CA2988050A1 - Methods for the production of tcr gamma delta+ t cells - Google Patents

Methods for the production of tcr gamma delta+ t cells Download PDF

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Publication number
CA2988050A1
CA2988050A1 CA2988050A CA2988050A CA2988050A1 CA 2988050 A1 CA2988050 A1 CA 2988050A1 CA 2988050 A CA2988050 A CA 2988050A CA 2988050 A CA2988050 A CA 2988050A CA 2988050 A1 CA2988050 A1 CA 2988050A1
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Prior art keywords
cells
interleukin
cell
delta
gamma
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Pending
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CA2988050A
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English (en)
French (fr)
Inventor
Diogo Antonio Remechido ANJOS
Daniel Vargas Correia
Afonso Rocha MARTINS DE ALMEIDA
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GammaDelta Therapeutics Ltd
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Lymphact - Lymphocyte Activation Technologies SA
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Publication of CA2988050A1 publication Critical patent/CA2988050A1/en
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/2321—Interleukin-21 (IL-21)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2988050A 2015-06-09 2016-06-08 Methods for the production of tcr gamma delta+ t cells Pending CA2988050A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PT20151000047568 2015-06-09
PT2015047568 2015-06-09
PT20161000032002 2016-05-12
PT2016032002 2016-05-12
PCT/EP2016/063077 WO2016198480A1 (en) 2015-06-09 2016-06-08 Methods for the production of tcr gamma delta+ t cells

Publications (1)

Publication Number Publication Date
CA2988050A1 true CA2988050A1 (en) 2016-12-15

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CA2988050A Pending CA2988050A1 (en) 2015-06-09 2016-06-08 Methods for the production of tcr gamma delta+ t cells

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US (2) US11166983B2 (https=)
EP (2) EP3307875B1 (https=)
JP (1) JP6799895B2 (https=)
CN (2) CN108350428B (https=)
AU (3) AU2016274633B2 (https=)
CA (1) CA2988050A1 (https=)
EA (1) EA201890013A1 (https=)
WO (1) WO2016198480A1 (https=)
ZA (1) ZA201800121B (https=)

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CN114958738A (zh) 2022-08-30
EP3307875A1 (en) 2018-04-18
EP3623468A1 (en) 2020-03-18
EA201890013A1 (ru) 2018-07-31
US11166983B2 (en) 2021-11-09
AU2025202866A1 (en) 2025-05-15
AU2022205271A1 (en) 2022-08-11
CN108350428A (zh) 2018-07-31
US20250152630A1 (en) 2025-05-15
EP3307875B1 (en) 2021-12-15
JP6799895B2 (ja) 2020-12-16
US20180169147A1 (en) 2018-06-21
NZ738912A (en) 2025-05-02
JP2018516586A (ja) 2018-06-28
ZA201800121B (en) 2019-08-28
WO2016198480A1 (en) 2016-12-15
CN108350428B (zh) 2022-04-22
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AU2016274633A1 (en) 2018-02-01
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