EA201890013A1 - Способы получения tcr гамма дельтат-клеток - Google Patents
Способы получения tcr гамма дельтат-клетокInfo
- Publication number
- EA201890013A1 EA201890013A1 EA201890013A EA201890013A EA201890013A1 EA 201890013 A1 EA201890013 A1 EA 201890013A1 EA 201890013 A EA201890013 A EA 201890013A EA 201890013 A EA201890013 A EA 201890013A EA 201890013 A1 EA201890013 A1 EA 201890013A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cells
- methods
- deltat
- tcr gamma
- obtaining tcr
- Prior art date
Links
- 230000001902 propagating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
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- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/23—Interleukins [IL]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/2307—Interleukin-7 (IL-7)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
- C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT2015047568 | 2015-06-09 | ||
| PT2016032002 | 2016-05-12 | ||
| PCT/EP2016/063077 WO2016198480A1 (en) | 2015-06-09 | 2016-06-08 | Methods for the production of tcr gamma delta+ t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201890013A1 true EA201890013A1 (ru) | 2018-07-31 |
Family
ID=56132913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890013A EA201890013A1 (ru) | 2015-06-09 | 2016-06-08 | Способы получения tcr гамма дельтат-клеток |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11166983B2 (https=) |
| EP (2) | EP3307875B1 (https=) |
| JP (1) | JP6799895B2 (https=) |
| CN (2) | CN108350428B (https=) |
| AU (3) | AU2016274633B2 (https=) |
| CA (1) | CA2988050A1 (https=) |
| EA (1) | EA201890013A1 (https=) |
| WO (1) | WO2016198480A1 (https=) |
| ZA (1) | ZA201800121B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016081518A2 (en) * | 2014-11-17 | 2016-05-26 | Adicet Bio, Inc. | Engineered gamma delta t-cells |
| KR102663157B1 (ko) | 2015-06-09 | 2024-05-13 | 감마델타 테라퓨틱스 엘티디 | Tcr감마 델타 양성 t 세포의 생산 방법 |
| EP4148124A1 (en) * | 2015-10-30 | 2023-03-15 | Cancer Research Technology Limited | Expansion of non-haematopoietic tissue-resident gamma delta t cells and uses of these cells |
| EP3454870A4 (en) * | 2016-05-12 | 2020-03-04 | Adicet Bio Inc. | METHOD FOR SELECTIVE EXPANSION OF GAMMA DELTA T CELL POPULATIONS AND COMPOSITIONS THEREOF |
| AU2017326173B2 (en) * | 2016-09-16 | 2022-08-18 | Baylor College Of Medicine | Platform for activation and expansion of virus-specific T-cells |
| GB201707048D0 (en) * | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| WO2018229163A1 (en) * | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| WO2019099744A1 (en) | 2017-11-15 | 2019-05-23 | Adicet Bio, Inc. | METHODS FOR SELECTIVE EXPANSION OF δ3 γδ T-CELL POPULATIONS AND COMPOSITIONS THEREOF |
| US10519236B2 (en) * | 2018-01-23 | 2019-12-31 | New York University | Antibodies specific to delta 1 chain of T cell receptor |
| GB201804701D0 (en) | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| AU2019354391A1 (en) | 2018-10-01 | 2021-05-06 | Adicet Therapeutics, Inc. | Compositions and methods regarding engineered and non- engineered γδ-Τ cells for treatment of hematological tumors |
| CN113272016A (zh) | 2018-10-01 | 2021-08-17 | 阿迪塞特生物股份有限公司 | 关于治疗实体肿瘤的工程化和非工程化γδ-T细胞的组合物和方法 |
| GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| US12084500B2 (en) | 2019-01-23 | 2024-09-10 | New York University | Antibodies specific to delta 1 chain of T cell receptor |
