EA201991294A1 - Замещенное производное бензимидазола в качестве модулятора активности tnf - Google Patents
Замещенное производное бензимидазола в качестве модулятора активности tnfInfo
- Publication number
- EA201991294A1 EA201991294A1 EA201991294A EA201991294A EA201991294A1 EA 201991294 A1 EA201991294 A1 EA 201991294A1 EA 201991294 A EA201991294 A EA 201991294A EA 201991294 A EA201991294 A EA 201991294A EA 201991294 A1 EA201991294 A1 EA 201991294A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- disorders
- benzimidazole derivative
- substituted benzimidazole
- tnf activity
- activity modulator
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение относится к 2-(5-{1-[2-(дифторметокси)-6-фторбензил]-2-метил-1H-бензимидазол-6-ил}пиримидин-2-ил)пропан-2-олу или его фармацевтически приемлемой соли, который является активным модулятором активности TNFα человека и поэтому может быть полезным для лечения и/или предупреждения различных заболеваний человека, включая аутоиммунные и воспалительные нарушения; неврологические и нейродегенеративные нарушения; боль и ноцицептивные нарушения; сердечно-сосудистые нарушения; метаболические нарушения; офтальмологические нарушения и онкологические нарушения.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1620948.8A GB201620948D0 (en) | 2016-12-09 | 2016-12-09 | Therapeutic agents |
| PCT/EP2017/082092 WO2018104534A1 (en) | 2016-12-09 | 2017-12-08 | A substituted benzimidazole derivative as a modulator of tnf activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201991294A1 true EA201991294A1 (ru) | 2019-12-30 |
| EA037199B1 EA037199B1 (ru) | 2021-02-18 |
Family
ID=58222106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201991294A EA037199B1 (ru) | 2016-12-09 | 2017-12-08 | Замещенное производное бензимидазола в качестве модулятора активности tnf |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10669263B2 (ru) |
| EP (1) | EP3551624B1 (ru) |
| JP (1) | JP6983238B2 (ru) |
| KR (1) | KR20190091328A (ru) |
| CN (1) | CN110023300B (ru) |
| AU (1) | AU2017371443B2 (ru) |
| BR (1) | BR112019008766A2 (ru) |
| CA (1) | CA3041081A1 (ru) |
| CL (1) | CL2019001511A1 (ru) |
| CO (1) | CO2019007115A2 (ru) |
| CY (1) | CY1124158T1 (ru) |
| DK (1) | DK3551624T3 (ru) |
| EA (1) | EA037199B1 (ru) |
| ES (1) | ES2853981T3 (ru) |
| GB (1) | GB201620948D0 (ru) |
| HR (1) | HRP20210405T1 (ru) |
| HU (1) | HUE054184T2 (ru) |
| IL (1) | IL266874B (ru) |
| LT (1) | LT3551624T (ru) |
| MX (1) | MX2019006033A (ru) |
| PL (1) | PL3551624T3 (ru) |
| PT (1) | PT3551624T (ru) |
| RU (1) | RU2019120527A (ru) |
| SG (1) | SG11201903655VA (ru) |
| SI (1) | SI3551624T1 (ru) |
| WO (1) | WO2018104534A1 (ru) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030016229A (ko) * | 2000-02-18 | 2003-02-26 | 다케다 야쿠힌 고교 가부시키가이샤 | ＴＮＦ-α 억제제 |
| TW200810754A (en) * | 2006-03-23 | 2008-03-01 | Synta Pharmaceuticals Corp | Benzimidazolyl-pyridine compounds for inflammation and immune-related uses |
| CN104428293B (zh) * | 2012-06-11 | 2018-06-08 | Ucb生物制药私人有限公司 | 调节TNFα的苯并咪唑类 |
| US10202405B2 (en) | 2014-10-03 | 2019-02-12 | Ucb Biopharma Sprl | Fused pentacyclic imidazole derivatives |
