EA201890108A1 - Ингибиторы vmat2 для лечения неврологических заболеваний или расстройств - Google Patents

Ингибиторы vmat2 для лечения неврологических заболеваний или расстройств

Info

Publication number
EA201890108A1
EA201890108A1 EA201890108A EA201890108A EA201890108A1 EA 201890108 A1 EA201890108 A1 EA 201890108A1 EA 201890108 A EA201890108 A EA 201890108A EA 201890108 A EA201890108 A EA 201890108A EA 201890108 A1 EA201890108 A1 EA 201890108A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disorders
neurological diseases
treatment
vmat2 inhibitors
vmat2
Prior art date
Application number
EA201890108A
Other languages
English (en)
Other versions
EA036837B1 (ru
Inventor
Кристофер Ф. О'Брайен
Original Assignee
Нейрокрин Байосайенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Нейрокрин Байосайенсиз, Инк. filed Critical Нейрокрин Байосайенсиз, Инк.
Publication of EA201890108A1 publication Critical patent/EA201890108A1/ru
Publication of EA036837B1 publication Critical patent/EA036837B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В настоящем документе предусмотрены способы лечения мании при расстройствах настроения и других неврологических заболеваний или расстройств. Предусмотренные в настоящем документе способы предусматривают введение ингибитора VMAT2 нуждающемуся в этом субъекту. Ингибитор VMAT2, применимый в предусмотренных в настоящем документе способах, включает в себя (2R,3R,11bR)-3-изобутил-9,10-диметокси-1,3,4,6,7,11b-гексагидро-2H-пиридо[2,1-a]изохинолин-2-иловый эфир (S)-2-амино-3-метилмасляной кислоты.
EA201890108A 2015-06-23 2016-06-23 Ингибиторы vmat2 для лечения неврологических заболеваний или расстройств EA036837B1 (ru)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US201562183519P 2015-06-23 2015-06-23
US201562183530P 2015-06-23 2015-06-23
US201562183520P 2015-06-23 2015-06-23
US201562183525P 2015-06-23 2015-06-23
US201562248803P 2015-10-30 2015-10-30
US201562248797P 2015-10-30 2015-10-30
US201562251019P 2015-11-04 2015-11-04
US201562251007P 2015-11-04 2015-11-04
US201562251009P 2015-11-04 2015-11-04
US201562251012P 2015-11-04 2015-11-04
US201562251018P 2015-11-04 2015-11-04
US201562251023P 2015-11-04 2015-11-04
US201562262856P 2015-12-03 2015-12-03
US201562262860P 2015-12-03 2015-12-03
US201662290839P 2016-02-03 2016-02-03
US201662290864P 2016-02-03 2016-02-03
PCT/US2016/039098 WO2016210180A2 (en) 2015-06-23 2016-06-23 Vmat2 inhibitors for treating neurological diseases or disorders

Publications (2)

Publication Number Publication Date
EA201890108A1 true EA201890108A1 (ru) 2018-06-29
EA036837B1 EA036837B1 (ru) 2020-12-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890108A EA036837B1 (ru) 2015-06-23 2016-06-23 Ингибиторы vmat2 для лечения неврологических заболеваний или расстройств

Country Status (14)

Country Link
US (1) US20190015396A1 (ru)
EP (1) EP3313402B1 (ru)
JP (4) JP6919099B2 (ru)
KR (1) KR20180015260A (ru)
CN (2) CN113713108A (ru)
AU (2) AU2016282790B9 (ru)
CA (1) CA2990194A1 (ru)
EA (1) EA036837B1 (ru)
HK (1) HK1248116A1 (ru)
IL (1) IL256380A (ru)
MX (2) MX2017017015A (ru)
MY (1) MY189806A (ru)
PH (1) PH12017502417A1 (ru)
WO (1) WO2016210180A2 (ru)

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Also Published As

Publication number Publication date
MX2022002715A (es) 2022-04-06
AU2016282790A1 (en) 2018-02-08
AU2016282790B9 (en) 2020-01-30
CA2990194A1 (en) 2016-12-29
MY189806A (en) 2022-03-08
US20190015396A1 (en) 2019-01-17
EP3313402B1 (en) 2023-12-27
AU2016282790B2 (en) 2019-10-03
EP3313402A2 (en) 2018-05-02
CN107921032A (zh) 2018-04-17
AU2019280071A1 (en) 2020-01-16
HK1248116A1 (zh) 2018-10-12
KR20180015260A (ko) 2018-02-12
CN107921032B (zh) 2021-09-24
JP2023181540A (ja) 2023-12-21
PH12017502417A1 (en) 2018-06-25
JP6919099B2 (ja) 2021-08-18
JP2022031433A (ja) 2022-02-18
CN113713108A (zh) 2021-11-30
BR112017027839A2 (pt) 2018-09-04
EA036837B1 (ru) 2020-12-25
JP2018518499A (ja) 2018-07-12
WO2016210180A2 (en) 2016-12-29
IL256380A (en) 2018-02-28
MX2017017015A (es) 2018-02-26
JP2020176151A (ja) 2020-10-29
WO2016210180A3 (en) 2017-02-02
EP3313402C0 (en) 2023-12-27
JP7155206B2 (ja) 2022-10-18

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