EA201700215A1 - METHOD OF OBTAINING A BIOACTIVE COATING WITH ANTI-BACTERIAL EFFECT - Google Patents

METHOD OF OBTAINING A BIOACTIVE COATING WITH ANTI-BACTERIAL EFFECT

Info

Publication number
EA201700215A1
EA201700215A1 EA201700215A EA201700215A EA201700215A1 EA 201700215 A1 EA201700215 A1 EA 201700215A1 EA 201700215 A EA201700215 A EA 201700215A EA 201700215 A EA201700215 A EA 201700215A EA 201700215 A1 EA201700215 A1 EA 201700215A1
Authority
EA
Eurasian Patent Office
Prior art keywords
implants
additive
bioactive coating
bioactive
obtaining
Prior art date
Application number
EA201700215A
Other languages
Russian (ru)
Other versions
EA033318B1 (en
Inventor
Евгений Александрович Левашов
Александр Евгеньевич Кудряшов
Евгения Игоревна Замулаева
Дмитрий Владимирович Штанский
Юрий Сергеевич Погожев
Артем Юрьевич Потанин
Наталия Владимировна Швындина
Original Assignee
Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский технологический университет "МИСиС"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2014142171/15A external-priority patent/RU2580628C1/en
Priority claimed from RU2014142170/15A external-priority patent/RU2580627C1/en
Application filed by Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский технологический университет "МИСиС" filed Critical Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский технологический университет "МИСиС"
Publication of EA201700215A1 publication Critical patent/EA201700215A1/en
Publication of EA033318B1 publication Critical patent/EA033318B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/06—Coatings containing a mixture of two or more compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Dental Prosthetics (AREA)

Abstract

Изобретение относится к поверхностной обработке металлов и их сплавов медицинского назначения и может быть использовано при изготовлении имплантатов, предназначенных для замены поврежденных участков костной ткани, к которым относятся, в частности, ортопедические и дентальные имплантаты, имплантаты для челюстно-лицевой хирургии и хирургии позвоночника, искусственные сочленения, фиксаторы и др. Технический результат, достигаемый в предложенном способе, заключается в обеспечении получения на имплантатах, изготовленных из специальных сплавов медицинского назначения, сплошных биосовместимых, биоактивных покрытий с антибактериальным эффектом с высокой величиной адгезии (более 100 Н), высокой износостойкостью и с заданным рельефом. Технический результат достигается следующим образом. Способ получения биоактивного покрытия с антибактериальным эффектом включает электроискровую обработку поверхности подложки обрабатывающим электродом следующего состава (вес.%): биоактивная добавка - 5-40, антибактериальная металлическая добавка - 0,5-5, биосовместимая добавка в виде металла или тугоплавкого соединения - остальное. Электроискровую обработку проводят при следующих режимах: 100≤N≤10000, 10≤f≤100000, 0,01≤v≤0,6, где N- мощность единичного импульсного разряда, Вт; f - частота импульсных разрядов, Гц; v - линейная скорость перемещения обрабатывающего электрода, м/мин.The invention relates to the surface treatment of metals and their alloys for medical purposes and can be used in the manufacture of implants intended to replace damaged areas of bone tissue, which include, in particular, orthopedic and dental implants, implants for maxillofacial surgery and spinal surgery, artificial joints, clamps, etc. The technical result achieved in the proposed method is to ensure that the implants made from special melts medical purposes, solid biocompatible, bioactive coating with antibacterial effect with high adhesion value (more than 100 N), high wear resistance and with a given relief. The technical result is achieved as follows. The method of obtaining a bioactive coating with an antibacterial effect includes an electrospark surface treatment of the substrate with a processing electrode of the following composition (wt.%): Bioactive additive - 5-40, antibacterial metal additive - 0.5-5, biocompatible additive in the form of a metal or refractory compound - the rest. Electrical spark treatment is carried out under the following modes: 100≤N≤10000, 10≤f≤100000, 0.01≤v≤0.6, where N is the power of a single pulse discharge, W; f is the frequency of pulse discharges, Hz; v - linear speed of movement of the processing electrode, m / min.

EA201700215A 2014-10-21 2015-01-30 Method of producing a bioactive coating with antibacterial effect EA033318B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2014142171/15A RU2580628C1 (en) 2014-10-21 2014-10-21 Method for producing bioactive coating with antibacterial effect
RU2014142170/15A RU2580627C1 (en) 2014-10-21 2014-10-21 Method for producing bioactive coating with antibacterial effect
PCT/RU2015/000055 WO2016064296A1 (en) 2014-10-21 2015-01-30 Method of producing the bioactive coating with antibacterial effect

Publications (2)

Publication Number Publication Date
EA201700215A1 true EA201700215A1 (en) 2017-08-31
EA033318B1 EA033318B1 (en) 2019-09-30

Family

ID=55761216

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201700215A EA033318B1 (en) 2014-10-21 2015-01-30 Method of producing a bioactive coating with antibacterial effect

Country Status (2)

Country Link
EA (1) EA033318B1 (en)
WO (1) WO2016064296A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115120783A (en) * 2022-06-29 2022-09-30 湖南华翔医疗科技有限公司 Porous titanium-based antibacterial active material, and preparation method and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2524654C1 (en) * 2013-06-21 2014-07-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Национальный исследовательский технологический университет "МИСиС" Multicomponent bioactive nanocomposite coating with antibacterial effect

Also Published As

Publication number Publication date
EA033318B1 (en) 2019-09-30
WO2016064296A1 (en) 2016-04-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ KG TJ TM RU