-
2016
- 2016-12-09 GB GBGB1620948.8A patent/GB201620948D0/en not_active Ceased
-
2017
- 2017-12-08 SI SI201730672T patent/SI3551624T1/sl unknown
- 2017-12-08 KR KR1020197019326A patent/KR20190091328A/ko not_active Application Discontinuation
- 2017-12-08 BR BR112019008766A patent/BR112019008766A2/pt not_active IP Right Cessation
- 2017-12-08 CA CA3041081A patent/CA3041081A1/en not_active Abandoned
- 2017-12-08 MX MX2019006033A patent/MX2019006033A/es unknown
- 2017-12-08 PL PL17811318T patent/PL3551624T3/pl unknown
- 2017-12-08 SG SG11201903655VA patent/SG11201903655VA/en unknown
- 2017-12-08 WO PCT/EP2017/082092 patent/WO2018104534A1/en unknown
- 2017-12-08 ES ES17811318T patent/ES2853981T3/es active Active
- 2017-12-08 PT PT178113189T patent/PT3551624T/pt unknown
- 2017-12-08 EA EA201991294A patent/EA037199B1/ru unknown
- 2017-12-08 US US16/349,734 patent/US10669263B2/en not_active Expired - Fee Related
- 2017-12-08 JP JP2019529481A patent/JP6983238B2/ja active Active
- 2017-12-08 DK DK17811318.9T patent/DK3551624T3/da active
- 2017-12-08 HU HUE17811318A patent/HUE054184T2/hu unknown
- 2017-12-08 AU AU2017371443A patent/AU2017371443B2/en not_active Ceased
- 2017-12-08 LT LTEP17811318.9T patent/LT3551624T/lt unknown
- 2017-12-08 CN CN201780073716.6A patent/CN110023300B/zh not_active Expired - Fee Related
- 2017-12-08 EP EP17811318.9A patent/EP3551624B1/en active Active
- 2017-12-08 RU RU2019120527A patent/RU2019120527A/ru not_active Application Discontinuation
-
2019
- 2019-05-26 IL IL266874A patent/IL266874B/en unknown
- 2019-06-04 CL CL2019001511A patent/CL2019001511A1/es unknown
- 2019-07-02 CO CONC2019/0007115A patent/CO2019007115A2/es unknown
-
2021
- 2021-03-10 HR HRP20210405TT patent/HRP20210405T1/hr unknown
- 2021-03-22 CY CY20211100245T patent/CY1124158T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK3551624T3 (da) | 2021-03-22 |
| PL3551624T3 (pl) | 2021-07-05 |
| RU2019120527A (ru) | 2021-01-13 |
| EP3551624A1 (en) | 2019-10-16 |
| CL2019001511A1 (es) | 2019-09-06 |
| GB201620948D0 (en) | 2017-01-25 |
| AU2017371443A1 (en) | 2019-05-23 |
| US10669263B2 (en) | 2020-06-02 |
| IL266874A (en) | 2019-07-31 |
| KR20190091328A (ko) | 2019-08-05 |
| ES2853981T3 (es) | 2021-09-20 |
| RU2019120527A3 (ru) | 2021-01-13 |
| CN110023300A (zh) | 2019-07-16 |
| JP6983238B2 (ja) | 2021-12-17 |
| WO2018104534A1 (en) | 2018-06-14 |
| EA037199B1 (ru) | 2021-02-18 |
| SG11201903655VA (en) | 2019-05-30 |
| JP2020502081A (ja) | 2020-01-23 |
| US20190284170A1 (en) | 2019-09-19 |
| HUE054184T2 (hu) | 2021-08-30 |
| AU2017371443B2 (en) | 2021-07-22 |
| BR112019008766A2 (pt) | 2019-07-16 |
| CO2019007115A2 (es) | 2019-07-10 |
| CA3041081A1 (en) | 2018-06-14 |
| MX2019006033A (es) | 2019-08-12 |
| LT3551624T (lt) | 2021-04-26 |
| EP3551624B1 (en) | 2021-01-20 |
| IL266874B (en) | 2022-03-01 |
| SI3551624T1 (sl) | 2021-04-30 |
| CY1124158T1 (el) | 2022-05-27 |
| CN110023300B (zh) | 2022-03-01 |
| PT3551624T (pt) | 2021-02-01 |
| HRP20210405T1 (hr) | 2021-04-16 |
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