| US20220088074A1 (en) * | 2019-02-21 | 2022-03-24 | Regents Of The University Of Minnesota | Genetically modified gamma delta t cells and methods of making and using |
| MX2021015448A (es) * | 2019-06-14 | 2022-06-08 | G Tech Bio Llc | Células linfocíticas activadas y métodos para usarlas para tratar cáncer y afecciones infecciosas. |
| US20220290101A1 (en) | 2019-08-16 | 2022-09-15 | GammaDelta Therapeutics Limited | Ex vivo gamma delta t cell populations |
| CA3145523A1 (en) | 2019-08-16 | 2021-02-25 | GammaDelta Therapeutics Limited | Therapeutic uses of anti-tcr delta variable 1 antibodies |
| EP4045635A4 (en) * | 2019-10-17 | 2023-10-25 | The University of Hong Kong | METHODS FOR PREPARING EXOSOMES DERIVED FROM T-V LYMPHOCYTES FOR THE TREATMENT OF CANCERS ASSOCIATED WITH EPSTEIN-BARR VIRUS |
| US20210130461A1 (en) | 2019-10-31 | 2021-05-06 | Morphosys Ag | Anti-tumor combination therapy comprising anti-cd19 antibody and gamma delta t-cells |
| GB202002581D0 (en) * | 2020-02-24 | 2020-04-08 | Gammadelta Therapeutics Ltd | Novel antibodies |
| KR20230013022A (ko) | 2020-03-20 | 2023-01-26 | 감마델타 테라퓨틱스 엘티디 | 골수성 악성종양의 치료를 위한 v 델타1+ t 세포 |
| US20210290674A1 (en) * | 2020-03-20 | 2021-09-23 | GammaDelta Therapeutics Ltd. | Methods for treating myeloid malignancies |
| CN113913384A (zh) * | 2020-07-09 | 2022-01-11 | 杭州优凯瑞医药科技有限公司 | 一种制备靶点特异性nk细胞的方法及其应用 |
| EP4198120A4 (en) * | 2020-08-14 | 2024-05-08 | Shanghai Xinghua Bio Pharmaceutical Science & Technology Co., Ltd | METHOD FOR PREPARING UNIVERSAL IMMUNE CELLS AND THEIR USE |
| LT4269444T (lt) | 2020-08-14 | 2024-09-25 | GammaDelta Therapeutics Limited | Daugiaspecifiniai anti-tcr kintamos delta 1 antikūnai |
| CA3202233A1 (en) * | 2020-11-18 | 2022-05-27 | Kiromic BioPharma, Inc. | Gamma-delta t cell manufacturing processes and chimeric pd1 receptor molecules |
| TW202246338A (zh) * | 2021-02-17 | 2022-12-01 | 英商適應生物治療有限公司 | 抗TCRδ可變1抗體 |
| AU2022222299A1 (en) | 2021-02-17 | 2023-09-07 | F-Star Therapeutics Limited | Multispecific anti-tcr delta variable 1 antibodies |
| KR20240040799A (ko) | 2021-08-03 | 2024-03-28 | 감마델타 테라퓨틱스 엘티디 | 감마 델타 t 세포 및 이의 조성물의 조작 |
| MX2024010047A (es) | 2022-02-16 | 2024-08-26 | Priothera Sas | Metodos de tratamiento con celulas car en combinacion con moduladores del receptor s1p. |
| WO2023194915A1 (en) | 2022-04-04 | 2023-10-12 | Gammadelta Therapeutics Ltd | Novel gene armoring |
| GB202204926D0 (en) | 2022-04-04 | 2022-05-18 | Gammadelta Therapeutics Ltd | Method for expanding gammadelta T cells |
| US11750950B1 (en) * | 2022-05-26 | 2023-09-05 | Omnivision Technologies, Inc. | Voltage domain global shutter readout circuit timing |
| CN115678846B (zh) * | 2022-09-01 | 2023-06-16 | 广东龄值生物科技有限公司 | 一种肿瘤特异性γδT细胞及其制备方法 |
| EP4680729A1 (en) * | 2023-03-17 | 2026-01-21 | Legend Biotech Ireland Limited | Methods of culturing v delta 1 t cells |
| EP4687923A1 (en) | 2023-04-07 | 2026-02-11 | Takeda Pharmaceutical Company Limited | T cells for use in treating relapsed or refractory acute myeloid leukemia |
| WO2026013616A1 (en) | 2024-07-10 | 2026-01-15 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating cancer |
