inc. Methods and compositions for treatment of polycystic kidney disease
WO2025193584A1 (en) * 2024-03-11 2025-09-18 Regulus Therapeutics Inc. Compound for use in methods for treatment of polycystic kidney disease

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KR20240148005A (ko) 2024-10-10
US20190345494A1 (en) 2019-11-14
MA46970A (fr) 2019-10-09
EA201991370A1 (ru) 2019-12-30
NZ794203A (en) 2026-03-27
IL266989B1 (en) 2024-08-01
IL266989B2 (en) 2024-12-01
MX2019006337A (es) 2019-09-26
CN110225747A (zh) 2019-09-10
AU2017372695B2 (en) 2023-07-20
EP3548011A1 (en) 2019-10-09
JP2019536803A (ja) 2019-12-19
MY202466A (en) 2024-04-30
AU2017372695A1 (en) 2019-06-13
CL2019001526A1 (es) 2019-10-18
EP3548011B1 (en) 2023-06-14
US20200392501A1 (en) 2020-12-17
BR112019011597A2 (pt) 2019-10-22
US20260055406A1 (en) 2026-02-26
CA3045461A1 (en) 2018-06-14
JP7105775B2 (ja) 2022-07-25
US20220213483A1 (en) 2022-07-07
US20240141350A1 (en) 2024-05-02
NZ753811A (en) 2026-03-27
KR102780365B1 (ko) 2025-03-18
KR20190093207A (ko) 2019-08-08
WO2018106568A1 (en) 2018-06-14
IL266989A (en) 2019-07-31
ZA201903608B (en) 2021-10-27

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