EA201790186A1 - Замещенные азаспиро(4.5)декановые производные - Google Patents
Замещенные азаспиро(4.5)декановые производныеInfo
- Publication number
- EA201790186A1 EA201790186A1 EA201790186A EA201790186A EA201790186A1 EA 201790186 A1 EA201790186 A1 EA 201790186A1 EA 201790186 A EA201790186 A EA 201790186A EA 201790186 A EA201790186 A EA 201790186A EA 201790186 A1 EA201790186 A1 EA 201790186A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- decane derivatives
- substituted azaspiro
- substituted
- compounds
- preparation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
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- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение относится к замещенным спироциклическим циклогексановым производным, которые обладают аффинностью к μопиоидному рецептору и ORL1 рецептору, способам их получения, лекарственным средствам, содержащим такие соединения, и применению таких соединений для получения лекарственных средств.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14002438 | 2014-07-15 | ||
PCT/EP2015/001446 WO2016008583A1 (de) | 2014-07-15 | 2015-07-14 | Substituierte aza-spiro(4.5)decan-derivate |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201790186A1 true EA201790186A1 (ru) | 2017-07-31 |
Family
ID=51211483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790186A EA201790186A1 (ru) | 2014-07-15 | 2015-07-14 | Замещенные азаспиро(4.5)декановые производные |
Country Status (22)
Country | Link |
---|---|
US (1) | US10202345B2 (ru) |
EP (1) | EP3169665B1 (ru) |
JP (1) | JP6490187B2 (ru) |
CN (1) | CN106536514A (ru) |
AU (1) | AU2015291468B2 (ru) |
BR (1) | BR112017000766A2 (ru) |
CA (1) | CA2955073A1 (ru) |
CY (1) | CY1120443T1 (ru) |
DK (1) | DK3169665T3 (ru) |
EA (1) | EA201790186A1 (ru) |
ES (1) | ES2680820T3 (ru) |
HR (1) | HRP20180940T1 (ru) |
HU (1) | HUE039604T2 (ru) |
LT (1) | LT3169665T (ru) |
MX (1) | MX2017000519A (ru) |
PL (1) | PL3169665T3 (ru) |
PT (1) | PT3169665T (ru) |
RS (1) | RS57388B1 (ru) |
SI (1) | SI3169665T1 (ru) |
TR (1) | TR201809663T4 (ru) |
TW (1) | TW201607923A (ru) |
WO (1) | WO2016008583A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2955071A1 (en) * | 2014-07-15 | 2016-01-21 | Grunenthal Gmbh | Substituted azaspiro(4.5)decane derivatives |
WO2019152688A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
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ZA827340B (en) * | 1981-11-12 | 1983-10-26 | Upjohn Co | Analgesic 1-oxa-,aza-and thia-spirocyclic compounds |
DE3928182A1 (de) | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von gabapentin |
DE19608653A1 (de) | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
CA2309175A1 (en) | 1997-11-04 | 1999-05-14 | Pfizer Products Inc. | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
WO2000073300A1 (en) * | 1999-06-02 | 2000-12-07 | Warner-Lambert Company | Amino heterocycles useful as pharmaceutical agents |
HUP9902374A3 (en) | 1999-07-15 | 2002-11-28 | Sanofi Aventis | Process for producing spiro[(4-cyclohexanone)-[3h]indol-2'[1'h]-on derivatives and intermediates |
DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
CA2445159C (en) | 2001-04-24 | 2012-09-11 | Massachusetts Institute Of Technology | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
DE10210190A1 (de) * | 2002-03-07 | 2003-09-25 | Sanol Arznei Schwarz Gmbh | Aza-Spiroverbindungen |
NZ538307A (en) | 2002-09-09 | 2008-04-30 | Janssen Pharmaceutica Nv | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
DE10252665A1 (de) * | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10360793A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
CN101018781A (zh) | 2004-09-13 | 2007-08-15 | 默克公司 | 双环n-酰苯胺螺内酰胺cgrp受体拮抗剂 |
CN101061112A (zh) | 2004-09-17 | 2007-10-24 | Osi制药公司 | 作为c-Kit原癌基因抑制剂的(螺环基酰氨基)氨基噻吩化合物 |
DE102005016460A1 (de) | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
DE102005038141A1 (de) * | 2005-08-12 | 2007-02-15 | Grünenthal GmbH | Substituierte 8-(3-Aminopropyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-on-Derivate |
TW200800999A (en) | 2005-09-06 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
JP5225098B2 (ja) | 2005-12-14 | 2013-07-03 | ブリストル−マイヤーズ スクイブ カンパニー | 第XIa因子インヒビターとしてのアリールプロピオンアミド、アリールアクリルアミド、アリールプロピンアミド、またはアリールメチルウレアアナログ |
DE102005061428A1 (de) | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
BRPI0710231A2 (pt) | 2006-04-25 | 2011-08-02 | Lilly Co Eli | composto, composição farmacêutica, e, intermediário para a preparação de um composto |
DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