| WO2026033421A1 (en) | 2024-08-05 | 2026-02-12 | Takeda Pharmaceutical Company Limited | IDENTIFICATION OF SUITABLE DONORS OF γδ T CELLS |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6537812B1 (en) * | 1998-11-04 | 2003-03-25 | Hemosol Inc. | Methods for the production of TcRγδ+ T cells |
| ATE449162T1 (de) | 2000-04-03 | 2009-12-15 | Therapure Biopharma Inc | Herstellung von tcr gamma delta t-zellen |
| US20030157060A1 (en) | 2000-04-03 | 2003-08-21 | Bell David N | Production of tcr gamma delta t cells |
| EP1778836B1 (en) * | 2004-08-19 | 2010-08-04 | University College Cardiff Consultants Limited | Preparation of antigen-presenting human gamma delta t cells and use in immunotherapy |
| CN101313061B (zh) * | 2005-11-18 | 2013-05-15 | 大学健康网络 | 扩增双阴性t细胞的方法 |
| WO2008111430A1 (ja) * | 2007-03-09 | 2008-09-18 | Takara Bio Inc. | γδT細胞集団の製造方法 |
| BR112013009454B1 (pt) | 2010-10-21 | 2018-10-23 | Syngenta Limited | método para redução da viscosidade de um concentrado agroquímico aquoso, concentrado agroquímico aquoso, utilização de um sulfonato de arila e isopirazam para redução da viscosidade de um concentrado agroquímico aquoso e método para controlar ou prevenir a infestação de plantas por micro-organismos fitopatógenos |
| CN103635573B (zh) * | 2011-05-19 | 2016-05-11 | 分子医学研究所 | 包含γδT细胞的淋巴细胞系、其组合物及生产方法 |
| JP2016539929A (ja) * | 2013-10-25 | 2016-12-22 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 免疫療法のためのポリクローナルγδT細胞 |
| EP3484862B1 (en) | 2016-07-18 | 2021-09-01 | Arthrosi Therapeutics, Inc. | Compounds, compositions and methods for treating or preventing a symptom associated with gout or hyperuricemia |
| CN106399245A (zh) * | 2016-11-30 | 2017-02-15 | 广州赛莱拉干细胞科技股份有限公司 | 一种γδT细胞的培养方法 |
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2016
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- 2016-06-08 JP JP2017564369A patent/JP6799895B2/ja active Active
- 2016-06-08 EA EA201890013A patent/EA201890013A1/ru unknown
- 2016-06-08 WO PCT/EP2016/063077 patent/WO2016198480A1/en not_active Ceased
- 2016-06-08 EP EP16729531.0A patent/EP3307875B1/en active Active
- 2016-06-08 EP EP19207256.9A patent/EP3623468A1/en active Pending
- 2016-06-08 US US15/735,371 patent/US11166983B2/en active Active
- 2016-06-08 CA CA2988050A patent/CA2988050A1/en active Pending
- 2016-06-08 CN CN202210397884.3A patent/CN114958738A/zh active Pending
-
2018
- 2018-01-08 ZA ZA2018/00121A patent/ZA201800121B/en unknown
-
2022
- 2022-07-15 AU AU2022205271A patent/AU2022205271A1/en not_active Abandoned
-
2024
- 2024-11-21 US US18/955,830 patent/US20250152630A1/en active Pending
-
2025
- 2025-04-23 AU AU2025202866A patent/AU2025202866A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN114958738A (zh) | 2022-08-30 |
| EP3307875A1 (en) | 2018-04-18 |
| EP3623468A1 (en) | 2020-03-18 |
| US11166983B2 (en) | 2021-11-09 |
| AU2025202866A1 (en) | 2025-05-15 |
| AU2022205271A1 (en) | 2022-08-11 |
| CN108350428A (zh) | 2018-07-31 |
| US20250152630A1 (en) | 2025-05-15 |
| EP3307875B1 (en) | 2021-12-15 |
| JP6799895B2 (ja) | 2020-12-16 |
| US20180169147A1 (en) | 2018-06-21 |
| NZ738912A (en) | 2025-05-02 |
| JP2018516586A (ja) | 2018-06-28 |
| ZA201800121B (en) | 2019-08-28 |
| CA2988050A1 (en) | 2016-12-15 |
| WO2016198480A1 (en) | 2016-12-15 |
| CN108350428B (zh) | 2022-04-22 |
| HK1245831A1 (zh) | 2018-08-31 |
| AU2016274633A1 (en) | 2018-02-01 |
| AU2016274633B2 (en) | 2022-04-21 |
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