DE102006033109A1 (de) | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
DE602007007497D1 (de) | 2006-09-18 | 2010-08-12 | Hoffmann La Roche | Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel |
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DE102007009319A1 (de) | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102007009235A1 (de) * | 2007-02-22 | 2008-09-18 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
MX2009009355A (es) | 2007-03-01 | 2009-09-11 | Mitsubishi Tanabe Pharma Corp | Compuesto de bencimidazol y uso farmaceutico del mismo. |
GB0707934D0 (en) | 2007-04-24 | 2007-05-30 | Glaxo Group Ltd | Chemical compounds |
WO2009111056A1 (en) | 2008-03-06 | 2009-09-11 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
DK2260042T3 (da) | 2008-03-27 | 2011-10-31 | Gruenenthal Gmbh | Substituerede spirocykliske cyklohexan-derivater |
ES2663398T3 (es) * | 2008-03-27 | 2018-04-12 | Grünenthal GmbH | Derivados de 4-aminociclohexano sustituidos |
WO2009118174A1 (de) | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | Substituierte cyclohexyldiamine |
CL2009000732A1 (es) | 2008-03-27 | 2009-05-15 | Gruenethal Gmbh | Compuestos derivados de hidroximetil ciclohexilaminas sustituidos; composicion farmaceutica que contiene a dicho compuesto y sus uso como moduladores del receptor de opiodes u y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso del alcohol, hipertension, anorexia, obesidad y diarrea. |
MX2010010337A (es) * | 2008-03-27 | 2010-10-07 | Gruenenthal Gmbh | Derivados de espiro(5.5)undecano. |
PT2326651E (pt) | 2008-07-30 | 2014-02-12 | Purdue Pharma Lp | Análogos de buprenorfina |
UA107943C2 (en) | 2009-11-16 | 2015-03-10 | Lilly Co Eli | Compounds of spiropiperidines as antagonists of the orl-1 receptors |
GB201111775D0 (en) | 2011-07-08 | 2011-08-24 | Univ Bath | Compounds and uses thereof |
CN107266345B (zh) * | 2011-10-20 | 2021-08-17 | 奥瑞泽恩基因组学股份有限公司 | 作为lsd1抑制剂的(杂)芳基环丙胺化合物 |
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2015
- 2015-07-13 TW TW104122500A patent/TW201607923A/zh unknown
- 2015-07-14 EA EA201790186A patent/EA201790186A1/ru unknown
- 2015-07-14 MX MX2017000519A patent/MX2017000519A/es unknown
- 2015-07-14 EP EP15737988.4A patent/EP3169665B1/de active Active
- 2015-07-14 CA CA2955073A patent/CA2955073A1/en not_active Abandoned
- 2015-07-14 PL PL15737988T patent/PL3169665T3/pl unknown
- 2015-07-14 LT LTEP15737988.4T patent/LT3169665T/lt unknown
- 2015-07-14 BR BR112017000766A patent/BR112017000766A2/pt not_active Application Discontinuation
- 2015-07-14 WO PCT/EP2015/001446 patent/WO2016008583A1/de active Application Filing
- 2015-07-14 PT PT157379884T patent/PT3169665T/pt unknown
- 2015-07-14 HU HUE15737988A patent/HUE039604T2/hu unknown
- 2015-07-14 AU AU2015291468A patent/AU2015291468B2/en not_active Ceased
- 2015-07-14 CN CN201580038748.3A patent/CN106536514A/zh active Pending
- 2015-07-14 TR TR2018/09663T patent/TR201809663T4/tr unknown
- 2015-07-14 SI SI201530295T patent/SI3169665T1/en unknown
- 2015-07-14 RS RS20180789A patent/RS57388B1/sr unknown
- 2015-07-14 ES ES15737988T patent/ES2680820T3/es active Active
- 2015-07-14 JP JP2017502128A patent/JP6490187B2/ja not_active Expired - Fee Related
- 2015-07-14 DK DK15737988.4T patent/DK3169665T3/en active
- 2015-07-15 US US14/799,872 patent/US10202345B2/en not_active Expired - Fee Related
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2018
- 2018-06-18 HR HRP20180940TT patent/HRP20180940T1/hr unknown
- 2018-07-11 CY CY20181100722T patent/CY1120443T1/el unknown
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Publication number | Publication date |
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LT3169665T (lt) | 2018-07-10 |
DK3169665T3 (en) | 2018-06-25 |
PT3169665T (pt) | 2018-07-12 |
MX2017000519A (es) | 2017-05-01 |
CY1120443T1 (el) | 2019-07-10 |
RS57388B1 (sr) | 2018-09-28 |
SI3169665T1 (en) | 2018-08-31 |
HUE039604T2 (hu) | 2019-01-28 |
AU2015291468B2 (en) | 2019-01-24 |
JP6490187B2 (ja) | 2019-03-27 |
BR112017000766A2 (pt) | 2017-11-21 |
AU2015291468A1 (en) | 2017-03-02 |
PL3169665T3 (pl) | 2018-12-31 |
TW201607923A (zh) | 2016-03-01 |
ES2680820T3 (es) | 2018-09-11 |
CA2955073A1 (en) | 2016-01-21 |
US10202345B2 (en) | 2019-02-12 |
TR201809663T4 (tr) | 2018-07-23 |
EP3169665B1 (de) | 2018-05-09 |
US20160016903A1 (en) | 2016-01-21 |
WO2016008583A1 (de) | 2016-01-21 |
HRP20180940T1 (hr) | 2018-07-27 |
CN106536514A (zh) | 2017-03-22 |
EP3169665A1 (de) | 2017-05-24 |
JP2017520599A (ja) | 2017-07-27 |
WO2016008583A8 (de) | 2016-03-31 |
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